Leptin and Leptin Signaling in Multiple Sclerosis: A Narrative Review

Ahmed, M., Kimura, K., Soliman, M., Yamaji, D., Okamatsu-Ogura, Y., Makondo, K., Inanami, O., & Saito, M. (2007). Effects of Leptin and Tumor Necrosis Factor-α on Degranulation and Superoxide Production of Polymorphonuclear Neutrophils from Holstein Cows. J. Vet. Med. Sci, 69(2). http://rsb.info.nih.gov/nih-image/

Angelucci, F., Mirabella, M., Caggiula, M., Frisullo, G., Patanella, K., Sancricca, C., Nociti, V., Tonali, P. A., & Batocchi, A. P. (2005). Evidence of involvement of leptin and IL-6 peptides in the action of interferon-beta in secondary progressive multiple sclerosis. Peptides, 26(11), 2289–2293. https://doi.org/10.1016/J.PEPTIDES.2005.03.037

Article  CAS  PubMed  Google Scholar 

Baecher-Allan, C., Kaskow, B. J., & Weiner, H. L. (2018). Multiple sclerosis: Mechanisms and immunotherapy. Neuron, 97(4), 742–768. https://doi.org/10.1016/J.NEURON.2018.01.021

Article  CAS  PubMed  Google Scholar 

Baharnoori, M., Wilson, R., Saxena, S., Gonzalez, C. T., Sotiropoulos, M. G., Keyhanian, K., Healy, B. C., & Chitnis, T. (2021). Altered adipokine levels are associated with dimethyl fumarate treatment in multiple sclerosis patients. Multiple Sclerosis and Related Disorders. https://doi.org/10.1016/j.msard.2021.103311

Article  PubMed  Google Scholar 

Bapat, S. P., Whitty, C., Mowery, C. T., Liang, Y., Yoo, A., Jiang, Z., Peters, M. C., Zhang, L. J., Vogel, I., Zhou, C., Nguyen, V. Q., Li, Z., Chang, C., Zhu, W. S., Hastie, A. T., He, H., Ren, X., Qiu, W., Gayer, S. G., … & Marson, A. (2022). Obesity alters pathology and treatment response in inflammatory disease. Nature, 604(7905), 337–342. https://doi.org/10.1038/s41586-022-04536-0

Batocchi, A. P., Rotondi, M., Caggiula, M., Frisullo, G., Odoardi, F., Nociti, V., Carella, C., Tonali, P. A., & Mirabella, M. (2003). Leptin as a marker of multiple sclerosis activity in patients treated with interferon-beta. Journal of Neuroimmunology, 139(1–2), 150–154. https://doi.org/10.1016/S0165-5728(03)00154-1

Article  CAS  PubMed  Google Scholar 

Biström, M., Hultdin, J., Andersen, O., Alonso-Magdalena, L., Jons, D., Gunnarsson, M., Vrethem, M., & Sundström, P. (2021). Leptin levels are associated with multiple sclerosis risk. Multiple Sclerosis Journal, 27(1), 19–27. https://doi.org/10.1177/1352458520905033

Article  CAS  PubMed  Google Scholar 

Blüher, M., & Mantzoros, C. S. (2015). From leptin to other adipokines in health and disease: Facts and expectations at the beginning of the 21st century. Metabolism. https://doi.org/10.1016/j.metabol.2014.10.016

Article  PubMed  Google Scholar 

Bove, R., Musallam, A., Xia, Z., Baruch, N., Messina, S., Healy, B. C., & Chitnis, T. (2016). Longitudinal BMI trajectories in multiple sclerosis: Sex differences in association with disease severity. Multiple Sclerosis and Related Disorders, 8, 136–140. https://doi.org/10.1016/J.MSARD.2016.05.019

Article  CAS  PubMed  Google Scholar 

Briggs, F. B. S., Yu, J. C., Davis, M. F., Jiangyang, J., Fu, S., Parrotta, E., Gunzler, D. D., & Ontaneda, D. (2018). Multiple sclerosis risk factors contribute to onset heterogeneity. Multiple Sclerosis and Related Disorders. https://doi.org/10.1016/j.msard.2018.12.007

Article  PubMed  Google Scholar 

Bruno, A., Conus, S., Schmid, I., & Simon, H.-U. (2005). Apoptotic pathways are inhibited by leptin receptor activation in neutrophils. The Journal of Immunology, 174(12), 8090–8096. https://doi.org/10.4049/JIMMUNOL.174.12.8090

Article  CAS  PubMed  Google Scholar 

Carvalho-Tavares, J., Hickey, M. J., Hutchison, J., Michaud, J., Sutcliffe, I. T., & Kubes, P. (2000). A role for platelets and endothelial selectins in tumor necrosis factor-alpha-induced leukocyte recruitment in the brain microvasculature. Circulation Research, 87(12), 1141–1148. https://doi.org/10.1161/01.RES.87.12.1141

Article  CAS  PubMed  Google Scholar 

Chai, J., & Song, Q. (2014). Quantitative and multiplexed study of endothelial cell inflammation. Cell Biochemistry and Biophysics, 70(3), 1783–1790. https://doi.org/10.1007/S12013-014-0129-8

Article  CAS  PubMed  Google Scholar 

Chitnis, T., Graves, J., Weinstock-Guttman, B., Belman, A., Olsen, C., Misra, M., Aaen, G., Benson, L., Candee, M., Gorman, M., Greenberg, B., Krupp, L., Lotze, T., Mar, S., Ness, J., Rose, J., Rubin, J., Schreiner, T., Tillema, J., … & Waubant, E. (2016). Distinct effects of obesity and puberty on risk and age at onset of pediatric MS. Annals of Clinical and Translational Neurology, 3(12), 897–907. https://doi.org/10.1002/ACN3.365

Choi, I. Y., Piccio, L., Childress, P., Bollman, B., Ghosh, A., Brandhorst, S., Suarez, J., Michalsen, A., Cross, A. H., Morgan, T. E., Wei, M., Paul, F., Bock, M., & Longo, V. D. (2016). A diet mimicking fasting promotes regeneration and reduces autoimmunity and multiple sclerosis symptoms. Cell Reports, 15(10), 2136–2146. https://doi.org/10.1016/J.CELREP.2016.05.009

Article  CAS  PubMed  Google Scholar 

Cinkir, U., Bir, L. S., Topsakal, S., Cicek, E. A., & Tekin, S. (2021). Investigation of blood leptin and adropin levels in patients with multiple sclerosis A CONSORT-clinical study. Medicine (United States). https://doi.org/10.1097/MD.0000000000027247

Article  Google Scholar 

Çoban, A., Çevik, D., Özyurt, S., Gencer, M., Tüzün, E., & Türkoʇlu, R. (2015). The association between obesity and oligoclonal band formation in multiple sclerosis patients. Obesity Research and Clinical Practice, 9(5), 533–535. https://doi.org/10.1016/j.orcp.2015.07.001

Article  PubMed  Google Scholar 

Considine, R. V., Sinha, M. K., Heiman, M. L., Kriauciunas, A., Stephens, T. W., Nyce, M. R., Ohannesian, J. P., Marco, C. C., McKee, L. J., Bauer, T. L., & Caro, J. F. (1996). Serum immunoreactive-leptin concentrations in normal-weight and obese humans. The New England Journal of Medicine, 334(5), 292–295. https://doi.org/10.1056/NEJM199602013340503

Article  CAS  PubMed  Google Scholar 

Correale, J., & Marrodan, M. (2022). Multiple sclerosis and obesity: The role of adipokines. Frontiers in Immunology. https://doi.org/10.3389/fimmu.2022.1038393

Article  PubMed  PubMed Central  Google Scholar 

Cortese, M., Yuan, C., Chitnis, T., Ascherio, A., & Munger, K. L. (2017). No association between dietary sodium intake and the risk of multiple sclerosis. Neurology, 89(13), 1322–1329. https://doi.org/10.1212/WNL.0000000000004417

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cowley, M. A., Smart, J. L., Rubinstein, M., Cerdán, M. G., Diano, S., Horvath, T. L., Cone, R. D., & Low, M. J. (2001). Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature, 411(6836), 480–484. https://doi.org/10.1038/35078085

Article  CAS  PubMed  Google Scholar 

Dahlman, I., Elsen, M., Tennagels, N., Korn, M., Brockmann, B., Sell, H., Eckel, J., & Arner, P. (2012). Functional annotation of the human fat cell secretome. Archives of Physiology and Biochemistry, 118(3), 84–91. https://doi.org/10.3109/13813455.2012.685745

Article  CAS  PubMed  Google Scholar 

Dargahi, N., Katsara, M., Tselios, T., Androutsou, M. E., De Courten, M., Matsoukas, J., & Apostolopoulos, V. (2017). Multiple Sclerosis: Immunopathology and treatment update. Brain Sciences, 7(7), 78. https://doi.org/10.3390/BRAINSCI7070078

Article  PubMed  PubMed Central  Google Scholar 

Davanzo, G. G., Castro, G., Monteiro, L. B., Castelucci, B. G., Jaccomo, V. H., da Silva, F. C., Marques, A. M., Francelin, C., de Campos, B. B., de Aguiar, C. F., Joazeiro, P. P., Consonni, S. R., Farias, A. S., & Moraes-Vieira, P. M. (2023). Obesity increases blood-brain barrier permeability and aggravates the mouse model of multiple sclerosis. Multiple Sclerosis and Related Disorders, 72, 104605. https://doi.org/10.1016/J.MSARD.2023.104605

Article  CAS  PubMed  Google Scholar 

Dayakar, A., Chandrasekaran, S., Veronica, J., & Maurya, R. (2016). Leptin induces the phagocytosis and protective immune response in Leishmania donovani infected THP-1 cell line and human PBMCs. Experimental Parasitology, 160, 54–59. https://doi.org/10.1016/J.EXPPARA.2015.12.002

Article  CAS  PubMed  Google Scholar 

de Candia, P., & Matarese, G. (2018). Leptin and ghrelin: Sewing metabolism onto neurodegeneration. Neuropharmacology, 136(Pt B), 307–316. https://doi.org/10.1016/J.NEUROPHARM.2017.12.025

Article  PubMed  Google Scholar 

Fisniku, L. K., Chard, D. T., Jackson, J. S., Anderson, V. M., Altmann, D. R., Miszkiel, K. A., Thompson, A. J., & Miller, D. H. (2008). Gray matter atrophy is related to long-term disability in multiple sclerosis. Annals of Neurology, 64(3), 247–254. https://doi.org/10.1002/ANA.21423

Article  PubMed  Google Scholar 

Fitzgerald, K. C., Vizthum, D., Henry-Barron, B., Schweitzer, A., Cassard, S. D., Kossoff, E., Hartman, A. L., Kapogiannis, D., Sullivan, P., Baer, D. J., Mattson, M. P., Appel, L. J., & Mowry, E. M. (2018). Effect of intermittent vs. daily calorie restriction on changes in weight and patient-reported outcomes in people with multiple sclerosis. Multiple Sclerosis and Related Disorders, 23, 33–39. https://doi.org/10.1016/J.MSARD.2018.05.002

Article  PubMed  PubMed Central  Google Scholar 

Flores-Cordero, J. A., Pérez-Pérez, A., Jiménez-Cortegana, C., Alba, G., Flores-Barragán, A., & Sánchez-Margalet, V. (2022). Obesity as a risk factor for dementia and Alzheimer’s Disease: The role of leptin. International Journal of Molecular Sciences. https://doi.org/10.3390/IJMS23095202

Article  PubMed  PubMed Central 

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