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Peroxisome, neuropeptide, and inflammation signaling pathways uniquely impacted by opioid exposure in the hypothalamus of males and females
Key neurotransmission and signaling pathways, such as the glutamatergic synapse and neuropeptide processes, display sex-de...
P2X7 receptor augments kainic acid-induced nitrosative stress by abrogating GS-HSP25-mediated iNOS inhibition and GSH synthesis in the mouse hippocampus
Seizures are defined as symptoms and signs due to aberrant neuronal hyperexcitability and hyper-synchronization in the bra...
RBM15 relies on m6A modification to inhibit UBE2C, alleviating hippocampal neuronal injury by limiting microglial inflammation
Epilepsy is a common chronic neurological disorders with various etiologies and is characterized by abnormal firing of hyp...
Interrogating mediators of single-cell transcriptional changes in the acute damaged cerebral cortex: Insights into endothelial-astrocyte interactions
TBI is the leading cause of injury, disability, and death across the world, with age, sex, and population being associated...
Exosome-based therapeutics: Advancing drug delivery for neurodegenerative diseases
Neurodegenerative diseases (NDs) are illnesses that affect the central nervous system, resulting in neuronal death and pro...
Olfactory bulb interneurons – The developmental timeline and targeting defined by embryonic neurogenesis
The olfactory bulb (OB), together with the hippocampus, is one of the few regions of the brain that retains adult neurogen...
GSK-3β dysregulation in aging: Implications for tau pathology and Alzheimer's disease progression
AD is the most common neurodegenerative disorder worldwide and is responsible for 60–70 % of dementia cases (DeTure and Di...
Single subanesthetic dose of ketamine exerts antioxidant and antidepressive-like effect in ACTH-induced preclinical model of depression
Globally, around 350 million people suffer from depression (Schmaal et al., 2017). Major depressive disorder (MDD) is a ch...
One nanoparticle delivers two different neuroprotective amino acids into ischemic brain and protects against neuronal death in rat cerebral ischemia injury
Most neuroprotective drugs had nutrition, repair and protection functions to the central nervous system (CNS), but the ent...
Estradiol activates the CaMKKβ/AMPK pathway to enhance neurite outgrowth in cultured adult sensory neurons
Adult rat dorsal root ganglion (DRG) sensory neurons express estrogen receptors (ERs) α and β. Estrogen regulates multiple...
RNA-based therapies for neurodegenerative disease: Targeting molecular mechanisms for disease modification
Neurodegenerative diseases (NDDs) encompass a spectrum of age-associated conditions marked by progressive deterioration an...
The role of alarmins in neuroinflammation following spinal cord injury: A systematic review of the literature
BackgroundAlarmins, or damage-associated molecular patterns (DAMPs), are a diverse class of molecules essential for cellul...
Striatal damage may underlie motor learning impairment following experimental mild traumatic brain injury in mice
Traumatic brain injury (TBI) is a well-known cause of disability and mortality worldwide, affecting millions of individual...
Apelin-13 can regulate adipose-derived mesenchymal stem cells to improve traumatic brain injury
Traumatic brain injury (TBI) is divided into primary injury and secondary injury based on its pathophysiological processes...
A potential role for NADPH oxidase (NOX1/2) in mutant huntingtin-induced anomalous neurite outgrowth
Neurite growth is regulated by NADPH Oxidase (NOX1 and 2) and in this study, we investigate whether neuritic abnormalities...
Regulation of hippocampal excitatory synapse development by the adhesion G-protein coupled receptor brain-specific angiogenesis inhibitor 2 (BAI2/ADGRB2)
Glutamatergic synapses and their associated dendritic spines are critical information processing sites within the brain. P...
β2-adrenoceptor agonist formoterol attenuates NLRP3 inflammasome activation and GSDMD-mediated pyroptosis in microglia through enhancing IκBα/NF-κB inhibition, SQSTM1/p62-dependent selective autophagy and ESCRT-III-mediated plasma membrane repair
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Study on the involvement of microglial S100A8 in neuroinflammation and microglia activation during migraine attacks
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Interneurons in the CA1 stratum oriens expressing αTTP may play a role in the delayed-ageing Pol μ mouse model
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Cannabinoid receptor 2 agonist AM1241 alleviates epileptic seizures and epilepsy-associated depression via inhibiting neuroinflammation in a pilocarpine-induced chronic epilepsy mouse model
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Corrigendum to “Progress of reprogramming astrocytes into neuron” [Molecular and Cellular Neuroscience, Volume 130, September 2024, 103947, DOI: 10.1016/j.mcn.2024.103947]
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β-Hydroxybutyrate enhances astrocyte glutamate uptake through EAAT1 expression regulation
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Transcriptomic changes in the hypothalamus of mice with chronic migraine: Activation of pathways associated with neuropathic inflammation and central sensitization
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SUMOylation modulates mitochondrial dynamics in an in vitro rotenone model of Parkinson's disease
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Knockdown of BMP7 induced oligodendrocyte apoptosis, demyelination and motor function loss
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The neuroprotective effect of short-chain fatty acids against hypoxia-reperfusion injury
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Astrocytes initiate autophagic flux and maintain cell viability after internalizing non-active native extracellular α-synuclein
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Vulnerability of neurofilament-expressing neurons in frontotemporal dementia
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Inhibition of phosphodiesterase 10A mitigates neuronal injury by modulating apoptotic pathways in cold-induced traumatic brain injury
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TAT-PPA1 protects against oxidative stress-induced loss of dopaminergic neurons
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