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Associations Between Gut Microbiota and Alcohol Abuse: A Mendelian Randomisation and Bioinformatics Study
Associations Between Gut Microbiota and Alcohol Abuse: A Mendelian Randomisation and Bioinformatics Study
Alcohol abuse, also known as Alcohol Use Disorder (AUD), is a substance dependency psychiatric disorder. We aimed to estab...
Regulation of Hippocamposeptal Synaptic Transmission by GABABRs Is Altered in 5XFAD Mice in a Sex- and Age-Dependent Manner
Regulation of Hippocamposeptal Synaptic Transmission by GABABRs Is Altered in 5XFAD Mice in a Sex- and Age-Dependent Manner
Hippocamposeptal (HS) neurons send GABAergic projections from the hippocampus to the medial septum/diagonal band of Broca ...
Sedative Effects of Daidzin, Possibly Through the GABAA Receptor Interaction Pathway: In Vivo Approach with Molecular Dynamic Simulations
Sedative Effects of Daidzin, Possibly Through the GABAA Receptor Interaction Pathway: In Vivo Approach with Molecular Dynamic Simulations
The soy isoflavone daidzin (DZN) has been considered a hopeful bioactive compound having diverse biological activities, in...
REV-ERBα Mitigates Astrocyte Activation and Protects Dopaminergic Neurons from Damage
REV-ERBα Mitigates Astrocyte Activation and Protects Dopaminergic Neurons from Damage
Parkinson’s disease (PD) is characterized by astrocyte activation and disruptions in circadian rhythm. Within the as...
Sex-Specific ADNP/NAP (Davunetide) Regulation of Cocaine-Induced Plasticity
Sex-Specific ADNP/NAP (Davunetide) Regulation of Cocaine-Induced Plasticity
Cocaine use disorder (CUD) is a chronic neuropsychiatric disorder estimated to effect 1–3% of the population. Activi...
Involvement of CXCL10 rs4256246, CXCR4 rs2228014, CCR2 rs1799864 and CXCL16 rs2277680 in the Predisposition to Schizophrenia
Involvement of CXCL10 rs4256246, CXCR4 rs2228014, CCR2 rs1799864 and CXCL16 rs2277680 in the Predisposition to Schizophrenia
Chemokine ligands and their receptors have acquired less attention than pro- and anti-inflammatory cytokines in schizophre...
Identification and Validation of Endoplasmic Reticulum Stress-Related Gene in Traumatic Brain Injury
Identification and Validation of Endoplasmic Reticulum Stress-Related Gene in Traumatic Brain Injury
Endoplasmic reticulum stress (ERS) plays an essential role in the development of traumatic brain injury (TBI). We aimed to...
Lactoferrin Protects Against Rotenone-Induced Toxicity in Dopaminergic SH-SY5Y Cells through the Modulation of Apoptotic-Associated Pathways
Lactoferrin Protects Against Rotenone-Induced Toxicity in Dopaminergic SH-SY5Y Cells through the Modulation of Apoptotic-Associated Pathways
Parkinson’s disease (PD) is a common motor neurodegenerative disease that still lacks effective therapeutic options....
An early Transcriptomic Investigation in Adult Patients with Spinal Muscular Atrophy Under Treatment with Nusinersen
An early Transcriptomic Investigation in Adult Patients with Spinal Muscular Atrophy Under Treatment with Nusinersen
Spinal muscular atrophy (SMA) is a rare degenerative disorder with loss of motor neurons caused by mutations in the SMN1 g...
Exploring the hub Genes and Potential Mechanisms of Complement system-related Genes in Parkinson Disease: Based on Transcriptome Sequencing and Mendelian Randomization
Exploring the hub Genes and Potential Mechanisms of Complement system-related Genes in Parkinson Disease: Based on Transcriptome Sequencing and Mendelian Randomization
An accurate diagnosis of Parkinson’s disease (PD) remains challenging and the exact cause of the disease is unclean....
Neuroprotective Effect of Sterculia setigera Leaves Hydroethanolic Extract
Neuroprotective Effect of Sterculia setigera Leaves Hydroethanolic Extract
Plants are a valuable source of information for pharmacological research and new drug discovery. The present study aimed t...
Genetic and Phenotypic Profiling of Triptan Users in a Swedish Cluster Headache Cohort
Genetic and Phenotypic Profiling of Triptan Users in a Swedish Cluster Headache Cohort
Up to 25% of individuals who live with cluster headache (CH), an extremely painful primary headache disorder, do not adequ...
Expression Patterns of miRNAs in Egyptian Children with ADHD: Clinical Study with Correlation Analysis
Expression Patterns of miRNAs in Egyptian Children with ADHD: Clinical Study with Correlation Analysis
ADHD has huge knowledge gaps concerning its etiology. MicroRNAs (miRNAs) provide promising diagnostic biomarkers of human ...
A Prognostic Methylation-Driven Two-Gene Signature in Medulloblastoma
A Prognostic Methylation-Driven Two-Gene Signature in Medulloblastoma
Medulloblastoma (MB) is one of the most common pediatric brain tumors and it is estimated that one-third of patients will ...
Predictive Model to Identify the Long Time Survivor in Patients with Glioblastoma: A Cohort Study Integrating Machine Learning Algorithms
Predictive Model to Identify the Long Time Survivor in Patients with Glioblastoma: A Cohort Study Integrating Machine Learning Algorithms
We aimed to develop and validate a predictive model for identifying long-term survivors (LTS) among glioblastoma (GB) pati...
Behavioral and Metabolic Effects of ABCG4 KO in the APPswe,Ind (J9) Mouse Model of Alzheimer’s Disease
Behavioral and Metabolic Effects of ABCG4 KO in the APPswe,Ind (J9) Mouse Model of Alzheimer’s Disease
The pathogenesis of Alzheimer’s disease (AD) is complex and involves an imbalance between production and clearance o...
Aneuploidy is Linked to Neurological Phenotypes Through Oxidative Stress
Aneuploidy is Linked to Neurological Phenotypes Through Oxidative Stress
Aneuploidy, having an aberrant genome, is gaining increasing attention in neurodegenerative diseases. It gives rise to pro...
Biomarkers of Alzheimer’s Disease Associated with Programmed Cell Death Reveal Four Repurposed Drugs
Biomarkers of Alzheimer’s Disease Associated with Programmed Cell Death Reveal Four Repurposed Drugs
Alzheimer’s disease (AD) is a neurodegenerative disorder and the most common cause of dementia. Programmed cell deat...
Glutamine Metabolism Heterogeneity in Glioblastoma Unveils an Innovative Combination Therapy Strategy
Glutamine Metabolism Heterogeneity in Glioblastoma Unveils an Innovative Combination Therapy Strategy
Treatment of glioblastoma multiforme (GBM) remains challenging. Unraveling the orchestration of glutamine metabolism may p...
Reversibility of Endoplasmic Reticulum Stress Markers During Long-Term Glucose Starvation in Astrocytes
Reversibility of Endoplasmic Reticulum Stress Markers During Long-Term Glucose Starvation in Astrocytes
Previous studies have demonstrated a brain volume decrease linked to long-term starvation in patients with anorexia nervos...
Transcriptomic Analysis of Lipid Metabolism Genes in Alzheimer’s Disease: Highlighting Pathological Outcomes and Compartmentalized Immune Status
Transcriptomic Analysis of Lipid Metabolism Genes in Alzheimer’s Disease: Highlighting Pathological Outcomes and Compartmentalized Immune Status
The dysregulation of lipid metabolism has been strongly associated with Alzheimer’s disease (AD) and has intricate c...
Discovery of Potential Drug Targeting Key Genes in Alzheimer’s Disease: Insights from Transcriptome Analysis and Molecular Docking
Discovery of Potential Drug Targeting Key Genes in Alzheimer’s Disease: Insights from Transcriptome Analysis and Molecular Docking
Alzheimer’s disease (AD) is a prevalent neurodegenerative disorder that presents a significant global health challen...
Evaluating CXCL12 for Effects on Reactive Gene Expression in Primary Astrocytes
Evaluating CXCL12 for Effects on Reactive Gene Expression in Primary Astrocytes
Upon injury to the CNS, astrocytes undergo morphological and functional changes commonly referred to as astrocyte reactivi...
BCI Improves Alcohol-Induced Cognitive and Emotional Impairments by Restoring pERK-BDNF
BCI Improves Alcohol-Induced Cognitive and Emotional Impairments by Restoring pERK-BDNF
Binge drinking causes a range of problems especially damage to the nervous system, and the specific neural mechanism of br...
Calycosin promotes axon growth by inhibiting PTPRS and alleviates spinal cord injury
Calycosin promotes axon growth by inhibiting PTPRS and alleviates spinal cord injury
Our former studies have identified the alleviating effect of Calycosin (CA) on spinal cord injury (SCI). In this study, ou...
Association Between Diverse Cell Death Patterns Related Gene Signature and Prognosis, Drug Sensitivity, and Immune Microenvironment in Glioblastoma
Association Between Diverse Cell Death Patterns Related Gene Signature and Prognosis, Drug Sensitivity, and Immune Microenvironment in Glioblastoma
Glioblastoma (GBM) is the most invasive type of glioma and is difficult to treat. Diverse programmed cell death (PCD) patt...
Uncovering the Therapeutic Potential of Phosphocreatine in Diabetic Retinopathy: Mitigating Mitochondrial Dysfunction and Apoptosis via JAK2/STAT3 Signaling Pathway
Uncovering the Therapeutic Potential of Phosphocreatine in Diabetic Retinopathy: Mitigating Mitochondrial Dysfunction and Apoptosis via JAK2/STAT3 Signaling Pathway
Diabetic retinopathy (DR) stands as a prevalent complication of diabetes mellitus, causing damage to the delicate retinal ...
Identification of Immune Infiltration and Iron Metabolism–Related Subgroups in Autism Spectrum Disorder
Identification of Immune Infiltration and Iron Metabolism–Related Subgroups in Autism Spectrum Disorder
Autism spectrum disorder (ASD) is a prevalent neurodevelopmental disorder with a broad spectrum of symptoms and prognoses....
Multi-faceted Anti-obesity Effects of N-Methyl-D-Aspartate (NMDA) Receptor Modulators: Central-Peripheral Crosstalk
Multi-faceted Anti-obesity Effects of N-Methyl-D-Aspartate (NMDA) Receptor Modulators: Central-Peripheral Crosstalk
Hypothalamus is central to food intake and satiety. Recent data unveiled the expression of N-methyl-D-aspartate receptors ...
Transcriptional Inhibition of the Mecp2 Promoter by MeCP2E1 and MeCP2E2 Isoforms Suggests Negative Auto-Regulatory Feedback that can be Moderated by Metformin
Transcriptional Inhibition of the Mecp2 Promoter by MeCP2E1 and MeCP2E2 Isoforms Suggests Negative Auto-Regulatory Feedback that can be Moderated by Metformin
The epigenetic factor Methyl-CpG-Binding Protein 2 (MeCP2) is a nuclear protein that binds methylated DNA molecules (both ...
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