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Extracellular ATP regulates phagocytic activity, mitochondrial respiration, and cytokine secretion of human astrocytic cells
Extracellular ATP regulates phagocytic activity, mitochondrial respiration, and cytokine secretion of human astrocytic cells
The two main glial cell types of the central nervous system (CNS), astrocytes and microglia, are responsible for neuroimmu...
A adenosine receptor-triggered intracellular calcium mobilization: Cell type-dependent involvement of G, G, G proteins and protein kinase C
A adenosine receptor-triggered intracellular calcium mobilization: Cell type-dependent involvement of G, G, G proteins and protein kinase C
Activation of PLCβ enzymes by Giβγ and Gαq/11 proteins is a common mechanism to trigger cytosolic Ca2+...
SCH58261 effectively prevents the reduction in excitability of striatal MSNs in mice following 20 h of sleep deprivation
SCH58261 effectively prevents the reduction in excitability of striatal MSNs in mice following 20 h of sleep deprivation
Adenosine, a sleep-associated neuromodulator, is crucial in various physiological and pathological processes. Previous stu...
Ligand-directed covalent labelling of adenosine receptors
Ligand-directed covalent labelling of adenosine receptors
Adenosine signalling pathways have a significant role in many physiological processes involving immune response, regulatio...
First evidence of Borelli, 1899 (Buthidae) venom altering purine metabolism in rat blood cells
First evidence of Borelli, 1899 (Buthidae) venom altering purine metabolism in rat blood cells
Purinergic signaling pathways play crucial roles in regulating hemostatic and inflammatory responses, both of which are im...
Combined oral contraceptives alter ectonucleotidase and adenosine deaminase activities in peripheral blood cells
Combined oral contraceptives alter ectonucleotidase and adenosine deaminase activities in peripheral blood cells
Hormonal contraceptives, one of the most widely used contraceptive methods, are associated with the development of thrombo...
Establishment and behavioural characterization of a novel constitutive P2X7 receptor knockout mouse line
Establishment and behavioural characterization of a novel constitutive P2X7 receptor knockout mouse line
The P2X7 receptor is an adenosine triphosphate (ATP)-gated ion channel expressed in different cell types of the brain. Pol...
A step-by-step protocol based on data mining to explore purinergic signaling in glioblastoma
A step-by-step protocol based on data mining to explore purinergic signaling in glioblastoma
Over the past few years, transcriptomics has emerged as a pillar for modern scientific research, enabling the comprehensiv...
Patients with periodontal disease demonstrates changes in purinergic and inflammatory markers in PBMCs, serum and saliva
Patients with periodontal disease demonstrates changes in purinergic and inflammatory markers in PBMCs, serum and saliva
Periodontal disease (PD) is characterized by the presence of a chronic inflammatory process, due to the accumulation of ba...
The anti-inflammatory effect of physical exercise on type 2 diabetes: the role of purinergic signaling
The anti-inflammatory effect of physical exercise on type 2 diabetes: the role of purinergic signaling
This study investigated the effects of physical exercise (PE) on the modulation of purinergic signaling and inflammatory p...
Involvement of purinergic signalling in the vasomotor response to hypochlorous acid in porcine coronary artery
Involvement of purinergic signalling in the vasomotor response to hypochlorous acid in porcine coronary artery
Hypochlorous acid (HOCl) is generated by neutrophils during the innate immune response. ATP is released from cells by vari...
P2Y6 promoted pruning of FSTL1 nerves by cutaneous macrophages to reset pain threshold and cardiac function
P2Y6 promoted pruning of FSTL1 nerves by cutaneous macrophages to reset pain threshold and cardiac function
Hyperactivation of cutaneous macrophages promotes the development of chronic pain. Stimulation of nociceptive regions prom...
Purinergic signaling in liver disease: calcium signaling and induction of inflammation
Purinergic signaling in liver disease: calcium signaling and induction of inflammation
Purinergic signaling regulates many metabolic functions and is implicated in liver physiology and pathophysiology. Liver f...
Astrocytic P2X7 receptor regulates depressive-like behavioral reactions of mice in response to acute stressful stimulation
Astrocytic P2X7 receptor regulates depressive-like behavioral reactions of mice in response to acute stressful stimulation
Acute stress causes depressive-like reactions in the tail suspension (TST) and forced swim tests (FST) of mice. Similarly,...
Molecular insights into P2X signalling cascades in acute kidney injury
Molecular insights into P2X signalling cascades in acute kidney injury
Acute kidney injury (AKI) is a critical health issue with high mortality and morbidity rates in hospitalized indi...
Purines and purinergic receptors in primary tumors of the central nervous system
Purines and purinergic receptors in primary tumors of the central nervous system
Purine nucleotides and nucleosides play critical roles in various pathological conditions, including tumor cell growth. Ad...
Limited contribution of the of P2X4 receptor to LPS-induced microglial reaction in mice
Limited contribution of the of P2X4 receptor to LPS-induced microglial reaction in mice
Sepsis is life-threatening condition that can trigger long-term neurological sequelae, including cognitive impairment in s...
P2 purinergic receptor expression and function in tumor-related immune cells
P2 purinergic receptor expression and function in tumor-related immune cells
P2 purinergic receptor expression is dysregulated in multiple cancer subtypes and is associated with worse outcomes. Studi...
P2X7 receptor in macrophage polarization and its implications in neuroblastoma tumor behavior
P2X7 receptor in macrophage polarization and its implications in neuroblastoma tumor behavior
Tumor-associated macrophages (TAMs) exhibit antitumor or protumor responses related to inflammatory (or M1) and alternativ...
Screening herbal and natural product libraries to aid discovery of novel allosteric modulators of human P2X7
Screening herbal and natural product libraries to aid discovery of novel allosteric modulators of human P2X7
 P2X7 is an emerging therapeutic target for several disorders and diseases due to its role in inflammatory signal...
A2B adenosine receptor signaling and regulation
A2B adenosine receptor signaling and regulation
The A2B adenosine receptor (A2BR) is one of the four adenosine-activated G protein-coupled receptors. In addition to adeno...
Role and recent progress of P2Y12 receptor in cancer development
Role and recent progress of P2Y12 receptor in cancer development
P2Y12 receptor (P2Y12R) is an adenosine-activated G protein-coupled receptor (GPCR) that plays a central role in platelet ...
Exploring novel dilazep derivatives as hENT1 inhibitors and potentially covalent molecular tools
Exploring novel dilazep derivatives as hENT1 inhibitors and potentially covalent molecular tools
The human equilibrative nucleoside transporter 1 (SLC29A1, hENT1) is a solute carrier that modulates the passive transport...
Microglial purinergic signaling in Alzheimer’s disease
Microglial purinergic signaling in Alzheimer’s disease
Alzheimer’s disease (AD) is a progressive and fatal neurodegenerative disease. The prevalent features of AD pathogen...
P2X7 and P2Y1 receptors in DRG mediate electroacupuncture to inhibit peripheral sensitization in rats with IBS visceral pain
P2X7 and P2Y1 receptors in DRG mediate electroacupuncture to inhibit peripheral sensitization in rats with IBS visceral pain
Although multiple purinergic receptors mediate the analgesic effects of acupuncture, it remains unclear whether there is m...
The role of purinergic signaling in acupuncture-mediated relief of neuropathic and inflammatory pain
The role of purinergic signaling in acupuncture-mediated relief of neuropathic and inflammatory pain
Acupuncture is a traditional medicinal practice in China that has been increasingly recognized in other countries in recen...
Targeting adenosine A2A receptors for early intervention of retinopathy of prematurity
Targeting adenosine A2A receptors for early intervention of retinopathy of prematurity
Retinopathy of prematurity (ROP) continues to pose a significant threat to the vision of numerous children worldwide, prim...
The impact of purine nucleosides on neuroplasticity in the adult brain
The impact of purine nucleosides on neuroplasticity in the adult brain
Neuroplasticity refers to the nervous system’s ability to adapt and reorganize its cell structures and neuronal netw...
Regulation of nerve-evoked contractions of the murine vas deferens
Regulation of nerve-evoked contractions of the murine vas deferens
Stimulation of sympathetic nerves in the vas deferens yields biphasic contractions consisting of a rapid transient compone...
Genetic and functional modulation by agonist MRS5698 and allosteric enhancer LUF6000 at the native A3 adenosine receptor in HL-60 cells
Genetic and functional modulation by agonist MRS5698 and allosteric enhancer LUF6000 at the native A3 adenosine receptor in HL-60 cells
The A3 adenosine receptor (AR) is an important inflammatory and immunological target. However, the underlying mechanisms a...
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