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Correction to: EMP2 induces cytostasis and apoptosis via the TGFβ/SMAD/SP1 axis and recruitment of P2RX7 in urinary bladder urothelial carcinoma
Correction to: EMP2 induces cytostasis and apoptosis via the TGFβ/SMAD/SP1 axis and recruitment of P2RX7 in urinary bladder urothelial carcinoma
Department of Medical Research, Chi-Mei Medical Center, Tainan, TaiwanChien-Feng Li & Ti-Chun ChanNational Cancer Rese...
Tertiary lymphoid structures and their therapeutic implications in cancer
Tertiary lymphoid structures and their therapeutic implications in cancer
Tertiary lymphoid structures (TLSs) are ectopic lymphoid aggregates formed by the structured accumulation of immune cells ...
Targeting tumor associated macrophages (TAMs) reprograms tumor immune microenvironment to promote solid tumor immunotherapy
Targeting tumor associated macrophages (TAMs) reprograms tumor immune microenvironment to promote solid tumor immunotherapy
A.V.R. Kornepati, R.K. Vadlamudi, T.J. Curiel, Programmed death ligand 1 signals in cancer cells. Nat. Rev. Cancer. 22, 17...
Panoramic tumor microenvironment in pancreatic ductal adenocarcinoma
Panoramic tumor microenvironment in pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is notorious for its resistance to various treatment modalities. The genetic heter...
Unveiling therapeutic avenues targeting xCT in head and neck cancer
Unveiling therapeutic avenues targeting xCT in head and neck cancer
Head and neck cancer (HNC) remains a major global health burden, prompting the need for innovative therapeutic strategies....
Mitochondria in tumor immune surveillance and tumor therapies targeting mitochondria
Mitochondria in tumor immune surveillance and tumor therapies targeting mitochondria
Mitochondria play a central role in cellular energy production and metabolic regulation, and their function has been ident...
Tumour cell-released autophagosomes promote lung metastasis by upregulating PD-L1 expression in pulmonary vascular endothelial cells in breast cancer
Tumour cell-released autophagosomes promote lung metastasis by upregulating PD-L1 expression in pulmonary vascular endothelial cells in breast cancer
Establishing an immunosuppressive premetastatic niche (PMN) in distant organs is crucial for breast cancer metastasis. Vas...
ALKBH4 functions as a hypoxia-responsive tumor suppressor and inhibits metastasis and tumorigenesis
ALKBH4 functions as a hypoxia-responsive tumor suppressor and inhibits metastasis and tumorigenesis
The human AlkB homolog (ALKBH) dioxygenase superfamily plays a crucial role in gene regulation and is implicated in cancer...
Targeting the Notch-Furin axis with 2-hydroxyoleic acid: a key mechanism in glioblastoma therapy
Targeting the Notch-Furin axis with 2-hydroxyoleic acid: a key mechanism in glioblastoma therapy
Glioblastomas (GBMs) are highly treatment-resistant and aggressive brain tumors. 2OHOA, which is currently running a phase...
BCAT1 contributes to the development of TKI-resistant CML
BCAT1 contributes to the development of TKI-resistant CML
Although most of chronic myeloid leukemia (CML) patients can be effectively treated by the tyrosine kinase inhibitors (TKI...
The long non-coding RNA NEAT1 contributes to aberrant STAT3 signaling in pancreatic cancer and is regulated by a metalloprotease-disintegrin ADAM8/miR-181a-5p axis
The long non-coding RNA NEAT1 contributes to aberrant STAT3 signaling in pancreatic cancer and is regulated by a metalloprotease-disintegrin ADAM8/miR-181a-5p axis
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers and several studies demonstrate that STAT3 has c...
Integrating bulk and single-cell transcriptomics to elucidate the role and potential mechanisms of autophagy in aging tissue
Integrating bulk and single-cell transcriptomics to elucidate the role and potential mechanisms of autophagy in aging tissue
Autophagy is frequently observed in tissues during the aging process, yet the tissues most strongly correlated with autoph...
USP28 promotes tumor progression and glycolysis by stabilizing PKM2/Hif1-α in cholangiocarcinoma
USP28 promotes tumor progression and glycolysis by stabilizing PKM2/Hif1-α in cholangiocarcinoma
Ubiquitination is one of the important modification of proteins which can be reversed by deubiquitinating enzymes (DUBs). ...
SUMOylation regulates the aggressiveness of breast cancer-associated fibroblasts
SUMOylation regulates the aggressiveness of breast cancer-associated fibroblasts
Cancer-associated fibroblasts (CAFs) are the most abundant stromal cellular component in the tumor microenvironment (TME)....
Correction to: Microbial metabolite trimethylamine-N-oxide induces intestinal carcinogenesis through inhibiting farnesoid X receptor signaling
Correction to: Microbial metabolite trimethylamine-N-oxide induces intestinal carcinogenesis through inhibiting farnesoid X receptor signaling
Correction to: Cellular OncologyIn the abstract of this article the line ‘Gut microbi...
Chordoma cells possess bone-dissolving activity at the bone invasion front
Chordoma cells possess bone-dissolving activity at the bone invasion front
Chordomas are malignant tumors that destroy bones, compress surrounding nerve tissues and exhibit phenotypes that recapitu...
Exploring the impact of PDGFD in osteosarcoma metastasis through single-cell sequencing analysis
Exploring the impact of PDGFD in osteosarcoma metastasis through single-cell sequencing analysis
The overall survival rate for metastatic osteosarcoma hovers around 20%. Responses to second-line chemotherapy, targeted t...
LILRB2 promotes immune escape in breast cancer cells via enhanced HLA-A degradation
LILRB2 promotes immune escape in breast cancer cells via enhanced HLA-A degradation
Increased expression of leukocyte immunoglobulin-like receptor subfamily B member 2 (LILRB2) is associated with immune eva...
Rituximab potentially improves clinical outcomes of CAR-T therapy for r/r B-ALL via sensitizing leukemia cells to CAR-T-mediated cytotoxicity and reducing CAR-T exhaustion
Rituximab potentially improves clinical outcomes of CAR-T therapy for r/r B-ALL via sensitizing leukemia cells to CAR-T-mediated cytotoxicity and reducing CAR-T exhaustion
Despite chimeric antigen receptor (CAR) T-cell therapy has achieved great advances in recent year, approximately 50% of re...
Targeting Dectin-1 and or VISTA enhances anti-tumor immunity in melanoma but not colorectal cancer model
Targeting Dectin-1 and or VISTA enhances anti-tumor immunity in melanoma but not colorectal cancer model
Acquired resistance to immune checkpoint blockers (ICBs) is a major barrier in cancer treatment, emphasizing the need for ...
Research advances in the molecular classification of gastric cancer
Research advances in the molecular classification of gastric cancer
Gastric cancer (GC) is a malignant tumor with one of the lowest five-year survival rates. Traditional first-line treatment...
SPG21, a potential oncogene targeted by miR-128-3p, amplifies HBx-induced carcinogenesis and chemoresistance via activation of TRPM7-mediated JNK pathway in hepatocellular carcinoma
SPG21, a potential oncogene targeted by miR-128-3p, amplifies HBx-induced carcinogenesis and chemoresistance via activation of TRPM7-mediated JNK pathway in hepatocellular carcinoma
Chronic hepatitis B virus (HBV) infection is the primary risk factor for the malignant progression of hepatocellular carci...
Deciphering fatty acid biosynthesis-driven molecular subtypes in pancreatic ductal adenocarcinoma with prognostic insights
Deciphering fatty acid biosynthesis-driven molecular subtypes in pancreatic ductal adenocarcinoma with prognostic insights
Pancreatic ductal adenocarcinoma (PDAC) poses a significant challenge due to its high heterogeneity and aggressiveness. Re...
Targeted gene delivery systems for T-cell engineering
Targeted gene delivery systems for T-cell engineering
T lymphocytes are indispensable for the host systems of defense against pathogens, tumors, and environmental threats. The ...
OrganoIDNet: a deep learning tool for identification of therapeutic effects in PDAC organoid-PBMC co-cultures from time-resolved imaging data
OrganoIDNet: a deep learning tool for identification of therapeutic effects in PDAC organoid-PBMC co-cultures from time-resolved imaging data
Pancreatic Ductal Adenocarcinoma (PDAC) remains a challenging disease due to its complex biology and aggressive behavior w...
A systematic review on the culture methods and applications of 3D tumoroids for cancer research and personalized medicine
A systematic review on the culture methods and applications of 3D tumoroids for cancer research and personalized medicine
Cancer is a highly heterogeneous disease, and thus treatment responses vary greatly between patients. To improve therapy e...
HVEM in acute lymphocytic leukemia facilitates tumour immune escape by inhibiting CD8+ T cell function
HVEM in acute lymphocytic leukemia facilitates tumour immune escape by inhibiting CD8+ T cell function
Leukaemia remains a major contributor to global mortality, representing a significant health risk for a substantial number...
ONECUT2 is a druggable driver of luminal to basal breast cancer plasticity
ONECUT2 is a druggable driver of luminal to basal breast cancer plasticity
Tumor heterogeneity complicates patient treatment and can be due to transitioning of cancer cells across phenotypic cell s...
IRE1α inhibitor enhances paclitaxel sensitivity of triple-negative breast cancer cells
IRE1α inhibitor enhances paclitaxel sensitivity of triple-negative breast cancer cells
Breast cancer is the most commonly diagnosed cancer in women, and triple-negative breast cancer (TNBC) accounts for approx...
Deciphering the molecular landscape: evolutionary progression from gynecomastia to aggressive male breast cancer
Deciphering the molecular landscape: evolutionary progression from gynecomastia to aggressive male breast cancer
Gynecomastia denotes the benign proliferation of glandular breast tissue and stands as a recognized risk factor for male b...
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