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Pharmacological characterization of sex differences in the effects of dopaminergic drugs on effort-based decision making in rats
Pharmacological characterization of sex differences in the effects of dopaminergic drugs on effort-based decision making in rats
Motivational dysfunctions related to effort exertion are common in psychiatric disorders. Dopamine systems regulate exerti...
Ellagic Acid Reverses Alterations in the Expression of AMPA Receptor and Its Scaffolding Proteins in the Cerebral Cortex and Memory Decline in STZ-sporadic Alzheimer’ s Disease Mouse Model
Ellagic Acid Reverses Alterations in the Expression of AMPA Receptor and Its Scaffolding Proteins in the Cerebral Cortex and Memory Decline in STZ-sporadic Alzheimer’ s Disease Mouse Model
Alzheimer’s disease (AD), an age-dependent devastating neuropsychiatric disorder, is a leading cause of learning, me...
Acute nicotine administration reduces the efficacy of punishment in curbing remifentanil consumption in a seeking-taking chain schedule of reinforcement
Acute nicotine administration reduces the efficacy of punishment in curbing remifentanil consumption in a seeking-taking chain schedule of reinforcement
Nicotine dependence is highly comorbid with opioid use disorders (OUDs). The use of nicotine-containing products increases...
Elucidating the molecular symphony: unweaving the transcriptional & epigenetic pathways underlying neuroplasticity in opioid dependence and withdrawal
Elucidating the molecular symphony: unweaving the transcriptional & epigenetic pathways underlying neuroplasticity in opioid dependence and withdrawal
The persistent use of opioids leads to profound changes in neuroplasticity of the brain, contributing to the emergence and...
Hypocretin-1 receptor antagonism improves inhibitory control during the Go/No-Go task in highly motivated, impulsive male mice
Hypocretin-1 receptor antagonism improves inhibitory control during the Go/No-Go task in highly motivated, impulsive male mice
Motivation and inhibitory control are dominantly regulated by the dopaminergic (DA) and noradrenergic (NA) systems, respec...
Choice of alcohol over a natural reward: an experimental study in light and heavy social drinkers
Choice of alcohol over a natural reward: an experimental study in light and heavy social drinkers
A core symptom of alcohol use disorder (AUD) is a progressively increased choice of alcohol over alternative rewards despi...
Oxytocin differentially modulates reward system responses to social and non-social incentives
Oxytocin differentially modulates reward system responses to social and non-social incentives
Oxytocin has been shown to modulate behavior related to processing of monetary incentives and to regulate social and repro...
Perceived changes in mental health and social engagement attributed to a single psychedelic experience in autistic adults: results from an online survey
Perceived changes in mental health and social engagement attributed to a single psychedelic experience in autistic adults: results from an online survey
Anecdotal reports suggest that psychedelic drugs can improve psychological wellbeing and social engagement in autistic peo...
Orexin mechanisms in the prelimbic cortex modulate the expression of contextual conditioned fear
Orexin mechanisms in the prelimbic cortex modulate the expression of contextual conditioned fear
Despite the existing anatomical and physiological evidence pointing to the involvement of orexinergic projections from the...
Assessment of pharmacological effects and abuse potential of 5F-EDMB-PICA, CUMYL-PEGACLONE, and NM-2201 in mice
Assessment of pharmacological effects and abuse potential of 5F-EDMB-PICA, CUMYL-PEGACLONE, and NM-2201 in mice
The newly emerging synthetic cannabinoids (SCs) 5F-EDMB-PICA, CUMYL-PEGACLONE, and NM-2201 have been observed to produce e...
Dose-dependent effect of acute THC on extinction memory recall and fear renewal: a randomized, double-blind, placebo-controlled study
Dose-dependent effect of acute THC on extinction memory recall and fear renewal: a randomized, double-blind, placebo-controlled study
Prior work from our lab and others demonstrates that the endocannabinoid system is a promising avenue for improving fear m...
Aerobic exercise prevents and improves cognitive dysfunction caused by morphine withdrawal via regulating endogenous opioid peptides in the brain
Aerobic exercise prevents and improves cognitive dysfunction caused by morphine withdrawal via regulating endogenous opioid peptides in the brain
Morphine withdrawal leads to serious cognitive deficits in which dynorphins are directly involved. Recently, exercise has ...
Immediate effects of propofol on mood: a randomized comparison of two doses in a cohort with depression
Immediate effects of propofol on mood: a randomized comparison of two doses in a cohort with depression
The intravenous anesthetic propofol is known to induce positive mood effects during routine clinical use, suggesting it mi...
Exploring the efficacy of cholinergic agents for the treatment of psychostimulant use disorder: a systematic review
Exploring the efficacy of cholinergic agents for the treatment of psychostimulant use disorder: a systematic review
No drugs are currently validated to treat psychostimulant use disorder (PUD). Pathophysiological studies consistently high...
Glia dysfunction in schizophrenia: evidence of possible therapeutic effects of nervonic acid in a preclinical model
Glia dysfunction in schizophrenia: evidence of possible therapeutic effects of nervonic acid in a preclinical model
Neuroinflammation may inhibit oligodendrocyte and astrocyte differentiation, which causes demyelination and synaptic degen...
Curcumin alleviates arsenic trioxide-induced neural damage in the murine striatal region
Curcumin alleviates arsenic trioxide-induced neural damage in the murine striatal region
Arsenic-induced neurotoxicity, with dose-dependent effects, is well-documented in rodents. Curcumin (CUR), a cost-effectiv...
Ferulic acid ameliorates bisphenol A (BPA)-induced Alzheimer’s disease-like pathology through Akt-ERK crosstalk pathway in male rats
Ferulic acid ameliorates bisphenol A (BPA)-induced Alzheimer’s disease-like pathology through Akt-ERK crosstalk pathway in male rats
This study investigated the neuroprotective effect of ferulic acid (FA) against bisphenol A (BPA) induced Alzheimer’...
Pharmacologic profile of ITI-333: a novel molecule for treatment of substance use disorders
Pharmacologic profile of ITI-333: a novel molecule for treatment of substance use disorders
Medications are urgently needed to treat symptoms of drug withdrawal and mitigate dysphoria and psychiatric comorbidities ...
Efficacy of probiotic supplements in improving the symptoms of psychosis, anxiety, insomnia, and anorexia due to amphetamine and methamphetamine use: a randomized clinical trial
Efficacy of probiotic supplements in improving the symptoms of psychosis, anxiety, insomnia, and anorexia due to amphetamine and methamphetamine use: a randomized clinical trial
Changes in the density and diversity of gut microbiota in chronic use of methamphetamine have been mentioned as contributo...
Calcitriol attenuates lipopolysaccharide-induced neuroinflammation and depressive-like behaviors by suppressing the P2X7R/NLRP3/caspase-1 pathway
Calcitriol attenuates lipopolysaccharide-induced neuroinflammation and depressive-like behaviors by suppressing the P2X7R/NLRP3/caspase-1 pathway
Microglia-mediated neuroinflammation is a vital hallmark in progression of depression, while calcitriol exerts anti-inflam...
The effect of e-cigarettes on cognitive function: a scoping review
The effect of e-cigarettes on cognitive function: a scoping review
Much research has been conducted on the acute effects of nicotine on human cognitive performance, demonstrating both enhan...
Preeclampsia as a possible risk factor for memory impairment, anxiety- and depressive-like behavior in offspring
Preeclampsia as a possible risk factor for memory impairment, anxiety- and depressive-like behavior in offspring
Preeclampsia is a condition that can affect the health in offspring at adult life. The effect on several systems has been ...
Long-term disruption of tissue levels of glutamate and glutamatergic neurotransmission neuromodulators, taurine and kynurenic acid induced by amphetamine
Long-term disruption of tissue levels of glutamate and glutamatergic neurotransmission neuromodulators, taurine and kynurenic acid induced by amphetamine
Chronic amphetamine (AMPH) use leading to addiction results in adaptive changes within the central nervous system that per...
Light Cannabis Use and the Adolescent Brain: An 8-years Longitudinal Assessment of Mental Health, Cognition, and Reward Processing
Light Cannabis Use and the Adolescent Brain: An 8-years Longitudinal Assessment of Mental Health, Cognition, and Reward Processing
For decades, cannabis has been the most widely used illicit substance in the world, particularly among youth. Research sug...
Chronic REM sleep deprivation leads to manic- and OCD-related behaviors, and decreases hippocampal BDNF expression in female rats
Chronic REM sleep deprivation leads to manic- and OCD-related behaviors, and decreases hippocampal BDNF expression in female rats
Rapid-eye movement (REM) sleep deprivation (SD) can induce manic-like behaviors in rodents. On the other hand, lithium, as...
Knowledge by omission: the significance of omissions in the 5-choice serial reaction time task
Knowledge by omission: the significance of omissions in the 5-choice serial reaction time task
The 5-choice serial reaction time task (5-CSRTT) is commonly used to assess attention in rodents. Manipulation of this tas...
The efficacy and safety of Zuranolone for treatment of depression: A systematic review and meta-analysis
The efficacy and safety of Zuranolone for treatment of depression: A systematic review and meta-analysis
Zuranolone, a newly FDA-approved synthetic neurosteroid, shows promise in treating depression. Our aim is to evaluate Zura...
Preconception opioids interact with mouse strain to alter morphine withdrawal in the next generation
Preconception opioids interact with mouse strain to alter morphine withdrawal in the next generation
Transgenerational effects of preconception morphine exposure in female rats have been reported which suggest that epigenet...
The effects of pramipexole on motivational vigour during a saccade task: a placebo-controlled study in healthy adults
The effects of pramipexole on motivational vigour during a saccade task: a placebo-controlled study in healthy adults
Motivation allows us to energise actions when we expect reward and is reduced in depression. This effect, termed motivatio...
Sex differences in behavior, cognitive, and physiological recovery following methamphetamine administration
Sex differences in behavior, cognitive, and physiological recovery following methamphetamine administration
Intact executive functions are required for proper performance of cognitive tasks and relies on balance of excitatory and ...
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