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Curcumin Improves Hippocampal Cell Bioenergetics, Redox and Inflammatory Markers, and Synaptic Proteins, Regulating Mitochondrial Calcium Homeostasis
Curcumin Improves Hippocampal Cell Bioenergetics, Redox and Inflammatory Markers, and Synaptic Proteins, Regulating Mitochondrial Calcium Homeostasis
Mitochondria produces energy through oxidative phosphorylation (OXPHOS), maintaining calcium homeostasis, survival/death c...
Differentially Expressed Nedd4-binding Protein Ndfip1 Protects Neurons Against Methamphetamine-induced Neurotoxicity
Differentially Expressed Nedd4-binding Protein Ndfip1 Protects Neurons Against Methamphetamine-induced Neurotoxicity
To identify factors involved in methamphetamine (METH) neurotoxicity, we comprehensively searched for genes which were dif...
Exploring the Different Impacts of Ketamine on Neurotrophic Factors and Inflammatory Parameters in a Cecal Ligation and Puncture-Induced Sepsis Model
Exploring the Different Impacts of Ketamine on Neurotrophic Factors and Inflammatory Parameters in a Cecal Ligation and Puncture-Induced Sepsis Model
Given ketamine’s conflicting impacts on the central nervous system, investigating its effects within an inflammatory...
Glioprotective Effects of Resveratrol Against Glutamate-Induced Cellular Dysfunction: The Role of Heme Oxygenase 1 Pathway
Glioprotective Effects of Resveratrol Against Glutamate-Induced Cellular Dysfunction: The Role of Heme Oxygenase 1 Pathway
Resveratrol, a natural polyphenol, has shown promising neuroprotective effects in several in vivo and in vitro experimenta...
Cannabidiol-Induced Autophagy Ameliorates Tau Protein Clearance
Cannabidiol-Induced Autophagy Ameliorates Tau Protein Clearance
Tau is a neuronal protein that confers stability to microtubules; however, its hyperphosphorylation and accumulation can l...
Restoration of MPTP-induced Dopamine and Tyrosine Hydroxylase Depletion in the Mouse Brain Through Ethanol and Nicotine
Restoration of MPTP-induced Dopamine and Tyrosine Hydroxylase Depletion in the Mouse Brain Through Ethanol and Nicotine
Dopamine (DA) has long been considered a major factor in the development of Parkinson's disease (PD). Ethanol (EtOH) a...
Sex-Specific Outcomes in a Rat Model of Early-Life Stress Due to Adverse Caregiving
Sex-Specific Outcomes in a Rat Model of Early-Life Stress Due to Adverse Caregiving
Early parental care is critical for the development of cortico-limbic circuits regulating stress responses and emotional w...
The Effect of Naringin on Cognitive-Behavioral Functions, CREB/BDNF Signaling, Cholinergic Activity, and Neuronal Density in the Hippocampus of an MSG-Induced Obesity Rat Model
The Effect of Naringin on Cognitive-Behavioral Functions, CREB/BDNF Signaling, Cholinergic Activity, and Neuronal Density in the Hippocampus of an MSG-Induced Obesity Rat Model
The global rise in obesity and overweight over the past few decades has led to numerous associated disorders, including co...
Evaluation of the Memory Enhancement Effects of Aminopyrimidine Derivatives Using the Scopolamine Model of Dementia in Mice
Evaluation of the Memory Enhancement Effects of Aminopyrimidine Derivatives Using the Scopolamine Model of Dementia in Mice
Aminopyrimidine compounds have been gaining traction in the field of drug discovery in recent years due to their emergence...
Multi-Omics Analysis of Hippocampus in Rats Administered Trimethyltin Chloride
Multi-Omics Analysis of Hippocampus in Rats Administered Trimethyltin Chloride
Trimethyltin chloride (TMT) is a neurotoxicant that damages the central nervous system (CNS) and triggers neurodegeneratio...
Protective Effect of -Inositol Against Decitabine-Induced Neural Tube Defects in Embryonic Zebrafish
Protective Effect of -Inositol Against Decitabine-Induced Neural Tube Defects in Embryonic Zebrafish
Neural tube defects (NTDs) are severe congenital anomalies affecting 1–2 infants per 1000 births, and are influenced...
Metformin Protects Human Induced Pluripotent Stem Cell (hiPSC)-Derived Neurons from Oxidative Damage Through Antioxidant Mechanisms
Metformin Protects Human Induced Pluripotent Stem Cell (hiPSC)-Derived Neurons from Oxidative Damage Through Antioxidant Mechanisms
The antidiabetic drug metformin possesses antioxidant and cell protective effects including in neuronal cells, suggesting ...
Oxytetracycline and its Non-Antibiotic Derivative DOT Protect Midbrain Dopamine Neurons from Iron-Driven Oxidative Damage
Oxytetracycline and its Non-Antibiotic Derivative DOT Protect Midbrain Dopamine Neurons from Iron-Driven Oxidative Damage
This study aimed to investigate the neuroprotective potential of the tetracycline (TC) antibiotic oxytetracycline (OT) and...
Mechanistic Analysis of Decabromodiphenyl Ether-Induced Neurotoxicity in Humans Using Network Toxicology and Molecular Docking
Mechanistic Analysis of Decabromodiphenyl Ether-Induced Neurotoxicity in Humans Using Network Toxicology and Molecular Docking
Commercial decabromodiphenyl ether (c-decaBDE) is a widely used additive flame retardant in textiles and plastics. This fo...
Kynurenine Pathway in Epilepsy: Unraveling Its Role in Glutamate Excitotoxicity, GABAergic Dysregulation, Neuroinflammation, and Mitochondrial Dysfunction
Kynurenine Pathway in Epilepsy: Unraveling Its Role in Glutamate Excitotoxicity, GABAergic Dysregulation, Neuroinflammation, and Mitochondrial Dysfunction
Epilepsy is a chronic noncommunicable neurological disorder characterized by recurrent seizures and ranks as the seventh m...
Exploring the potential role of microtubule associated proteins-2 in the pathogenesis of HIV associated neurocognitive disorders
Exploring the potential role of microtubule associated proteins-2 in the pathogenesis of HIV associated neurocognitive disorders
HIV-associated neurocognitive disorder (HAND) persists in people living with HIV (PLWH) despite antiretroviral therapy. HA...
Associations among Angiotensin-Converting Enzyme, Neuroinflammation, and Cerebrospinal Fluid Biomarkers of Alzheimer's Disease in Non-Dementia Adults
Associations among Angiotensin-Converting Enzyme, Neuroinflammation, and Cerebrospinal Fluid Biomarkers of Alzheimer's Disease in Non-Dementia Adults
Recent studies have identified the angiotensin-converting enzyme (ACE) gene as a potential candidate influencing Alzheimer...
The Role and Mechanism of TRIM13 Regulation of TRAF6 Ubiquitination in the Synergy of Inflammatory Responses and Neurotoxicity Induced by METH and HIV- 1 Tat Protein in Astrocytes
The Role and Mechanism of TRIM13 Regulation of TRAF6 Ubiquitination in the Synergy of Inflammatory Responses and Neurotoxicity Induced by METH and HIV- 1 Tat Protein in Astrocytes
Methamphetamine (METH) abuse and HIV infection are major public health concerns worldwide. While both METH and HIV- 1 Tat ...
Exploring Retinal Neurodegeneration in Alzheimer’s Disease: A Molecular and Cellular Perspective
Exploring Retinal Neurodegeneration in Alzheimer’s Disease: A Molecular and Cellular Perspective
Increasing evidence of ocular impairments in Alzheimer’s disease (AD) has drawn the attention of researchers worldwi...
FABP3 Induces Mitochondrial Autophagy to Promote Neuronal Cell Apoptosis in Brain Ischemia-Reperfusion Injury
FABP3 Induces Mitochondrial Autophagy to Promote Neuronal Cell Apoptosis in Brain Ischemia-Reperfusion Injury
This study elucidates the molecular mechanisms by which FABP3 regulates neuronal apoptosis via mitochondrial autophagy in ...
Monomeric Amyloid Peptide-induced Toxicity in Human Oligodendrocyte Cell Line and Mouse Brain Primary Mixed-glial Cell Cultures: Evidence for a Neuroprotective Effect of Neurosteroid 3α-O-allyl-allopregnanolone
Monomeric Amyloid Peptide-induced Toxicity in Human Oligodendrocyte Cell Line and Mouse Brain Primary Mixed-glial Cell Cultures: Evidence for a Neuroprotective Effect of Neurosteroid 3α-O-allyl-allopregnanolone
Amyloid-peptide (Aβ) monomeric forms (ABM) occurring in presymptomatic Alzheimer’s disease (AD) brain are thoug...
Blunted Melatonin Circadian Rhythm in Parkinson’s Disease: Express Bewilderment
Blunted Melatonin Circadian Rhythm in Parkinson’s Disease: Express Bewilderment
Melatonin (MTN) is a neuro-hormone released from the pineal gland. MTN secretion is regulated by different neuronal circui...
Methylphenidate Exposing During Neurodevelopment Alters Amino Acid Profile, Astrocyte Marker and Glutamatergic Excitotoxicity in the Rat Striatum
Methylphenidate Exposing During Neurodevelopment Alters Amino Acid Profile, Astrocyte Marker and Glutamatergic Excitotoxicity in the Rat Striatum
There is a public health concern about the use of methylphenidate (MPH) since the higher prescription for young individual...
The Role of Vitamin C on ATPases Activities in Monosodium Glutamate-Induced Oxidative Stress in Rat Striatum and Cerebellum
The Role of Vitamin C on ATPases Activities in Monosodium Glutamate-Induced Oxidative Stress in Rat Striatum and Cerebellum
Monosodium glutamate (MSG) is a silent excitotoxin used as a flavour enhancer but exerts serious health hazards to consume...
Pharmacology of Adenosine A1 Receptor Agonist in a Humanized Esterase Mouse Seizure Model Following Soman Intoxication
Pharmacology of Adenosine A1 Receptor Agonist in a Humanized Esterase Mouse Seizure Model Following Soman Intoxication
Recently a novel genetically modified mouse strain with serum carboxylesterase knocked-out and the human acetylcholinester...
Impact of 5-Lipoxygenase Deficiency on Dopamine-Mediated Behavioral Responses
Impact of 5-Lipoxygenase Deficiency on Dopamine-Mediated Behavioral Responses
The 5-lipoxygenase/leukotriene system has been implicated in both physiological and pathological states within the central...
How is Excitotoxicity Being Modelled in iPSC-Derived Neurons?
How is Excitotoxicity Being Modelled in iPSC-Derived Neurons?
Excitotoxicity linked either to environmental causes (pesticide and cyanotoxin exposure), excitatory neurotransmitter imba...
Enriched Environment Inhibits Neurotoxic Reactive Astrocytes via JAK2-STAT3 to Promote Glutamatergic Synaptogenesis and Cognitive Improvement in Chronic Cerebral Hypoperfusion Rats
Enriched Environment Inhibits Neurotoxic Reactive Astrocytes via JAK2-STAT3 to Promote Glutamatergic Synaptogenesis and Cognitive Improvement in Chronic Cerebral Hypoperfusion Rats
Chronic cerebral hypoperfusion (CCH) is a primary contributor to cognitive decline in the elderly. Enriched environment (E...
Prenylated Flavanone Isolated from Dalea Species as a Potential Multitarget-Neuroprotector in an In Vitro Alzheimer’s Disease Mice Model
Prenylated Flavanone Isolated from Dalea Species as a Potential Multitarget-Neuroprotector in an In Vitro Alzheimer’s Disease Mice Model
Alzheimer’s disease (AD) involves a neurodegenerative process that has not yet been prevented, reversed, or stopped....
Melatonin is a Neuroprotective and Antioxidant Agent against Neurotoxicity Induced by an Intrahippocampal Injection of Nickel in Rats
Melatonin is a Neuroprotective and Antioxidant Agent against Neurotoxicity Induced by an Intrahippocampal Injection of Nickel in Rats
The investigation into the hippocampal function and its response to heavy metal exposure is crucial for understanding the ...
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