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Caffeic Acid Attenuates Neuronal Apoptosis, Oxidative Stress, and Memory Deficits via Antioxidant Properties in Aging Rats Induced by D-Galactose
Caffeic Acid Attenuates Neuronal Apoptosis, Oxidative Stress, and Memory Deficits via Antioxidant Properties in Aging Rats Induced by D-Galactose
Aging is a main factor related to cognitive deficits. D-Galactose (D-gal), a monosaccharide, increases oxidative stress le...
Copper Mitigates Atrazine-Induced Neurotoxicity in Parkinson’s Disease Models
Copper Mitigates Atrazine-Induced Neurotoxicity in Parkinson’s Disease Models
Atrazine (ATR), one of the most prevalent herbicides used worldwide, has been associated with various environmental health...
Integrated Profiling Identifies Long-Term Molecular Consequences of Prenatal Dexamethasone Treatment in the Rat Brain—Potential Triggers of Depressive Phenotype and Cognitive Impairment
Integrated Profiling Identifies Long-Term Molecular Consequences of Prenatal Dexamethasone Treatment in the Rat Brain—Potential Triggers of Depressive Phenotype and Cognitive Impairment
Prenatal excess of glucocorticoids (GCs) is considered to be one of the highly impacting factors contributing to depressio...
The Impact of the Histone Deacetylase Inhibitor—Sodium Butyrate on Complement-Mediated Synapse Loss in a Rat Model of Neonatal Hypoxia–Ischemia
The Impact of the Histone Deacetylase Inhibitor—Sodium Butyrate on Complement-Mediated Synapse Loss in a Rat Model of Neonatal Hypoxia–Ischemia
Perinatal asphyxia is one of the most important causes of morbidity and mortality in newborns. One of the key pathogenic f...
Alpha‑Asarone Ameliorates Neuronal Injury After Ischemic Stroke and Hemorrhagic Transformation by Attenuating Blood–Brain Barrier Destruction, Promoting Neurogenesis, and Inhibiting Neuroinflammation
Alpha‑Asarone Ameliorates Neuronal Injury After Ischemic Stroke and Hemorrhagic Transformation by Attenuating Blood–Brain Barrier Destruction, Promoting Neurogenesis, and Inhibiting Neuroinflammation
Recombinant tissue-type plasminogen activator (rt-PA), the primary drug for acute ischemic stroke (IS), has a narrow thera...
Parkinson's Disease and the Microbiota-Gut-Brain Axis: Metabolites, Mechanisms, and Innovative Therapeutic Strategies Targeting the Gut Microbiota
Parkinson's Disease and the Microbiota-Gut-Brain Axis: Metabolites, Mechanisms, and Innovative Therapeutic Strategies Targeting the Gut Microbiota
The human gut microbiota is diverse and abundant and plays important roles in regulating health by participating in metabo...
Upregulation of C1QC as a Mediator of Blood–Brain Barrier Damage in Type 2 Diabetes Mellitus
Upregulation of C1QC as a Mediator of Blood–Brain Barrier Damage in Type 2 Diabetes Mellitus
The blood–brain barrier (BBB) is a neurovascular structure that safeguards the brain by inhibiting the passage of ha...
Microglia Sing the Prelude of Neuroinflammation-Associated Depression
Microglia Sing the Prelude of Neuroinflammation-Associated Depression
Major depressive disorder (MDD) is a psychiatric condition characterized by sadness and anhedonia and is closely linked to...
Early-Life Stress Influences the Transcriptional Activation of Alpha-2A Adrenergic Receptor and Associated Protein Kinase A Signaling Molecules in the Frontal Cortex of Rats
Early-Life Stress Influences the Transcriptional Activation of Alpha-2A Adrenergic Receptor and Associated Protein Kinase A Signaling Molecules in the Frontal Cortex of Rats
Early life is a highly sensitive period associated with profound changes in brain structure and function. Adverse experien...
Deletion of the Transient Receptor Potential Melastatin 2 Gene Mitigates the 6-Hydroxydopamine-Induced Parkinson’s Disease–Like Pathology
Deletion of the Transient Receptor Potential Melastatin 2 Gene Mitigates the 6-Hydroxydopamine-Induced Parkinson’s Disease–Like Pathology
Pharmacological inhibition of the transient receptor potential melastatin 2 (TRPM2), an oxidative stress–activated c...
Lactylation and Ischemic Stroke: Research Progress and Potential Relationship
Lactylation and Ischemic Stroke: Research Progress and Potential Relationship
Ischemic stroke is caused by interrupted cerebral blood flow and is a leading cause of mortality and disability worldwide....
Functional Outcome Prediction of Acute Ischemic Stroke Based on the Oral and Gut Microbiota
Functional Outcome Prediction of Acute Ischemic Stroke Based on the Oral and Gut Microbiota
Although several studies have identified a distinct gut microbiota in individuals with acute ischemic stroke (AIS), there ...
Oxidative Stress-mediated Loss of Hippocampal Parvalbumin Interneurons Contributes to Memory Precision Decline After Acute Sleep Deprivation
Oxidative Stress-mediated Loss of Hippocampal Parvalbumin Interneurons Contributes to Memory Precision Decline After Acute Sleep Deprivation
Sleep is pivotal to memory consolidation, and sleep deprivation (SD) after learning can impede this process, leading to me...
Sodium Danshensu Inhibits Macrophage Inflammation in Atherosclerosis via the miR-200a-3p/MEKK3/NF-κB Signaling Pathway
Sodium Danshensu Inhibits Macrophage Inflammation in Atherosclerosis via the miR-200a-3p/MEKK3/NF-κB Signaling Pathway
Macrophages are fundamental cellular components of atherosclerotic plaques, and inhibition of macrophage inflammation can ...
Integration of Single-Cell and Spatial Transcriptomic Data Reveals Spatial Architecture and Potential Biomarkers in Alzheimer’s Disease
Integration of Single-Cell and Spatial Transcriptomic Data Reveals Spatial Architecture and Potential Biomarkers in Alzheimer’s Disease
Alzheimer’s disease (AD) is a complex neurodegenerative disorder characterized by the gradual loss of neurons and th...
Serum Mature and Precursor Brain-Derived Neurotrophic Factors and Their Association with Neurocognitive Function in ART-Naïve Adults Living with HIV in Sub-Saharan Africa
Serum Mature and Precursor Brain-Derived Neurotrophic Factors and Their Association with Neurocognitive Function in ART-Naïve Adults Living with HIV in Sub-Saharan Africa
This study investigates the association between serum mature brain-derived neurotrophic factor (mBDNF), its precursor proB...
Identification and Validation of Oxidative Stress-Related Hub Genes in Parkinson’s Disease
Identification and Validation of Oxidative Stress-Related Hub Genes in Parkinson’s Disease
Accumulating evidence suggests that oxidative stress plays a crucial role in the pathogenesis of Parkinson’s disease...
Mechanism of N6-Methyladenosine Modification in the Pathogenesis of Depression
Mechanism of N6-Methyladenosine Modification in the Pathogenesis of Depression
N6-methyladenosine (m6A) is one of the most common post-transcriptional RNA modifications, which plays a critical role in ...
Significance of Melatonin in the Regulation of Circadian Rhythms and Disease Management
Significance of Melatonin in the Regulation of Circadian Rhythms and Disease Management
Melatonin, the ‘hormone of darkness’ is a neuronal hormone secreted by the pineal gland and other extra pineal...
Prenatal Programming of Monocyte Chemotactic Protein-1 Signaling in Autism Susceptibility
Prenatal Programming of Monocyte Chemotactic Protein-1 Signaling in Autism Susceptibility
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder that involves functional and structural defects in...
The Axonal Actin Filament Cytoskeleton: Structure, Function, and Relevance to Injury and Degeneration
The Axonal Actin Filament Cytoskeleton: Structure, Function, and Relevance to Injury and Degeneration
Early investigations of the neuronal actin filament cytoskeleton gave rise to the notion that, although growth cones exhib...
Circadian Clock Gene bmal1 Acts as a Tumor Suppressor Gene in a Mice Model of Human Glioblastoma
Circadian Clock Gene bmal1 Acts as a Tumor Suppressor Gene in a Mice Model of Human Glioblastoma
Glioblastomas derived from malignant astrocytes are the most common primary tumors of the central nervous system in humans...
Mutation of TRPML1 Channel and Pathogenesis of Neurodegeneration in Haimeria
Mutation of TRPML1 Channel and Pathogenesis of Neurodegeneration in Haimeria
Neurodegenerative diseases, a group of debilitating disorders, have garnered increasing attention due to their escalating ...
A Single-Cell Transcriptomic Analysis of the Mouse Hippocampus After Voluntary Exercise
A Single-Cell Transcriptomic Analysis of the Mouse Hippocampus After Voluntary Exercise
Exercise has been recognized as a beneficial factor for cognitive health, particularly in relation to the hippocampus, a v...
Rapamycin Alleviates Neuronal Injury and Modulates Microglial Activation After Cerebral Ischemia
Rapamycin Alleviates Neuronal Injury and Modulates Microglial Activation After Cerebral Ischemia
Neurons and microglia are sensitive to cerebral microcirculation and their responses play a crucial part in the pathologic...
TRPM7 Mediates Neuropathic Pain by Activating mTOR Signaling in Astrocytes after Spinal Cord Injury in Rats
TRPM7 Mediates Neuropathic Pain by Activating mTOR Signaling in Astrocytes after Spinal Cord Injury in Rats
In this study, we investigated whether transient receptor melastatin 7 (TRPM7), known as a non-selective cation channel, i...
Exosome Content–Mediated Signaling Pathways in Multiple Sclerosis
Exosome Content–Mediated Signaling Pathways in Multiple Sclerosis
Exosomes are small extracellular vesicles with a complex lipid-bilayer surface and 30–150 nm diameter. Thes...
Cellular and Molecular Responses to Mitochondrial DNA Deletions in Kearns-Sayre Syndrome: Some Underlying Mechanisms
Cellular and Molecular Responses to Mitochondrial DNA Deletions in Kearns-Sayre Syndrome: Some Underlying Mechanisms
Kearns-Sayre syndrome (KSS) is a rare multisystem mitochondrial disorder. It is caused by mitochondrial DNA (mtDNA) rearra...
Histone 3 Trimethylation Patterns are Associated with Resilience or Stress Susceptibility in a Rat Model of Major Depression Disorder
Histone 3 Trimethylation Patterns are Associated with Resilience or Stress Susceptibility in a Rat Model of Major Depression Disorder
Major Depressive Disorder (MDD) is a severe and multifactorial psychiatric condition. Evidence has shown that environmenta...
Overexpression of Motopsin, an Extracellular Serine Protease Related to Intellectual Disability, Promotes Adult Neurogenesis and Neuronal Responsiveness in the Dentate Gyrus
Overexpression of Motopsin, an Extracellular Serine Protease Related to Intellectual Disability, Promotes Adult Neurogenesis and Neuronal Responsiveness in the Dentate Gyrus
Motopsin, a serine protease encoded by PRSS12, is secreted by neuronal cells into the synaptic clefts in an activity-depen...
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