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Efficacy and safety of SGLT2 inhibitors in nondiabetic patients with CKD: a review of recent evidence

Background: Sodium-glucose cotransporter-2 inhibitors (SGLT2i) were initially developed as glucose-lowering agents in pati...

Kidney Diseases

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Strategies to improve long-term outcomes for patients with chronic kidney disease in China

Background: Chronic kidney disease (CKD) is an incurable disease requiring lifelong management. China has a high prevalenc...

Kidney Diseases

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Kidney Involvement in Autoinflammatory Diseases

Background: Autoinflammatory diseases (AIDs) were first proposed 20 years ago and ca...

Kidney Diseases

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From physiology to pathology: the role of mitochondria in acute kidney injuries and chronic kidney diseases

Background: Renal diseases remain an increasing public health issue affecting millions of people. The kidney is a highly e...

Kidney Diseases

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Therapeutic potential targeting podocyte mitochondrial dysfunction in focal segmental glomerulosclerosis

Background：Podocytes are essential components of the glomerular filtration barrier and essential for the proper filtration...

Kidney Diseases

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Develop and Validate a Risk Score in Predicting Renal Failure in Focal Segmental Glomerulosclerosis

Introduction The aim of this study is to develop and validate a risk score for end stage kidney disease (ESKD) in patients...

Kidney Diseases

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Role of IL-6 family cytokines in organ fibrosis

Background: Organ fibrosis remains an important cause of high incidence rate and mortality worldwide. The prominent role o...

Kidney Diseases

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Hospitalizations of chronic dialysis patients: a national study in China

Background Patients receiving chronic dialysis are usually with multiple comorbidities and at high-risk for hospitalizatio...

Kidney Diseases

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Nephropathy is aggravated by fatty acids in diabetic kidney disease through tubular epithelial cell necroptosis and is alleviated by an RIPK-1 inhibitor

Introduction: Diabetic kidney disease (DKD), one of the leading causes of end-stage renal disease, has complex pathogenic ...

Kidney Diseases

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A panoramic view of ferroptosis in cardiovascular disease

Background: Cardiovascular disease (CVD) remains the leading cause of disease burden worldwide. Ferroptosis, an iron-depen...

Kidney Diseases

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Impact of Angiopoietin-2 on Kidney Diseases

Background: Angiopoietins (Ang) are essential angiogenic factors involved in angioge...

Kidney Diseases

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Clinical Outcomes in Patients on Hemodialysis with Congestive Heart Failure

Introduction: Congestive heart failure (CHF) is one of the common complications in patients with end-stage kidney disease....

Kidney Diseases

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Renal involvement in autoinflammatory diseases

Background: Autoinflammatory diseases (AIDs) were first proposed 20 years ago and caused by dysregulation of the innate im...

Kidney Diseases

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Exosomes in Diabetic Kidney Disease

Background: Diabetic kidney disease (DKD) is a major complication of diabetes mellitus and a common cause of end-stage kid...

Kidney Diseases

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Efficacy and safety of belimumab in lupus nephritis patients: a real-world observational study in China

BACKGROUND: This study aimed to describe disease activity, clinical outcome and overall patterns of lupus nephritis care i...

Kidney Diseases

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Defining biventricular abnormalities by cardiac magnetic resonance in pre-dialysis patients with chronic kidney disease

Introduction: To investigate biventricular structural and functional abnormalities in pre-dialysis patients across stages ...

Kidney Diseases

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Evaluation of Therapies for Secondary Hyperparathyroidism Associated with Vitamin D Insufficiency in Chronic Kidney Disease

Abstract Introduction: Parathyroid hormone-lowering responses after administration of three different therapies capable o...

Kidney Diseases

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IL-37 Ameliorates Renal Fibrosis by Restoring CPT1A Mediated Fatty Acid Oxidation in Diabetic Kidney Disease

Introduction: Diabetic kidney disease (DKD) is a major source of chronic kidney disease (CKD) and end-stage renal disease ...

Kidney Diseases

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Clinical characteristics and management of patients with secondary hyperparathyroidism undergoing hemodialysis: a feasibility analysis of electronic health records using Natural Language Processing

Introduction: This study aimed to assess the feasibility of applying Natural Language Processing (NLP) to analyze real-wor...

Kidney Diseases

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Impact of Weight Gain on the Subsequent Survival of New Peritoneal Dialysis Patients

Introduction: Obesity at the initiation of dialysis was reported to adversely affect the clinical outcome of peritoneal di...

Kidney Diseases

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Intra-Brain and Plasma Levels of L-Serine Are Associated with Cognitive Status in Patients with Chronic Kidney Disease

Introduction: The number of patients with chronic kidney disease (CKD) is increasing...

Kidney Diseases

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Nonsteroidal Mineralocorticoid Receptor Antagonist Eliciting Cardiorenal Protection Is a New Option for Patients with Chronic Kidney Disease

Background: Mineralocorticoid receptor antagonists (MRAs) protect cardiorenal functi...

Kidney Diseases

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Efficacy and Safety of Sevelamer Carbonate in Chinese Nondialysis Chronic Kidney Disease Patients with Hyperphosphatemia: A Randomized, Double-Blind, Parallel-Group Study

Introduction: Previous studies suggested that sevelamer carbonate is well tolerated with a favorable efficacy and safety p...

Kidney Diseases

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Role of C-Reactive Protein in Kidney Diseases

Background: C-reactive protein (CRP) is an acute phase protein and has been found to be a risk factor for acute renal inj...

Kidney Diseases

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Loss of Pten in renal tubular cells leads to water retention by upregulating AQP2

Introduction: Phosphatase and tensin (PTEN) is a multifunctional gene associated with the normal development and physiolog...

Kidney Diseases

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Acute Kidney Injury: Clinical Characteristics and Short-Term Outcomes in 1,519 Patients

Introduction: Complex integrated information on disease mechanisms and in-hospital o...

Kidney Diseases

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Musculoskeletal ultrasound evaluates renal injury and predicts renal outcome in patients with gout

Introduction. Kidney injury diagnosis is often delayed in patients with gout. We aimed to determine the characteristics of...

Kidney Diseases

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Eosinophils: A Friend or Foe in human health and diseases

Since their discovery, around 150 years, eosinophils research has been a field of changing perspective, and new directions...

Kidney Diseases

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The Mechanism of Delayed Ischemic Preconditioning in Alleviating Acute Ischemia/Reperfusion Renal Injury through Treg Mediated by Immature CD11c+ Dendritic Cells

Introduction: Renal ischemia-reperfusion injury (IRI) is one of the major causes of ...

Kidney Diseases

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Non-steroidal Mineralocorticoid Receptor Antagonist Eliciting Cardiorenal Protection is a New Option for Patients with Chronic Kidney Disease

Background: Mineralocorticoid receptor antagonists (MRAs) protect cardiorenal function by robust anti-inflammatory and an...

Kidney Diseases

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