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Dual-responsive synthetic gene circuit for dynamic biologic drug delivery via inflammatory and circadian signaling pathways
Dual-responsive synthetic gene circuit for dynamic biologic drug delivery via inflammatory and circadian signaling pathways
Engineered cells provide versatile tools for precise, tunable drug delivery, especially when synthetic stimulus-responsive...
Core-shell nanofiber dressings with zinc oxide nanoparticles and cell-free fat extract: boosting fibroblast activity and antibacterial efficacy
Core-shell nanofiber dressings with zinc oxide nanoparticles and cell-free fat extract: boosting fibroblast activity and antibacterial efficacy
This study presents the development and characterization of innovative core-shell nanofiber wound dressings incorporating ...
Enhancing in vitro osteogenic differentiation of mesenchymal stem cells via sustained dexamethasone delivery in 3D-Printed hybrid scaffolds based on polycaprolactone-nanohydroxyapatite/alginate-gelatin for bone regeneration
Enhancing in vitro osteogenic differentiation of mesenchymal stem cells via sustained dexamethasone delivery in 3D-Printed hybrid scaffolds based on polycaprolactone-nanohydroxyapatite/alginate-gelatin for bone regeneration
Layer-by-layer 3D-printing was effectively applied to prepare a biomimetic combined structure composing hard composite (PC...
Bio-engineered thermo-sensitive alginate/PNIA-g-CS co-polymeric injectable hydrogel laden with GDF-5 to stimulate nucleus pulposus for IVD regeneration
Bio-engineered thermo-sensitive alginate/PNIA-g-CS co-polymeric injectable hydrogel laden with GDF-5 to stimulate nucleus pulposus for IVD regeneration
Chronic back pain and disability are primarily caused by intervertebral disc degeneration (IDD) that requires novel therap...
Codon usage modulates the relationship between the burden and yield of protein overexpression
Codon usage modulates the relationship between the burden and yield of protein overexpression
Excess utilization of translational resources is a critical source of burden on cells engineered to overexpress exogenous ...
Chitosan biomineralized with ions-doped nano-hydroxyapatite tunes osteoblasts metabolism and DNA damage
Chitosan biomineralized with ions-doped nano-hydroxyapatite tunes osteoblasts metabolism and DNA damage
Hydroxyapatite (HA) is a bioceramic material widely used as a bone biomimetic substitute and can be synthesized by biomine...
Integrative analysis of gene expression, protein abundance, and metabolomic profiling elucidates complex relationships in chronic hyperglycemia-induced changes in human aortic smooth muscle cells
Integrative analysis of gene expression, protein abundance, and metabolomic profiling elucidates complex relationships in chronic hyperglycemia-induced changes in human aortic smooth muscle cells
Type 2 diabetes mellitus (T2DM) is a major public health concern with significant cardiovascular complications (CVD). Desp...
Biovalorization of whey waste as economic nutriment for mycogenic production of single cell oils with promising antibiofilm and anticancer potentiality
Biovalorization of whey waste as economic nutriment for mycogenic production of single cell oils with promising antibiofilm and anticancer potentiality
The production of value-added bio-compounds from rejuvenated sources and their recruitment for healthcare services are par...
Evaluating ATP testing for distribution system monitoring: comparison to HPC, impact of chlorine quenching, and hold time dependency
Evaluating ATP testing for distribution system monitoring: comparison to HPC, impact of chlorine quenching, and hold time dependency
Adenosine triphosphate (ATP) assays have a faster turnaround time and higher sensitivity than traditional cultivation meth...
Nonthermal biocompatible plasma in stimulating osteogenic differentiation by targeting p38/ FOXO1 and PI3K/AKT pathways in hBMSCs
Nonthermal biocompatible plasma in stimulating osteogenic differentiation by targeting p38/ FOXO1 and PI3K/AKT pathways in hBMSCs
Osteoporosis is manifested by decreased bone density and deterioration of bone architecture, increasing the risk of bone f...
Hypoxia and re-oxygenation effects on human cardiomyocytes cultured on polycaprolactone and polyurethane nanofibrous mats
Hypoxia and re-oxygenation effects on human cardiomyocytes cultured on polycaprolactone and polyurethane nanofibrous mats
Heart diseases are caused mainly by chronic oxygen insufficiency (hypoxia), leading to damage and apoptosis of cardiomyocy...
Role of mesenchymal stem cell-derived exosomes in the regeneration of different tissues
Role of mesenchymal stem cell-derived exosomes in the regeneration of different tissues
Exosomes are nanovesicles with multiple components used in several applications. Mesenchymal stem cells (MSCs) are well kn...
Synthesis of metformin-derived fluorescent quantum dots: uptake, cytotoxicity, and inhibition in human breast cancer cells through autophagy pathway
Synthesis of metformin-derived fluorescent quantum dots: uptake, cytotoxicity, and inhibition in human breast cancer cells through autophagy pathway
Breast cancer remains a challenge for physicians. Metformin, an antidiabetic drug, show promising anticancer properties ag...
Isolation methods and characterization of primary rat neurovascular cells
Isolation methods and characterization of primary rat neurovascular cells
There is significant interest in isolating cells of the blood-brain barrier (BBB) for use in in vitro screening of therape...
Chitosan as a promising materials for the construction of nanocarriers for diabetic retinopathy: an updated review
Chitosan as a promising materials for the construction of nanocarriers for diabetic retinopathy: an updated review
Diabetic retinopathy (DR) is a condition that causes swelling of the blood vessels of the retina and leaks blood and fluid...
An innovative lab-scale production for a novel therapeutic DNA vaccine candidate against rheumatoid arthritis
An innovative lab-scale production for a novel therapeutic DNA vaccine candidate against rheumatoid arthritis
Recent therapeutic-plasmid DNA vaccine strategies for rheumatoid arthritis (RA) have significantly improved. Our pcDNA-CCO...
Structural and practical identifiability analysis in bioengineering: a beginner’s guide
Structural and practical identifiability analysis in bioengineering: a beginner’s guide
Advancements in digital technology have brought modelling to the forefront in many disciplines from healthcare to architec...
Construction and applications of the EOMA spheroid model of Kaposiform hemangioendothelioma
Construction and applications of the EOMA spheroid model of Kaposiform hemangioendothelioma
Kaposiform hemangioendothelioma (KHE) is a rare intermediate vascular tumor with unclear pathogenesis. Recently, three dim...
3D-printed nanohydroxyapatite/methylacrylylated silk fibroin scaffold for repairing rat skull defects
3D-printed nanohydroxyapatite/methylacrylylated silk fibroin scaffold for repairing rat skull defects
The repair of bone defects remains a major challenge in the clinic, and treatment requires bone grafts or bone replacement...
Systematic comparison of nonviral gene delivery strategies for efficient co-expression of two transgenes in human mesenchymal stem cells
Systematic comparison of nonviral gene delivery strategies for efficient co-expression of two transgenes in human mesenchymal stem cells
Human mesenchymal stem cells (hMSCs) are being researched for cell-based therapies due to a host of unique properties, how...
Challenges and progress of neurodrug: bioactivities, production and delivery strategies of nerve growth factor protein
Challenges and progress of neurodrug: bioactivities, production and delivery strategies of nerve growth factor protein
Nerve growth factor (NGF) is a vital cytokine that plays a crucial role in the development and regeneration of the nervous...
Research progress of biomimetic materials in oral medicine
Research progress of biomimetic materials in oral medicine
Biomimetic materials are able to mimic the structure and functional properties of native tissues especially natural oral t...
Discrimination between the effects of pulsed electrical stimulation and electrochemically conditioned medium on human osteoblasts
Discrimination between the effects of pulsed electrical stimulation and electrochemically conditioned medium on human osteoblasts
Electrical stimulation is used for enhanced bone fracture healing. Electrochemical processes occur during the electrical s...
Preparation and in vitro evaluation of biological agents based on Zinc-laponite- curcumin incorporated in alginate hydrogel
Preparation and in vitro evaluation of biological agents based on Zinc-laponite- curcumin incorporated in alginate hydrogel
Due to their outstanding structures and properties, three-dimensional (3D) hydrogels and nanoparticles have been widely st...
Bilayer osteochondral graft in rabbit xenogeneic transplantation model comprising sintered 3D-printed bioceramic and human adipose-derived stem cells laden biohydrogel
Bilayer osteochondral graft in rabbit xenogeneic transplantation model comprising sintered 3D-printed bioceramic and human adipose-derived stem cells laden biohydrogel
Reconstruction of severe osteochondral defects in articular cartilage and subchondral trabecular bone remains a challengin...
Follicular reconstruction and neo-oogenesis in xenotransplantation of human ovarian isolated cells derived from chemotherapy-induced POF patients
Follicular reconstruction and neo-oogenesis in xenotransplantation of human ovarian isolated cells derived from chemotherapy-induced POF patients
Developing new strategies to restore fertility in patients with chemotherapy-induced Premature Ovarian Failure (Chemo-POF)...
Dual-drug (Curcumin/Ciprofloxacin) loading and release from chitosan-based hydrogels embedded with magnetic Montmorillonite/Hyaluronic acid for enhancing wound healing
Dual-drug (Curcumin/Ciprofloxacin) loading and release from chitosan-based hydrogels embedded with magnetic Montmorillonite/Hyaluronic acid for enhancing wound healing
Montmorillonite (MMt) is extensively applied as an efficient drug-carrier in designing drug delivery systems (DDS) due to ...
Antler stem cell-derived exosomes promote regenerative wound healing via fibroblast-to-myofibroblast transition inhibition
Antler stem cell-derived exosomes promote regenerative wound healing via fibroblast-to-myofibroblast transition inhibition
The typical outcome of mammalian wound healing is scarring, a fibrotic process mediated by myofibroblast aggregation. Perf...
Label-free multimodal electro-thermo-mechanical (ETM) phenotyping as a novel biomarker to differentiate between normal, benign, and cancerous breast biopsy tissues
Label-free multimodal electro-thermo-mechanical (ETM) phenotyping as a novel biomarker to differentiate between normal, benign, and cancerous breast biopsy tissues
Technologies for quick and label-free diagnosis of malignancies from breast tissues have the potential to be a significant...
Seaweed-based alginate/hydroxyapatite composite for the effective removal of bacteria, cyanobacteria, algae, and crystal violet from water
Seaweed-based alginate/hydroxyapatite composite for the effective removal of bacteria, cyanobacteria, algae, and crystal violet from water
A novel cost-effective and multifunctional nanocomposite was developed based on sustainable macroalgae biomass. The brown ...
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