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Transcriptional regulation mechanism of PARP1 and its application in disease treatment
Transcriptional regulation mechanism of PARP1 and its application in disease treatment
Poly (ADP-ribose) polymerase 1 (PARP1) is a multifunctional nuclear enzyme that catalyzes poly-ADP ribosylation in eukaryo...
DNA methylation correlates of chronological age in diverse human tissue types
DNA methylation correlates of chronological age in diverse human tissue types
While the association of chronological age with DNA methylation (DNAm) in whole blood has been extensively studied, the ti...
The role of hexokinases in epigenetic regulation: altered hexokinase expression and chromatin stability in yeast
The role of hexokinases in epigenetic regulation: altered hexokinase expression and chromatin stability in yeast
Human hexokinase 2 (HK2) plays an important role in regulating Warburg effect, which metabolizes glucose to lactate acid e...
Transcriptional silencing in Saccharomyces cerevisiae: known unknowns
Transcriptional silencing in Saccharomyces cerevisiae: known unknowns
Transcriptional silencing in Saccharomyces cerevisiae is a persistent and highly stable form of gene repression. It involv...
PRKACB is a novel imprinted gene in marsupials
PRKACB is a novel imprinted gene in marsupials
Genomic imprinting results in parent-of-origin-specific gene expression and, among vertebrates, is found only in therian m...
Su(Hw) interacts with Combgap to establish long-range chromatin contacts
Su(Hw) interacts with Combgap to establish long-range chromatin contacts
Insulator-binding proteins (IBPs) play a critical role in genome architecture by forming and maintaining contact domains. ...
Chromatin profiling and state predictions reveal insights into epigenetic regulation during early porcine development
Chromatin profiling and state predictions reveal insights into epigenetic regulation during early porcine development
Given their physiological similarities to humans, pigs are increasingly used as model organisms in human-oriented biomedic...
Native and tagged CENP-A histones are functionally inequivalent
Native and tagged CENP-A histones are functionally inequivalent
Over the past several decades, the use of biochemical and fluorescent tags has elucidated mechanistic and cytological proc...
Imprinted DNA methylation of the H19 ICR is established and maintained in vivo in the absence of Kaiso
Imprinted DNA methylation of the H19 ICR is established and maintained in vivo in the absence of Kaiso
Paternal allele-specific DNA methylation of the imprinting control region (H19 ICR) controls genomic imprinting at the Igf...
Folate deficiency reduced aberrant level of DOT1L-mediated histone H3K79 methylation causes disruptive SHH gene expression involved in neural tube defects
Folate deficiency reduced aberrant level of DOT1L-mediated histone H3K79 methylation causes disruptive SHH gene expression involved in neural tube defects
Neural tube defects (NTDs) are one of the most severe congenital abnormalities characterized by failures of the neural tub...
O-GlcNAcylation: the sweet side of epigenetics
O-GlcNAcylation: the sweet side of epigenetics
Histones display a wide variety of post-translational modifications, including acetylation, methylation, and phosphorylati...
Role of sex in immune response and epigenetic mechanisms
Role of sex in immune response and epigenetic mechanisms
The functioning of the human immune system is highly dependent on the sex of the individual, which comes by virtue of sex ...
Chromatin accessibility and cell cycle progression are controlled by the HDAC-associated Sin3B protein in murine hematopoietic stem cells
Chromatin accessibility and cell cycle progression are controlled by the HDAC-associated Sin3B protein in murine hematopoietic stem cells
Blood homeostasis requires the daily production of millions of terminally differentiated effector cells that all originate...
A low-input high resolution sequential chromatin immunoprecipitation method captures genome-wide dynamics of bivalent chromatin
A low-input high resolution sequential chromatin immunoprecipitation method captures genome-wide dynamics of bivalent chromatin
Bivalent chromatin is an exemplar of epigenetic plasticity. This co-occurrence of active-associated H3K4me3 and inactive-a...
The functions of SET domain bifurcated histone lysine methyltransferase 1 (SETDB1) in biological process and disease
The functions of SET domain bifurcated histone lysine methyltransferase 1 (SETDB1) in biological process and disease
Histone methyltransferase SETDB1 (SET domain bifurcated histone lysine methyltransferase 1, also known as ESET or KMT1E) i...
Chromatin balances cell redox and energy homeostasis
Chromatin balances cell redox and energy homeostasis
Chromatin plays a central role in the conversion of energy in cells: alteration of chromatin structure to make DNA accessi...
Expression analysis suggests that DNMT3L is required for oocyte de novo DNA methylation only in Muridae and Cricetidae rodents
Expression analysis suggests that DNMT3L is required for oocyte de novo DNA methylation only in Muridae and Cricetidae rodents
During early mammalian development, DNA methylation undergoes two waves of reprogramming, enabling transitions between som...
Estimating genome-wide DNA methylation heterogeneity with methylation patterns
Estimating genome-wide DNA methylation heterogeneity with methylation patterns
In a heterogeneous population of cells, individual cells can behave differently and respond variably to the environment. T...
Differential usage of DNA modifications in neurons, astrocytes, and microglia
Differential usage of DNA modifications in neurons, astrocytes, and microglia
Cellular identity is determined partly by cell type-specific epigenomic profiles that regulate gene expression. In neurosc...
EphrinA5 regulates cell motility by modulating Snhg15/DNA triplex-dependent targeting of DNMT1 to the Ncam1 promoter
EphrinA5 regulates cell motility by modulating Snhg15/DNA triplex-dependent targeting of DNMT1 to the Ncam1 promoter
Cell–cell communication is mediated by membrane receptors and their ligands, such as the Eph/ephrin system, orchestr...
Development of super-specific epigenome editing by targeted allele-specific DNA methylation
Development of super-specific epigenome editing by targeted allele-specific DNA methylation
Epigenome editing refers to the targeted reprogramming of genomic loci using an EpiEditor which may consist of an sgRNA/dC...
Analyses of POL30 (PCNA) reveal positional effects in transient repression or bi-modal active/silent state at the sub-telomeres of S. cerevisiae
Analyses of POL30 (PCNA) reveal positional effects in transient repression or bi-modal active/silent state at the sub-telomeres of S. cerevisiae
Classical studies on position effect variegation in Drosophila have demonstrated the existence of bi-modal Active/Silent s...
Vitamin C activates young LINE-1 elements in mouse embryonic stem cells via H3K9me3 demethylation
Vitamin C activates young LINE-1 elements in mouse embryonic stem cells via H3K9me3 demethylation
Vitamin C (vitC) enhances the activity of 2-oxoglutarate-dependent dioxygenases, including TET enzymes, which catalyse DNA...
The application of epiphenotyping approaches to DNA methylation array studies of the human placenta
The application of epiphenotyping approaches to DNA methylation array studies of the human placenta
Genome-wide DNA methylation (DNAme) profiling of the placenta with Illumina Infinium Methylation bead arrays is often used...
Knockout tales: the versatile roles of histone H3.3 in development and disease
Knockout tales: the versatile roles of histone H3.3 in development and disease
Histone variant H3.3 plays novel roles in development as compared to canonical H3 proteins and is the most commonly mutate...
Histone crotonylation of peripheral blood mononuclear cells is a potential biomarker for diagnosis of colorectal cancer
Histone crotonylation of peripheral blood mononuclear cells is a potential biomarker for diagnosis of colorectal cancer
Blood-based tests have public appeal in screening cancers due to their minimally invasive nature, ability to integrate wit...
Nucleophosmin 1 cooperates with the methyltransferase DOT1L to preserve peri-nucleolar heterochromatin organization by regulating H3K27me3 levels and DNA repeats expression
Nucleophosmin 1 cooperates with the methyltransferase DOT1L to preserve peri-nucleolar heterochromatin organization by regulating H3K27me3 levels and DNA repeats expression
NPM1 is a phosphoprotein highly abundant in the nucleolus. However, additional nuclear functions have been attributed to N...
Elucidating disease-associated mechanisms triggered by pollutants via the epigenetic landscape using large-scale ChIP-Seq data
Elucidating disease-associated mechanisms triggered by pollutants via the epigenetic landscape using large-scale ChIP-Seq data
Despite well-documented effects on human health, the action modes of environmental pollutants are incompletely understood....
Altered cfDNA fragmentation profile in hypomethylated regions as diagnostic markers in breast cancer
Altered cfDNA fragmentation profile in hypomethylated regions as diagnostic markers in breast cancer
Breast cancer, the most common malignancy in women worldwide, has been proven to have both altered plasma cell-free DNA (c...
Co-effects of m6A and chromatin accessibility dynamics in the regulation of cardiomyocyte differentiation
Co-effects of m6A and chromatin accessibility dynamics in the regulation of cardiomyocyte differentiation
Cardiomyocyte growth and differentiation rely on precise gene expression regulation, with epigenetic modifications emergin...
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