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A Reduced Expression of BCL-xL in the Hippocampus Is Accompanied by a Depression-Like Phenotype in Rats
A Reduced Expression of BCL-xL in the Hippocampus Is Accompanied by a Depression-Like Phenotype in Rats
The previously identified ability of the anti-apoptotic protein Bcl-xL to increase expression in the hippocampus in respon...
Expression of Pro- and Mature Brain-Derived Neurotrophic Factor and Bcl-xL in the Hippocampus of Neonatal Rats under Dexamethasone Treatment
Expression of Pro- and Mature Brain-Derived Neurotrophic Factor and Bcl-xL in the Hippocampus of Neonatal Rats under Dexamethasone Treatment
Due to the key role of neurotrophins in brain development and plasticity, the question of whether and how the precursor of...
Clock and Bmal1: The Positive Arm Proteins of Circadian Rhythm are not Regulated by Tyrosine Phosphorylation in Morphine Dependence
Clock and Bmal1: The Positive Arm Proteins of Circadian Rhythm are not Regulated by Tyrosine Phosphorylation in Morphine Dependence
The present study has been designed to determine any role of tyrosine phosphorylation in regulating clock components durin...
Clinical Effects of Fufang Haishe Capsule Combined with Aniracetam and Nicergoline in the Treatment of Vascular Dementia in the Elderly
Clinical Effects of Fufang Haishe Capsule Combined with Aniracetam and Nicergoline in the Treatment of Vascular Dementia in the Elderly
This study aimed to investigate the clinical effects of Fufang Haishe capsules combined with aniracetam and nicergoline in...
Analysis of the Melanocortin Brain System of Krushinsky–Molodkina Rats with Genetic Predisposition to Audiogenic Seizures
Analysis of the Melanocortin Brain System of Krushinsky–Molodkina Rats with Genetic Predisposition to Audiogenic Seizures
The study was performed with 4-month-old male rats of the Krushinsky–Molodkina (KM) strain genetically predisposed t...
Selection Signal in C-Kit Ligand Gene Is Linked to Glucocorticoid-Regulated Neuroplasticity: A New View on Domestication Mechanisms
Selection Signal in C-Kit Ligand Gene Is Linked to Glucocorticoid-Regulated Neuroplasticity: A New View on Domestication Mechanisms
Domestication profoundly shapes the evolutionary trajectories of both humans and animals. Despite significant scientific i...
Anxiogenic Effect of Pentylenetetrazole at a Subconvulsive Dose Is Accompanied by Decreased Cellular Proliferation and Neuronal NO-Synthase Expression in the Posterior Part of the Hippocampus
Anxiogenic Effect of Pentylenetetrazole at a Subconvulsive Dose Is Accompanied by Decreased Cellular Proliferation and Neuronal NO-Synthase Expression in the Posterior Part of the Hippocampus
In our previous studies, we have found a suppressive effect of a single administration of pentylenetetrazole (PTZ) at a su...
Interaction of Basolateral Amygdala and Prelimbic Cortex Glucocorticoid Receptors with the Endocannabinoid System in Inhibitory Avoidance Memory Consolidation in Rats
Interaction of Basolateral Amygdala and Prelimbic Cortex Glucocorticoid Receptors with the Endocannabinoid System in Inhibitory Avoidance Memory Consolidation in Rats
Considering the crucial neuromodulatory role of cannabinoid and glucocorticoid signaling in the memory processing, the put...
Changes in the Concentration of Catecholamines in the Blood as a Risk Factor for the Development of Atherosclerotic Vascular Damage in Children with Family Hypercholesterolemia
Changes in the Concentration of Catecholamines in the Blood as a Risk Factor for the Development of Atherosclerotic Vascular Damage in Children with Family Hypercholesterolemia
Catecholamines are a class of chemical neurotransmitters and hormones that occupy key positions in the regulation of vario...
Long-Term Memory: The Role of Light and Learning in Coping with Stress in
Long-Term Memory: The Role of Light and Learning in Coping with Stress in
The formation of a conditional connection allows the organism to change its reactions to various environmental factors, co...
Glucocorticoid Receptor Expression in the Different Cell Types of the Neonatal Rat Hippocampus and Cortex
Glucocorticoid Receptor Expression in the Different Cell Types of the Neonatal Rat Hippocampus and Cortex
Glucocorticoids (GCs) are crucial regulators of organism homeostasis and function. Despite severe consequences, glucocorti...
Possible Interaction of Oxidative Stress, Inflammatory, and Nitric Oxide Pathways in the Anticonvulsant Effect of Vortioxetine on Pentylenetetrazole-Induced Seizures in Rats
Possible Interaction of Oxidative Stress, Inflammatory, and Nitric Oxide Pathways in the Anticonvulsant Effect of Vortioxetine on Pentylenetetrazole-Induced Seizures in Rats
Antidepressants are known to demonstrate various effects on the nervous system. As a new antidepressant, vortioxetine is u...
Effects of Prolonged Exposure to Manganese Chloride on the Brain Serotonin Metabolism and Serotonin-Regulated Behavior in Zebrafish
Effects of Prolonged Exposure to Manganese Chloride on the Brain Serotonin Metabolism and Serotonin-Regulated Behavior in Zebrafish
Manganese ions are toxic for the central nervous system and cause motor impairments. Zebrafish (Danio rerio) are widely us...
Nikolay Nikolaevich Dygalo in the Memories of Students and Friends–Colleagues Working at the Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences
Nikolay Nikolaevich Dygalo in the Memories of Students and Friends–Colleagues Working at the Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences
Publisher’s Note. Pleiades Publishing remains neutral with regard to jurisdictional clai...
Activation of the Sympathoadrenal System under the Influence of Glucagon-Like Peptide-1 Mimetic in Rats
Activation of the Sympathoadrenal System under the Influence of Glucagon-Like Peptide-1 Mimetic in Rats
Glucagon-like peptide-1 (GLP-1) is the main incretin that provides insulin secretion and normalization of postprandial gly...
Exploring Treatment Potential: Clinical and Genetic Insights into Biotinidase Deficiency in Six Patients: A Tertiary Care Hospital Experience
Exploring Treatment Potential: Clinical and Genetic Insights into Biotinidase Deficiency in Six Patients: A Tertiary Care Hospital Experience
Biotinidase deficiency (BTD) is a rare metabolic disorder characterized by impaired biotin recycling, leading to neurologi...
Effects of Ingested Sulfite on Glutamate Synthesis and Release in the Rat Hippocampus
Effects of Ingested Sulfite on Glutamate Synthesis and Release in the Rat Hippocampus
While the negative effects of sulfite on learning and memory are shown in experimental studies; the mechanisms of effects ...
Dexamethasone Reduces Cytokine mRNA Levels and Microglial Activity in the Brainstem of Newborn Rats
Dexamethasone Reduces Cytokine mRNA Levels and Microglial Activity in the Brainstem of Newborn Rats
During the perinatal period of ontogeny, microglia performs functions of a critical key-regulator of the angio-, neuro-, a...
Changes in the Level of Neurotransmitters and Markers of Neurodegeneration in the Brain of Rats with Experimental Parkinson’s Disease after Therapy with Steroid Glycoalkaloids
Changes in the Level of Neurotransmitters and Markers of Neurodegeneration in the Brain of Rats with Experimental Parkinson’s Disease after Therapy with Steroid Glycoalkaloids
Abstract—Parkinson’s disease is a chronic neurodegenerative disease, one of the pathobiochemical manifestation...
Activation of P2Y2 Receptors Promotes Neuromuscular Junction Formation during Muscle Reinnervation
Activation of P2Y2 Receptors Promotes Neuromuscular Junction Formation during Muscle Reinnervation
Extracellular adenosine 5′-triphosphate (ATP), as neurotransmitter, is known to be an activity-dependent signaling m...
Comparison of Coblation versus Traditional Tonsillectomy for Patients with Chronic Tonsillitis: Impact on Serum Stress Indicators, Inflammatory Mediator Levels, Postoperative Pain, and Complications
Comparison of Coblation versus Traditional Tonsillectomy for Patients with Chronic Tonsillitis: Impact on Serum Stress Indicators, Inflammatory Mediator Levels, Postoperative Pain, and Complications
This study aims to compare the clinical efficacy of coblation tonsillectomy with that of conventional tonsillectomy for th...
Therapeutic Effects of Citral Nanoliposome on Parkinson’s Treatment in a Rat Model: Modulation via Neurochemical, Inflammatory and Antioxidant Pathways
Therapeutic Effects of Citral Nanoliposome on Parkinson’s Treatment in a Rat Model: Modulation via Neurochemical, Inflammatory and Antioxidant Pathways
Parkinson’s disease is the most common neurodegenerative movement disorder, the pathogenesis of which is partly rela...
Effect of Noopept on the Content of Neurotransmitter Amino Acids in the Hippocampus in Alcoholized Rats Using In Vivo Microdialysis
Effect of Noopept on the Content of Neurotransmitter Amino Acids in the Hippocampus in Alcoholized Rats Using In Vivo Microdialysis
Abstract—The aim of the present work was to study the dynamics of neurotransmitter amino acids after acute Noopept (...
The Anti-Convulsant Effects of Carvacrol in Penicillin- and Pentylenetetrazole-Induced Rat Models of Epilepsy
The Anti-Convulsant Effects of Carvacrol in Penicillin- and Pentylenetetrazole-Induced Rat Models of Epilepsy
Epileptic seizures are caused by abnormal neuronal excitation. It is well established that carvacrol, a monoterpenoid phen...
The Study of the State of Monoaminergic Systems in the Brain Structures of the Offsprings of Female BALB/c Mice at Different Stages of Formation of Autism Spectrum Disorders
The Study of the State of Monoaminergic Systems in the Brain Structures of the Offsprings of Female BALB/c Mice at Different Stages of Formation of Autism Spectrum Disorders
Abstract—The study of the status of norepinephrine-, dopamine- and serotonergic neurotransmitter systems of BALB/C m...
miR-885-5p Predicts the Risk and Development of Intracranial Hemorrhage in Traumatic Brain Injury and Regulates Inflammation in Microglia
miR-885-5p Predicts the Risk and Development of Intracranial Hemorrhage in Traumatic Brain Injury and Regulates Inflammation in Microglia
Intracranial hemorrhage (ICH) is the most critical secondary lesion of traumatic brain injury (TBI). Identifying novel bio...
Unveiling the Protective Potential of Sugammadex against PTZ-Induced Epileptic Seizures in Mice: A Comprehensive Study on Oxidative Stress, Apoptosis, and Autophagy
Unveiling the Protective Potential of Sugammadex against PTZ-Induced Epileptic Seizures in Mice: A Comprehensive Study on Oxidative Stress, Apoptosis, and Autophagy
Sugammadex (SUG) is a modified γ-cyclodextrin molecule used in patients under general anesthesia to reverse the effec...
Caspase-3 Activity and Autophagy Intensity in the Development of Neuronal Resistance to Glutamate Toxicity
Caspase-3 Activity and Autophagy Intensity in the Development of Neuronal Resistance to Glutamate Toxicity
Two periods of autophagy activation with a different significance for the development of resistance were demonstrated in t...
Effects of 5-HT1A Receptor Antagonist and 5-HT2A Receptor Agonist on Morphine Withdrawal
Effects of 5-HT1A Receptor Antagonist and 5-HT2A Receptor Agonist on Morphine Withdrawal
Chronic administration of morphine causes physical dependence, possibly through serotonin 5‑HT1A receptor (5-HT1AR) ...
Decreased Volumes of Selected Cortical and Limbic Structures of the Brain Are Associated with Post-Stroke Cognitive and Affective Disorders: Multiple Hit Scenarios?
Decreased Volumes of Selected Cortical and Limbic Structures of the Brain Are Associated with Post-Stroke Cognitive and Affective Disorders: Multiple Hit Scenarios?
Post-stroke depressive disorders (PSD) and post-stroke cognitive impairments (PCI) are frequent consequences of ischemic s...
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