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PD-1 deficiency disrupts in vivo neural activity in mouse Hippocampus and cortex
Programmed cell death 1 (PD-1), encoded by the Pdcd1 gene, was identified as a target in cancer immunotherapy but may resu...
Frequency-coded spatiotemporal control of telencephalic ictal oscillations and inter-cortical coherence by thalamus
Many epileptic seizures (hereafter abbreviated as seizures) are characterized by overly synchronized oscillating activitie...
Immune control of the basal ganglia network: Interleukin-17 as a key modulator of striatal synaptic plasticity
The basal ganglia (BG) network exerts a key role in the integration of cortical inputs and is fundamental to motor learnin...
Effect of primary structural variation on cervid prion protein in flexibility, stability, and spontaneous misfolding propensity
Protein misfolding is central to numerous neurodegenerative disorders, collectively known as proteinopathies, which includ...
Impaired plasma membrane calcium ATPase activity and mitochondrial dysfunction contribute to calcium dysregulation in Fabry disease-related painful neuropathy
Volume 213, September 2025, 107000Author links open overlay panel, , , , , , , , , , Highlights•Elevated calcium in α-Gal ...
Targeted neuromodulation of spinal interneurons enhances breathing in chronic spinal cord injury
Respiratory dysfunction is a debilitating consequence of cervical spinal cord injury (cSCI) with few available treatment o...
Inhibitory circuit dysfunction as a potential contributor to cortical reorganization in Glioblastoma progression
Glioblastoma (GBM) is a highly aggressive brain tumor that infiltrates surrounding brain tissue, profoundly affecting adja...
Neuromodulation of voltage-gated sodium channels by Gβ1γ2 subunits: Implications for GNB1-linked encephalopathy
All data reported in this paper will be shared by the lead contact upon request. This paper does not report original code....
Hypo-connected pattern in Parkinson's disease with pure apathy: A dynamic functional connectivity perspective
BackgroundApathy, a decline in goal-directed motivated behavior, is a common non-motor symptom in Parkinson's disease (PD)...
Unconsciousness reshapes the oscillatory topography of the subthalamic nucleus: A comparative study
BackgroundMany centers perform Deep Brain Stimulation (DBS) surgery under general anesthesia (GA), known as asleep DBS. Lo...
Klinefelter syndrome: A neurodevelopmental disease of the synapse
All data and information required to generate, evaluate, and interpret the findings presented in this paper are provided i...
Interneuron transcriptomics reveals pathologic markers of Alzheimer's disease progression
Alzheimer's disease (AD) exhibits imbalance between neuronal excitation and inhibition, likely secondary to interneuron dy...
Sphingomyelin-induced glucocorticoid receptor alterations lead to impaired presynaptic plasticity in acid sphingomyelinase deficient neurons
Acid sphingomyelinase deficiency (ASMD) is a rare disease caused by mutations in the gene encoding ASM, an enzyme that deg...
Age-related cerebral amyloid angiopathy accumulation in the APPSw mouse model is associated with perivascular inflammation and brain-wide vascular and inflammatory gene and protein changes
Cerebral amyloid angiopathy (CAA) is an extremely common pathology of Alzheimer's disease (AD) included under vascular con...
[18F]FDG PET metabolic correlates of cerebrospinal fluid TAR DNA-binding protein 43 in prodromal Alzheimer's disease
IntroductionLimbic-predominant age-related TDP-43 encephalopathy neuropathological changes (LATE-NC) are characterized by ...
Inhibition of PTPRS function does not affect the survival or regeneration of dopaminergic neurons but alters synaptic function in the nigrostriatal pathway
Materials availability: This study did not generate new unique reagents. Data and code availability: Microscopy data repor...
A novel stable transgenic zebrafish line expressing mCherry-tagged human alpha-synuclein in the nervous system and exhibiting all the key features of Lewy body disorders at larval stage
Lewy Bodies, proteinaceous inclusions containing α-Synuclein fibrillary aggregates, are defining neuropathological hallmar...
Increased BNIP3-mediated mitophagy attenuates GDAP1 loss of function - implications for Charcot-Marie-Tooth disease 4A
Charcot-Marie-Tooth disease type 4 A ((CMT4A), an autosomal recessive neuropathy, is caused by mutations in ganglioside-in...
Nuclear localization of platelet activating factor receptor accounts for microglial phagocytosis in ischemic stroke
Ischemic stroke (IS) is a leading cause of global morbidity and mortality. A critical strategy for improving the prognosis...
The complex phenotype and function of spinal cord microglia during ALS progression and the impact of metabotropic glutamate receptor type 5 down-regulation in SOD1G93A mice
Over the last few decades, scientists' attention has shifted from neuronal to non-neuronal cells to explain the mechanisms...
Brain organoid models for studying the function of iPSC-derived microglia in neurodegeneration and brain tumours
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Impairments of inhibitory neurons in amyotrophic lateral sclerosis and frontotemporal dementia
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Linking human cerebral and ocular waste clearance: Insights from tear fluid and ultra-high field MRI
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Wireless optogenetic stimulation on the prelimbic to the nucleus accumbens core circuit attenuates cocaine-induced behavioral sensitization
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Synergistic effect of Wharton's jelly-derived mesenchymal stem cells and insulin on Schwann cell proliferation in Charcot-Marie-Tooth disease type 1A treatment
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Diaphragm relaxation causes seizure-related apnoeas in chronic and acute seizure models in rats
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Activation of hypoactive parvalbumin-positive fast-spiking interneurons restores dentate inhibition to reduce electrographic seizures in the mouse intrahippocampal kainate model of temporal lobe epilepsy
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Developmental and physiological impacts of pathogenic human huntingtin protein in the nervous system
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PTEN deletion in the adult dentate gyrus induces epilepsy
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The effect of a dominant kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy on brain development and neuropathology
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