Casamassimi A, Federico A, Rienzo M, Esposito S, Ciccodicola A (2017) Transcriptome profiling in human diseases: new advances and perspectives. IJMS 18:1652. https://doi.org/10.3390/ijms18081652

Article  PubMed  PubMed Central  CAS  Google Scholar 

Kleverov, M.; Zenkova, D.; Kamenev, V.; Sablina, M.; Artyomov, M.N.; Sergushichev, A.A. Phantasus: web-application for visual and interactive gene expression analysis 2022.

Stark R, Grzelak M, Hadfield J (2019) RNA sequencing: the teenage years. Nat Rev Genet 20:631–656. https://doi.org/10.1038/s41576-019-0150-2

Article  PubMed  CAS  Google Scholar 

Byrd JB, Greene AC, Prasad DV, Jiang X, Greene CS (2020) Responsible, practical genomic data sharing that accelerates research. Nat Rev Genet 21:615–629. https://doi.org/10.1038/s41576-020-0257-5

Article  PubMed  PubMed Central  CAS  Google Scholar 

Barrett T, Wilhite SE, Ledoux P, Evangelista C, Kim IF, Tomashevsky M, Marshall KA, Phillippy KH, Sherman PM, Holko M et al (2012) NCBI GEO: archive for functional genomics data sets—update. Nucleic Acids Res 41:D991–D995. https://doi.org/10.1093/nar/gks1193

Article  PubMed  PubMed Central  CAS  Google Scholar 

Chin L, Andersen JN, Futreal PA (2011) Cancer genomics: from discovery science to personalized medicine. Nat Med 17:297–303. https://doi.org/10.1038/nm.2323

Article  PubMed  CAS  Google Scholar 

Miller KD, Ostrom QT, Kruchko C, Patil N, Tihan T, Cioffi G, Fuchs HE, Waite KA, Jemal A, Siegel RL et al (2021) Brain and other central nervous system tumor statistics, 2021. CA A Cancer J Clin 71:381–406. https://doi.org/10.3322/caac.21693

Article  Google Scholar 

Drill M, Powell KL, Kan LK, Jones NC, O’Brien TJ, Hamilton JA, Monif M (2020) Inhibition of Purinergic P2X Receptor 7 (P2X7R) Decreases granulocyte-macrophage colony-stimulating factor (GM-CSF) expression in U251 glioblastoma cells. Sci Rep 10:14844. https://doi.org/10.1038/s41598-020-71887-x

Article  PubMed  PubMed Central  CAS  Google Scholar 

Kan LK, Drill M, Jayakrishnan PC, Sequeira RP, Galea E, Todaro M, Sanfilippo PG, Hunn M, Williams DA, O’Brien TJ et al (2023) P2X7 receptor antagonism by AZ10606120 significantly reduced in vitro tumour growth in human glioblastoma. Sci Rep 13:8435. https://doi.org/10.1038/s41598-023-35712-5

Article  PubMed  PubMed Central  CAS  Google Scholar 

Kan LK, Williams D, Drummond K, O’Brien T, Monif M (2019) The role of microglia and P2X7 receptors in gliomas. J Neuroimmunol 332:138–146. https://doi.org/10.1016/j.jneuroim.2019.04.010

Article  PubMed  CAS  Google Scholar 

Vénéreau, E.; Ceriotti, C.; Bianchi, M.E. DAMPs from cell death to new life. Front. Immunol. 2015, 6, https://doi.org/10.3389/fimmu.2015.00422.

Monif M, O’Brien TJ, Drummond KJ, Reid CA, Liubinas SV, Williams DA (2014) P2X7 receptors are a potential novel target for anti-glioma therapies. J Inflamm 11:25. https://doi.org/10.1186/s12950-014-0025-4

Article  CAS  Google Scholar 

Braganhol E, De Andrade GPB, Santos GT, Stefani MA (2024) ENTPD1 (CD39) and NT5E (CD73) expression in human glioblastoma: an in silico analysis. Purinergic Signalling 20:285–289. https://doi.org/10.1007/s11302-023-09951-0

Article  PubMed  CAS  Google Scholar 

Wang J, Matosevic S (2019) NT5E/CD73 as correlative factor of patient survival and natural killer cell infiltration in glioblastoma. JCM 8:1526. https://doi.org/10.3390/jcm8101526

Article  PubMed  PubMed Central  CAS  Google Scholar 

TCGA Barcode.Pdf.

De Bruijn I, Kundra R, Mastrogiacomo B, Tran TN, Sikina L, Mazor T, Li X, Ochoa A, Zhao G, Lai B et al (2023) Analysis and visualization of longitudinal genomic and clinical data from the AACR project GENIE biopharma collaborative in cBioPortal. Can Res 83:3861–3867. https://doi.org/10.1158/0008-5472.CAN-23-0816

Article  Google Scholar 

Cerami E, Gao J, Dogrusoz U, Gross BE, Sumer SO, Aksoy BA, Jacobsen A, Byrne CJ, Heuer ML, Larsson E et al (2012) The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov 2:401–404. https://doi.org/10.1158/2159-8290.CD-12-0095

Article  PubMed  Google Scholar 

Gao, J.; Aksoy, B.A.; Dogrusoz, U.; Dresdner, G.; Gross, B.; Sumer, S.O.; Sun, Y.; Jacobsen, A.; Sinha, R.; Larsson, E.; et al. Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci. Signal. 2013, 6, https://doi.org/10.1126/scisignal.2004088.

Khan Y, Hammarström D, Ellefsen S, Ahmad R (2022Jun 18) Normalization of gene expression data revisited: the three viewpoints of the transcriptome in human skeletal muscle undergoing load-induced hypertrophy and why they matter. BMC Bioinformatics 23(1):241. https://doi.org/10.1186/s12859-022-04791-y

Article  PubMed  PubMed Central  CAS  Google Scholar 

Giuliani, A. The application of principal component analysis to drug discovery and biomedical data, Drug Discovery Today, Volume 22, Issue 7, 2017, https://doi.org/10.1016/j.drudis.2017.01.005.

Ikotun AM, Ezugwu AE (2022Aug 11) Boosting k-means clustering with symbiotic organisms search for automatic clustering problems. PLoS ONE 17(8):e0272861. https://doi.org/10.1371/journal.pone.0272861

Article  PubMed  PubMed Central  CAS  Google Scholar 

Vranas KC, Jopling JK, Sweeney TE, Ramsey MC, Milstein AS, Slatore CG, Escobar GJ, Liu VX (2017) Identifying distinct subgroups of ICU patients: a machine learning approach*. Crit Care Med 45:1607–1615. https://doi.org/10.1097/CCM.0000000000002548

Article  PubMed  PubMed Central  Google Scholar 

Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W, Smyth GK (2015) Limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res 43:e47–e47. https://doi.org/10.1093/nar/gkv007

Article  PubMed  PubMed Central  CAS  Google Scholar 

Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES et al (2005) Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA 102:15545–15550. https://doi.org/10.1073/pnas.0506580102

Article  PubMed  PubMed Central  CAS  Google Scholar