The Role of Sirt1 in Regulating Inflammatory Cytokines and Oxidative Stress in the Transition Mechanism from Depressive Disorder to Alzheimer’s Disease

Diniz BS, Butters MA, Albert SM, Dew MA, Reynolds CF III et al (2013) Late-life depression and risk of vascular dementia and Alzheimer’s disease: systematic review and meta-analysis of community-based cohort studies. Br J Psychiatry 202:329–335

Article  PubMed  PubMed Central  Google Scholar 

Enache D, Winblad B, Aarsland D (2011) Depression in dementia: epidemiology, mechanisms, and treatment. Curr Opin Psychiatry 24:461–472

Article  PubMed  Google Scholar 

Yang X, Bao T, Ruan Ye (2020) An overview of the risk factors for Alzheimer’s disease. Sichuan Mental Health 33:6

CAS  Google Scholar 

Zhang Y, Guo C, Zhang Y (2021) Analysis of neuropsychological characteristics of cognitive impairment in Alzheimer’s disease. Chin J Alzheimers Dis Relat Disord 4:69–72

Google Scholar 

Dafsari FS, Jessen F (2020) Depression—an underrecognized target for prevention of dementia in Alzheimer’s disease. Transl Psychiatry 10:160

Article  PubMed  PubMed Central  Google Scholar 

Manjula R, Anuja K, Alcain FJ (2021) SIRT1 and SIRT2 activity control in neurodegenerative diseases. Front Pharmacol 11:585821

Article  PubMed  PubMed Central  Google Scholar 

Lin QQ, Yan CF, Lin QQ, Yan CF, Lin R, Zhang JY, Wang WR, Yang LN, Zhang KF et al (2012) SIRT1 regulates TNF-α-induced expression of CD40 in 3T3-L1 adipocytes via NF-κB pathway. Cytokine 60(2):447–455

Article  PubMed  CAS  Google Scholar 

Kishi T, Yoshimura R, Kitajima T, Okochi T, Okumura T, Tsunoka T et al (2010) SIRT1 gene is associated with major depressive disorder in the Japanese population. J Affect Disord 126:167–173

Article  PubMed  CAS  Google Scholar 

Wongchitrat P, Pakpian N, Kitidee K, Phopin K, Dharmasaroja PA, Govitrapong P (2019) Alterations in the expression of amyloid precursor protein cleaving enzymes mRNA in Alzheimer peripheral blood. Curr Alzheimer Res 16(1):29–38

Article  PubMed  CAS  Google Scholar 

Kong S, McBurney MW, Fang D (2012) Sirtuin 1 in immune regulation and autoimmunity. Immunol Cell Biol 90:6–13

Article  PubMed  CAS  Google Scholar 

Kobayashi Y, Furukawa-Hibi Y, Chen C, Horio Y, Isobe K, Ikeda K et al (2005) SIRT1 is critical regulator of FOXO-mediated transcription in response to oxidative stress. Int J Mol Med 16:237–243

PubMed  CAS  Google Scholar 

Lan KC, Chao SC, Wu HY, Chiang CL, Wang CC, Liu SH et al (2017) Salidroside ameliorates sepsis-induced acute lung injury and mortality via downregulating NF-κB and HMGB1 pathways through the upregulation of SIRT1. Sci Rep 7:12026

Article  PubMed  PubMed Central  Google Scholar 

Kang H, Park YK, Lee JY (2021) Nicotinamide riboside, an NAD(+) precursor, attenuates inflammation and oxidative stress by activating sirtuin 1 in alcohol-stimulated macrophages. Lab Invest 101:1225–1237

Article  PubMed  CAS  Google Scholar 

Ma Y, Nie H, Chen H, Li J, Hong Y, Wang B et al (2015) NAD⁺/NADH metabolism and NAD⁺-dependent enzymes in cell death and ischemic brain injury: current advances and therapeutic implications. Curr Med Chem 22:1239–1247

Article  PubMed  CAS  Google Scholar 

Caito S, Rajendrasozhan S, Cook S, Chung S, Yao H, Friedman AE et al (2010) SIRT1 is a redox-sensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress. FASEB J 24:3145–3159

Article  PubMed  PubMed Central  CAS  Google Scholar 

Willner P, Towell A, Sampson D, Sophokleous S, Muscat R (1987) Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant. Psychopharmacology 93:358–364

Article  PubMed  CAS  Google Scholar 

Hou J, Wei S, Xiyang Du, Zhang H (2012) Depression in rat model sucrose preference test data analysis of aggregation. Lab Anim Comp Med 32:5

Google Scholar 

Yao TH, Pataer P, Regmi KP, Gu XW, Li QY, Du JT et al (2018) Propranolol induces hemangioma endothelial cell apoptosis via a p53-BAX mediated pathway. Mol Med Rep 18:684–694

PubMed  PubMed Central  CAS  Google Scholar 

Young Y, Abreu MT (2006) Advances in the pathogenesis of inflammatory bowel disease. Curr Gastroenterol Rep 8:470–477

Article  PubMed  Google Scholar 

Cartwright T, Perkins ND, Wilson LC (2016) NFKB1: a suppressor of inflammation, ageing and cancer. FEBS J 283:1812–1822

Article  PubMed  CAS  Google Scholar 

Chen SN, Lombardi R, Karmouch J, Tsai JY, Czernuszewicz G, Taylor MRG et al (2019) DNA damage response/TP53 pathway is activated and contributes to the pathogenesis of dilated cardiomyopathy associated with LMNA (Lamin A/C) mutations. Circ Res 124:856–873

Article  PubMed  PubMed Central  CAS  Google Scholar 

Zhang X, Liu Z, Yang W, Zhao F, Zhang C, Feng H et al (2022) Tetrahydrofolate alleviates the inhibitory effect of oxidative stress on neural stem cell proliferation through PTEN/Akt/mTOR pathway. Oxid Med Cell Longev 2022:9021474

Article  PubMed  PubMed Central  Google Scholar 

Rangarajan P, Karthikeyan A, Lu J, Ling EA, Dheen ST (2015) Sirtuin 3 regulates Foxo3a-mediated antioxidant pathway in microglia. Neuroscience 311:398–414

Article  PubMed  CAS  Google Scholar 

Sundaresan NR, Gupta M, Kim G, Rajamohan SB, Isbatan A, Gupta MP (2009) Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice. J Clin Invest 119:2758–2771

PubMed  PubMed Central  CAS  Google Scholar 

Bakhtiyari S, Meshkani R, Taghikhani M, Larijani B, Adeli K (2010) Protein tyrosine phosphatase-1B (PTP-1B) knockdown improves palmitate-induced insulin resistance in C2C12 skeletal muscle cells. Lipids 45:237–244

Article  PubMed  CAS  Google Scholar 

Xiao X, Shi D, Liu L, Wang J, Xie X, Kang T et al (2011) Quercetin suppresses cyclooxygenase-2 expression and angiogenesis through inactivation of P300 signaling. PLoS ONE 6:e22934

Article  PubMed  PubMed Central  CAS  Google Scholar 

Gabasa M, Radisky ES, Ikemori R, Bertolini G, Arshakyan M, Hockla A et al (2021) MMP1 drives tumor progression in large cell carcinoma of the lung through fibroblast senescence. Cancer Lett 507:1–12

Article  PubMed  PubMed Central  CAS  Google Scholar 

Wang S, Tang YJ (2021) Sulforaphane ameliorates amyloid-β-induced inflammatory injury by suppressing the PARP1/SIRT1 pathway in retinal pigment epithelial cells. Bioengineered 12:7079–7089

PubMed  CAS  Google Scholar 

Xu M, Bi XY, Xue XR, Lu XZ, Li QG, Jian Q et al (2021) Activation of the M3AChR and Notch1/HSF1 signaling pathway by choline alleviates angiotensin II-induced cardiomyocyte apoptosis. Oxid Med Cell Longev 2021:9979706

Article  PubMed  PubMed Central  Google Scholar 

Zhang GM, Guo YX, Deng MT, Wan YJ, Deng KP, Xiao SH et al (2019) Effect of PPARGC1A on the development and metabolism of early rabbit embryos in vitro. Mol Reprod Dev 86:1758–1770

Article  PubMed  CAS  Google Scholar 

Candido S, Tomasello B, Lavoro A, Falzone L, Gattuso G, Russo A et al (2022) Bioinformatic analysis of the LCN2-SLC22A17-MMP9 network in cancer: the role of DNA methylation in the modulation of tumor microenvironment. Front Cell Dev Biol 10:945586

Article  PubMed  PubMed Central  Google Scholar 

Muniz-Bongers LR, McClain CB, Saxena M, Bongers G, Merad M, Bhardwaj N (2021) MMP2 and TLRs modulate immune responses in the tumor microenvironment. JCI Insights 6(12):e144913

Article  Google Scholar 

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