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Variation in uptake of sodium glucose cotransporter 2 inhibitors and glucagon-like peptide-1 receptor analogues in adults with type 2 diabetes at high cardiovascular risk
Variation in uptake of sodium glucose cotransporter 2 inhibitors and glucagon-like peptide-1 receptor analogues in adults with type 2 diabetes at high cardiovascular risk
We quantified variation in the uptake of sodium-glucose co-transporter 2 inhibitors (SGLT2i) and glucagon-like peptide-1 r...
Pretomanid can significantly increase plasma rivaroxaban concentrations—a case report
Pretomanid can significantly increase plasma rivaroxaban concentrations—a case report
Rivaroxaban, a direct factor Xa inhibitor, is an oral anticoagulant used in the prevention and treatment of thromboembolic...
Dosing prediction of valproic acid in pediatric patients with epilepsy: population pharmacokinetic model or machine learning model?
Dosing prediction of valproic acid in pediatric patients with epilepsy: population pharmacokinetic model or machine learning model?
This study develops and compares population pharmacokinetics (PopPK) models and machine learning methods, including neural...
A meta-analysis and systematic review of the first Trop-2-targeting antibody–drug conjugate (sacituzumab govitecan) in treating metastatic breast cancer
A meta-analysis and systematic review of the first Trop-2-targeting antibody–drug conjugate (sacituzumab govitecan) in treating metastatic breast cancer
To assess the effectiveness and safety of sacituzumab govitecan in metastatic breast cancer (MBC), we performed a meta-ana...
Post-marketing safety signals of imatinib: pharmacovigilance insights from the FDA Adverse Event Reporting System (FAERS) and implications for clinical practice
Post-marketing safety signals of imatinib: pharmacovigilance insights from the FDA Adverse Event Reporting System (FAERS) and implications for clinical practice
To evaluate the safety profile of imatinib using the FDA Adverse Event Reporting System (FAERS) database, identifying both...
Optimization of vitamin K antagonist treatment: Near patient monitoring versus standard of care a parallel group clinical trial in older patients with atrial fibrillation
Optimization of vitamin K antagonist treatment: Near patient monitoring versus standard of care a parallel group clinical trial in older patients with atrial fibrillation
Atrial fibrillation (AF) is common in the elderly population and is associated with a high risk of thromboembolic events. ...
Cost-effectiveness of abortive and preventative treatments in patients with migraine: a systematic review
Cost-effectiveness of abortive and preventative treatments in patients with migraine: a systematic review
Migraine imposes significant personal, societal, and economic burdens globally. Both abortive and preventative medications...
Effectiveness and safety of concomitant use of direct oral anticoagulants and antiarrhythmic drugs: a systematic review of observational studies
Effectiveness and safety of concomitant use of direct oral anticoagulants and antiarrhythmic drugs: a systematic review of observational studies
Concomitant use of antiarrhythmic drugs (AAs) may affect the effectiveness and safety of direct oral anticoagulants (DOACs...
The effects of trazodone exposure during pregnancy on fetal outcomes: a systematic review
The effects of trazodone exposure during pregnancy on fetal outcomes: a systematic review
Trazodone, a medication primarily used for anxiety and insomnia, is increasingly prescribed during pregnancy despite limit...
Pharmacogenetics and pharmacometabolomics predictors of clozapine and norclozapine pharmacokinetic exposure in healthy volunteers
Pharmacogenetics and pharmacometabolomics predictors of clozapine and norclozapine pharmacokinetic exposure in healthy volunteers
Clozapine is the only effective medication for unresponsive schizophrenia. However, it has a complicated dose-concentratio...
External validation of population pharmacokinetic models of oxcarbazepine active metabolite in Chinese children with epilepsy
External validation of population pharmacokinetic models of oxcarbazepine active metabolite in Chinese children with epilepsy
To assess the predictive performance of published population pharmacokinetic models of the oxcarbazepine (OXC) active meta...
Barriers and solutions for the European prescribing exam: a qualitative world café study
Barriers and solutions for the European prescribing exam: a qualitative world café study
To harmonize and modernize clinical pharmacology and therapeutics (CPT) education across Europe, we developed the European...
Long-term results of a multidisciplinary medication optimization program for older adults including primary care and hospital team
Long-term results of a multidisciplinary medication optimization program for older adults including primary care and hospital team
Therapeutic optimization and deprescribing in older adults face multiple barriers, whereas drug-related hospitalization in...
Study on disproportionality in the detection of potential signals between quetiapine and diabetic ketoacidosis
Study on disproportionality in the detection of potential signals between quetiapine and diabetic ketoacidosis
Quetiapine is an atypical second-generation antipsychotic. Diabetic ketoacidosis (DKA) is an acute metabolic complication,...
The cost-effectiveness analysis of semaglutide for the treatment of adult and adolescent patients with overweight and obesity: a systematic review
The cost-effectiveness analysis of semaglutide for the treatment of adult and adolescent patients with overweight and obesity: a systematic review
The present study aimed to systematically collect and synthesize available cost-effectiveness studies of semaglutide in pa...
Sodium-glucose cotransporter 2 inhibitors and renal cancer in the US FDA adverse event reporting system
Sodium-glucose cotransporter 2 inhibitors and renal cancer in the US FDA adverse event reporting system
Recent evidence suggests an association between sodium-glucose cotransporter 2 (SGLT2) inhibitors and a higher risk of ren...
Efficacy of tacrolimus versus cyclosporine after lung transplantation: an updated systematic review, meta-analysis, and trial sequential analysis of randomized controlled trials
Efficacy of tacrolimus versus cyclosporine after lung transplantation: an updated systematic review, meta-analysis, and trial sequential analysis of randomized controlled trials
Little data supports using tacrolimus versus cyclosporin for immunosuppression concerning acute rejection and bronchioliti...
Efficacy and safety of ticagrelor monotherapy following a brief DAPT vs. prolonged 12-month DAPT in ACS patients post-PCI: a meta-analysis of RCTs
Efficacy and safety of ticagrelor monotherapy following a brief DAPT vs. prolonged 12-month DAPT in ACS patients post-PCI: a meta-analysis of RCTs
As per current guidelines, acute coronary syndrome (ACS) patients who undergo percutaneous coronary intervention (PCI) sho...
Comment on “Use of statins and risks of ovarian, uterine, and cervical diseases: a cohort study in the UK Biobank”
Comment on “Use of statins and risks of ovarian, uterine, and cervical diseases: a cohort study in the UK Biobank”
Cite this articleChung, PY., Liao, KF. & Lai, SW. Comment on “Use of statins and risks of ovarian, uterine, and cervic...
Dose reduction and discontinuation due to the combination of CDK4/6 inhibitors and endocrine drugs: a systematic review and meta-analysis
Dose reduction and discontinuation due to the combination of CDK4/6 inhibitors and endocrine drugs: a systematic review and meta-analysis
With the widespread use of CDK4/6 inhibitors, the number of discontinuations and reductions due to adverse events is incre...
Pharmacokinetics-pharmacodynamics of first-line antitubercular drugs: a comparative study in tuberculosis patients with and without concomitant diabetes mellitus
Pharmacokinetics-pharmacodynamics of first-line antitubercular drugs: a comparative study in tuberculosis patients with and without concomitant diabetes mellitus
To observe the variability in the plasma concentrations and pharmacokinetic-pharmacodynamic (PK-PD) profiles of first-line...
Evaluation of the predictive performance of an online voriconazole dose calculator in children
Evaluation of the predictive performance of an online voriconazole dose calculator in children
The dosing of voriconazole is challenging in pediatrics. One approach to improve the dosing is through the use of Bayesian...
Preventive effects of first-generation antihistamine on emergence agitation or delirium: a systematic review
Preventive effects of first-generation antihistamine on emergence agitation or delirium: a systematic review
The effects of first-generation antihistamines in preventing postoperative emergence agitation or delirium are unclear. De...
The impact of age and renal function on the pharmacokinetics and protein binding characteristics of fludarabine in paediatric and adult patients undergoing allogeneic haematopoietic stem cell transplantation conditioning
The impact of age and renal function on the pharmacokinetics and protein binding characteristics of fludarabine in paediatric and adult patients undergoing allogeneic haematopoietic stem cell transplantation conditioning
To evaluate the population pharmacokinetics of unbound F-Ara-A (the circulating metabolite of fludarabine) in 211 patients...
A critical review on approaches to generate and validate virtual population for physiologically based pharmacokinetic models: Methodologies, case studies and way forward
A critical review on approaches to generate and validate virtual population for physiologically based pharmacokinetic models: Methodologies, case studies and way forward
In silico modeling and simulation techniques such as physiologically based pharmacokinetic (PBPK) and physiologically base...
Identification of the most cost-saving disease-modifying therapies and factors affecting the budget in the pharmacotherapy of multiple sclerosis: a systematic review
Identification of the most cost-saving disease-modifying therapies and factors affecting the budget in the pharmacotherapy of multiple sclerosis: a systematic review
Multiple sclerosis (MS) is an immune-mediated disease that has a considerable health-related quality of life interference....
Is nivolumab alone or in combination with ipilimumab more effective for treating lung cancer? a meta-analysis
Is nivolumab alone or in combination with ipilimumab more effective for treating lung cancer? a meta-analysis
Nivolumab and ipilimumab combination immunotherapy has become a standard treatment option for certain cancers. However, th...
Serious gaming as potential training tool for recognition of adverse drug reactions: side-effect exposure—medical education (SeeMe)
Serious gaming as potential training tool for recognition of adverse drug reactions: side-effect exposure—medical education (SeeMe)
The recognition of adverse drug reactions (ADRs) is an important part of daily clinical work. However, medical education i...
Prognostic effect of a vasopressin V2 receptor antagonist in acute congestive heart failure patients with hypoperfusion, the wet–cold pattern
Prognostic effect of a vasopressin V2 receptor antagonist in acute congestive heart failure patients with hypoperfusion, the wet–cold pattern
This study investigated whether the oral vasopressin V2 receptor antagonist tolvaptan has beneficial effects on mortality ...
Treatment-related adverse events in patients with advanced breast cancer receiving adjuvant AKT inhibitors: a meta-analysis of randomized controlled trials
Treatment-related adverse events in patients with advanced breast cancer receiving adjuvant AKT inhibitors: a meta-analysis of randomized controlled trials
Incorporation of AKT inhibitors into adjuvant therapy for advanced or metastatic breast cancer has improved clinical outco...
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