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Exploring the Role of Microglia Activation in Ischemia Stroke Based on the circDnajc1/miR-27a-5p/C1qc Signaling Axis
Exploring the Role of Microglia Activation in Ischemia Stroke Based on the circDnajc1/miR-27a-5p/C1qc Signaling Axis
To date, our understanding of the relationship between middle cerebral artery occlusion/reperfusion (MCAO/R)-induced ische...
Exercise Training Promotes Neural Remodeling and Vascular Regeneration in Cerebral Ischemic Rats Through the JNK/c-jun Signaling Pathway
Exercise Training Promotes Neural Remodeling and Vascular Regeneration in Cerebral Ischemic Rats Through the JNK/c-jun Signaling Pathway
Exercise training can exert favorable effects on the remodeling of neural structures, functional reconstruction, and the r...
Nicotine Attenuates Pathogenesis of Parkinson’s Disease via α7-nAChR-Mediated Lipid Metabolic Reprogramming and Anti-inflammatory Signaling
Nicotine Attenuates Pathogenesis of Parkinson’s Disease via α7-nAChR-Mediated Lipid Metabolic Reprogramming and Anti-inflammatory Signaling
Nicotine—an abundant tobacco alkaloid—has been epidemiologically linked to a lower incidence of Parkinson̵...
Correction to: N‑Acetylcysteine Mitigates Ketamine Neurotoxicity in Young Rats by Modulating ROS‑Mediated Pyroptosis and Ferroptosis
Correction to: N‑Acetylcysteine Mitigates Ketamine Neurotoxicity in Young Rats by Modulating ROS‑Mediated Pyroptosis and Ferroptosis
Correction to: Mol Neurobiol (2025)This is concerning with our article titled “N‑Acet...
The AMPK/GDF15 Axis: A Novel Target for the Neuroprotective Effects of Metformin in Ischemic Stroke
The AMPK/GDF15 Axis: A Novel Target for the Neuroprotective Effects of Metformin in Ischemic Stroke
Metformin is an anti-diabetic drug used in the management of type 2 diabetes (T2D). Metformin has different pleiotropic ef...
The Role of Sirt1 in Regulating Inflammatory Cytokines and Oxidative Stress in the Transition Mechanism from Depressive Disorder to Alzheimer’s Disease
The Role of Sirt1 in Regulating Inflammatory Cytokines and Oxidative Stress in the Transition Mechanism from Depressive Disorder to Alzheimer’s Disease
This study aimed to investigate the role of Sirt1 in the transition from depressive disorder (DD) to Alzheimer’s dis...
Localization and Pathological Implications of Lipopolysaccharide in the Brains of 5XFAD Mice
Localization and Pathological Implications of Lipopolysaccharide in the Brains of 5XFAD Mice
Alzheimer’s disease (AD) is an irreversible disease characterized by a complex pathophysiology. Recent evidence cons...
Intra-nasal Delivery of Quercetin-Loaded Nanostructured Lipid Carriers (NLCs) in the Management of Alzheimer’s Disease: Formulation, In Vitro and In Vivo assessment
Intra-nasal Delivery of Quercetin-Loaded Nanostructured Lipid Carriers (NLCs) in the Management of Alzheimer’s Disease: Formulation, In Vitro and In Vivo assessment
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterised by dementia and neuronal damage. ...
Artemether Improves Aβ-Induced Mitochondrial Dysfunction and Protects Against Blood–Brain Barrier Damage Through Activating the CAMKK2/AMPK/PGC1α Signaling Pathway
Artemether Improves Aβ-Induced Mitochondrial Dysfunction and Protects Against Blood–Brain Barrier Damage Through Activating the CAMKK2/AMPK/PGC1α Signaling Pathway
Alzheimer’s disease (AD) represents the most common manifestation of dementia. Cerebrovascular dysfunction constitut...
Unraveling Predominantly Inattentive ADHD (ADHD-PI): Insights from Proteomic Analysis of the Striatum of Thyroid Hormone-Responsive Protein (THRSP)–Overexpressing Mice
Unraveling Predominantly Inattentive ADHD (ADHD-PI): Insights from Proteomic Analysis of the Striatum of Thyroid Hormone-Responsive Protein (THRSP)–Overexpressing Mice
Attention-deficit/hyperactivity disorder, or ADHD, is a neurodevelopmental disorder with poorly understood molecular mecha...
The Quaternary Structure of the Sodium Pump Regulatory Complex Is Altered by Mutations of a Site Associated with Familial Hemiplegic Migraine
The Quaternary Structure of the Sodium Pump Regulatory Complex Is Altered by Mutations of a Site Associated with Familial Hemiplegic Migraine
The sodium–potassium ATPase (Na+/K+-ATPase, NKA) is a P-type ATPase that plays a central role in cell physiology, es...
Sex-Specific Differences in the Transport and Availability of Energy Substrates in the Hippocampus of Rats During Neurodevelopment
Sex-Specific Differences in the Transport and Availability of Energy Substrates in the Hippocampus of Rats During Neurodevelopment
The mammalian brain uses several energy substrates during development, such as lactate, ketone bodies, and glucose, to avo...
bFGF Knockdown Inhibits mTOR Signaling by Suppressing Caveolin-1 and Aggravates Cognitive Damage After Arterial Ischemic Brain Injury in Juvenile Rats
bFGF Knockdown Inhibits mTOR Signaling by Suppressing Caveolin-1 and Aggravates Cognitive Damage After Arterial Ischemic Brain Injury in Juvenile Rats
Pediatric arterial ischemic stroke (AIS) is the leading cause of stroke in children and approximately two-thirds of affect...
Multi-omics Analysis of Energy Metabolism Pathways Across Major Psychiatric Disorders
Multi-omics Analysis of Energy Metabolism Pathways Across Major Psychiatric Disorders
The brain requires a large amount of energy, primarily obtained through glucose metabolism, which appears to be disrupted ...
Differential Transcript Expression and Alternative RNA Splicing Patterns to Differentiate Focal vs. Generalized-Onset Seizures
Differential Transcript Expression and Alternative RNA Splicing Patterns to Differentiate Focal vs. Generalized-Onset Seizures
Retrospective diagnosis of a seizure type is pivotal for effective management and treatment of epilepsy. Previously, we de...
Amelioration of Chemotherapy Induced Neuropathic Pain using Novel Nicotinic Acid Derivatives with possible HCN channel binding ability
Amelioration of Chemotherapy Induced Neuropathic Pain using Novel Nicotinic Acid Derivatives with possible HCN channel binding ability
One of the major debilitating side effects of cancer chemotherapy is neuropathic pain, which results from abnormal neural ...
Prediction of Post-Stroke Cognitive Impairment Based on Iron Metabolism Parameters: Results From A Prospective Study
Prediction of Post-Stroke Cognitive Impairment Based on Iron Metabolism Parameters: Results From A Prospective Study
Disruption of iron homeostasis is associated with the pathogenesis of neurological disorders. This study aims to elucidate...
Polyphenols and Exercise in Mitochondrial Biogenesis: Focus on Age-Related CNS Disorders
Polyphenols and Exercise in Mitochondrial Biogenesis: Focus on Age-Related CNS Disorders
Age-related central nervous system (CNS) disorders, including neurodegenerative diseases, represent a growing global healt...
Microglia in the Rostral Ventromedial Medulla Mediate Synaptic Pruning via the C1q/C3-CR3 Signaling Pathway—A Mechanism for the Chronic Orofacial Pain
Microglia in the Rostral Ventromedial Medulla Mediate Synaptic Pruning via the C1q/C3-CR3 Signaling Pathway—A Mechanism for the Chronic Orofacial Pain
The mechanism of chronic orofacial pain was investigated by examining the interaction between activated microglia, C1q, an...
Altered Lipid Homeostasis in Mutant Astrocytes from HiPSCs
Altered Lipid Homeostasis in Mutant Astrocytes from HiPSCs
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by motor neuron loss, leading...
Caffeic Acid Attenuates Neuronal Apoptosis, Oxidative Stress, and Memory Deficits via Antioxidant Properties in Aging Rats Induced by D-Galactose
Caffeic Acid Attenuates Neuronal Apoptosis, Oxidative Stress, and Memory Deficits via Antioxidant Properties in Aging Rats Induced by D-Galactose
Aging is a main factor related to cognitive deficits. D-Galactose (D-gal), a monosaccharide, increases oxidative stress le...
Copper Mitigates Atrazine-Induced Neurotoxicity in Parkinson’s Disease Models
Copper Mitigates Atrazine-Induced Neurotoxicity in Parkinson’s Disease Models
Atrazine (ATR), one of the most prevalent herbicides used worldwide, has been associated with various environmental health...
Integrated Profiling Identifies Long-Term Molecular Consequences of Prenatal Dexamethasone Treatment in the Rat Brain—Potential Triggers of Depressive Phenotype and Cognitive Impairment
Integrated Profiling Identifies Long-Term Molecular Consequences of Prenatal Dexamethasone Treatment in the Rat Brain—Potential Triggers of Depressive Phenotype and Cognitive Impairment
Prenatal excess of glucocorticoids (GCs) is considered to be one of the highly impacting factors contributing to depressio...
The Impact of the Histone Deacetylase Inhibitor—Sodium Butyrate on Complement-Mediated Synapse Loss in a Rat Model of Neonatal Hypoxia–Ischemia
The Impact of the Histone Deacetylase Inhibitor—Sodium Butyrate on Complement-Mediated Synapse Loss in a Rat Model of Neonatal Hypoxia–Ischemia
Perinatal asphyxia is one of the most important causes of morbidity and mortality in newborns. One of the key pathogenic f...
Alpha‑Asarone Ameliorates Neuronal Injury After Ischemic Stroke and Hemorrhagic Transformation by Attenuating Blood–Brain Barrier Destruction, Promoting Neurogenesis, and Inhibiting Neuroinflammation
Alpha‑Asarone Ameliorates Neuronal Injury After Ischemic Stroke and Hemorrhagic Transformation by Attenuating Blood–Brain Barrier Destruction, Promoting Neurogenesis, and Inhibiting Neuroinflammation
Recombinant tissue-type plasminogen activator (rt-PA), the primary drug for acute ischemic stroke (IS), has a narrow thera...
Parkinson's Disease and the Microbiota-Gut-Brain Axis: Metabolites, Mechanisms, and Innovative Therapeutic Strategies Targeting the Gut Microbiota
Parkinson's Disease and the Microbiota-Gut-Brain Axis: Metabolites, Mechanisms, and Innovative Therapeutic Strategies Targeting the Gut Microbiota
The human gut microbiota is diverse and abundant and plays important roles in regulating health by participating in metabo...
Upregulation of C1QC as a Mediator of Blood–Brain Barrier Damage in Type 2 Diabetes Mellitus
Upregulation of C1QC as a Mediator of Blood–Brain Barrier Damage in Type 2 Diabetes Mellitus
The blood–brain barrier (BBB) is a neurovascular structure that safeguards the brain by inhibiting the passage of ha...
Microglia Sing the Prelude of Neuroinflammation-Associated Depression
Microglia Sing the Prelude of Neuroinflammation-Associated Depression
Major depressive disorder (MDD) is a psychiatric condition characterized by sadness and anhedonia and is closely linked to...
Early-Life Stress Influences the Transcriptional Activation of Alpha-2A Adrenergic Receptor and Associated Protein Kinase A Signaling Molecules in the Frontal Cortex of Rats
Early-Life Stress Influences the Transcriptional Activation of Alpha-2A Adrenergic Receptor and Associated Protein Kinase A Signaling Molecules in the Frontal Cortex of Rats
Early life is a highly sensitive period associated with profound changes in brain structure and function. Adverse experien...
Deletion of the Transient Receptor Potential Melastatin 2 Gene Mitigates the 6-Hydroxydopamine-Induced Parkinson’s Disease–Like Pathology
Deletion of the Transient Receptor Potential Melastatin 2 Gene Mitigates the 6-Hydroxydopamine-Induced Parkinson’s Disease–Like Pathology
Pharmacological inhibition of the transient receptor potential melastatin 2 (TRPM2), an oxidative stress–activated c...
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