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Alzheimer’s disease pathogenesis: standing at the crossroad of lipid metabolism and immune response
Alzheimer’s disease pathogenesis: standing at the crossroad of lipid metabolism and immune response
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by macroscopic features such as cortical atro...
The many connections of UFMylation with Alzheimer’s disease: a comprehensive review
The many connections of UFMylation with Alzheimer’s disease: a comprehensive review
Alzheimer’s disease (AD) is a complex neurodegenerative disorder that is characterized by the accumulation of pathol...
The UNC5C T835M mutation associated with Alzheimer’s disease leads to neurodegeneration involving oxidative stress and hippocampal atrophy in aged mice
The UNC5C T835M mutation associated with Alzheimer’s disease leads to neurodegeneration involving oxidative stress and hippocampal atrophy in aged mice
Alzheimer’s disease (AD) is characterized by amyloid plaques, neurofibrillary tangles, and synaptic and neuronal los...
CD2AP at the junction of nephropathy and Alzheimer’s disease
CD2AP at the junction of nephropathy and Alzheimer’s disease
Polymorphisms in the gene encoding CD2-associated protein (CD2AP) are associated with an increased risk for developing Alz...
Extracellular vesicles in TDP-43 proteinopathies: pathogenesis and biomarker potential
Extracellular vesicles in TDP-43 proteinopathies: pathogenesis and biomarker potential
Extracellular vesicles (EVs) are membrane-enclosed nanoparticles released by most cell types, and from multiple sub-cellul...
HDGFL2 cryptic protein: a portal to detection and diagnosis in neurodegenerative disease
HDGFL2 cryptic protein: a portal to detection and diagnosis in neurodegenerative disease
Neumann M, Sampathu DM, Kwong LK, Truax AC, Micsenyi MC, Chou TT, et al. Ubiquitinated TDP-43 in frontotemporal lobar dege...
HDGFL2 cryptic protein: a portal to detection and diagnosis in neurodegenerative disease
HDGFL2 cryptic protein: a portal to detection and diagnosis in neurodegenerative disease
Neumann M, Sampathu DM, Kwong LK, Truax AC, Micsenyi MC, Chou TT, et al. Ubiquitinated TDP-43 in frontotemporal lobar dege...
Proteomic analysis of APOEε4 carriers implicates lipid metabolism, complement and lymphocyte signaling in cognitive resilience
Proteomic analysis of APOEε4 carriers implicates lipid metabolism, complement and lymphocyte signaling in cognitive resilience
Apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for late onset Alzheimer’s disease (AD)....
Proteomic analysis of APOEε4 carriers implicates lipid metabolism, complement and lymphocyte signaling in cognitive resilience
Proteomic analysis of APOEε4 carriers implicates lipid metabolism, complement and lymphocyte signaling in cognitive resilience
Apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for late onset Alzheimer’s disease (AD)....
CSF proteins of inflammation, proteolysis and lipid transport define preclinical AD and progression to AD dementia in cognitively unimpaired individuals
CSF proteins of inflammation, proteolysis and lipid transport define preclinical AD and progression to AD dementia in cognitively unimpaired individuals
This preclinical AD CSF proteome study identified a panel of 12-CSF markers detecting amyloid positivity and clinical prog...
CSF proteins of inflammation, proteolysis and lipid transport define preclinical AD and progression to AD dementia in cognitively unimpaired individuals
CSF proteins of inflammation, proteolysis and lipid transport define preclinical AD and progression to AD dementia in cognitively unimpaired individuals
This preclinical AD CSF proteome study identified a panel of 12-CSF markers detecting amyloid positivity and clinical prog...
Contribution of amyloid deposition from oligodendrocytes in a mouse model of Alzheimer’s disease
Contribution of amyloid deposition from oligodendrocytes in a mouse model of Alzheimer’s disease
The accumulation of β-amyloid (Aβ) peptides into insoluble plaques is an early pathological feature of Alzheimer...
Contribution of amyloid deposition from oligodendrocytes in a mouse model of Alzheimer’s disease
Contribution of amyloid deposition from oligodendrocytes in a mouse model of Alzheimer’s disease
The accumulation of β-amyloid (Aβ) peptides into insoluble plaques is an early pathological feature of Alzheimer...
Are oligodendrocytes the missing link in Alzheimer’s disease and related dementia research?
Are oligodendrocytes the missing link in Alzheimer’s disease and related dementia research?
Auguste YSS, Ferro A, Kahng JA, Xavier AM, Dixon JR, Vrudhula U, et al. Oligodendrocyte precursor cells engulf synapses du...
Are oligodendrocytes the missing link in Alzheimer’s disease and related dementia research?
Are oligodendrocytes the missing link in Alzheimer’s disease and related dementia research?
Auguste YSS, Ferro A, Kahng JA, Xavier AM, Dixon JR, Vrudhula U, et al. Oligodendrocyte precursor cells engulf synapses du...
Mis-localization of endogenous TDP-43 leads to ALS-like early-stage metabolic dysfunction and progressive motor deficits
Mis-localization of endogenous TDP-43 leads to ALS-like early-stage metabolic dysfunction and progressive motor deficits
The key pathological signature of ALS/ FTLD is the mis-localization of endogenous TDP-43 from the nucleus to the cytoplasm...
Anti-acetylated-tau immunotherapy is neuroprotective in tauopathy and brain injury
Anti-acetylated-tau immunotherapy is neuroprotective in tauopathy and brain injury
Tau is aberrantly acetylated in various neurodegenerative conditions, including Alzheimer’s disease, frontotemporal ...
The interplay of inflammation and remyelination: rethinking MS treatment with a focus on oligodendrocyte progenitor cells
The interplay of inflammation and remyelination: rethinking MS treatment with a focus on oligodendrocyte progenitor cells
Multiple sclerosis (MS) therapeutic goals have traditionally been dichotomized into two distinct avenues: immune-modulator...
Tau protein profiling in tauopathies: a human brain study
Tau protein profiling in tauopathies: a human brain study
Abnormal accumulation of misfolded and hyperphosphorylated tau protein in brain is the defining feature of several neurode...
APOE4 genotype and aging impair injury-induced microglial behavior in brain slices, including toward Aβ, through P2RY12
APOE4 genotype and aging impair injury-induced microglial behavior in brain slices, including toward Aβ, through P2RY12
Microglia are highly dynamic cells that play a critical role in tissue homeostasis through the surveillance of brain paren...
Rejuvenating aged microglia by p16ink4a-siRNA-loaded nanoparticles increases amyloid-β clearance in animal models of Alzheimer’s disease
Rejuvenating aged microglia by p16ink4a-siRNA-loaded nanoparticles increases amyloid-β clearance in animal models of Alzheimer’s disease
Age-dependent accumulation of amyloid plaques in patients with sporadic Alzheimer’s disease (AD) is associated with ...
A partial Drp1 knockout improves autophagy flux independent of mitochondrial function
A partial Drp1 knockout improves autophagy flux independent of mitochondrial function
Dynamin-related protein 1 (Drp1) plays a critical role in mitochondrial dynamics. Partial inhibition of this protein is pr...
MLKL deficiency alleviates neuroinflammation and motor deficits in the α-synuclein transgenic mouse model of Parkinson’s disease
MLKL deficiency alleviates neuroinflammation and motor deficits in the α-synuclein transgenic mouse model of Parkinson’s disease
Parkinson’s disease (PD), one of the most devastating neurodegenerative brain disorders, is characterized by the pro...
Sleep restoration by optogenetic targeting of GABAergic neurons reprograms microglia and ameliorates pathological phenotypes in an Alzheimer’s disease model
Sleep restoration by optogenetic targeting of GABAergic neurons reprograms microglia and ameliorates pathological phenotypes in an Alzheimer’s disease model
Alzheimer’s disease (AD) patients exhibit memory disruptions and profound sleep disturbances, including disruption o...
Microglial function, INPP5D/SHIP1 signaling, and NLRP3 inflammasome activation: implications for Alzheimer’s disease
Microglial function, INPP5D/SHIP1 signaling, and NLRP3 inflammasome activation: implications for Alzheimer’s disease
Recent genetic studies on Alzheimer’s disease (AD) have brought microglia under the spotlight, as loci associated wi...
Non-invasive systemic viral delivery of human alpha-synuclein mimics selective and progressive neuropathology of Parkinson’s disease in rodent brains
Non-invasive systemic viral delivery of human alpha-synuclein mimics selective and progressive neuropathology of Parkinson’s disease in rodent brains
Alpha-synuclein (α-syn) aggregation into proteinaceous intraneuronal inclusions, called Lewy bodies (LBs), is the neu...
Alzheimer’s genes in microglia: a risk worth investigating
Alzheimer’s genes in microglia: a risk worth investigating
Despite expressing many key risk genes, the role of microglia in late-onset Alzheimer’s disease pathophysiology is s...
Donald Lowell Price, M.D. In memoriam
Donald Lowell Price, M.D. In memoriam
Molecu...
Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons
Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons
Progranulin (PGRN) is a lysosomal glycoprotein implicated in various neurodegenerative diseases, including frontotemporal ...
Roles of peripheral lipoproteins and cholesteryl ester transfer protein in the vascular contributions to cognitive impairment and dementia
Roles of peripheral lipoproteins and cholesteryl ester transfer protein in the vascular contributions to cognitive impairment and dementia
This narrative review focuses on the role of cholesteryl ester transfer protein (CETP) and peripheral lipoproteins in the ...
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