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Chapter Three - Insight gained from using animal models to study pain in Parkinson’s disease
Chapter Three - Insight gained from using animal models to study pain in Parkinson’s disease
Pain is one of the key non-motor symptoms experienced by a large proportion of people living with Parkinson’s disease (PD)...
Chapter Four - Investigating affective neuropsychiatric symptoms in rodent models of Parkinson’s disease
Chapter Four - Investigating affective neuropsychiatric symptoms in rodent models of Parkinson’s disease
Affective neuropsychiatric disorders such as depression, anxiety and apathy are among the most frequent non-motor symptoms...
Chapter Five - Macro and micro-sleep dysfunctions as translational biomarkers for Parkinson’s disease
Chapter Five - Macro and micro-sleep dysfunctions as translational biomarkers for Parkinson’s disease
Parkinson’s disease (PD) is the second most common neurodegenerative disease, afflicting about 1% of people over 65 years ...
Chapter One - AUD in perspective
Chapter One - AUD in perspective
Alcohol is a major cause of pre-mature death and individual suffering worldwide, and the importance of diagnosing and trea...
Chapter Two - Alcohol and the dopamine system
Chapter Two - Alcohol and the dopamine system
The mesolimbic dopamine pathway plays a major role in drug reinforcement and is likely involved also in the development of...
Chapter Three - GABAergic mechanisms in alcohol dependence
Chapter Three - GABAergic mechanisms in alcohol dependence
In 2014, it was estimated that brain diseases were responsible for 35% of Europe’s disease burden, with addictions having ...
Chapter Four - Current treatments of alcohol use disorder
Chapter Four - Current treatments of alcohol use disorder
Emerging treatments for alcohol dependence reveal an intricate interplay of neurobiological, psychological, and circumstan...
Chapter Five - Repurposing drugs for treatment of alcohol use disorder
Chapter Five - Repurposing drugs for treatment of alcohol use disorder
Repurposing drugs for the treatment of alcohol dependence involves the use of drugs that were initially developed for othe...
Chapter Six - Substitution therapy for patients with alcohol dependence: Mechanisms of action and efficacy
Chapter Six - Substitution therapy for patients with alcohol dependence: Mechanisms of action and efficacy
Julien Guiraud is employed by Vergio, Clichy, France and was employed by D&A Pharma until March 2022.Wim van den Brink...
Chapter Seven - Reducing the harms of alcohol: nutritional interventions and functional alcohol alternatives
Chapter Seven - Reducing the harms of alcohol: nutritional interventions and functional alcohol alternatives
While GABA is the main inhibitory transmitter in the brain, the last three decades have seen an increased appreciation of ...
Chapter Eight - Designing and testing treatments for alcohol use disorder
Chapter Eight - Designing and testing treatments for alcohol use disorder
Developing new treatments for AUD or personalizing existing treatments for AUD requires extensive consideration of researc...
Chapter Nine - Phosphatidylethanol (B-PEth) and other direct and indirect biomarkers of alcohol consumption
Chapter Nine - Phosphatidylethanol (B-PEth) and other direct and indirect biomarkers of alcohol consumption
Correct information of the actual alcohol intake is essential to assess the correlation with alcohol risk level consumptio...
Macro and micro-sleep dysfunctions as translational biomarkers for Parkinson’s disease
Macro and micro-sleep dysfunctions as translational biomarkers for Parkinson’s disease
Parkinson’s disease (PD) is the second most common neurodegenerative disease, afflicting about 1% of people over 65 years ...