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Gene clusters-based pathway enrichment analysis identifies four pan-cancer subtypes with distinct molecular and clinical features
Gene clusters-based pathway enrichment analysis identifies four pan-cancer subtypes with distinct molecular and clinical features
Pathways-based clustering methods have been proposed to explore tumor heterogeneity. However, such methods are currently d...
Serine related gene CCT6A promotes metastasis of hepatocellular carcinoma via interacting with RPS3
Serine related gene CCT6A promotes metastasis of hepatocellular carcinoma via interacting with RPS3
Metastasis is responsible for approximately 90% of lethality from solid tumors. Metabolic abnormalities are one of the key...
Xuanhong Dingchuan Tang suppresses bronchial asthma inflammation via the microRNA-107-3p/PTGS2/MAPK axis
Xuanhong Dingchuan Tang suppresses bronchial asthma inflammation via the microRNA-107-3p/PTGS2/MAPK axis
This study aimed to investigate the mechanism of Xuanhong Dingchuan Tang (XHDCT) in delaying bronchial asthma inflammation...
Barley stripe mosaic virus-induced gene silencing for functional validation of abiotic stress in barley
Barley stripe mosaic virus-induced gene silencing for functional validation of abiotic stress in barley
The barley stripe mosaic virus (BSMV) uses its genomic RNA components (alpha, beta, and gamma) as an efficient method for ...
Unraveling the organellar genomic landscape of the therapeutic and entheogenic plant Mimosa tenuiflora: insights into genetic, structural, and evolutionary dynamics
Unraveling the organellar genomic landscape of the therapeutic and entheogenic plant Mimosa tenuiflora: insights into genetic, structural, and evolutionary dynamics
Mimosa tenuiflora, popularly known as “Jurema-Preta”, is a perennial tree or shrub native to the tropical regi...
Circular RNAs in the pathogenesis of SARS-CoV-2: potential diagnostic biomarkers and therapeutic targets
Circular RNAs in the pathogenesis of SARS-CoV-2: potential diagnostic biomarkers and therapeutic targets
Since December 2019, the global dissemination of a novel coronavirus has precipitated a notable public health crisis, prom...
Towards assembling functional cyanobacterial β-carboxysomes in Oryza sativa chloroplasts
Towards assembling functional cyanobacterial β-carboxysomes in Oryza sativa chloroplasts
The major limiting factor of photosynthesis in C3 plants is the enzyme, rubisco which inadequately distinguishes between c...
A cutting-edge investigation of the multifaceted role of SOX family genes in cancer pathogenesis through the modulation of various signaling pathways
A cutting-edge investigation of the multifaceted role of SOX family genes in cancer pathogenesis through the modulation of various signaling pathways
This detailed study examines the complex role of the SOX family in various tumorigenic contexts, offering insights into ho...
Epigenetic modification mediated by PHF20/METTL14/HOXA13 signaling axis modulates osteogenic differentiation of mesenchymal stem cells
Epigenetic modification mediated by PHF20/METTL14/HOXA13 signaling axis modulates osteogenic differentiation of mesenchymal stem cells
This study investigates the mechanism of PHF20 in osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs)...
Application of a high-throughput swarm-based deep neural network Algorithm reveals SPAG5 downregulation as a potential therapeutic target in adult AML
Application of a high-throughput swarm-based deep neural network Algorithm reveals SPAG5 downregulation as a potential therapeutic target in adult AML
Gene‒gene interactions play pivotal roles in disease pathogenesis and are fundamental in the development of targeted...
Impact of structural variations and genome partitioning on bread wheat hybrid performance
Impact of structural variations and genome partitioning on bread wheat hybrid performance
The agronomical interest of hybrid wheat has long been a matter of debate. Compared to maize where hybrids have been succe...
pmiRScan: a LightGBM based method for prediction of animal pre-miRNAs
pmiRScan: a LightGBM based method for prediction of animal pre-miRNAs
MicroRNAs (miRNA) are categorized as short endogenous non-coding RNAs, which have a significant role in post-transcription...
Transcription factor MAZ activates the transcription of hypomethylated TYMP in ccRCC
Transcription factor MAZ activates the transcription of hypomethylated TYMP in ccRCC
Clear cell renal cell carcinoma (ccRCC) is a highly malignant tumor characterized by a significant prope...
Unraveling the potential mechanism and prognostic value of pentose phosphate pathway in hepatocellular carcinoma: a comprehensive analysis integrating bulk transcriptomics and single-cell sequencing data
Unraveling the potential mechanism and prognostic value of pentose phosphate pathway in hepatocellular carcinoma: a comprehensive analysis integrating bulk transcriptomics and single-cell sequencing data
Hepatocellular carcinoma (HCC) remains a malignant and life-threatening tumor with an extremely poor prognosis, posing a s...
Narciclasine attenuates sepsis-associated acute kidney injury through the ESR1/S100A11 axis
Narciclasine attenuates sepsis-associated acute kidney injury through the ESR1/S100A11 axis
Narciclasine (Ncs) was effective in sepsis management due to its antioxidant properties. The present study dissected the p...
Elucidating circRNA-miRNA-mRNA competing endogenous regulatory RNA network during leaf rust pathogenesis in wheat (Triticum aestivum L.)
Elucidating circRNA-miRNA-mRNA competing endogenous regulatory RNA network during leaf rust pathogenesis in wheat (Triticum aestivum L.)
Advancements in bioinformatic tools and breakthroughs in high throughput RNA sequencing have unveiled the potential role o...
A review on advancements in feature selection and feature extraction for high-dimensional NGS data analysis
A review on advancements in feature selection and feature extraction for high-dimensional NGS data analysis
Recent advancements in biomedical technologies and the proliferation of high-dimensional Next Generation Sequencing (NGS) ...
QTL-seq identifies genomic region associated with the crown root development under Jasmonic acid response
QTL-seq identifies genomic region associated with the crown root development under Jasmonic acid response
Rice root system plays a crucial role in plant adaptation under adverse conditions, particularly drought stress. However, ...
Regulatory axis of circular RNA DTNB, microRNA-485-5p, and myeloid cell leukemia 1 attenuates inflammation and apoptosis in caerulein-treated AR42J cells
Regulatory axis of circular RNA DTNB, microRNA-485-5p, and myeloid cell leukemia 1 attenuates inflammation and apoptosis in caerulein-treated AR42J cells
Acute pancreatitis (AP) is an inflammatory disease of the pancreas and the main cause of hospital admissions for gastroint...
Whole-genome sequencing and identification of antimicrobial peptide coding genes in parsley (Petroselinum crispum), an important culinary and medicinal Apiaceae species
Whole-genome sequencing and identification of antimicrobial peptide coding genes in parsley (Petroselinum crispum), an important culinary and medicinal Apiaceae species
Parsley is a commonly cultivated Apiaceae species of culinary and medicinal importance. Parsley has several recognized hea...
Infection by a multidrug-resistant Corynebacterium diphtheriae strain: prediction of virulence factors, CRISPR-Cas system analysis, and structural implications of mutations conferring rifampin resistance
Infection by a multidrug-resistant Corynebacterium diphtheriae strain: prediction of virulence factors, CRISPR-Cas system analysis, and structural implications of mutations conferring rifampin resistance
Cases of diphtheria, even in immunized individuals, are still reported in several parts of the world, including in Brazil....
Application of single cell sequencing technology in ovarian cancer research (review)
Application of single cell sequencing technology in ovarian cancer research (review)
Ovarian cancer is a malignant tumor of ovary. It has the characteristics of difficult early diagnosis, poor late curative ...
Clinical trials and recent progress in HIV vaccine development
Clinical trials and recent progress in HIV vaccine development
The greatest obstacle for scientists is to develop an effective HIV vaccine. An effective vaccine represents the last hope...
Signaling molecules in the microenvironment of hepatocellular carcinoma
Signaling molecules in the microenvironment of hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a major fatal cancer that is known for its high recurrence and metastasis. An increasing...
Modulatory effects of miRNAs in doxorubicin resistance: A mechanistic view
Modulatory effects of miRNAs in doxorubicin resistance: A mechanistic view
MicroRNAs (miRNAs) are a group of small non-coding RNAs and play an important role in controlling vital biological process...
Integrative analyses of long and short-read RNA sequencing reveal the spliced isoform regulatory network of seedling growth dynamics in upland cotton
Integrative analyses of long and short-read RNA sequencing reveal the spliced isoform regulatory network of seedling growth dynamics in upland cotton
The polyploid genome of cotton has significantly increased the transcript complexity. Recent advances in full-length trans...
Biotechnological frontiers in harnessing allelopathy for sustainable crop production
Biotechnological frontiers in harnessing allelopathy for sustainable crop production
Allelopathy, the phenomenon in which plants release biochemical compounds that influence the growth and development of nei...
Genetic diversity and evolution of G12P[6] DS-1-like and G12P[9] AU-1-like Rotavirus strains in Brazil
Genetic diversity and evolution of G12P[6] DS-1-like and G12P[9] AU-1-like Rotavirus strains in Brazil
In the early 2000s, the global emergence of rotavirus (RVA) G12P[8] genotype was noted, while G12P[6] and G12P[9] combinat...
Circular RNAs: a small piece in the heart failure puzzle
Circular RNAs: a small piece in the heart failure puzzle
Cardiovascular disease, specifically heart failure (HF), remains a significant concern in the realm of healthcare, necessi...
Identification of flowering genes in Camellia perpetua by comparative transcriptome analysis
Identification of flowering genes in Camellia perpetua by comparative transcriptome analysis
Camellia perpetua has the excellent characteristic of flowering multiple times throughout the year, which is of great impo...
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