Abbas MG, Shoji H, Soya S, Hondo M, Miyakawa T, Sakurai T (2015) Comprehensive behavioral analysis of male Ox1r (-/-) mice showed implication of orexin receptor-1 in mood, anxiety, and social behavior. Front in Behav Neurosci 9:324

Article  Google Scholar 

Aran A, Shors I, Lin L, Mignot E, Schimmel MS (2012) CSF levels of hypocretin-1 (orexin-A) peak during early infancy in humans. Sleep 35(2):187–191

Article  PubMed  PubMed Central  Google Scholar 

Arthaud S, Varin C, Gay N, Libourel PA, Chauveau F, Fort P, Luppi PH, Peyron C (2015) Paradoxical (REM) sleep deprivation in mice using the small-platforms-over-water method: polysomnographic analyses and melanin-concentrating hormone and hypocretin/orexin neuronal activation before, during and after deprivation. J Sleep Res 24:309–319. https://doi.org/10.1111/jsr.12269

Article  PubMed  Google Scholar 

Başoğlu C, Öner O, Güneş C, Semiz UB, Ateş AM, Algül A, Ebrinç S, Çetin M, Özcan O, İpçioğlu O (2010) Plasma orexin A, ghrelin, cholecystokinin, visfatin, leptin and agouti-related protein levels during 6-week olanzapine treatment in first-episode male patients with psychosis. Int Clin Psychopharmacol 25:165–171

Article  PubMed  Google Scholar 

Benedetti F, Colombo C (2011) Sleep deprivation in mood disorders. Neuropsychobiology 64:141–151. https://doi.org/10.1159/000328947

Article  PubMed  Google Scholar 

Borgland SL, Labouebe G (2010) Orexin/hypocretin in psychiatric disorders: present state of knowledge and future potential. Neuropsychopharmacol Rev 35:353–354

Article  Google Scholar 

Braff DL, Geyer MA (1990) Sensorimotor gating and schizophrenia: Human and animal model studies. Arch Gen Psychiat 47:181–188

Article  CAS  PubMed  Google Scholar 

Braff DL, Geyer MA, Swerdlow NR (2001) Human studies of prepulse inhibition of startle: normal subjects, patient groups, and pharmacological studies. Psychopharmacology 156:234–258

Article  CAS  PubMed  Google Scholar 

Briggs C, Hirasawa M, Semba K (2018) Sleep deprivation distinctly alters glutamate transporter 1 apposition and excitatory transmission to orexin and MCH neurons. J Neurosci 38:2505–2518. https://doi.org/10.1523/JNEUROSCI.2179-17.2018

Article  CAS  PubMed  PubMed Central  Google Scholar 

Briggs C, Bowes SC, Semba K, Hirasawa M (2019) Sleep deprivation-induced pre- and postsynaptic modulation of orexin neurons. Neuropharmacology 154:50–60. https://doi.org/10.1016/j.neuropharm.2018.12.025

Article  CAS  PubMed  Google Scholar 

Broberg BV, Oranje B, Glenthøj BY, Fejgin K, Plath N, Bastlund JF (2010) Assesment of auditory sensory processing in a neurodevelopmental animal model of schizophrenia—gating of auditory-evoked potentials and prepulse inhibition. Behav Brain Res 213:142–147

Article  PubMed  Google Scholar 

Carter ME, Adamantidis A, Ohtsu H, Deisseroth K, de Lecea L (2009) Sleep homeostasis modulates hypocretin-mediated sleep-to-wake transitions. J Neurosci 29:10939–10949

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chang HA, Liu YP, Tung CS, Chang CC, Tzeng NS, Huang SY (2014) Effects of REM sleep deprivation on sensorimotor gating and startle habituation in rats: role of social isolation in early development. Neurosci Lett 575:63–67

Article  CAS  PubMed  Google Scholar 

Chen PY, Chen CH, Chang CK, Kao CF, Lu ML, Lin SK, Huang MC, Hwang LL, Mondelli V (2019) Orexin-A levels in relation to the risk of metabolic syndrome in patients with schizophrenia taking antipsychotics. Int J Neuropsychopharmacol 55:6362–6368. https://doi.org/10.1093/ijnp/pyy075

Article  CAS  Google Scholar 

Chien YL, Liua C, Shana JC, Leef HJ, Hsieha MH, Hwua HG, Chioud LC (2015) Elevated plasma orexin A levels in a subgroup of patients with schizophrenia associated with fewer negative and disorganized symptoms. Psychoneuroendocrinol 53:1–9

Article  CAS  Google Scholar 

Choy KHC, Luo JK, Wannan CMJ, Laskaris L, Merritt A, Syeda WT, Sexton PM, Christopoulos A, Pantelis C, Nithianantharajah J (2021) Cognitive behavioral markers of neurodevelopmental trajectories in rodents. Transl Psychiatry 11:556

Article  PubMed  PubMed Central  Google Scholar 

de Porter DP, Coborn JE, Teske JA (2017) Partial sleep deprivation reduces the efficacy of orexin-A to stimulate physical activity and energy expenditure. Obesity 25:1716–1722. https://doi.org/10.1002/oby.21944

Article  CAS  Google Scholar 

Deadwyler SA, Porrino L, Siegel JM, Hampson RE (2007) Systemic and nasal delivery of orexin-A (Hypocretin-1) reduces the effects of sleep deprivation on cognitive performance in nonhuman primates. J Neurosci 27:14329–14347

Article  Google Scholar 

Demidova A, Kahl E, Fendt M (2022) Orexin-deficiency affects sensorimotor gating and its amphetamine-induced impairment. Prog Neuropsycopharmacol Biol Psychiatry 116:110517

Article  CAS  Google Scholar 

Deutch AY, Bubser M (2007) The orexins/hypocretins and schizophrenia. Schizophr Bull 33:1277–1283

Article  PubMed  PubMed Central  Google Scholar 

Faiola E, Meyhöfer I, Steffens M, Kasparbauer AM, Kumari V, Ettinger U (2018) Combining trait and state model systems of psychosis: the effect of sleep deprivation on cognitive functions in schizotypal individuals. Psychiatry Res 270:639–648

Article  PubMed  Google Scholar 

Frau R, Orrù M, Puligheddu M, Gessa GL, Mereu G, Marrosu F, Bortolato M (2008) Sleep deprivation disrupts prepulse inhibition of the startle reflex: reversal by antipsychotic drugs. Int J Neuropsychopharmacol 11:947–955

Article  CAS  PubMed  Google Scholar 

Fronczek R, van Geest S, Frölich M, Overeem S, Roelandse F, Lammers G, Swaab D (2012) Hypocretin (orexin) loss in Alzheimer’s disease. Neurobiol Aging 33:1642–1650

Article  CAS  PubMed  Google Scholar 

Fukunaka Y, Shinkai T, Hwang R, Hori H, Utsunomiya K, Sakata S (2007) The orexin 1 receptor (HCRTR1) gene as a susceptibility gene contribut- ing to polydipsia-hyponatremia in schizophrenia. Neuromol Med 9:292–297

Article  CAS  Google Scholar 

Graham F (1975) The more or less startling effects of weak prestimuli. Psychophysiology 12:238–248

Article  CAS  PubMed  Google Scholar 

Hunt NJ, Rodriguez ML, Waters KA, Machaalani R (2015) Changes in orexin (hypocretin) neuronal expression with normal aging in the human hypothalamus. Neurobiol Aging 36(1):292–300

Article  CAS  PubMed  Google Scholar 

Jafari Z, Kolb BE, Mohajerani MH (2020) Prepulse inhibition of the acoustic startle reflex and P50 gating in aging and Alzheimer’s Disease. Ageing Res Rev 101028. https://doi.org/10.1016/j.arr.2020.101028

Kanbayashi T, Yano T, Ishiguro H, Kawanishi K, Chiba S, Aizawa R, Shimizu T (2002) Hypocretin-1 (orexin-A) levels in human lumbar CSF in different age groups: infants to elderly persons. Sleep 25(3):337–339

Article  PubMed  Google Scholar 

Kang JE, Lim MM, Bateman RJ, Lee JJ, Smyth LP, Cirrito JR, Fujiki N, Nishino S, Holtzman DM (2009) Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle. Science 326:1005–1007

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kaya Yertutanol FD, Uzbay IT, Çevreli B, Bolay Belen H (2020) Effect of gabapentin on sleep-deprivation-induced disruption of prepulse inhibition. Psychopharmacology 237:2993–3006

Article  CAS  PubMed  Google Scholar 

Kessler BA, Stanley EM, Frederick-Duus D, Fadel J (2011) Age-related loss of orexin/hypocretin neurons. Neuroscience 178:82–88

Article  CAS  PubMed  Google Scholar 

Kumari V, Ettinger U (2020) Controlled sleep deprivation as an experimental medicine model of schizophrenia : an update. https://doi.org/10.1016/j.schres.2020.03.064

Article  Google Scholar 

Lambe EK, Liu RJ, Aghajanian GK (2007) Schizophrenia, hypocretin (orexin), and the thalamocortical activating system. Schizoph Bull 33:1284–1290

Article  PubMed  PubMed Central  Google Scholar 

Liguori C (2016) Orexin and alzheimer’s disease. In: Lawrence AJ, de Lecea L (eds) Behavioral Neuroscience of Orexin/Hypocretin. Springer International Publishing, Germany, pp 305–322

Chapter  Google Scholar 

Liu Z, Zhang Y, Zhao T, Wang J, Xia L, Zhong Y, Yang Y, Ning X, Zhang Y, Ren Z, Liu H (2020) A higher body mass index in Chinese inpatients with chronic schizophrenia is associated with elevated plasma orexin-A levels and fewer negative symptoms. Nord J Psychiatry 74(7):525–532. https://doi.org/10.1080/08039488.2020.1755995

Lu J, Huang ML, Li JH, Jin KY, Li HM, Mou TT, Fronczek R, Duan JF, Xu WJ, Swaab D, Bao AM (2021) Changes in hypocretin (orexin) system in schizophrenia : from plasma to brain. Schizophr Bull 47(5):1310–1319. https://doi.org/10.1093/schbul/sbab042

Martins PJ, Marques MS, Tufik S, D’Almeida V (2010) Orexin activation precedes increased NPY expression, hyperphagia, and metabolic changes in response to sleep deprivation. Am J Physiol Endocrinol Metab 298:E726–E734. https://doi.org/10.1152/ajpendo.00660.2009

Article  CAS  PubMed  Google Scholar 

Matsuki T, Takasu M, Hirose Y, Murakoshi N, Sinton CM, Motoike T, Yanagisawa M (2015) GABAA receptor-mediated input change on orexin neurons following sleep deprivation in mice. Neurosci 284:217–224

Article  CAS  Google Scholar 

Matsumura T, Nakayama M, Nomura A, Naito A, Kamahara K, Kadono K, Sekizawa K (2002) Age-related changes in plasma orexin-A concentrations. Exp Gerontol 37(8–9):1127–1130

Article  CAS  PubMed  Google Scholar 

Meerabux J, Iwayama Y, Sakurai T, Ohba H, Toyota T, Yamada K, Nagata R, Irukayama-Tomobe Y, Shimizu H, Yoshitsugu K, Ohta K, Yoshikawa T (2005) Association of an orexin 1 receptor 408Val variant with polydipsia-hyponatremia in schizophrenic subjects. Biol Psychiatry 58:401–407

Article