World Health Organization. Infertility prevalence estimates: 1990–2021 Report No. 9240068317 (WHO, 2023).
Eisenberg, M. L. et al. Male infertility. Nat. Rev. Dis. Primers 9, 49 (2023).
Cox, C. M. et al. Infertility prevalence and the methods of estimation from 1990 to 2021: a systematic review and meta-analysis. Hum. Reprod. Open. 2022, hoac051 (2022).
Article CAS PubMed PubMed Central Google Scholar
Abebe, M. S., Afework, M. & Abaynew, Y. Primary and secondary infertility in Africa: systematic review with meta-analysis. Fertil. Res. Pract. 6, 20 (2020).
Article PubMed PubMed Central Google Scholar
Hewitson, L. & Schatten, G. The use of primates as models for assisted reproduction. Reprod. Biomed. Online 5, 50–55 (2002).
Article CAS PubMed Google Scholar
Aponte, P. M., Gutierrez-Reinoso, M. A. & Garcia-Herreros, M. Bridging the gap: animal models in next-generation reproductive technologies for male fertility preservation. Life 14, 17 (2024).
Giacomotto, J. & Ségalat, L. High-throughput screening and small animal models, where are we? Br. J. Pharmacol. 160, 204–216 (2010).
Article CAS PubMed PubMed Central Google Scholar
Alegria, A. D. et al. High-throughput genetic manipulation of multicellular organisms using a machine-vision guided embryonic microinjection robot. Genetics 226, iyae025 (2024).
Article PubMed PubMed Central Google Scholar
Schlegel, P. N. Human spermatogenesis: insights from the clinical care of men with infertility. Front. Endocrinol. 13, 889959 (2022).
Phillips, K. A. et al. Why primate models matter. Am. J. Primatol. 76, 801–827 (2014).
Article PubMed PubMed Central Google Scholar
Wolf, D. P., Stouffer, R. L. & Brenner, R. M. In Vitro Fertilization and Embryo Transfer in Primates (Springer, 1993).
Chellman, G. J. et al. Developmental and reproductive toxicology studies in nonhuman primates. Birth Defects Res. B Dev. Reprod. Toxicol. 86, 446–462 (2009).
Article CAS PubMed Google Scholar
Gibbs, R. A. et al. Evolutionary and biomedical insights from the rhesus macaque genome. Science 316, 222–234 (2007).
Article CAS PubMed Google Scholar
Kumar, S. & Hedges, S. B. A molecular timescale for vertebrate evolution. Nature 392, 917–920 (1998).
Article CAS PubMed Google Scholar
Wang, J. et al. Genetic diversity of 1,845 rhesus macaques improves genetic variation interpretation and identifies disease models. Nat. Commun. 15, 5658 (2024).
Article CAS PubMed PubMed Central Google Scholar
Wolfe-Coote, S. The Laboratory Primate (Elsevier, 2005).
Wei, Y.-L., She, Z.-Y., Huang, T., Zhang, H.-T. & Wang, X.-R. Male reproductive systems of Macaca mulatta: Gonadal development, spermatogenesis and applications in spermatogonia stem cell transplantation. Res. Vet. Sci. 137, 127–137 (2021).
Article CAS PubMed Google Scholar
Wang, X. et al. In utero MRI identifies consequences of early-gestation alcohol drinking on fetal brain development in rhesus macaques. Proc. Natl Acad. Sci. 117, 10035–10044 (2020).
Article CAS PubMed PubMed Central Google Scholar
Guo, G. et al. Peripheral infusion of human umbilical cord mesenchymal stem cells rescues acute liver failure lethality in monkeys. Stem Cell Res. Ther. 10, 1–13 (2019).
Van Doremalen, N. et al. ChAdOx1 nCoV-19 vaccine prevents SARS-CoV-2 pneumonia in rhesus macaques. Nature 586, 578–582 (2020).
Article PubMed PubMed Central Google Scholar
Talbot, C. F. et al. A psychometrically robust screening tool to rapidly identify socially impaired monkeys in the general population. Autism Res. 13, 1465–1475 (2020).
Article PubMed PubMed Central Google Scholar
Stouffer, R. L. & Woodruff, T. K. Nonhuman primates: a vital model for basic and applied research on female reproduction, prenatal development, and women’s health. ILAR J. 58, 281–294 (2017).
Article CAS PubMed PubMed Central Google Scholar
Hedges, J. C. et al. Chronic exposure to delta-9-tetrahydrocannabinol impacts testicular volume and male reproductive health in rhesus macaques. Fertil. Steril. 117, 698–707 (2022).
Article CAS PubMed PubMed Central Google Scholar
Ford, M. M. et al. GDNF gene therapy for alcohol use disorder in male non-human primates. Nat. Med. 29, 2030–2040 (2023).
Article CAS PubMed PubMed Central Google Scholar
Hardneck, F., de Villiers, C. & Maree, L. Effect of copper sulphate and cadmium chloride on non-human primate sperm function in vitro. Int. J. Environ. Res. Public Health 18, 6200 (2021).
Article CAS PubMed PubMed Central Google Scholar
Bishop, C. V. et al. Individual and combined effects of 5-year exposure to hyperandrogenemia and Western-style diet on metabolism and reproduction in female rhesus macaques. Hum. Reprod. 36, 444–454 (2021).
Article CAS PubMed Google Scholar
Sitzmann, B. D. et al. Effects of moderate calorie restriction on testosterone production and semen characteristics in young rhesus macaques (Macaca mulatta). Biol. Reprod. 83, 635–640 (2010).
Article CAS PubMed PubMed Central Google Scholar
Ball, E. E. et al. Zika virus persistence in the male macaque reproductive tract. PLoS Negl. Trop. Dis. 16, e0010566 (2022).
Article CAS PubMed PubMed Central Google Scholar
Schmidt, J. K. et al. Zika virus in rhesus macaque semen and reproductive tract tissues: a pilot study of acute infection†. Biol. Reprod. 103, 1030–1042 (2020).
Article PubMed PubMed Central Google Scholar
Liang, M. et al. SARS-CoV-2 infection induces testicular injury in Rhesus macaque. Virol. Sin. 37, 934–937 (2022).
Article CAS PubMed PubMed Central Google Scholar
Ramsey, C. & Hanna, C. in Comparative Embryo Culture: Methods and Protocols (ed J. R. Herrick) 341–353 (Springer, 2019).
Chan, A. W., Chong, K. Y., Martinovich, C., Simerly, C. & Schatten, G. Transgenic monkeys produced by retroviral gene transfer into mature oocytes. Science 291, 309–312 (2001).
Article CAS PubMed Google Scholar
Kang, Y., Chu, C., Wang, F. & Niu, Y. CRISPR/Cas9-mediated genome editing in nonhuman primates. Dis. Model. Mech. 12, dmm039982 (2019).
Article CAS PubMed PubMed Central Google Scholar
Fayomi, A. P. et al. Autologous grafting of cryopreserved prepubertal rhesus testis produces sperm and offspring. Science 363, 1314–1319 (2019).
Article CAS PubMed PubMed Central Google Scholar
Silber, S. in Fundamentals of Male Infertility 19–21 (Springer International Publishing, 2018).
Tijani, K. H., Oyende, B. O., Awosanya, G. O., Ojewola, R. W. & Yusuf, A. O. Assessment of testicular volume: a comparison of fertile and sub-fertile West African me
Comments (0)