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Association of Gene Polymorphisms and Neurological Disorders: Insights from Integrated Bioinformatics and Meta-Analysis
Association of Gene Polymorphisms and Neurological Disorders: Insights from Integrated Bioinformatics and Meta-Analysis
Interleukin 6 (IL6) is an inflammatory biomarker linked to central and peripheral nervous system diseases. This study comb...
Extract Diminish Hypoxia-Induced Anxiety by Regulating HIF-1α Signaling and Enhancing the Antioxidant Defense System in Hippocampus
Extract Diminish Hypoxia-Induced Anxiety by Regulating HIF-1α Signaling and Enhancing the Antioxidant Defense System in Hippocampus
Hypoxia is a significant stressor, and stabilized hypoxia-inducible factor-1α (HIF-1α) regulates the expression ...
Seipin Deficiency Impairs Motor Coordination in Mice by Compromising Spinal Cord Myelination
Seipin Deficiency Impairs Motor Coordination in Mice by Compromising Spinal Cord Myelination
The integrity of the myelin sheath of the spinal cord (SC) is essential for motor coordination. Seipin is an endoplasmic r...
Time of the Day of Traumatic Brain Injury has Minimal Effects on Behavioral and Histological Outcomes in Mice of Both Sexes
Time of the Day of Traumatic Brain Injury has Minimal Effects on Behavioral and Histological Outcomes in Mice of Both Sexes
Transcription of > 50% of the mammalian coding genes follows circadian rhythm in an organ-specific mann...
The Role of Lactic Acid Bacteria in Improving Behavioral Deficits, Serum Levels of Vitamin D3, B12 and Reducing Oxidative Stress and Demyelination in a Cuprizone-induced Demyelination Model of Rat
The Role of Lactic Acid Bacteria in Improving Behavioral Deficits, Serum Levels of Vitamin D3, B12 and Reducing Oxidative Stress and Demyelination in a Cuprizone-induced Demyelination Model of Rat
Multiple sclerosis constitutes a chronic, inflammatory, and demyelinating disorder affecting the central nervous system, w...
Therapeutic Potential of TUBB6 Inhibition for Hematoma Reduction, Microtubule Stabilization, and Neurological Recovery in an In Vivo Model of Intracerebral Hemorrhage
Therapeutic Potential of TUBB6 Inhibition for Hematoma Reduction, Microtubule Stabilization, and Neurological Recovery in an In Vivo Model of Intracerebral Hemorrhage
This in vivo study explored the impact of TUBB6 inhibition in intracerebral hemorrhage (ICH), focusing on its effects on h...
Annexin A’s Life in Pan-Cancer: Especially in Glioma Immune Cells
Annexin A’s Life in Pan-Cancer: Especially in Glioma Immune Cells
The Annexin A (ANXA) family plays a critical role in cancer, with particular emphasis on their prognostic significance in ...
ADAR1 Promotes NUPR1 A-to-I RNA Editing to Exacerbate Ischemic Brain Injury by Microglia Mediated Neuroinflammation
ADAR1 Promotes NUPR1 A-to-I RNA Editing to Exacerbate Ischemic Brain Injury by Microglia Mediated Neuroinflammation
Microglial cells occupy a crucial position as potential therapeutic targets in the context of ischemic stroke (IS). Noneth...
Variant Position Affects the Phenotype at the Pluripotent Stem Cell Level in CADASIL
Variant Position Affects the Phenotype at the Pluripotent Stem Cell Level in CADASIL
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common ge...
Leptin and Leptin Signaling in Multiple Sclerosis: A Narrative Review
Leptin and Leptin Signaling in Multiple Sclerosis: A Narrative Review
Obesity, a pandemic health problem, is now considered as a chronic inflammatory state, related to many autoimmune diseases...
The Peripheral Amyloid-β Nexus: Connecting Alzheimer’s Disease with Atherosclerosis through Shared Pathophysiological Mechanisms
The Peripheral Amyloid-β Nexus: Connecting Alzheimer’s Disease with Atherosclerosis through Shared Pathophysiological Mechanisms
Alzheimer’s disease (AD) and atherosclerosis (AS) are two chronic diseases with seemingly distinct pathologies. Howe...
The Role of G-Protein-Coupled Receptor Kinase 4 in Modulating Mitophagy and Oxidative Stress in Cerebral Ischemia–Reperfusion Injury
The Role of G-Protein-Coupled Receptor Kinase 4 in Modulating Mitophagy and Oxidative Stress in Cerebral Ischemia–Reperfusion Injury
Cerebral ischemia–reperfusion injury (CIRI) causes significant neuronal damage through oxidative stress, inflammatio...
SP3-Mediated Transcriptional Activation of GRIK1 is Involved in Alzheimer’s Disease-Induced Cognitive Decline by Inducing Inflammasome Activation in Microglia
SP3-Mediated Transcriptional Activation of GRIK1 is Involved in Alzheimer’s Disease-Induced Cognitive Decline by Inducing Inflammasome Activation in Microglia
GRIK1 has been identified to suppress the activation of NLRP3 inflammasome. The present study investigated the damaging ef...
Folic Acid Promotes Peripheral Nerve Injury Repair via Regulating DNM3-AKT Pathway Through Mediating Methionine Cycle Metabolism
Folic Acid Promotes Peripheral Nerve Injury Repair via Regulating DNM3-AKT Pathway Through Mediating Methionine Cycle Metabolism
Emerging evidence suggests that folic acid (FA) supports nerve repair, but its beneficial effects in peripheral nerve inju...
5-Repurposed Drug Candidates Identified in Motor Neurons and Muscle Tissues with Amyotrophic Lateral Sclerosis by Network Biology and Machine Learning Based on Gene Expression
5-Repurposed Drug Candidates Identified in Motor Neurons and Muscle Tissues with Amyotrophic Lateral Sclerosis by Network Biology and Machine Learning Based on Gene Expression
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder that leads to motor neuron degeneration, m...
Exploring NLRP3 Inhibition as a Key Modulator in Neonatal Hypoxic-Ischemic Brain Injury
Exploring NLRP3 Inhibition as a Key Modulator in Neonatal Hypoxic-Ischemic Brain Injury
Neonatal hypoxic-ischemic (HI) injury is a critical condition associated with significant acute brain damage and long-term...
CaMKIIα-NpHR-Mediated Optogenetic Inhibition of DRG Glutamatergic Neurons by Flexible Optic Fiber Alleviates Chronic Neuropathic Pain
CaMKIIα-NpHR-Mediated Optogenetic Inhibition of DRG Glutamatergic Neurons by Flexible Optic Fiber Alleviates Chronic Neuropathic Pain
Glutamatergic neurons of the dorsal root ganglion (DRGg) exert a significant effect on peripheral nociceptive signal trans...
Neuropeptide Signaling in Glioblastoma: A Comprehensive Review of the Current State and Future Direction
Neuropeptide Signaling in Glioblastoma: A Comprehensive Review of the Current State and Future Direction
Glioblastoma multiforme (GBM) is a highly aggressive brain tumor characterized by complex pathophysiology and significant ...
Unraveling the Role of NeuroD2 in Ischemic Pathophysiology: Insight into Neuroprotection Mechanisms Associated with AKT Survival Kinase
Unraveling the Role of NeuroD2 in Ischemic Pathophysiology: Insight into Neuroprotection Mechanisms Associated with AKT Survival Kinase
NeuroD2 (ND2), a neuron-specific transcription factor, is essential in neural differentiation and neuroplasticity, yet its...
Astaxanthin Rescues Memory Impairments in Rats with Vascular Dementia by Protecting Against Neuronal Death in the Hippocampus
Astaxanthin Rescues Memory Impairments in Rats with Vascular Dementia by Protecting Against Neuronal Death in the Hippocampus
Vascular dementia (VaD) is a cognitive disorder characterized by a decline in cognitive function resulting from cerebrovas...
The CD44s Isoform is a Potential Biomarker for Predicting Craniopharyngioma Recurrence in Children
The CD44s Isoform is a Potential Biomarker for Predicting Craniopharyngioma Recurrence in Children
Adamantinomatous craniopharyngioma (ACP) is an intracranial tumor considered partly malignant due to its ability to infilt...
Physical Exercise Inhibits Cognitive Impairment and Memory Loss in Aged Mice, and Enhances Pre- and Post-Synaptic Proteins in the Hippocampus of Young and Aged Mice
Physical Exercise Inhibits Cognitive Impairment and Memory Loss in Aged Mice, and Enhances Pre- and Post-Synaptic Proteins in the Hippocampus of Young and Aged Mice
The aim of this study was to evaluate the effects of swimming in the brain and behavior of young and aged mice. Forty-eigh...
Evaluation of Neuroprotective Effect of Gut Microbe in Parkinson's Disease: An In Silico and In Vivo Approach
Evaluation of Neuroprotective Effect of Gut Microbe in Parkinson's Disease: An In Silico and In Vivo Approach
Parkinson's disease is a progressive neurodegenerative disorder marked by the death of dopaminergic neurons in the sub...
Activation of GPR30 Ameliorates Cerebral Ischemia–Reperfusion Injury by Suppressing Ferroptosis Through Nrf2/GPX4 Signaling Pathway
Activation of GPR30 Ameliorates Cerebral Ischemia–Reperfusion Injury by Suppressing Ferroptosis Through Nrf2/GPX4 Signaling Pathway
The newly identified estrogen receptor, G protein-coupled receptor 30 (GPR30), is prevalent in the brain and has been show...
Exosomal GDNF from Bone Marrow Mesenchymal Stem Cells Moderates Neuropathic Pain in a Rat Model of Chronic Constriction Injury
Exosomal GDNF from Bone Marrow Mesenchymal Stem Cells Moderates Neuropathic Pain in a Rat Model of Chronic Constriction Injury
Both of exosomes derived from mesenchymal stem cells (MSCs) and glial cell line-derived neurotrophic factor (GDNF) show po...
Neuroprotective Effects of VGLUT1 Inhibition in HT22 Cells Overexpressing VGLUT1 Under Oxygen Glucose Deprivation Conditions
Neuroprotective Effects of VGLUT1 Inhibition in HT22 Cells Overexpressing VGLUT1 Under Oxygen Glucose Deprivation Conditions
Glutamate (Glu) is a major excitatory neurotransmitter in the brain, essential for synaptic plasticity, neuronal activity,...
Dysregulated Purinergic Signalling in Fragile X Syndrome Cortical Astrocytes
Dysregulated Purinergic Signalling in Fragile X Syndrome Cortical Astrocytes
The symptoms of fragile X syndrome (FXS), caused by a single gene mutation to Fmr1, have been increasingly linked to disor...
Inhibition of CRMP2 Phosphorylation Suppresses Microglia Activation in the Retina and Optic Nerve and Promotes Optic Nerve Regeneration After Optic Nerve Injury
Inhibition of CRMP2 Phosphorylation Suppresses Microglia Activation in the Retina and Optic Nerve and Promotes Optic Nerve Regeneration After Optic Nerve Injury
As the primary connection between the eye and brain, the optic nerve plays a pivotal role in visual information transmissi...
The Blood-Cerebrospinal Fluid Barrier Dysfunction in Brain Disorders and Stroke: Why, How, What For?
The Blood-Cerebrospinal Fluid Barrier Dysfunction in Brain Disorders and Stroke: Why, How, What For?
Ischemic stroke (IS) results in the interruption of blood flow to the brain, which can cause significant damage. The patho...
Identification of Disulfidptosis-Related Genes in Ischemic Stroke by Combining Single-Cell Sequencing, Machine Learning Algorithms, and In Vitro Experiments
Identification of Disulfidptosis-Related Genes in Ischemic Stroke by Combining Single-Cell Sequencing, Machine Learning Algorithms, and In Vitro Experiments
Ischemic stroke (IS) is a severe neurological disorder with a pathogenesis that remains incompletely understood. Recently,...
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