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Efficient Induction of Apoptosis in Lung Cancer Cells Using Bismuth Sulfide Nanoparticles
Background: The use of nanomaterial-based radiosensitizers to improve the therapeutic ratio has gained attraction inradiot...
Thymoquinone Nanoparticle Induces Apoptosis and Cell Migration Retardation through Modulating of SUMOylation Process Genes in Breast Cancer Cell Line
Background: Due to the heterogeneity of breast cancer, most advanced-stage patients are resistant to therapy. Disruption o...
Network Cluster Analysis of PPI and Phenotype Ontology for Type 1 Diabetes Mellitus
Background: Our knowledge of Type 1 Diabetes Mellitus (T1DM) etiology is incomplete; however, the pathogenesis ofthe disea...
Recombinant Expression and Functional Assessment of Uricase from a Pertinent Origin of the Enzyme, Streptomyces sp. Strain 17-1
Background: Uricase or urate oxidase, as a therapeutic enzyme, is extensively applied to oxidize accumulated uric acidin t...
Antimicrobial Activity of Chitosan Scaffold Loaded with Soluble Factors of Different Probiotic Strains Against Multidrug Resistant Pseudomonas aeruginosa
Background: Bacterial infection remains the most frequent complication of burn injury, which can lead to sepsis, evenif an...
Beauveria Bassiana Amylase-Polygalacturonase Production Using Lignocellulosic Biomass and Application in Juice Processing
Background: The search for sources of industrial biocatalysts, which are non-pathogenic and can utilise cheap nutrientsour...
Growing Conditions and Varietal Ecologies Differently Regulates the Growth-regulating-factor (GRFs) Gene Family in Rice
Background Growth-regulating factors (GRFs) are crucial in rice for controlling plant growth and development. Amongthe ric...
The Effect of Bacillus Cereus on the Ion Homeostasis, Growth Parameters, and the Expression of Some Genes of Artemisinin Biosynthesis Pathway in Artemisia Absinthium Under Salinity Stress
Background: Soil salinity is a major problem in the world that affects the growth and yield of plants. Application of newa...
Controlling Tomato Fusarium Wilt Disease through Bacillus thuringiensis-Mediated Defense Primining
Background: Fusarium wilt caused by the fungus Fusarium oxysporum f. sp. lycopersici (Fol) (Sacc.) W.C. Snyder andH.N. Han...
Time and Cost-Effective Genome Editing Protocol for Simultaneous Caspase 8 Associated Protein 2 Gene Knock in/out in Chinese Hamster Ovary Cells Using CRISPR-Cas9 System
Background: CHO cells are preferred for producing biopharmaceuticals, and genome editing technologies offeropportunities t...
Identification of a New Compound (4-Fluoro-2-Trifluoromethyl Imidazole) Extracted From a New Halophilic Bacillus aquimaris Strain Persiangulf TA2 Isolated From the Northern Persian Gulf With Broad-Spectrum Antimicrobial Effect
Background: The unique ecosystem of the Persian Gulf has made it a rich source of natural antimicrobial compounds produced...
Molecular identification of Juglans regia endophyte LTL-G3, its antifungal potential and bioactive substances
Background: Endophyte is one of the potential biocontrol agents for inhibiting plant pathogens. However, the mechanisms an...
Enhancement of Essential Oil Production and Expression of Some Menthol Biosynthesis-Related Genes in Mentha piperita Using Cyanobacteria
Background: Mentha piperita L. is one of the most important aromatic crops and is cultivated worldwide for essential oils ...
Green Synthesis of Polylactic acid/Fe3O4@β-Cyclodextrin Nanofibrous Nanocomposite Loaded with Ferulago Angulata Extract as a Novel Nano-biosorbent: Evaluation of Diazinon Removal and Antibacterial Activity
Background: Organophosphate pesticides are one of the most extensively applied insecticides in agriculture. These insectic...
Gene Networks Analysis of Salmonella Typhimurium Reveals New Insights on Key Genes Involved in Response to Low Water Activity
Background: When Salmonella enterica serovar Typhimurium, a foodborne bacterium, is exposed to osmotic stress, cellular ad...
Research on Circular RNA Expression Profiles in the Photoaging Mouse Model
Background: Nude mouse has been widely used to study photoaging induced by long-term chronic UV exposure. Circular RNAs (c...
CRISPR/Cas9-Induced Fam83h knock-out Leads to Impaired Wnt/β-Catenin Pathway and Altered Expression of Tooth Mineralization Genes in Mice
Background: Dental enamel formation is a complex process that is regulated by various genes. One such gene, Family With Se...
Introns and their therapeutic applications in biomedical researches: A Review
Context: Although for a long time, it was thought that intervening sequences (introns) were junk DNA without any function,...
A Comprehensive Review of the Key Characteristics of the Genus Mentha, Natural Compounds and Biotechnological Approaches for the Production of Secondary Metabolites
Context: The genus Mentha is one of the most aromatic and well-known members of the Lamiaceae family. A wide range of bioa...
Optimization of Affinity Chromatography Based on Sepharose 4Bchitin for Rapid Purification of Urtica dioica Agglutinin
Background: Today, numerous antimicrobial and anticancer properties have been reported for plant lectins due to theirabili...
The Effect of Collagen and Fibrin Hydrogels Encapsulated with Adipose Tissue Mesenchymal Stem Cell-Derived Exosomes for Treatment of Spinal Cord Injury in a Rat Model
Background: Mesenchymal stem cell (MSC) derived exosomes (MSC-DE) have been demonstrated to be potential candidates for th...
SOX2 Overlapping Transcript (SOX2-OT) enhances the Lung cancer malignancy through interaction with miR-194-5p/SOX5 axis
Background: Lung cancer is one of the most common types of cancer and a leading cause of cancer-related deaths worldwide. ...
Cloning, Prokaryotic Expression and Functional Characterization of nifH Gene from the Associative Nitrogen-fixing Bacteria Klebsiella variicola DX120E
Background: Biological nitrogen fixation (BNF) is a unique mechanism in which microorganisms utilize the nitrogenase enzym...
MiRNA-145-5p restrains malignant behaviors of breast cancer cells via downregulating H2AFX expression
Background: Breast cancer is a prevalent tumor with high aggressiveness among female populations. MiRNA-145-5p plays an im...
In vitro gluten degradation using recombinant Eurygaster integriceps prolyl endoprotease : Implications for Celiac Disease
Background: Celiac disease (CD) is a gluten-sensitive chronic autoimmune enteropathy. A strict life-long gluten-free diet ...
Data-mining of Barley to identify salt stress hub genes, gene expression analysis, and recombinant plasmid construction
Background: Salinity is one of the major abiotic stresses that limit the production and yields of crops worldwide. Objecti...
PPI Identification of immune-related biomarkers in esophageal cancer on the basis of gene co-expression network
Background: The mortality rate of esophageal cancer is on the continuous increase. Fortunately, with the development of im...
Optimization of Affinity Chromatography Based on Sepharose 4B-chitin for Rapid Purification of Urtica dioica Agglutinin
Background: Today, numerous antimicrobial and anticancer properties have been reported for plant lectins due to their abil...
Anti-inflammatory properties of extract of the hairy root of native Portulaca oleracea L. and its effect on some inflammatory genes expression in rat microglial cells
Background: Most herbs play significant roles in the treatment of various diseases. Because dopamine functions in the anti...
Dexmedetomidine suppresses glutamate-stimulated neuronal injury via microRNA-433/Janus kinase 2/Signal transducer and activator of transcription 3 pathway
Objective: To explore the protective action and mechanism of dexmedetomidine (Dex) on HT22. Materials and Methods: Constru...
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