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CNPY2 protects against ER stress and is expressed by corticostriatal neurons together with CTIP2 in a mouse model of Huntington’s disease
CNPY2 protects against ER stress and is expressed by corticostriatal neurons together with CTIP2 in a mouse model of Huntington’s disease
Introduction Alterations in protein homeostasis and cell signaling pathways accompany many human neurological diseases a...
Functions of TRPs in retinal tissue in physiological and pathological conditions
Functions of TRPs in retinal tissue in physiological and pathological conditions
1 Introduction The visual system is one of the most important senses, contributing to the defense and survival of animal...
Further validation of the association between MAPT haplotype-tagging polymorphisms and Alzheimer’s disease: neuropsychological tests, cerebrospinal fluid biomarkers, and APOE genotype
Further validation of the association between MAPT haplotype-tagging polymorphisms and Alzheimer’s disease: neuropsychological tests, cerebrospinal fluid biomarkers, and APOE genotype
1 Introduction Alzheimer’s disease (AD) is a complex condition influenced by both genetic and environmental factors. Ana...
The complexities of salt taste reception: insights into the role of TMC4 in chloride taste detection
The complexities of salt taste reception: insights into the role of TMC4 in chloride taste detection
Introduction Taste is a sensory reception that is widely shared among many species. It receives stimulus from the extern...
Molecular determinants of resurgent sodium currents mediated by Navβ4 peptide and A-type FHFs
Molecular determinants of resurgent sodium currents mediated by Navβ4 peptide and A-type FHFs
Introduction Voltage-gated sodium channels (VGSCs) can generate classic sodium current and atypical sodium current named...
Risk factors for poor prognosis in patients with zoster-associated neuralgia who underwent interventional pain management
Risk factors for poor prognosis in patients with zoster-associated neuralgia who underwent interventional pain management
1 Introduction Herpes zoster-associated neuralgia (ZAN) is the most common complication of herpes zoster (HZ) and leads ...
A review of the pathogenesis of epilepsy based on the microbiota-gut-brain-axis theory
A review of the pathogenesis of epilepsy based on the microbiota-gut-brain-axis theory
1 Introduction Epilepsy (Wirrell et al., 2022) is an episodic neurological disorder in which nerve cells in the brain hy...
Cellular signaling pathways in the nervous system activated by various mechanical and electromagnetic stimuli
Cellular signaling pathways in the nervous system activated by various mechanical and electromagnetic stimuli
Introduction The mammalian brain and spinal cord are viscoelastic tissues composed of heterogeneous cell populations, in...
Dynamic micro-optical coherence tomography enables structural and metabolic imaging of the mammalian cochlea
Dynamic micro-optical coherence tomography enables structural and metabolic imaging of the mammalian cochlea
1 Introduction Sensorineural hearing loss (SNHL) is caused by the loss or dysfunction of cochlear hair cells and/or spir...
Inflammation and olfactory loss are associated with at least 139 medical conditions
Inflammation and olfactory loss are associated with at least 139 medical conditions
1 Introduction 1.1 Observations linking olfactory loss and medical conditions: correlation, precedence, and prediction 1....
Unraveling the socio-cognitive consequences of KCC2 disruption in zebrafish: implications for neurodevelopmental disorders and therapeutic interventions
Unraveling the socio-cognitive consequences of KCC2 disruption in zebrafish: implications for neurodevelopmental disorders and therapeutic interventions
1 Introduction A delicate equilibrium between excitation and inhibition (E/I) of neurons and neuronal networks is crucia...
Inactivity of Stat3 in sensory and non-sensory cells of the mature cochlea
Inactivity of Stat3 in sensory and non-sensory cells of the mature cochlea
1 Introduction The organ of Corti is the receptor organ for hearing located in the cochlea. It consists of various highl...
Pharmacological targeting of smoothened receptor cysteine-rich domain by Budesonide promotes in vitro myelination
Pharmacological targeting of smoothened receptor cysteine-rich domain by Budesonide promotes in vitro myelination
Introduction Throughout adulthood, the central nervous system (CNS) myelin sheath can be damaged by environmental factor...
Ziconotide and psychosis: from a case report to a scoping review
1 Introduction Ziconotide is a non-opioid analgesic that has contributed to a paradigm shift in pain treatment. It is a ...
Editorial: ATF3: a crucial stress-responsive gene of glia and neurons in CNS
within 1 day after spinal cord injury (SCI) or ischemic stroke in mice 8,11 . Additionally, ATF3 protein levels in mouse b...
Editorial: Protein post-translational modifications in the nervous system: from development to disease and ageing
Three articles assessed the neurodegenerative diseases Alzheimer (AD) and Parkinson (PD) as well as key regulators of agei...
Follicle-stimulating hormone induces depression-like phenotype by affecting synaptic function
1 Introduction Depression is a common medical condition characterized by significant distress, morbidity, and mortality,...
Liquid–liquid phase separation and conformational strains of α-Synuclein: implications for Parkinson’s disease pathogenesis
1 Introduction Parkinson’s disease (PD) is recognized as the second most common neurodegenerative disease (Du et al., 20...
Dissection of signaling pathways regulating TrkB-dependent gephyrin clustering
1 Introduction The GABAergic system is the primary inhibitory system essential for the proper functioning of the central...
Flight to insight: maximizing the potential of Drosophila models of C9orf72-FTD
Flight to insight: maximizing the potential of Drosophila models of C9orf72-FTD
Introduction Frontotemporal dementia (FTD) comprises a spectrum of rare neurodegenerative disorders resulting from neuro...
ARHGEF5 binds Drebrin and affects α-tubulin acetylation to direct neuronal morphogenesis and migration during mouse brain development
ARHGEF5 binds Drebrin and affects α-tubulin acetylation to direct neuronal morphogenesis and migration during mouse brain development
1 Introduction Rho guanine nucleotide exchange factors (Rho GEFs) stimulate the exchange of GDP for GTP to generate the ...
Deletion of a core APC/C component reveals APC/C function in regulating neuronal USP1 levels and morphology
Deletion of a core APC/C component reveals APC/C function in regulating neuronal USP1 levels and morphology
IntroductionThe Anaphase Promoting Complex (APC/C), an E3 ubiquitin ligase, plays a key role in cell cycle control, but it...
Mechanisms of inflammation after ischemic stroke in brain-peripheral crosstalk
Mechanisms of inflammation after ischemic stroke in brain-peripheral crosstalk
1 Introduction Stroke is the second leading cause of death and the third leading cause of adult disability worldwide (Sa...
Changes of cerebrospinal fluid pressure gradient in different body positions under experimental impairment of cerebrospinal fluid pathway: new insight into hydrocephalus development
Changes of cerebrospinal fluid pressure gradient in different body positions under experimental impairment of cerebrospinal fluid pathway: new insight into hydrocephalus development
1 Introduction In accordance to the classical hypothesis of cerebrospinal fluid (CSF) hydrodinamics (Davson et al., 1987...
Recovery kinetics of dual AAV-mediated human otoferlin expression
Recovery kinetics of dual AAV-mediated human otoferlin expression
Deafness-causing deficiencies in otoferlin (OTOF) have been addressed preclinically using dual adeno-associated virus (AAV...
Tackling neurodegeneration in vitro with omics: a path towards new targets and drugs
Tackling neurodegeneration in vitro with omics: a path towards new targets and drugs
1 Introduction Neurodegenerative diseases (NDDs) represent a growing societal and public health burden affecting million...
Editorial: Restoring neural circuits after spinal cord injury
Editorial: Restoring neural circuits after spinal cord injury
Although there are reports of restoring neural circuits to treat spinal cord injury, the results are not ideal. Lots of ...
Editorial: Molecular and cellular mechanisms of sensory functions in insect models, volume II
Sensory systems are indispensable for all organisms to receive dynamic information from their surrounding environment. A...
Novel insights into STIM1's role in store-operated calcium entry and its implications for T-cell mediated inflammation in trigeminal neuralgia
Novel insights into STIM1's role in store-operated calcium entry and its implications for T-cell mediated inflammation in trigeminal neuralgia
This investigation aims to elucidate the novel role of Stromal Interaction Molecule 1 (STIM1) in modulating store-operated...
The role of Foxo3a in neuron-mediated cognitive impairment
1 Introduction Cognitive impairment (COI) is a brain disorder involved in impaired memory, language, reasoning, calculati...
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