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Comparative analysis of the effects of different hypoxia mimetic agents on the secretome contents of conditioned medium obtained from mesenchymal stem/stromal cells cultured in 2 or 3-dimensional cell culture systems
Comparative analysis of the effects of different hypoxia mimetic agents on the secretome contents of conditioned medium obtained from mesenchymal stem/stromal cells cultured in 2 or 3-dimensional cell culture systems
Paracrine factors secreted by mesenchymal stem/stromal cells (MSCs) have been demonstrated to have significant therapeutic...
Animal origins free products in cell culture media: a new frontier
Animal origins free products in cell culture media: a new frontier
Despite the importance of finding replacements for fetal bovine serum (FBS), very few studies have focused on this subject...
Triptolide attenuates LPS-induced chondrocyte inflammation by inhibiting inflammasome activation via the Wnt/β-catenin and NF-κB signaling pathways
Triptolide attenuates LPS-induced chondrocyte inflammation by inhibiting inflammasome activation via the Wnt/β-catenin and NF-κB signaling pathways
Osteoarthritis (OA) is a common form of arthritis characterized by subchondral bone proliferation and articular cartilage ...
Phillygenin regulates the colorectal cancer tumor microenvironment by inhibiting hypoxia-inducible factor 1 alpha
Phillygenin regulates the colorectal cancer tumor microenvironment by inhibiting hypoxia-inducible factor 1 alpha
The tumor microenvironment (TME) is important in the recurrence and metastasis of colorectal cancer (CRC). Phillygenin is ...
Green synthesis of silver nanoparticles using Amomum nilgiricum leaf extracts: preparation, physicochemical characterization and ameliorative effect against human cancer cell lines
Green synthesis of silver nanoparticles using Amomum nilgiricum leaf extracts: preparation, physicochemical characterization and ameliorative effect against human cancer cell lines
The present study to production of silver nanoparticles (AgNPs) by leaf extracts of A. nilgiricum and to evaluate the acti...
High mobility group protein N2 inhibits the progression of hepatocellular carcinoma and the related molecular mechanisms
High mobility group protein N2 inhibits the progression of hepatocellular carcinoma and the related molecular mechanisms
High mobility group protein N2 (HMGN2) related pathways are involved in chromatin regulation/acetylation. It has been repo...
Investigation of scaffold manufacturing conditions for 3-dimensional culture of myogenic cell line derived from black sea bream (Acanthopagrus schlegelii)
Investigation of scaffold manufacturing conditions for 3-dimensional culture of myogenic cell line derived from black sea bream (Acanthopagrus schlegelii)
Culturing fish myogenic cells in vitro holds significant potential to revolutionize aquaculture practices and support sust...
Docetaxel treatment together with CTLA-4 knockdown enhances reduction of cell viability and amplifies apoptosis stimulation of MCF-7 breast cancer cells
Docetaxel treatment together with CTLA-4 knockdown enhances reduction of cell viability and amplifies apoptosis stimulation of MCF-7 breast cancer cells
Breast cancer is the most frequent cancer in women with a 20% mortality rate. The fate of patients suffering from breast c...
Effect of pH on antitumor activity of Chinese cobra (Naja atra) cytotoxin-XII
Effect of pH on antitumor activity of Chinese cobra (Naja atra) cytotoxin-XII
Cytotoxins (CTXs), proteins found in cobra venom, selectively inhibit tumor cell proliferation. Herein, we selected CTX-XI...
Oxidative stress profile and auto-antibodies production in Tunisian patients with COVID-19
Oxidative stress profile and auto-antibodies production in Tunisian patients with COVID-19
The clinical evidence, complications and the pathogenesis of COVID-19 are not clearly understood. In COVID-19 patients, ce...
Comparing the growth kinetics and characteristics of Wharton’s jelly derived mesenchymal stem cells expanded using different culture mediums
Comparing the growth kinetics and characteristics of Wharton’s jelly derived mesenchymal stem cells expanded using different culture mediums
Wharton’s jelly-derived mesenchymal stem cells (WJ-MSCs) can be isolated from umbilical cords which is abundant and ...
Silencing of LINC01278 promotes sensitivity of non-small cell lung cancer cells to osimertinib by targeting miR-324-3p/ZFX axis
Silencing of LINC01278 promotes sensitivity of non-small cell lung cancer cells to osimertinib by targeting miR-324-3p/ZFX axis
Osimertinib has been demonstrated to be effective for improving the prognosis of patients with epidermal growth factor rec...
High impact works on stem cell transplantation in intervertebral disc degeneration
High impact works on stem cell transplantation in intervertebral disc degeneration
Low back pain is a major disorder that causes disability and is strongly associated with intervertebral disc degeneration ...
Heterologous Protein Production in CHO Cells
Heterologous Protein Production in CHO Cells
This book explores the use of Chinese hamster ovary (CHO) cells in the production of therapeutic protein products.
Engineering Natural Silk
Engineering Natural Silk
This book highlights the potential of silk in a vast array of applications, mainly in the field of medicine, electronics, ...
Bunyaviruses
Bunyaviruses
This volume explores advancements in the study of bunyaviruses, and covers virus manipulation, bunyavirus infection in ani...
KIAA1429 promotes the malignancy of oral squamous cell carcinoma by regulating CA9 m6A methylation
KIAA1429 promotes the malignancy of oral squamous cell carcinoma by regulating CA9 m6A methylation
KIAA1429 has been reported as a cancer regulator, but its role and mechanism in the progression of oral squamous cell carc...
FEV-mediated WNT2 transcription is involved in the progression of colorectal cancer via the Wnt signaling
FEV-mediated WNT2 transcription is involved in the progression of colorectal cancer via the Wnt signaling
Colorectal cancer (CRC) remains the third leading cause of cancer-related death worldwide. Here, we aimed to uncover the m...
CRISPR-edited, cell-based future-proof meat and seafood to enhance global food security and nutrition
CRISPR-edited, cell-based future-proof meat and seafood to enhance global food security and nutrition
Food security is a major concern due to the growing population and climate change. A method for increasing food production...
FOXA1 exacerbates LPS-induced vascular endothelial cell injury in sepsis by suppressing the transcription of NRP2
FOXA1 exacerbates LPS-induced vascular endothelial cell injury in sepsis by suppressing the transcription of NRP2
Endothelial dysfunction plays a critical role in the pathogenesis of sepsis. This study aims to explore the effect and mec...
Isolation of holostane-type saponins from the black sea cucumber Holothuria atra and evaluating their anti-allergic activity: in vitro and in silico study
Isolation of holostane-type saponins from the black sea cucumber Holothuria atra and evaluating their anti-allergic activity: in vitro and in silico study
Sea cucumbers are both versatile marine organisms and an Asian marine food known to have several medicinal effects. We eva...
Gellan gum-gelatin based cardiac models support formation of cellular networks and functional cardiomyocytes
Gellan gum-gelatin based cardiac models support formation of cellular networks and functional cardiomyocytes
Cardiovascular diseases remain as the most common cause of death worldwide. To reveal the underlying mechanisms in varying...
LncRNA RP11-818O24.3 promotes hair-follicle recovery via FGF2-PI3K/Akt signal pathway
LncRNA RP11-818O24.3 promotes hair-follicle recovery via FGF2-PI3K/Akt signal pathway
A previous study indicated that patients with androgenic alopecia (AGA) have significantly reduced levels of LncRNA RP11-8...
LINC00161 upregulated by M2-like tumor-associated macrophages promotes hepatocellular carcinoma progression by methylating HACE1 promoters
LINC00161 upregulated by M2-like tumor-associated macrophages promotes hepatocellular carcinoma progression by methylating HACE1 promoters
M2-like tumor-associated macrophages (M2-TAM) played an essential part in hepatocellular carcinoma (HCC) progression. Long...
Anti-cancer drug-mediated increase in mitochondrial mass limits the application of metabolic viability-based MTT assay in cytotoxicity screening
Anti-cancer drug-mediated increase in mitochondrial mass limits the application of metabolic viability-based MTT assay in cytotoxicity screening
The high-throughput metabolic viability-based colorimetric MTT test is commonly employed to screen the cytotoxicity of dif...
Schizandrin A enhances the sensitivity of gastric cancer cells to 5-FU by promoting ferroptosis
Schizandrin A enhances the sensitivity of gastric cancer cells to 5-FU by promoting ferroptosis
Schizandrin A (Sch A) exert anticancer and multidrug resistance-reversing effects in a variety of tumors, but its effect o...
LncRNA MIR181A2HG negatively regulates human keratinocytes proliferation by binding SRSF1
LncRNA MIR181A2HG negatively regulates human keratinocytes proliferation by binding SRSF1
Psoriasis is a common chronic inflammatory skin disease. Abnormal proliferation of keratinocytes plays an important role i...
Fructobacillus fructosus OS-1010 strain stimulates intestinal cells to secrete exosomes that activate muscle cells
Fructobacillus fructosus OS-1010 strain stimulates intestinal cells to secrete exosomes that activate muscle cells
Fructobacillus is a lactic-acid bacterium recently identified in fructose-rich environments. Fructobacillus is also known ...
LncRNA HOTAIR accelerates free fatty acid-induced inflammatory response in HepG2 cells by recruiting SRSF1 to stabilize MLXIPL mRNA
LncRNA HOTAIR accelerates free fatty acid-induced inflammatory response in HepG2 cells by recruiting SRSF1 to stabilize MLXIPL mRNA
LncRNA HOTAIR has been reported to be associated with metabolic diseases of the liver. However, the effect of HOTAIR on no...
Evodiamine ameliorates intervertebral disc degeneration through the Nrf2 and MAPK pathways
Evodiamine ameliorates intervertebral disc degeneration through the Nrf2 and MAPK pathways
Degradation of extracellular matrix (ECM), reactive oxygen species (ROS) production, and inflammation are critical players...
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