Walmsley GG, Maan ZN, Wong VW, Duscher D, Hu MS, Zielins ER, Wearda T, Muhonen E, McArdle A, Tevlin R, Atashroo DA, Senarath-Yapa K, Lorenz HP, Gurtner GC, Longaker MT. Scarless wound healing: chasing the holy grail. Plast Reconstr Surg. 2015;135:907–17.

Article  Google Scholar 

Martin P. Wound healing–aiming for perfect skin regeneration. Science. 1997;276:75–81.

Article  Google Scholar 

Gurtner GC, Werner S, Barrandon Y, Longaker MT. Wound repair and regeneration. Nature. 2008;453:314–21.

Article  Google Scholar 

Eming SA, Martin P, Tomic-Canic M. Wound repair and regeneration: mechanisms, signaling, and translation. Sci Transl Med. 2014;6:265sr6.

Article  Google Scholar 

Sun BK, Siprashvili Z, Khavari PA. Advances in skin grafting and treatment of cutaneous wounds. Science. 2014;346:941–5.

Article  Google Scholar 

Sen CK, Gordillo GM, Roy S, Kirsner R, Lambert L, Hunt TK, Gottrup F, Gurtner GC, Longaker MT. Human skin wounds: a major and snowballing threat to public health and the economy. Wound Repair Regen. 2009;17:763–71.

Article  Google Scholar 

Mascharak S, desJardins-Park HE, Davitt MF, Griffin M, Borrelli MR, Moore AL, Chen K, Duoto B, Chinta M, Foster DS, Shen AH, Januszyk M, Kwon SH, Wernig G, Wan DC, Lorenz HP, Gurtner GC, Longaker MT. Preventing Engrailed-1 activation in fibroblasts yields wound regeneration without scarring. Science. 2021;372:eaba2374.

Article  Google Scholar 

Bayat A, McGrouther DA, Ferguson MW. Skin scarring. BMJ. 2003;326:88–92.

Article  Google Scholar 

Pugliese E, Coentro JQ, Raghunath M, Zeugolis DI. Wound healing and scar wars. Adv Drug Deliv Rev. 2018;129:1–3.

Article  Google Scholar 

Hinz B. Myofibroblasts. Exp Eye Res. 2016;142:56–70.

Article  Google Scholar 

Wynn TA, Ramalingam TR. Mechanisms of fibrosis: therapeutic translation for fibrotic disease. Nat Med. 2012;18:1028–40.

Article  Google Scholar 

Reinke JM, Sorg H. Wound repair and regeneration. Eur Surg Res. 2012;49:35–43.

Article  Google Scholar 

Ojeh N, Pastar I, Tomic-Canic M, Stojadinovic O. Stem cells in skin regeneration, wound healing, and their clinical applications. Int J Mol Sci. 2015;16:25476–501.

Article  Google Scholar 

Duan M, Zhang Y, Zhang H, Meng Y, Qian M, Zhang G. Epidermal stem cell-derived exosomes promote skin regeneration by downregulating transforming growth factor-β1 in wound healing. Stem Cell Res Ther. 2020;11:452.

Article  Google Scholar 

Fang S, Xu C, Zhang Y, Xue C, Yang C, Bi H, Qian X, Wu M, Ji K, Zhao Y, Wang Y, Liu H, Xing X. Umbilical cord-derived mesenchymal stem cell-derived exosomal MicroRNAs suppress myofibroblast differentiation by inhibiting the transforming growth Factor-β/SMAD2 pathway during wound healing. Stem Cells Transl Med. 2016;5:1425–39.

Article  Google Scholar 

Abdelwahid E, Kalvelyte A, Stulpinas A, de Carvalho KA, Guarita-Souza LC, Foldes G. Stem cell death and survival in heart regeneration and repair. Apoptosis. 2016;21:252–68.

Article  Google Scholar 

Rong X, Zhang G, Yang Y, Gao C, Chu W, Sun H, Wang Y, Li C. Transplanted antler stem cells stimulated regenerative healing of radiation-induced cutaneous wounds in rats. Cell Transpl. 2020;29:963689720951549.

Article  Google Scholar 

Han Y, Li X, Zhang Y, Han Y, Chang F, Ding J. Mesenchymal stem cells for regenerative medicine. Cells. 2019;8:886.

Article  Google Scholar 

De Luca M, Aiuti A, Cossu G, Parmar M, Pellegrini G, Robey PG. Advances in stem cell research and therapeutic development. Nat Cell Biol. 2019;21:801–11.

Article  Google Scholar 

Li C, Chu W. The regenerating antler blastema: the derivative of stem cells resident in a pedicle stump. Front Biosci (Landmark Ed). 2016;21:455–67.

Article  Google Scholar 

Li C. Deer antler regeneration: a stem cell-based epimorphic process. Birth Defects Res C Embryo Today. 2012;96:51–62.

Article  Google Scholar 

Qin T, Zhang G, Zheng Y, Li S, Yuan Y, Li Q, Hu M, Si H, Wei G, Gao X, Cui X, Xia B, Ren J, Wang K, Ba H, Liu Z, Heller R, Li Z, Wang W, Huang J, Li C, Qiu Q. A population of stem cells with strong regenerative potential discovered in deer antlers. Science. 2023;379:840–7.

Article  Google Scholar 

Li C, Suttie JM, Clark DE. Histological examination of antler regeneration in red deer (Cervus elaphus). Anat Rec a Discov Mol Cell Evol Biol. 2005;282:163–74.

Article  Google Scholar 

Li C, Suttie JM, Clark DE. Morphological observation of antler regeneration in red deer (Cervus elaphus). J Morphol. 2004;262:731–40.

Article  Google Scholar 

Li C, Suttie JM. Histological studies of pedicle skin formation and its transformation to antler velvet in red deer (Cervus elaphus). Anat Rec. 2000;260:62–71.

Article  Google Scholar 

Li C. Exploration of the mechanism underlying neogenesis and regeneration of postnatal mammalian skin: deer antler velvet. Int J Med Biol Front. 2010;16:1–9.

Google Scholar 

Wang D, Berg D, Ba H, Sun H, Wang Z, Li C. Deer antler stem cells are a novel type of cells that sustain full regeneration of a mammalian organ-deer antler. Cell Death Dis. 2019;10:443.

Article  Google Scholar 

Lei J, Jiang X, Li W, Ren J, Wang D, Ji Z, Wu Z, Cheng F, Cai Y, Yu ZR, Belmonte JCI, Li C, Liu GH, Zhang W, Qu J, Wang S. Exosomes from antler stem cells alleviate mesenchymal stem cell senescence and osteoarthritis. Protein Cell. 2022;13:220–6.

Article  Google Scholar 

Rong X, Chu W, Zhang H, Wang Y, Qi X, Zhang G, Wang Y, Li C. Antler stem cell-conditioned medium stimulates regenerative wound healing in rats. Stem Cell Res Ther. 2019;10:326.

Article  Google Scholar 

Pegtel DM, Gould SJ. Exosomes. Annu Rev Biochem. 2019;88:487–514.

Article  Google Scholar 

Batrakova EV, Kim MS. Using exosomes, naturally-equipped nanocarriers, for drug delivery. J Control Release. 2015;219:396–405.

Article  Google Scholar 

Shi L, Ren J, Li J, Wang D, Wang Y, Qin T, Li X, Zhang G, Li C, Wang Y. Extracellular vesicles derived from umbilical cord mesenchymal stromal cells alleviate pulmonary fibrosis by means of transforming growth factor-β signaling inhibition. Stem Cell Res Ther. 2021;12:230.

Article  Google Scholar 

Zhang Y, Yan J, Liu Y, Chen Z, Li X, Tang L, Li J, Duan M, Zhang G. Human amniotic fluid stem cell-derived exosomes as a novel cell-free therapy for cutaneous regeneration. Front Cell Dev Biol. 2021;9: 685873.

Article  Google Scholar 

Zhang Y, Pan Y, Liu Y, Li X, Tang L, Duan M, Li J, Zhang G. Exosomes derived from human umbilical cord blood mesenchymal stem cells stimulate regenerative wound healing via transforming growth factor-β receptor inhibition. Stem Cell Res Ther. 2021;12:434.

Article  Google Scholar 

Zhang G, Wang D, Ren J, Sun H, Li J, Wang S, Shi L, Wang Z, Yao M, Zhao H, Li C. Velvet antler peptides reduce scarring via inhibiting the TGF-β signaling pathway during wound healing. Front Med (Lausanne). 2021;8:799789.

Article  Google Scholar 

Lim CH, Sun Q, Ratti K, Lee SH, Zheng Y, Takeo M, Lee W, Rabbani P, Plikus MV, Cain JE, Wang DH, Watkins DN, Millar S, Taketo MM, Myung P, Cotsarelis G, Ito M. Hedgehog stimulates hair follicle neogenesis by creating inductive dermis during murine skin wound healing. Nat Commun. 2018;9:4903.

Article  Google Scholar 

Li C, Yang F, Li G, Gao X, Xing X, Wei H, Deng X, Clark DE. Antler regeneration: a dependent process of stem tissue primed via interaction with its enveloping skin. J Exp Zool A Ecol Genet Physiol. 2007;307:95–105.

Article  Google Scholar 

Gao Z, Yang F, McMahon C, Li C. Mapping the morphogenetic potential of antler fields through deleting and transplanting subregions of antlerogenic periosteum in sika deer (Cervus nippon). J Anat. 2012;220:131–43.

Article  Google Scholar 

Guo Q, Liu Z, Zheng J, Zhao H, Li C. Substances for regenerative wound healing during antler renewal stimulated scar-less restoration of rat cutaneous wounds. Cell Tissue Res. 2021;386:99–116.

Article  Google Scholar 

Kalluri R, LeBleu VS. The biology, function, and biomedical applications of exosomes. Science. 2020;367:eaau6977.

Article  Google Scholar 

Sorg H, Tilkorn DJ, Hager S, Hauser J, Mirastschijski U. Skin wound healing: an update on the current knowledge and concepts. Eur Surg Res. 2017;58:81–94.

Article  Google Scholar 

Rippa AL, Kalabusheva EP, Vorotelyak EA. Regeneration of dermis: scarring and cells involved. Cells. 2019;8(6):607.

Article  Google Scholar 

Eyden BP. Brief review of the fibronexus and its significance for myofibroblastic differentiation and tumor diagnosis. Ultrastruct Pathol. 1993;17:611–22.

Article  Google Scholar 

Merkel JR, DiPaolo BR, Hallock GG, Rice DC. Type I and type III collagen content of healing wounds in fetal and adult rats. Proc Soc Exp Biol Med. 1988;187:493–7.

Article  Google Scholar 

Lichtman MK, Otero-Vinas M, Falanga V. Transforming growth factor beta (TGF-β) isoforms in wound healing and fibrosis. Wound Repair Regen. 2016;24:215–22.

Article  Google Scholar 

Kim KK, Sheppard D, Chapman HA. TGF-β1 signaling and tissue fibrosis. Cold Spring Harb Perspect Biol. 2018;10:a022293.

Article  Google Scholar 

Luo Z, Sun Y, Qi B, Lin J, Chen Y, Xu Y, Chen J. Human bone marrow mesenchymal stem cell-derived extracellular vesicles inhibit shoulder stiffness via let-7a/Tgfbr1 axis. Bioact Mater. 2022;17:344–59.

Google Scholar