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Transport of statins by multidrug resistance-associated proteins 1 and 5
Statins are widely used in the treatment of hypercholesterolemia but also associated with muscle-related adverse effects. ...
Evaluating polymer influence on resuspendability of indomethacin suspensions produced by microfluidization
Long-acting injectables improve treatment outcomes for chronic diseases by reducing dosing frequency. Long-acting injectab...
Comparative uptake of statins by hepatic organic anion transporting polypeptides
Uptake into hepatocytes by the organic anion transporting polypeptides (OATP) 1B1, 1B3, and 2B1 can form a rate-determinin...
In vitro identification of decreased function genetic variants of ABCB1
The efflux transporter ABCB1 (P-glycoprotein, P-gp) has an important role in drug disposition, and thus, genetic variants ...
Human organotypic colon in vitro microtissue: unveiling a new window into colonic drug disposition
The purpose of this study was to evaluate EpiColon, a novel human organotypic 3D colon microtissue prototype, developed to...
Synthesis and physicochemical characterization of new potential haptens and their precursors with morphine skeleton
Opiate analgetics are widely used therapeutic agents, but their side-effects can cause serious harm to users, and they are...
Co-milling of glass forming ability class III drugs: Comparing the impact of low and high glass transition temperatures
With an increasing focus on sustainable technologies in the pharmaceutical industry, milling provides a solvent-free appro...
Overcoming barriers in formulating practically insoluble loteprednol etabonate in ophthalmic nanoemulsion
Loteprednol etabonate (LE) is a soft corticosteroid recently approved for the short-term treatment of signs and symptoms o...
“Assessing impact of hinge flexibility on predicted second osmotic virial coefficients”
Monoclonal antibodies (MAbs) are a key modality for treating a range of diseases because of their unique biophysical prope...
The metabolic profiles of endogenous and exogenous substances in a poor metabolizer of humanized CYP2D6 model
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Comparison of ionizable lipids for lipid nanoparticle mediated DNA delivery
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