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Serious gaming as potential training tool for recognition of adverse drug reactions: side-effect exposure—medical education (SeeMe)
Serious gaming as potential training tool for recognition of adverse drug reactions: side-effect exposure—medical education (SeeMe)
The recognition of adverse drug reactions (ADRs) is an important part of daily clinical work. However, medical education i...
Prognostic effect of a vasopressin V2 receptor antagonist in acute congestive heart failure patients with hypoperfusion, the wet–cold pattern
Prognostic effect of a vasopressin V2 receptor antagonist in acute congestive heart failure patients with hypoperfusion, the wet–cold pattern
This study investigated whether the oral vasopressin V2 receptor antagonist tolvaptan has beneficial effects on mortality ...
Treatment-related adverse events in patients with advanced breast cancer receiving adjuvant AKT inhibitors: a meta-analysis of randomized controlled trials
Treatment-related adverse events in patients with advanced breast cancer receiving adjuvant AKT inhibitors: a meta-analysis of randomized controlled trials
Incorporation of AKT inhibitors into adjuvant therapy for advanced or metastatic breast cancer has improved clinical outco...
Population pharmacokinetics and dosage optimization of linezolid in Chinese older patients
Population pharmacokinetics and dosage optimization of linezolid in Chinese older patients
To assess the pharmacokinetics and pharmacodynamics of linezolid in a retrospective cohort of hospitalized Chinese older p...
Development and validation of individualized tacrolimus dosing software for Chinese pediatric liver transplantation patients: a population pharmacokinetic approach
Development and validation of individualized tacrolimus dosing software for Chinese pediatric liver transplantation patients: a population pharmacokinetic approach
We aim to describe the population pharmacokinetics (PPK) of tacrolimus in Chinese pediatric patients under 4 year...
Reliability and validity of the Swedish indicator ‘Drugs that should be avoided in older people’—an appraisal of a set of potentially inappropriate medications
Reliability and validity of the Swedish indicator ‘Drugs that should be avoided in older people’—an appraisal of a set of potentially inappropriate medications
To analyse the reliability and validity of the Swedish indicator ‘Drugs that should be avoided in older people’...
Quantitative evaluation of the efficacy and safety profiles of two types of targeted inhibitors combined with endocrine therapy in ER+/HER2− metastatic breast cancer
Quantitative evaluation of the efficacy and safety profiles of two types of targeted inhibitors combined with endocrine therapy in ER+/HER2− metastatic breast cancer
The aim of this study was to quantitatively compare the efficacy and safety of CDK4/6 inhibitors and PI3K/AKT/mTOR inhibit...
Apixaban plasma concentrations in patients with obesity
Apixaban plasma concentrations in patients with obesity
Routine therapeutic drug monitoring of apixaban is currently not recommended but may however be warranted in some situatio...
Population pharmacokinetic, pharmacodynamic and efficacy modeling of SB12 (proposed eculizumab biosimilar) and reference eculizumab
Population pharmacokinetic, pharmacodynamic and efficacy modeling of SB12 (proposed eculizumab biosimilar) and reference eculizumab
To describe, compare similarity of pharmacokinetic (PK), pharmacodynamic (PD) and efficacy of SB12 and reference eculizuma...
Trends in statin use for the primary prevention of atherosclerotic cardiovascular disease among US adults by demographic characteristics, 1999–2020
Trends in statin use for the primary prevention of atherosclerotic cardiovascular disease among US adults by demographic characteristics, 1999–2020
Atherosclerotic cardiovascular disease (ASCVD) is a leading cause of mortality worldwide. Statins, which are effective in ...
Synergizing pharmacometrics and pharmacovigilance for medication error management: the case of secukinumab
Synergizing pharmacometrics and pharmacovigilance for medication error management: the case of secukinumab
To demonstrate the effective integration of pharmacometrics and pharmacovigilance in managing medication errors, highlight...
Assessment of body mass-related covariates for rifampicin pharmacokinetics in healthy Caucasian volunteers
Assessment of body mass-related covariates for rifampicin pharmacokinetics in healthy Caucasian volunteers
Currently, body weight-based dosing of rifampicin is recommended. But lately, fat-free mass (FFM) was reported to be super...
The safety and efficacy of bevacizumab in treatment of recurrent low-grade glioma: a systematic review and meta-analysis
The safety and efficacy of bevacizumab in treatment of recurrent low-grade glioma: a systematic review and meta-analysis
Central nervous system (CNS) tumors are among the most common malignancies in various age ranges. Low-grade glioma (LGG) c...
Population pharmacokinetics of free and liposome-encapsulated mitoxantrone in patients with relapsed/refractory lymphoma or small cell lung cancer
Population pharmacokinetics of free and liposome-encapsulated mitoxantrone in patients with relapsed/refractory lymphoma or small cell lung cancer
This study is aimed at investigating the pharmacokinetic (PK) characteristics of pegylated liposomal mitoxantrone (PLM) in...
Assessment of a systematic approach for implementing novel medications in clinical practice: an observational study with dapagliflozin
Assessment of a systematic approach for implementing novel medications in clinical practice: an observational study with dapagliflozin
To assess a systematic implementation approach for introducing dapagliflozin to individuals with heart failure and reduced...
Challenges of pediatric pharmacotherapy: A narrative review of pharmacokinetics, pharmacodynamics, and pharmacogenetics
Challenges of pediatric pharmacotherapy: A narrative review of pharmacokinetics, pharmacodynamics, and pharmacogenetics
Personalized pharmacotherapy, including for the pediatric population, provides optimal treatment and has emerged as a majo...
Selective androgen receptor modulator use and related adverse events including drug-induced liver injury: Analysis of suspected cases
Selective androgen receptor modulator use and related adverse events including drug-induced liver injury: Analysis of suspected cases
Selective androgen receptor modulators (SARMs) have demonstrated agonist activity on the androgen receptor in various tiss...
Correction to: Empagliflozin and colchicine in patients with reduced left ventricular ejection fraction following ST-elevation myocardial infarction: a randomized, double-blinded, three-arm parallel-group, controlled trial
Correction to: Empagliflozin and colchicine in patients with reduced left ventricular ejection fraction following ST-elevation myocardial infarction: a randomized, double-blinded, three-arm parallel-group, controlled trial
Cite this articleKhiali, S., Taban-Sadeghi, M., Sarbakhsh, P. et al. Correction to: Empagliflozin and colchicine in patien...
Pharmacokinetics of oral spironolactone in infants up to 2 years of age
Pharmacokinetics of oral spironolactone in infants up to 2 years of age
Spironolactone is a potassium sparing diuretic used for decades. Until now, pharmacokinetic (PK) studies of spironolactone...
Serotonin syndrome: A pharmacovigilance comparative study of drugs affecting serotonin levels
Serotonin syndrome: A pharmacovigilance comparative study of drugs affecting serotonin levels
Serotonin syndrome is a rare and potentially fatal adverse drug reaction caused by serotonergic drugs and is due to an inc...
Effect of azilsartan on myocardial remodeling after acute myocardial infarction
Effect of azilsartan on myocardial remodeling after acute myocardial infarction
To investigate the effect of azilsartan on myocardial remodeling after acute myocardial infarction (AMI). A total of 200 A...
Antidepressant use and the risk of seizure: a meta-analysis of observational studies
Antidepressant use and the risk of seizure: a meta-analysis of observational studies
The association between antidepressant use and the risk of seizures remains controversial. Therefore, this meta-analysis e...
Direct oral anticoagulants and the risk of adverse clinical outcomes among patients with different body weight categories: a large hospital-based study
Direct oral anticoagulants and the risk of adverse clinical outcomes among patients with different body weight categories: a large hospital-based study
Through predictable pharmacokinetics—including a convenient fixed-dose regimen, direct oral anticoagulants (DOACs) a...
Untapped options to reduce waste from blister packaging for tablets and capsules
Untapped options to reduce waste from blister packaging for tablets and capsules
In Europe, most medicines are taken orally and primarily packaged as single solid oral dosage forms (SODF) in blister cham...
The reference range of lamotrigine in the treatment of epilepsy in children: a systematic review
The reference range of lamotrigine in the treatment of epilepsy in children: a systematic review
This study intends to assess the reference range of lamotrigine concentration for treating childhood epilepsy. PubMed, Ovi...
Area under the curve of tacrolimus using microsampling devices: towards precision medicine in solid organ transplantation?
Area under the curve of tacrolimus using microsampling devices: towards precision medicine in solid organ transplantation?
Therapeutic drug monitoring of tacrolimus using trough concentration (Cmin) is mandatory to ensure drug efficacy and safet...
Association of clozapine and norclozapine levels with patient and therapy characteristics—focus on interaction with valproic acid
Association of clozapine and norclozapine levels with patient and therapy characteristics—focus on interaction with valproic acid
The goal of the study was to examine clozapine (CLZ) and norclozapine (NCLZ) therapeutic drug monitoring (TDM) data and as...
Clinical pharmacokinetics and pharmacodynamics of ivosidenib in Chinese patients with relapsed or refractory IDH1-mutated acute myeloid leukemia
Clinical pharmacokinetics and pharmacodynamics of ivosidenib in Chinese patients with relapsed or refractory IDH1-mutated acute myeloid leukemia
This study aimed to assess the pharmacokinetics (PK) and pharmacodynamics (PD) of ivosidenib in Chinese patients with rela...
The benefit of omeprazole exposure on all-cause mortality and length of ICU/hospital stay might vary with age in critically ill pediatric patients: A cohort study
The benefit of omeprazole exposure on all-cause mortality and length of ICU/hospital stay might vary with age in critically ill pediatric patients: A cohort study
To investigate the association between proton pump inhibitors (PPIs) administration during hospitalization and mortality a...
Factors influencing methotrexate pharmacokinetics highlight the need for individualized dose adjustment: a systematic review
Factors influencing methotrexate pharmacokinetics highlight the need for individualized dose adjustment: a systematic review
To develop a population pharmacokinetic (PPK) model for methotrexate (MTX) dosage for all ages, assess the association bet...
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