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Alternative promoters activate oncogenic programmes
Use of alternative promoters by oncogene transcription factors increases as prostate tumours progress from benign to metas...
Microplastics in the penis
The presence of microplastics has been found in human penile tissue. This discovery has implications for male fertility an...
Increased xenokidney survival
Survival of xenograft kidneys in allosensitized recipients is extended when using kidneys from pigs with multiple genetic ...
Syphilis on the rise — a need for alternative therapies and vaccines
Syphilis, caused by the bacterium Treponema pallidum subsp. pallidum (TPA), re-emerged as a global health problem in the t...
Krause corpuscles act as genital vibration detectors
First described in the 1850s by Wilhelm Krause, the function and physiological functions of the sensory structures that be...
Paternal microbiome perturbations affect offspring outcomes
Paternal microbiome perturbations affect offspring outcomes
Paternal origins of health and disease is an emerging paradigm highlighting the influence of paternal environmental exposu...
Molecular biomarkers of progression in non-muscle-invasive bladder cancer — beyond conventional risk stratification
Molecular biomarkers of progression in non-muscle-invasive bladder cancer — beyond conventional risk stratification
The global incidence of bladder cancer is more than half a million diagnoses each year. Bladder cancer can be categorized ...
From foes to friends: rethinking the role of lymph nodes in prostate cancer
From foes to friends: rethinking the role of lymph nodes in prostate cancer
Clinically localized prostate cancer is often treated with radical prostatectomy combined with pelvic lymph node dissectio...
Sun, sea, sex and spaghetti as the ESSM hits Bari
Sun, sea, sex and spaghetti as the ESSM hits Bari
Delegates were treated to a fantastic menu of both science and gastronomy as the European Society for Sexual Medicine (ESS...
Targeting histone modifiers in bladder cancer therapy — preclinical and clinical evidence
Targeting histone modifiers in bladder cancer therapy — preclinical and clinical evidence
Bladder cancer in the most advanced, muscle-invasive stage is lethal, and very limited therapeutic advances have been repo...
Diversifying editorial boards to mitigate the global burden of genitourinary cancers
The growing global burden of genitourinary cancers is disproportionately shouldered by low- and middle-income countries. M...
Robotic kidney transplantation
Robotic kidney transplantation
Kidney transplantation is the best treatment option for patients with end-stage renal disease owing to improved survival a...
Overcoming antibiotic resistance in complicated UTI
Complicated urinary tract infection (UTI) is a debilitating condition often resulting in patient hospitalization and conse...
The ins and outs of penile erection
New discoveries concerning the function of fibroblasts in penile erection have improved our understanding of this physiolo...
Robots learning to imitate surgeons — challenges and possibilities
Robots learning to imitate surgeons — challenges and possibilities
Autonomous surgical robots have the potential to transform surgery and increase access to quality health care. Advances in...
Signatures of metabolic diseases on spermatogenesis and testicular metabolism
Signatures of metabolic diseases on spermatogenesis and testicular metabolism
Diets leading to caloric overload are linked to metabolic disorders and reproductive function impairment. Metabolic and ho...
Human-relevant urothelial model provides insight into infection strategies and host response
Use of a 3D urine-tolerant human urothelial model (3D-UHU), which recapitulates the crucial features of human urothelium, ...
Management and cost of stent encrustation in pregnancy
Ureteral stents are useful devices for urological management in pregnancy. However, stent encrustation occurs in up to 13%...
Clinical application of bladder MRI and the Vesical Imaging-Reporting And Data System
Diagnostic work-up and risk stratification in patients with bladder cancer before and after treatment must be refined to o...
Genetic and biological drivers of prostate cancer disparities in Black men
Genetic and biological drivers of prostate cancer disparities in Black men
Black men with prostate cancer have historically had worse outcomes than white men with prostate cancer. The causes of thi...
Generative AI in scientific publishing: disruptive or destructive?
Artificial intelligence (AI) has the potential to revolutionize scientific publishing. The influence of AI could be disrup...
Idea sprint: generating research priorities for urinary stone disease
The escalating global prevalence of urinary stone disease and its impact on public health reflects the need to synthesize ...
Prognostic and therapeutic potential of senescent stromal fibroblasts in prostate cancer
Prognostic and therapeutic potential of senescent stromal fibroblasts in prostate cancer
The stromal component of the tumour microenvironment in primary and metastatic prostate cancer can influence and promote d...
Bladder-sparing neoadjuvant therapy for MIBC
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Resolving the puzzle of same-sex sexual interactions
Sexual interactions between members of the same sex are common but the reasons for these behaviours are not always clear. ...
Hallmark discoveries in the biology of Wilms tumour
Hallmark discoveries in the biology of Wilms tumour
The modern study of Wilms tumour was prompted nearly 50 years ago, when Alfred Knudson proposed the ‘two-hit’ ...
Frequency, morbidity and equity — the case for increased research on male fertility
Frequency, morbidity and equity — the case for increased research on male fertility
Currently, most men with infertility cannot be given an aetiology, which reflects a lack of knowledge around gamete produc...
Family dynamics: fathers’ smoking affects children’s epigenetics
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Kidney xenotransplantation
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Unlocking the mystery of the human Y chromosome
Much of the Y chromosome has remained obscure owing to the challenge of sequencing repetitive genomic regions. Recently, t...
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