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Sigma-1 receptors and progesterone metabolizing enzymes in nociceptive sensory neurons of the female rat trigeminal ganglia: A neural substrate for the antinociceptive actions of progesterone
Sigma-1 receptors and progesterone metabolizing enzymes in nociceptive sensory neurons of the female rat trigeminal ganglia: A neural substrate for the antinociceptive actions of progesterone
Orofacial pain disorders are predominately experienced by women. Progesterone, a major ovarian hormone, is neuroprotective...
Inhibiting spinal secretory phospholipase A2 after painful nerve root injury attenuates established pain and spinal neuronal hyperexcitability by altering spinal glutamatergic signaling
Inhibiting spinal secretory phospholipase A2 after painful nerve root injury attenuates established pain and spinal neuronal hyperexcitability by altering spinal glutamatergic signaling
Neuropathic injury is accompanied by chronic inflammation contributing to the onset and maintenance of pain after an initi...
Endothelin receptor type A is involved in the development of oxaliplatin-induced mechanical allodynia and cold allodynia acting through spinal and peripheral mechanisms in rats
Endothelin receptor type A is involved in the development of oxaliplatin-induced mechanical allodynia and cold allodynia acting through spinal and peripheral mechanisms in rats
Oxaliplatin, a platinum-based chemotherapeutic agent, frequently causes severe neuropathic pain typically encompassing col...
Heparan sulfate 3-O-sulfotransferase 4 is genetically associated with herpes zoster and enhances varicella-zoster virus–mediated fusogenic activity
Heparan sulfate 3-O-sulfotransferase 4 is genetically associated with herpes zoster and enhances varicella-zoster virus–mediated fusogenic activity
Acute pain that is associated with herpes zoster (HZ) can become long-lasting neuropathic pain, known as chronic post-herp...
Molecular pain and the 2021 Nobel Prize in Physiology or Medicine
Molecular pain and the 2021 Nobel Prize in Physiology or Medicine
1. Caterina, MJ, Schumacher, MA, Tominaga, M, Rosen, TA, Levine, JD, Julius, D. The capsaicin receptor: a heat-activated i...
Tricyclic antidepressants and selective serotonin reuptake inhibitors but not anticonvulsants ameliorate pain, anxiety, and depression symptoms in an animal model of central post-stroke pain
Tricyclic antidepressants and selective serotonin reuptake inhibitors but not anticonvulsants ameliorate pain, anxiety, and depression symptoms in an animal model of central post-stroke pain
BackgroundCentral post-stroke pain (CPSP) is a type of neuropathic pain caused by dysfunction in the spinothalamocortical ...
The PKCγ neurons in anterior cingulate cortex contribute to the development of neuropathic allodynia and pain-related emotion
The PKCγ neurons in anterior cingulate cortex contribute to the development of neuropathic allodynia and pain-related emotion
BackgroundWhile the PKCγ neurons in spinal dorsal horn play an indispensable part in neuropathic allodynia, the exact effe...
Neurokinins and their receptors in the rat trigeminal system: Differential localization and release with implications for migraine pain
Neurokinins and their receptors in the rat trigeminal system: Differential localization and release with implications for migraine pain
Substance P (SP) and calcitonin gene-related peptide (CGRP) have both been considered potential drug candidates in migrain...
Corrigendum to “Short-term pre- and post-operative stress prolongs incision-induced pain hypersensitivity without changing basal pain perception”
Corrigendum to “Short-term pre- and post-operative stress prolongs incision-induced pain hypersensitivity without changing basal pain perception”
Access to society journal content varies across our titles. If you have access to a journal via a society or association ...
Analgesic characteristics of a newly developed α2δ ligand, mirogabalin, on inflammatory pain
Analgesic characteristics of a newly developed α2δ ligand, mirogabalin, on inflammatory pain
Mirogabalin is a novel α2δ ligand approved in Japan for the treatment of peripheral neuropathic pain. However, the sites o...
Epigenetic modifications in neuropathic pain
Epigenetic modifications in neuropathic pain
Neuropathic pain (NP) is a common symptom in many diseases of the somatosensory nervous system, which severely affects the...
Cortical mechanisms in migraine
Cortical mechanisms in migraine
Migraine is the second most prevalent disorder in the world; yet, its underlying mechanisms are still poorly understood. C...
Selective inhibition of adenylyl cyclase subtype 1 reduces inflammatory pain in chicken of gouty arthritis
Selective inhibition of adenylyl cyclase subtype 1 reduces inflammatory pain in chicken of gouty arthritis
Lack of uricase leads to the high incidence of gout in humans and poultry, which is different from rodents. Therefore, chi...
Circulating sex steroids and bladder pain sensitivity in dysmenorrhea
Circulating sex steroids and bladder pain sensitivity in dysmenorrhea
Although elevated estradiol levels facilitate chronic pelvic pain in animal models, it remains to be determined whether se...
A systematic review on descending serotonergic projections and modulation of spinal nociception in chronic neuropathic pain and after spinal cord stimulation
A systematic review on descending serotonergic projections and modulation of spinal nociception in chronic neuropathic pain and after spinal cord stimulation
Chronic neuropathic pain is a debilitating ordeal for patients worldwide and pharmacological treatment efficacy is still l...
Spinal pain in employees exposed to abusive supervision: Evidence of a sex and CRHR1 CTC haplotype interaction
Spinal pain in employees exposed to abusive supervision: Evidence of a sex and CRHR1 CTC haplotype interaction
Previous findings suggest that exposure to social stress in the form of abusive supervision may increase the risk of muscu...
Interferon-β suppresses inflammatory pain through activating µ-opioid receptor
Interferon-β suppresses inflammatory pain through activating µ-opioid receptor
Interferons (IFNs) are cytokines secreted by infected cells that can interfere with viral replication. Besides activating ...
Reduced concentrations of vaginal metabolites involved in steroid hormone biosynthesis are associated with increased vulvar vestibular pain and vaginal muscle tenderness in provoked vestibulodynia: An exploratory metabolomics study
Reduced concentrations of vaginal metabolites involved in steroid hormone biosynthesis are associated with increased vulvar vestibular pain and vaginal muscle tenderness in provoked vestibulodynia: An exploratory metabolomics study
Provoked vestibulodynia (PVD) is a chronic vulvar pain disorder characterized by hypersensitivity and severe pain with pre...
Tetrahydropalmatine exerts analgesic effects by promoting apoptosis and inhibiting the activation of glial cells in rats with inflammatory pain
Tetrahydropalmatine exerts analgesic effects by promoting apoptosis and inhibiting the activation of glial cells in rats with inflammatory pain
BackgroundPain is an unpleasant sensory experience that usually plays a protective role. Inflammatory pain is often severe...
Effects of GABAB receptor activation on excitability of IB4-positive maxillary trigeminal ganglion neurons: Possible involvement of TREK2 activation
Effects of GABAB receptor activation on excitability of IB4-positive maxillary trigeminal ganglion neurons: Possible involvement of TREK2 activation
IB4-positive maxillary trigeminal ganglion (TG) neurons are a subtype of afferent neurons involving nociception in orofaci...
MicroRNA-137-mediated inhibition of lysine-specific demethylase-1 prevents against rheumatoid arthritis in an association with the REST/mTOR axis
MicroRNA-137-mediated inhibition of lysine-specific demethylase-1 prevents against rheumatoid arthritis in an association with the REST/mTOR axis
BackgroundIt has been increasingly reported that microRNAs (miRNAs) are related to rheumatoid arthritis (RA) pathogenesis....
Blockade of BK channels attenuates chronic visceral hypersensitivity in an IBS-like rat model
Blockade of BK channels attenuates chronic visceral hypersensitivity in an IBS-like rat model
BackgroundVisceral hypersensitivity in irritable bowel syndrome (IBS) is still poorly understood, despite that chronic abd...
The brinker repressor system regulates injury-induced nociceptive sensitization in Drosophila melanogaster
The brinker repressor system regulates injury-induced nociceptive sensitization in Drosophila melanogaster
Chronic pain is a debilitating condition affecting millions of people worldwide, and an improved understanding of the path...
Severities in persistent mild traumatic brain injury related headache is associated with changes in supraspinal pain modulatory functions
Severities in persistent mild traumatic brain injury related headache is associated with changes in supraspinal pain modulatory functions
Emerging evidence suggests mild traumatic brain injury related headache (MTBI-HA) is a form of neuropathic pain state. Pre...
Spinally projecting noradrenergic neurons of the locus coeruleus display resistance to AAV2retro-mediated transduction
Spinally projecting noradrenergic neurons of the locus coeruleus display resistance to AAV2retro-mediated transduction
BackgroundThe locus coeruleus (LC) is the principal source of noradrenaline (NA) in the central nervous system. Projection...
Ion channels and pain in Fabry disease
Ion channels and pain in Fabry disease
Fabry disease (FD) is a progressive, X-linked inherited disorder of glycosphingolipid metabolism due to deficient or absen...
Seeding of breast cancer cell line (MDA-MB-231LUC+) to the mandible induces overexpression of substance P and CGRP throughout the trigeminal ganglion and widespread peripheral sensory neuropathy throughout all three of its divisions
Seeding of breast cancer cell line (MDA-MB-231LUC+) to the mandible induces overexpression of substance P and CGRP throughout the trigeminal ganglion and widespread peripheral sensory neuropathy throughout all three of its divisions
Some types of cancer are commonly associated with intense pain even at the early stages of the disease. The mandible is pa...
Agmatine requires GluN2B-containing NMDA receptors to inhibit the development of neuropathic pain
Agmatine requires GluN2B-containing NMDA receptors to inhibit the development of neuropathic pain
A decarboxylated form of L-arginine, agmatine, preferentially antagonizes NMDArs containing Glun2B subunits within the spi...
Voxel-based quantitative susceptibility mapping revealed increased cerebral iron over the whole brain in chronic migraine
Voxel-based quantitative susceptibility mapping revealed increased cerebral iron over the whole brain in chronic migraine
BackgroundThe previous documents demonstrated that iron deposition was identified in brain deep nuclei and periaqueductal ...
Electrophysiological properties of maxillary trigeminal Aβ-afferent neurons of rats
Electrophysiological properties of maxillary trigeminal Aβ-afferent neurons of rats
Aβ-afferents in maxillary or V2 trigeminal ganglion (TG) neurons are somatosensory neurons that may be involved in both no...
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