Allen, K. A., & Brandon, D. H. (2011). Hypoxic ischemic encephalopathy: pathophysiology and experimental treatments. Newborn and Infant Nursing Reviews, 11(3), 125–133. https://doi.org/10.1053/j.nainr.2011.07.004
Bernis, M. E., Schleehuber, Y., Zweyer, M., Maes, E., Felderhoff-Müser, U., Picard, D., & Sabir, H. (2022). Temporal characterization of microglia-associated pro- and anti-inflammatory genes in a neonatal inflammation-sensitized hypoxic-ischemic brain injury model. Oxidative Medicine and Cellular Longevity, 2022, 1–16. https://doi.org/10.1155/2022/2479626
Bonfante, S., Netto, M. B., de Oliveira Junior, A. N., Mathias, K., Machado, R. S., Joaquim, L., et al. (2024). Oxidative stress and mitochondrial dysfunction contributes to postoperative cognitive dysfunction in elderly rats dependent on NLRP3 activation. Metabolic Brain Disease, 40(1), 1. https://doi.org/10.1007/s11011-024-01425-5
Article CAS PubMed Google Scholar
Cai, Q., Shen, L., Zhang, X., Zhang, Z., & Wang, T. (2025). The IRE1-XBP1 axis regulates NLRP3 inflammasome-mediated microglia activation in hypoxic ischemic encephalopathy. Critical Reviews in Immunology, 45(1), 55–64. https://doi.org/10.1615/CritRevImmunol.2024053554
Cao, Y., Sun, Y., Cui, Q., He, X., & Li, Z. (2023). Artesunate alleviates hypoxic-ischemic brain damage in neonatal rats by inhibiting NLRP3 inflammasome activation and inflammatory cytokine secretion. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 39(5), 410–415.
Chen, A., Xu, Y., & Yuan, J. (2018a). Ginkgolide B ameliorates NLRP3 inflammasome activation after hypoxic-ischemic brain injury in the neonatal male rat. International Journal of Developmental Neuroscience, 69(1), 106–111. https://doi.org/10.1016/j.ijdevneu.2018.07.004
Article CAS PubMed Google Scholar
Chen, D., Dixon, B. J., Doycheva, D. M., Li, B., Zhang, Y., Hu, Q., et al. (2018b). IRE1α inhibition decreased TXNIP/NLRP3 inflammasome activation through miR-17-5p after neonatal hypoxic–ischemic brain injury in rats. Journal of Neuroinflammation, 15(1), 32. https://doi.org/10.1186/s12974-018-1077-9
Article CAS PubMed PubMed Central Google Scholar
Chen, Y., Li, X., Xiong, Q., Du, Y., Luo, M., Yi, L., et al. (2023b). Inhibiting NLRP3 inflammasome signaling pathway promotes neurological recovery following hypoxic-ischemic brain damage by increasing p97-mediated surface GluA1-containing AMPA receptors. Journal of Translational Medicine, 21(1), 567. https://doi.org/10.1186/s12967-023-04452-5
Article CAS PubMed PubMed Central Google Scholar
Chen, Y., Ye, X., Escames, G., Lei, W., Zhang, X., Li, M., et al. (2023a). The NLRP3 inflammasome: Contributions to inflammation-related diseases. Cellular & Molecular Biology Letters, 28(1), 51. https://doi.org/10.1186/s11658-023-00462-9
Chen, Z., Hu, Y., Lu, R., Ge, M., & Zhang, L. (2020). MicroRNA-374a-5p inhibits neuroinflammation in neonatal hypoxic-ischemic encephalopathy via regulating NLRP3 inflammasome targeted Smad6. Life Sciences, 252, 117664. https://doi.org/10.1016/j.lfs.2020.117664
Article CAS PubMed Google Scholar
Cheon, J., Kwon, S., & Kim, M. (2024). Exerkines mitigating Alzheimer’s disease progression by regulating inflammation: Focusing on macrophage/microglial NLRP3 inflammasome pathway. Alzheimer’s & Dementia. https://doi.org/10.1002/alz.14432
Danielski, L. G., Giustina, A. D., Bonfante, S., Barichello, T., & Petronilho, F. (2020a). The NLRP3 inflammasome and its role in sepsis development. Inflammation, 43(1), 24–31. https://doi.org/10.1007/s10753-019-01124-9
Danielski, L. G., Giustina, A. D., Bonfante, S., de Souza Goldim, M. P., Joaquim, L., Metzker, K. L., et al. (2020b). NLRP3 activation contributes to acute brain damage leading to memory impairment in sepsis-surviving rats. Molecular Neurobiology, 57(12), 5247–5262. https://doi.org/10.1007/s12035-020-02089-9
Article CAS PubMed Google Scholar
Di Martino, E., Ambikan, A., Ramsköld, D., Umekawa, T., Giatrellis, S., Vacondio, D., et al. (2024). Inflammatory, metabolic, and sex-dependent gene-regulatory dynamics of microglia and macrophages in neonatal hippocampus after hypoxia-ischemia. iScience, 27(4), 109346. https://doi.org/10.1016/j.isci.2024.109346
Article CAS PubMed PubMed Central Google Scholar
Ding, H.-S., Huang, Y., Qu, J.-F., Wang, Y.-J., Huang, Z.-Y., Wang, F.-Y., et al. (2023). Panaxynol ameliorates cardiac ischemia/reperfusion injury by suppressing NLRP3-induced pyroptosis and apoptosis via HMGB1/TLR4/NF-κB axis. International Immunopharmacology, 121, 110222. https://doi.org/10.1016/j.intimp.2023.110222
Article CAS PubMed Google Scholar
Ding, X., Pan, T., Tian, Q., Huang, W., Hayashi, L. S., Liu, Q., et al. (2022). Profiling temporal changes of the pineal transcriptomes at single cell level upon neonatal HIBD. Frontiers in Cell and Developmental Biology. https://doi.org/10.3389/fcell.2022.794012
Article PubMed PubMed Central Google Scholar
Fan, H., Fu, Q., Du, G., Qin, L., Shi, X., Wang, D., & Yang, Y. (2024). Microglial mayhem NLRP3 Inflammasome’s role in multiple sclerosis pathology. CNS Neuroscience & Therapeutics. https://doi.org/10.1111/cns.70135
Fan, Y., Du, L., Fu, Q., Zhou, Z., Zhang, J., Li, G., & Wu, J. (2018). Inhibiting the NLRP3 inflammasome with MCC950 ameliorates isoflurane-induced pyroptosis and cognitive impairment in aged mice. Frontiers in Cellular Neuroscience. https://doi.org/10.3389/fncel.2018.00426
Article PubMed PubMed Central Google Scholar
Fang, X., Gao, S., Li, Y., Xu, K., Huo, Q., Xiao, P., et al. (2025). Hypoxia-preconditioned human dental pulp stem cells transplantation alleviates hypoxic-ischemic brain damage via STAT3/NLRP3/caspase-1 axis in neonatal rats. NeuroReport. https://doi.org/10.1097/WNR.0000000000002144
Gao, S., Li, N., Lin, Z., Zhong, Y., Wang, Y., & Shen, X. (2024). Inhibition of NLRP3 inflammasome by MCC950 under hypoxia alleviates photoreceptor apoptosis via inducing autophagy in Müller glia. The FASEB Journal. https://doi.org/10.1096/fj.202301922RR
Generoso, J. S., Faller, C. J., Collodel, A., Catalão, C. H. R., Dominguini, D., Petronilho, F., et al. (2024). NLRP3 activation contributes to memory impairment in an experimental model of pneumococcal meningitis. Molecular Neurobiology, 61(1), 239–251. https://doi.org/10.1007/s12035-023-03549-8
Article CAS PubMed Google Scholar
Gorgij, E., Fanaei, H., Yaghmaei, P., Shahraki, M. R., & Mirahmadi, H. (2023). Maternal treadmill exercise ameliorates impairment of neurological outcome, caspase-1 and NLRP3 gene expression alteration in neonatal hypoxia-ischemia rats. Iranian Journal of Basic Medical Sciences, 26(2), 228–234. https://doi.org/10.22038/IJBMS.2022.66183.14544
Article PubMed PubMed Central Google Scholar
Hou, X., Yuan, Z., Wang, X., Cheng, R., Zhou, X., & Qiu, J. (2020). Peptidome analysis of cerebrospinal fluid in neonates with hypoxic-ischemic brain damage. Molecular Brain, 13(1), 133. https://doi.org/10.1186/s13041-020-00671-9
Article CAS PubMed PubMed Central Google Scholar
Hu, Y., Nan, Y., Lin, H., Zhao, Q., Chen, T., Tao, X., et al. (2024). Celastrol ameliorates hypoxic-ischemic brain injury in neonatal rats by reducing oxidative stress and inflammation. Pediatric Research. https://doi.org/10.1038/s41390-024-03246-9
Article PubMed PubMed Central Google Scholar
Hu, Y., Wang, P., & Han, K. (2022). Hydrogen attenuated inflammation response and oxidative in hypoxic ischemic encephalopathy via Nrf2 mediated the inhibition of NLRP3 and NF-κB. Neuroscience, 485, 23–36. https://doi.org/10.1016/j.neuroscience.2021.12.024
Article CAS PubMed Google Scholar
Hu, Z., Yuan, Y., Zhang, X., Lu, Y., Dong, N., Jiang, X., et al. (2021a). Human umbilical cord mesenchymal stem cell-derived exosomes attenuate oxygen-glucose deprivation/reperfusion-induced microglial pyroptosis by promoting FOXO3a-dependent mitophagy. Oxidative Medicine and Cellular Longevity. https://doi.org/10.1155/2021/6219715
Article PubMed PubMed Central Google Scholar
Hu, Z., Yuan, Y., Zhang, X., Lu, Y., Dong, N., Jiang, X., et al. (2021b). Human umbilical cord mesenchymal stem cell-derived exosomes attenuate oxygen-glucose deprivation/reperfusion-induced microglial pyroptosis by promoting FOXO3a-dependent mitophagy. Oxidative Medicine and Cellular Longevity. https://doi.org/10.1155/2021/6219715
Article PubMed PubMed Central Google Scholar
Huang, Y., Xu, W., & Zhou, R. (2021). NLRP3 inflammasome activation and cell death. Cellular & Molecular Immunology, 18(9), 2114–2127. https://doi.org/10.1038/s41423-021-00740-6
Comments (0)