Abd-El-Fattah, M. A., Abdelakader, N. F., & Zaki, H. F. (2014). Pyrrolidine dithiocarbamate protects against scopolamine-induced cognitive impairment in rats. European Journal of Pharmacology, 723, 330–338. https://doi.org/10.1016/j.ejphar.2013.11.008

Article  CAS  PubMed  Google Scholar 

Bahbah, E. I., Ghozy, S., Attia, M. S., Negida, A., Emran, T. B., Mitra, S., Albadrani, G. M., Abdel-Daim, M. M., Uddin, M. S., & Simal-Gandara, J. (2021). Molecular mechanisms of astaxanthin as a potential neurotherapeutic agent. Marine Drugs, 19(4), 201. https://doi.org/10.3390/md19040201

Article  CAS  PubMed  PubMed Central  Google Scholar 

Balendra, V., & Singh, S. K. (2021). Therapeutic potential of astaxanthin and superoxide dismutase in Alzheimer’s disease. Open Biology, 11(6), 210013. https://doi.org/10.1098/rsob.210013

Article  CAS  PubMed  PubMed Central  Google Scholar 

Belloso-Iguerategui, A., Zamarbide, M., Merino-Galan, L., Rodríguez-Chinchilla, T., Gago, B., Santamaria, E., Fernández-Irigoyen, J., Cotman, C. W., Prieto, G. A., Quiroga-Varela, A., & Rodríguez-Oroz, M. C. (2023). Hippocampal synaptic failure is an early event in experimental parkinsonism with subtle cognitive deficit. Brain. https://doi.org/10.1093/brain/awad227

Article  PubMed  PubMed Central  Google Scholar 

Bird, C. M., & Burgess, N. (2008). The hippocampus and memory: Insights from spatial processing. Nature Reviews Neuroscience, 9(3), 182–194. https://doi.org/10.1038/nrn2335

Article  CAS  PubMed  Google Scholar 

Bockaert, J., & Marin, P. (2015). mTOR in brain physiology and pathologies. Physiological Reviews, 95(4), 1157–1187. https://doi.org/10.1152/physrev.00038.2014

Article  CAS  PubMed  Google Scholar 

Cao, Y., Yang, L., Qiao, X., Xue, C., & Xu, J. (2021). Dietary astaxanthin: An excellent carotenoid with multiple health benefits. Critical Reviews in Food Science and Nutrition, 63(18), 3019–3045. https://doi.org/10.1080/10408398.2021.1983766

Article  CAS  PubMed  Google Scholar 

Carvalho, C., & Moreira, P. I. (2018). Oxidative stress: A major player in cerebrovascular alterations associated to neurodegenerative events. Frontiers in Physiology. https://doi.org/10.3389/fphys.2018.00806

Article  PubMed  PubMed Central  Google Scholar 

Che, H., Li, Q., Zhang, T., Wang, D., Yang, L., Xu, J., Yanagita, T., Xue, C., Chang, Y., & Wang, Y. (2018). Effects of astaxanthin and docosahexaenoic-acid-acylated astaxanthin on alzheimer’s disease in APP/PS1 double-transgenic mice. Journal of Agriculture and Food Chemistry, 66(19), 4948–4957. https://doi.org/10.1021/acs.jafc.8b00988

Article  CAS  Google Scholar 

Chen, X., Chen, L., Lin, G., Wang, Z., Kodali, M. C., Li, M., Chen, H., Lebovitz, S. G., Ortyl, T. C., Li, L., Ismael, S., Singh, P., Malik, K. U., Ishrat, T., Zhou, F. M., Zheng, W., & Liao, F. F. (2022). White matter damage as a consequence of vascular dysfunction in a spontaneous mouse model of chronic mild chronic hypoperfusion with eNOS deficiency. Molecular Psychiatry, 27(11), 4754–4769. https://doi.org/10.1038/s41380-022-01701-9

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen, Y. X., Yang, H., Wang, D. S., Yao, Y. T., Chen, T. T., Tao, L., Chen, Y., & Shen, X. C. (2023). Gastrodin relieves cognitive impairment by regulating autophagy via PI3K/AKT signaling pathway in vascular dementia. Biochemical and Biophysical Research Communications, 671, 246–254. https://doi.org/10.1016/j.bbrc.2023.06.011

Article  CAS  PubMed  Google Scholar 

Cheng, J., & Eroglu, A. (2021). The promising effects of astaxanthin on lung diseases. Advances in Nutrition, 12(3), 850–864. https://doi.org/10.1093/advances/nmaa143

Article  PubMed  Google Scholar 

Cunha, S. A., Borges, S., Baptista-Silva, S., Ribeiro, T., Oliveira-Silva, P., Pintado, M., & Batista, P. (2023). Astaxanthin impact on brain: Health potential and market perspective. Critical Reviews in Food Science and Nutrition. https://doi.org/10.1080/10408398.2023.2232866

Article  PubMed  Google Scholar 

Doyon, G., Sobolewski, M. D., Huber, K., McMahon, D., Mellors, J. W., & Sluis-Cremer, N. (2014). Discovery of a small molecule agonist of phosphatidylinositol 3-kinase p110α that reactivates latent HIV-1. PLoS ONE, 9(1), e84964. https://doi.org/10.1371/journal.pone.0084964

Article  CAS  PubMed  PubMed Central  Google Scholar 

Eichenbaum, H. (2004). Hippocampus: Cognitive processes and neural representations that underlie declarative memory. Neuron, 44(1), 109–120. https://doi.org/10.1016/j.neuron.2004.08.028

Article  CAS  PubMed  Google Scholar 

El-Agamy, S. E., Abdel-Aziz, A. K., Wahdan, S., Esmat, A., & Azab, S. S. (2018). Astaxanthin ameliorates doxorubicin-induced cognitive impairment (chemobrain) in experimental rat model: Impact on oxidative, inflammatory, and apoptotic machineries. Molecular Neurobiology, 55(7), 5727–5740. https://doi.org/10.1007/s12035-017-0797-7

Article  CAS  PubMed  Google Scholar 

Fakhri, S., Aneva, I. Y., Farzaei, M. H., & Sobarzo-Sánchez, E. (2019). The neuroprotective effects of astaxanthin: Therapeutic targets and clinical perspective. Molecules, 24(14), 2640. https://doi.org/10.3390/molecules24142640

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fakhri, S., Iranpanah, A., Gravandi, M. M., Moradi, S. Z., Ranjbari, M., Majnooni, M. B., Echeverría, J., Qi, Y., Wang, M., Liao, P., Farzaei, M. H., & Xiao, J. (2021). Natural products attenuate PI3K/Akt/mTOR signaling pathway: A promising strategy in regulating neurodegeneration. Phytomedicine, 91, 153664. https://doi.org/10.1016/j.phymed.2021.153664

Article  CAS  PubMed  Google Scholar 

Fraga, E., Medina, V., Cuartero, M. I., García-Culebras, A., Bravo-Ferrer, I., Hernández-Jiménez, M., Garcia-Segura, J. M., Hurtado, O., Pradillo, J. M., Lizasoain, I., & Moro, M. (2023). Defective hippocampal neurogenesis underlies cognitive impairment by carotid stenosis-induced cerebral hypoperfusion in mice. Frontiers in Cellular Neuroscience, 17, 1219847. https://doi.org/10.3389/fncel.2023.1219847

Article  PubMed  PubMed Central  Google Scholar 

Galasso, C., Orefice, I., Pellone, P., Cirino, P., Miele, R., Ianora, A., Brunet, C., & Sansone, C. (2018). On the neuroprotective role of astaxanthin: New perspectives? Marine Drugs, 16(8), 247. https://doi.org/10.3390/md16080247

Article  CAS  PubMed  PubMed Central  Google Scholar 

Goodman, R. A., Lochner, K. A., Thambisetty, M., Wingo, T. S., Posner, S. F., & Ling, S. M. (2017). Prevalence of dementia subtypes in United States medicare fee-for-service beneficiaries, 2011–2013. Alzheimer’s & Dementia, 13(1), 28–37. https://doi.org/10.1016/j.jalz.2016.04.002

Article  Google Scholar 

Head, E. (2009). Oxidative damage and cognitive dysfunction: Antioxidant treatments to promote healthy brain aging. Neurochemical Research, 34(4), 670–678. https://doi.org/10.1007/s11064-008-9808-4

Article  CAS  PubMed  Google Scholar 

Heredia-López, F. J., Álvarez-Cervera, F. J., Collí-Alfaro, J. G., Bata-García, J. L., Arankowsky-Sandoval, G., & Góngora-Alfaro, J. L. (2016). An automated Y-maze based on a reduced instruction set computer (RISC) microcontroller for the assessment of continuous spontaneous alternation in rats. Behavior Research Methods, 48(4), 1631–1643. https://doi.org/10.3758/s13428-015-0674-0

Article  PubMed  Google Scholar 

Iadecola, C. (2013). The pathobiology of vascular dementia. Neuron, 80(4), 844–866. https://doi.org/10.1016/j.neuron.2013.10.008

Article  CAS  PubMed  Google Scholar 

Iadecola, C., Duering, M., Hachinski, V., Joutel, A., Pendlebury, S. T., Schneider, J. A., & Dichgans, M. (2019). Vascular cognitive impairment and dementia: JACC scientific expert panel. Journal of the American College of Cardiology, 73(25), 3326–3344. https://doi.org/10.1016/j.jacc.2019.04.034

Article  PubMed  PubMed Central  Google Scholar 

Ishikawa, H., Shindo, A., Mizutani, A., Tomimoto, H., Lo, E. H., & Arai, K. (2023). A brief overview of a mouse model of cerebral hypoperfusion by bilateral carotid artery stenosis. Journal of Cerebral Blood Flow & Metabolism. https://doi.org/10.1177/0271678x231154597

Article  Google Scholar 

Jia, J., Wang, F., Wei, C., Zhou, A., Jia, X., Li, F., Tang, M., Chu, L., Zhou, Y., Zhou, C., Cui, Y., Wang, Q., Wang, W., Yin, P., Hu, N., Zuo, X., Song, H., Qin, W., Wu, L., … Dong, X. (2014). The prevalence of dementia in urban and rural areas of China. Alzheimer’s & Dementia, 10(1), 1–9. https://doi.org/10.1016/j.jalz.2013.01.012

Article