Jack CR, Bennett DA, Blennow K et al (2018) NIA-AA Research Framework: toward a biological definition of Alzheimer’s disease. Alzheimer’s Dementia 14:535–562. https://doi.org/10.1016/j.jalz.2018.02.018
Lanctôt KL, Hahn-Pedersen JH, Eichinger CS et al (2024) Burden of illness in people with Alzheimer’s disease: a systematic review of epidemiology comorbidities and mortality. J Prev Alzheimer’s Dis 11:97–107. https://doi.org/10.14283/jpad.2023.61
Breijyeh Z, Karaman R (2020) Comprehensive review on Alzheimer’s disease: causes and treatment. Molecules 25:5789. https://doi.org/10.3390/molecules25245789
Article CAS PubMed PubMed Central Google Scholar
Kumar A, Singh A, Ekavali (2015) A review on Alzheimer’s disease pathophysiology and its management: an update. Pharmacological Reports 67:195–203. https://doi.org/10.1016/j.pharep.2014.09.004
Raju M, Kunde SS, Auti ST et al (2021) Berberine loaded nanostructured lipid carrier for Alzheimer’s disease: design, statistical optimization and enhanced in vivo performance. Life Sci 285:119990. https://doi.org/10.1016/j.lfs.2021.119990
Article CAS PubMed Google Scholar
Madav Y, Wairkar S, Prabhakar B (2019) Recent therapeutic strategies targeting beta amyloid and tauopathies in Alzheimer’s disease. Brain Res Bull 146:171–184. https://doi.org/10.1016/j.brainresbull.2019.01.004
Article CAS PubMed Google Scholar
Kodl CT, Seaquist ER (2008) Cognitive dysfunction and diabetes mellitus. Endocr Rev 29:494–511. https://doi.org/10.1210/er.2007-0034
Article CAS PubMed PubMed Central Google Scholar
Zilliox LA, Chadrasekaran K, Kwan JY, Russell JW (2016) Diabetes and cognitive impairment. Curr Diab Rep 16:87. https://doi.org/10.1007/s11892-016-0775-x
Article CAS PubMed PubMed Central Google Scholar
Khan H, Ullah H, Aschner M et al (2019) Neuroprotective effects of quercetin in Alzheimer’s disease. Biomolecules 10:59. https://doi.org/10.3390/biom10010059
Article CAS PubMed PubMed Central Google Scholar
Devore EE, Kang JH, Breteler MMB, Grodstein F (2012) Dietary intakes of berries and flavonoids in relation to cognitive decline. Ann Neurol 72:135–143. https://doi.org/10.1002/ana.23594
Article CAS PubMed PubMed Central Google Scholar
Solanki I, Parihar P, Mansuri ML, Parihar MS (2015) Flavonoid-based therapies in the early management of neurodegenerative diseases. Adv Nutr 6:64–72. https://doi.org/10.3945/an.114.007500
Article CAS PubMed PubMed Central Google Scholar
Hasan S, Khatri N, Rahman ZN et al (2023) Neuroprotective potential of flavonoids in brain disorders. Brain Sci 13:1258. https://doi.org/10.3390/brainsci13091258
Article CAS PubMed PubMed Central Google Scholar
Maher P (2019) The potential of flavonoids for the treatment of neurodegenerative diseases. IJMS 20:3056. https://doi.org/10.3390/ijms20123056
Article CAS PubMed PubMed Central Google Scholar
Ayaz M, Ullah F, Sadiq A et al (2019) Editorial: natural products-based drugs: potential therapeutics against Alzheimer’s disease and other neurological disorders. Front Pharmacol 10:1417. https://doi.org/10.3389/fphar.2019.01417
Article PubMed PubMed Central Google Scholar
Brüll V, Burak C, Stoffel-Wagner B et al (2015) Effects of a quercetin-rich onion skin extract on 24 h ambulatory blood pressure and endothelial function in overweight-to-obese patients with (pre-)hypertension: a randomised double-blinded placebo-controlled cross-over trial. Br J Nutr 114:1263–1277. https://doi.org/10.1017/S0007114515002950
Article CAS PubMed PubMed Central Google Scholar
Rifaai RA, Mokhemer SA, Saber EA et al (2020) Neuroprotective effect of quercetin nanoparticles: a possible prophylactic and therapeutic role in alzheimer’s disease. J Chem Neuroanat 107:101795. https://doi.org/10.1016/j.jchemneu.2020.101795
Article CAS PubMed Google Scholar
Kandemir K, Tomas M, McClements DJ, Capanoglu E (2022) Recent advances on the improvement of quercetin bioavailability. Trends Food Sci Technol 119:192–200. https://doi.org/10.1016/j.tifs.2021.11.032
Nsairat H, Khater D, Sayed U et al (2022) Liposomes: structure, composition types and clinical applications. Heliyon 8:e09394. https://doi.org/10.1016/j.heliyon.2022.e09394
Article CAS PubMed PubMed Central Google Scholar
Mukherjee S, Ray S, Thakur R (2009) Solid lipid nanoparticles: a modern formulation approach in drug delivery system. Indian J Pharm Sci 71:349. https://doi.org/10.4103/0250-474X.57282
Article CAS PubMed PubMed Central Google Scholar
Asad M, Rasul A, Abbas G et al (2023) Self-emulsifying drug delivery systems: a versatile approach to enhance the oral delivery of BCS class III drug via hydrophobic ion pairing. PLoS ONE 18:e0286668. https://doi.org/10.1371/journal.pone.0286668
Article CAS PubMed PubMed Central Google Scholar
Goyal R, Mittal G, Khurana S et al (2024) Insights on quercetin therapeutic potential for neurodegenerativediseases and its nano-technological perspectives. CPB 25:1132–1141. https://doi.org/10.2174/1389201025666230830125410
Revankar AA, Patil AS, Karishetti R et al (2025) Enhanced bioavailability of quercetin-loaded niosomal in situ gel for the management of Parkinson’s disease. Front Pharmacol 15:1519649. https://doi.org/10.3389/fphar.2024.1519649
Article CAS PubMed PubMed Central Google Scholar
Kaur K, Kulkarni YA, Wairkar S (2024) Exploring the potential of quercetin in Alzheimer’s disease: pharmacodynamics, pharmacokinetics and nanodelivery systems. Brain Res 1834:148905. https://doi.org/10.1016/j.brainres.2024.148905
Article CAS PubMed Google Scholar
Zhuang CY, Li N, Wang M et al (2010) Preparation and characterization of vinpocetine loaded nanostructured lipid carriers (NLC) for improved oral bioavailability. Int J Pharm 394:179–185. https://doi.org/10.1016/j.ijpharm.2010.05.005
Article CAS PubMed Google Scholar
Zhao X, Deng Y, Xue X et al (2022) Research progress of quercetin delivery systems. CPD 28:727–742. https://doi.org/10.2174/1381612828666220317141923
Zhang W, Li X, Ye T et al (2013) Design, characterization, and in vitro cellular inhibition and uptake of optimized genistein-loaded NLC for the prevention of posterior capsular opacification using response surface methodology. Int J Pharm 454:354–366. https://doi.org/10.1016/j.ijpharm.2013.07.032
Article CAS PubMed Google Scholar
Dighe S, Jog S, Momin M et al (2023) Intranasal drug delivery by nanotechnology: advances in and challenges for Alzheimer’s disease management. Pharmaceutics 16:58. https://doi.org/10.3390/pharmaceutics16010058
Article CAS PubMed PubMed Central Google Scholar
Rajput A, Pingale P, Dhapte-Pawar V (2022) Nasal delivery of neurotherapeutics via nanocarriers: facets aspects and prospects. Front Pharmacol 13:979682. https://doi.org/10.3389/fphar.2022.979682
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