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The role of the Androgen Receptor (AR) in endometrial cancer aggressiveness: Correlation with other prognostic markers and therapeutic implications. A retrospective observational study
Endometrial carcinoma (EC) is the most common gynecological malignancy, with increasing incidence linked to rising risk fa...
A floating collagen matrix triggers ring formation and stemness characteristics in human colorectal cancer organoids
Volume 269, May 2025, 155890Author links open overlay panel, , , , , , Highlights•Collagen type I is a more physiological ...
Extended tumor area-based stratification score combining tumor budding and stroma identifies a high-risk, immune-depleted group in localized microsatellite-stable colon cancer patients
Microsatellite instability (MSI) is the most validated molecular marker associated with longer disease-free survival and l...
A novel variation in the LMX1B gene with nail-patella syndrome
Volume 269, May 2025, 155936Author links open overlay panel, , , , , , , , AbstractNail-patella syndrome (NPS; OMIM #16120...
Recent advances in CRISPR technology in the milieu of oral squamous cell carcinoma
Valsala Gopalakrishnan Abilash: Writing – review & editing, Visualization, Validation, Supervision, Software, Resource...
Papillary thyroid carcinoma and strumal carcinoid transformations of a mature cystic teratoma with NRAS codon 61 mutation: A case report
Mature cystic teratoma(MCT)2 is the most prevalent neoplasm derived from germ cells in females; its progression to maligna...
Crystal-storing histiocytosis of multiple myeloma with a novel multi-exon deletion of WRN: A case report and mini review of literature
Crystal-storing histiocytosis (CSH) is a rare condition that results from crystals accumulating in the cytoplasm of macrop...
Eosinophilic solid and cystic renal cell carcinoma: A case with two novel TSC2 mutations
BackgroundEosinophilic solid and cystic renal cell carcinoma (ESC RCC) is a recently identified subtype of renal tumors. D...
Unlocking the potential: Receptor-mediated targeted drug delivery in cancer therapy
Cancer is a serious threat to global health, with nearly 3 million PubMed entries focused on the subject [1], [2]. Early d...
Exploring the molecular pathways of advanced rectal cancer: A focus on genetic, RNA, and biological technique
Colorectal cancer (CRC) is the third most commonly diagnosed cancer in both men and women and ranks as the second leading ...
The function of circular RNAs in regulating Wnt/β-catenin signaling: An innovative therapeutic strategy for breast and gynecological cancers
Breast cancer (BC) and gynecological malignancies, including cervical, ovarian, and uterine cancers, are significant globa...
Targeting KRAS-G12C in lung cancer: The emerging role of PROTACs in overcoming resistance
Lung cancer is a cause of cancer-related death that continues to be one of the leading causes of cancer death throughout t...
Digital quantification of Ki67 and PRAME in challenging melanocytic lesions – A novel diagnostic tool
Volume 270, June 2025, 155953Author links open overlay panel, , , , , , AbstractThe interpretation of immunohistochemical ...
Prognostic impact of combined loss of RB1, p53 and p21 in muscle-invasive bladder cancer
Volume 270, June 2025, 155960Author links open overlay panel, , , , , , , , , , , , , , Highlights•Tissue microarrays from...
Integrating clinicopathological and molecular data to assess the biological behavior of uterine inflammatory myofibroblastic tumors
The inflammatory myofibroblastic tumor (IMT) is an uncommon mesenchymal neoplasm with an uncertain biological behavior. In...
SMARCD1 is a dual regulator of PD-L1 expression and cell proliferation facilitating tumor evasion
Colorectal cancer accounts for approximately 10 % of all newly diagnosed cancers and cancer-related deaths worldwide each ...
Role of artificial intelligence –based machine learning model in predicting HER2/neu gene status in breast cancer
HER2 (Human Epidermal growth factor Receptor) gene is a proto-oncogene, located on chromosome 17 q12–21.32, and is respons...
Insights into the impact of chromosome 3p mutations in advanced renal cell carcinoma treated with immune-based combinations or targeted therapy: A single-center experience
About 87 % of kidney cancer diagnoses per year is represented by renal cell carcinoma (RCC), which accounted for over 400,...
SFPQ::TFE3-rearranged PEComa: Differences and analogies with renal cell carcinoma carrying the same translocation
Among perivascular epithelioid cell neoplasms (PEComas), some tumors have been found to carry rearrangements of the TFE3 g...
Fibrin-associated large B-cell lymphoma arising in a cystic lymphangiomatous lesion of the adrenal gland: A case report and overview of the entity
Volume 270, June 2025, 155957Author links open overlay panel, , , , , , , , , , AbstractFibrin-associated large B-cell lym...
The combination of p16 and Rb expression pattern is helpful to predict high-risk HPV infection and the primary site in lymph node metastases of squamous cell carcinoma
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Exploring circulating MiRNA signature for osteosarcoma detection: Bioinformatics-based analyzing and validation
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Impact of estradiol in inducing endometrial cancer using RL95-2
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Expression of CD68 and CD163 in malignant epithelial cells of oral squamous cell carcinoma: Phenotypic shift or mere cell fusion
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miR-17–5p/STAT3/H19: A novel regulatory axis tuning ULBP2 expression in young breast cancer patients
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Unraveling the genetic and singaling landscapes of pediatric cancer
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Interleukin-12 treatment reduces tumor growth and modulates the expression of CASKA and MIR-203 in athymic mice bearing tumors induced by the HGC-27 gastric cancer cell line
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Cultures derived from pancreatic cancer xenografts with long-term gemcitabine treatment produce chemoresistant secondary xenografts: Establishment of isogenic gemcitabine-sensitive and -resistant models
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Expression of histone methyltransferase WHSC1 in invasive breast cancer and its correlation with clinical and pathological data
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Ensemble approach of deep learning models for binary and multiclass classification of histopathological images for breast cancer
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