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(Auto‑)Immunität bei fokaler Epilepsie: Mechanismen (auto‑)immun-inflammatorischer epileptogener Neurodegeneration
(Auto‑)Immunität bei fokaler Epilepsie: Mechanismen (auto‑)immun-inflammatorischer epileptogener Neurodegeneration
Während die neuronalen Mechanismen der epileptischen Übererregbarkeit („hyperexcitability“, HE) eing...
Entzündliche Ursachen von Schlaganfällen – Diagnostik und Therapie
Entzündliche Ursachen von Schlaganfällen – Diagnostik und Therapie
Entzündliche Schlaganfallursachen sind häufig und stellen oft eine diagnostische und therapeutische Herausforder...
Impact of CYP2D6*2, CYP2D6*35, rs5758550, and related haplotypes on risperidone clearance in vivo
Impact of CYP2D6*2, CYP2D6*35, rs5758550, and related haplotypes on risperidone clearance in vivo
The CYP2D6 gene exhibits significant polymorphism, contributing to variability in responses to drugs metabolized by CYP2D6...
Cutaneous Signs of Internal Malignancy
Cutaneous Signs of Internal Malignancy
The risk of internal malignancies increases with age with approximately 60% of malignancies occurring in patients greater ...
The acute effects of cannabis, with and without cannabidiol, on attentional bias to cannabis related cues: a randomised, double-blind, placebo-controlled, cross-over study
The acute effects of cannabis, with and without cannabidiol, on attentional bias to cannabis related cues: a randomised, double-blind, placebo-controlled, cross-over study
Attentional bias to drug-related stimuli is hypothesised to contribute towards addiction. However, the acute effects of &#...
Effects of arginine vasopressin on human anxiety and associations with sex, dose, and V1a-receptor genotype
Effects of arginine vasopressin on human anxiety and associations with sex, dose, and V1a-receptor genotype
Arginine vasopressin (AVP) has dose- and sex-specific effects on social behavior, and variation in social responses is rel...
Baseline prepulse inhibition dependency of orexin A and REM sleep deprivation
Baseline prepulse inhibition dependency of orexin A and REM sleep deprivation
Prepulse inhibition (PPI) impairment reflects sensorimotor gating problems, i.e. in schizophrenia. This study aims to enli...
Scopolamine infusion in the basolateral amygdala after saccharin intake induces conditioned taste avoidance in rats
Scopolamine infusion in the basolateral amygdala after saccharin intake induces conditioned taste avoidance in rats
Muscarinic receptor activity in the basolateral amygdala (BLA) is known to be involved in plasticity mechanisms that under...
N-Cadherin—a Potential Target for Psychopharmacology
N-Cadherin—a Potential Target for Psychopharmacology
Abstract—Glycoprotein N-cadherin (Neuronal cadherin) belongs to the family of calcium-dependent cell adhesion molecu...
Repeated Δ-9-Tetrahydrocannabinol administration dose dependently increases stablished schedule-induced drinking
Repeated Δ-9-Tetrahydrocannabinol administration dose dependently increases stablished schedule-induced drinking
Schedule-induced drinking (SID) reproduces an excessive and repetitive behavioural pattern that has led to propose this pr...
A dose-ranging study of the physiological and self-reported effects of repeated, rapid infusion of remifentanil in people with opioid use disorder and physical dependence on fentanyl
A dose-ranging study of the physiological and self-reported effects of repeated, rapid infusion of remifentanil in people with opioid use disorder and physical dependence on fentanyl
Understanding mechanisms of drug use decisions will inform the development of treatments for opioid use disorder (OUD). De...
Acute ethanol disrupts conditioned inhibition in the male rat
Acute ethanol disrupts conditioned inhibition in the male rat
Alcohol can disrupt conditioned sexual inhibition (CSI) established by first-order conditioning in male rats. CSI can also...
Withdrawal syndrome after antipsychotics discontinuation: an analysis of the WHO database of spontaneous reports (Vigibase) between 2000 and 2022
Withdrawal syndrome after antipsychotics discontinuation: an analysis of the WHO database of spontaneous reports (Vigibase) between 2000 and 2022
Withdrawal syndrome (WDS) has been described after discontinuation of antipsychotics. WDS could be the consequence of an o...
CaMKIIa+ neurons in the bed nucleus of the stria terminalis modulate pace of natural reward seeking depending on internal state
CaMKIIa+ neurons in the bed nucleus of the stria terminalis modulate pace of natural reward seeking depending on internal state
This study aims to investigate the underlying neurobiological mechanisms that regulate natural reward seeking behaviors, s...
Dorsal hippocampal astrocytes mediate the development of heroin withdrawal-enhanced fear learning
Dorsal hippocampal astrocytes mediate the development of heroin withdrawal-enhanced fear learning
There is a significant co-occurrence of opioid use disorder (OUD) and post-traumatic stress disorder (PTSD) in clinical po...
Attenuated incubation of ethanol-induced conditioned taste aversion in a model of dependence
Attenuated incubation of ethanol-induced conditioned taste aversion in a model of dependence
Preclinical studies report attenuated ethanol-induced conditioned taste aversion (CTA) following chronic ethanol exposure,...
In the new era of psychedelic assisted therapy: A systematic review of study methodology in randomized controlled trials
In the new era of psychedelic assisted therapy: A systematic review of study methodology in randomized controlled trials
Recent years have seen a resurgence in randomized, placebo controlled trials (RCTs) utilizing non-classical psychedelics (...
Relationship between opioid cross-tolerance during buprenorphine stabilization and return to opioid use during buprenorphine dose tapering
Relationship between opioid cross-tolerance during buprenorphine stabilization and return to opioid use during buprenorphine dose tapering
Opioid injection drug use (IDU) has been linked to a more severe pattern of use (e.g. tolerance, overdose risk) and shorte...
Pharmaco-toxicological effects of the novel tryptamine hallucinogen 5-MeO-MiPT on motor, sensorimotor, physiological, and cardiorespiratory parameters in mice—from a human poisoning case to the preclinical evidence
Pharmaco-toxicological effects of the novel tryptamine hallucinogen 5-MeO-MiPT on motor, sensorimotor, physiological, and cardiorespiratory parameters in mice—from a human poisoning case to the preclinical evidence
The 5-methoxy-N-methyl-N-isopropyltryptamine (5-MeO-MiPT, known online as “Moxy”) is a new psychedelic tryptam...
Long-term inhibition of ODC1 in APP/PS1 mice rescues amyloid pathology and switches astrocytes from a reactive to active state
Long-term inhibition of ODC1 in APP/PS1 mice rescues amyloid pathology and switches astrocytes from a reactive to active state
Alzheimer’s disease (AD) is characterized by the loss of memory due to aggregation of misphosphorylated tau and amyl...
Perspectives of healthcare workers on the integration of overdose detection technologies in acute care settings
Perspectives of healthcare workers on the integration of overdose detection technologies in acute care settings
People who use drugs (PWUD) face disproportionately high rates of hospitalizations and patient-initiated discharge (leavin...
Integrating rare genetic variants into DPYD pharmacogenetic testing may help preventing fluoropyrimidine-induced toxicity
Integrating rare genetic variants into DPYD pharmacogenetic testing may help preventing fluoropyrimidine-induced toxicity
Variability in genes involved in drug pharmacokinetics or drug response can be responsible for suboptimal treatment effica...
The acceptability of lifestyle medicine for the treatment of mental illness: perspectives of people with and without lived experience of mental illness
The acceptability of lifestyle medicine for the treatment of mental illness: perspectives of people with and without lived experience of mental illness
While lifestyle medicine can be highly effective for treating a range of mental illnesses these approaches are grossly und...
The impact of the COVID-19 pandemic on rates of adolescents receiving psychopharmacological medication in Austria
The impact of the COVID-19 pandemic on rates of adolescents receiving psychopharmacological medication in Austria
The COVID-19 pandemic has impacted many aspects of everyday life, including the (mental) healthcare system. An increase in...
PPI in psychiatry and the problem of knowledge
PPI in psychiatry and the problem of knowledge
This article begins by locating Patient and Public involvement ((PPI) historically and argues that ‘mental health...
Recovery-orientierte Behandlung und Genesungsbegleitung in der Psychiatrie
Recovery-orientierte Behandlung und Genesungsbegleitung in der Psychiatrie
Der Begriff Recovery ist national und international in der Versorgung psychisch erkrankter Menschen inzwischen fest etabli...
Aripiprazole and its adverse effects in the form of impulsive-compulsive behaviors: A systematic review of case reports
Aripiprazole and its adverse effects in the form of impulsive-compulsive behaviors: A systematic review of case reports
Aripiprazole is an efficacious treatment for both the positive and negative symptoms of schizophrenia and is also commonly...
Why is lithium [not] the drug of choice for bipolar disorder? a controversy between science and clinical practice
Why is lithium [not] the drug of choice for bipolar disorder? a controversy between science and clinical practice
During over half a century, science has shown that lithium is the most efficacious treatment for bipolar...
On mental pain and suicide risk in modern psychiatry
On mental pain and suicide risk in modern psychiatry
Facing suicide risk is probably the most difficult task for clinicians when dealing with patients in crisis. It requires p...
Biomarkers for neurodegeneration impact cognitive function: a longitudinal 1-year case–control study of patients with bipolar disorder and healthy control individuals
Biomarkers for neurodegeneration impact cognitive function: a longitudinal 1-year case–control study of patients with bipolar disorder and healthy control individuals
Abnormalities in cerebrospinal fluid (CSF)-amyloid-beta (Aβ)42, CSF-Aβ40, CSF-Aβ38, CSF-soluble amyloid pre...
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