Kalia LV, Lang AE (2015) Parkinson’s disease [J]. Lancet (London, England) 386(9996):896–912

Article  CAS  PubMed  Google Scholar 

Jankovic J, Tan EK (2020) Parkinson’s disease: etiopathogenesis and treatment [J]. J Neurol Neurosurg Psychiatry 91(8):795–808

Article  PubMed  Google Scholar 

Galper J, Dean NJ, Pickford R et al (2022) Lipid pathway dysfunction is prevalent in patients with Parkinson’s disease [J]. Brain : a journal of neurology 145(10):3472–3487

Article  PubMed  Google Scholar 

de Lau LM, Koudstaal PJ, Hofman A et al (2006) Serum cholesterol levels and the risk of Parkinson’s disease [J]. Am J Epidemiol 164(10):998–1002

Article  PubMed  Google Scholar 

Fortin DL, Troyer MD, Nakamura K et al (2004) Lipid rafts mediate the synaptic localization of alpha-synuclein [J]. The Journal of neuroscience : the official journal of the Society for Neuroscience 24(30):6715–6723

Article  CAS  PubMed  Google Scholar 

Sharon R, Goldberg MS, Bar-Josef I et al (2001) alpha-Synuclein occurs in lipid-rich high molecular weight complexes, binds fatty acids, and shows homology to the fatty acid-binding proteins [J]. Proc Natl Acad Sci USA 98(16):9110–9115

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nagatsu T, Mogi M, Ichinose H et al (2000) Cytokines in Parkinson’s disease [J]. J Neural Transm Suppl 58:143–151

Google Scholar 

Harms AS, Ferreira SA, Romero-Ramos M (2021) Periphery and brain, innate and adaptive immunity in Parkinson’s disease [J]. Acta Neuropathol 141(4):527–545

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ioannou MS, Jackson J, Sheu SH et al (2019) Neuron-astrocyte metabolic coupling protects against activity-induced fatty acid toxicity [J]. Cell 177(6):1522–35.e14

Article  CAS  PubMed  Google Scholar 

Yoon SY, Park YH, Lee HJ et al (2022) Lifestyle factors and Parkinson disease risk: Korean Nationwide Cohort Study with repeated health screening data [J]. Neurology 98(6):e641–e652

Article  CAS  PubMed  Google Scholar 

Jarvik ME (1991) Beneficial effects of nicotine [J]. Br J Addict 86(5):571–575

Article  CAS  PubMed  Google Scholar 

Carvajal-Oliveros A, Domínguez-Baleón C, Zárate RV et al (2021) Nicotine suppresses Parkinson’s disease like phenotypes induced by Synphilin-1 overexpression in Drosophila melanogaster by increasing tyrosine hydroxylase and dopamine levels [J]. Scientific reports 11(1):9579

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nicholatos JW, Francisco AB, Bender CA et al (2018) Nicotine promotes neuron survival and partially protects from Parkinson’s disease by suppressing SIRT6 [J]. Acta Neuropathol Commun 6(1):120

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sharma G, Vijayaraghavan S (2001) Nicotinic cholinergic signaling in hippocampal astrocytes involves calcium-induced calcium release from intracellular stores [J]. Proc Natl Acad Sci USA 98(7):4148–4153

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shytle RD, Mori T, Townsend K et al (2004) Cholinergic modulation of microglial activation by alpha 7 nicotinic receptors [J]. J Neurochem 89(2):337–343

Article  CAS  PubMed  Google Scholar 

Hawkins BT, Egleton RD, Davis TP (2005) Modulation of cerebral microvascular permeability by endothelial nicotinic acetylcholine receptors [J]. Am J Physiol Heart Circ Physiol 289(1):H212–H219

Article  CAS  PubMed  Google Scholar 

Egea J, Buendia I, Parada E et al (2015) Anti-inflammatory role of microglial alpha7 nAChRs and its role in neuroprotection [J]. Biochem Pharmacol 97(4):463–472

Article  CAS  PubMed  Google Scholar 

Zhao L, Xiao Y, Xiu J et al (2018) Protection against the neurotoxic effects of β-amyloid peptide on cultured neuronal cells by lovastatin involves elevated expression of α7 nicotinic acetylcholine receptors and activating phosphorylation of protein kinases [J]. Am J Pathol 188(4):1081–1093

Article  CAS  PubMed  Google Scholar 

Ryan RE, Ross SA, Drago J et al (2001) Dose-related neuroprotective effects of chronic nicotine in 6-hydroxydopamine treated rats, and loss of neuroprotection in alpha4 nicotinic receptor subunit knockout mice [J]. Br J Pharmacol 132(8):1650–1656

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bordia T, Campos C, Huang L et al (2008) Continuous and intermittent nicotine treatment reduces L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesias in a rat model of Parkinson’s disease [J]. J Pharmacol Exp Ther 327(1):239–247

Article  CAS  PubMed  Google Scholar 

Büttner-Ennever J. (1997) The rat brain in stereotaxic coordinates, 3rd edn. By George Paxinos and Charles Watson. (Pp. xxxiii+80; illustrated; £$69.95 paperback; ISBN 0 12 547623; comes with CD-ROM.) San Diego: Academic Press. 1996 [J]. Journal of Anatomy, 191(2): 315–7.

Itoh J, Ukai M, Kameyama T (1993) Dynorphin A-(1–13) markedly improves scopolamine-induced impairment of spontaneous alternation performance in mice [J]. Eur J Pharmacol 236(3):341–345

Article  CAS  PubMed  Google Scholar 

Hiramatsu M, Inoue K (1999) Nociceptin/orphanin FQ and nocistatin on learning and memory impairment induced by scopolamine in mice [J]. Br J Pharmacol 127(3):655–660

Article  CAS  PubMed  PubMed Central  Google Scholar 

Khuwaja G, Khan MM, Ishrat T et al (2011) Neuroprotective effects of curcumin on 6-hydroxydopamine-induced Parkinsonism in rats: behavioral, neurochemical and immunohistochemical studies [J]. Brain Res 1368:254–263

Article  CAS  PubMed  Google Scholar 

Holzmann C, Dräger D, Mix E et al (2012) Effects of intrastriatal botulinum neurotoxin A on the behavior of Wistar rats [J]. Behav Brain Res 234(1):107–16

Article  CAS  PubMed  Google Scholar 

Porritt MJ, Batchelor PE, Howells DW (2005) Inhibiting BDNF expression by antisense oligonucleotide infusion causes loss of nigral dopaminergic neurons [J]. Exp Neurol 192(1):226–234

Article  CAS  PubMed  Google Scholar 

Baquet ZC, Bickford PC, Jones KR (2005) Brain-derived neurotrophic factor is required for the establishment of the proper number of dopaminergic neurons in the substantia nigra pars compacta [J]. The Journal of neuroscience : the official journal of the Society for Neuroscience 25(26):6251–6259

Article  CAS  PubMed  Google Scholar 

Ma C, Liu Y, Li S et al (2023) Microglial cGAS drives neuroinflammation in the MPTP mouse models of Parkinson’s disease [J]. CNS Neurosci Ther 29(7):2018–2035

Article  CAS  PubMed  PubMed Central  Google Scholar 

Heidari A, Yazdanpanah N, Rezaei N (2022) The role of Toll-like receptors and neuroinflammation in Parkinson’s disease [J]. J Neuroinflammation 19(1):135

Article  CAS  PubMed  PubMed Central  Google Scholar 

Karpenko MN, Vasilishina AA, Gromova EA et al (2018) Interleukin-1β, interleukin-1 receptor antagonist, interleukin-6, interleukin-10, and tumor necrosis factor-α levels in CSF and serum in relation to the clinical diversity of Parkinson’s disease [J]. Cell Immunol 327:77–82

Article  CAS  PubMed  Google Scholar 

Hu G, Antikainen R, Jousilahti P et al (2008) Total cholesterol and the risk of Parkinson disease [J]. Neurology 70(21):1972–1979

Article  CAS  PubMed