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Genome-wide CRISPR activation screen identifies ARL11 as a sensitivity determinant of PARP inhibitor therapy
Genome-wide CRISPR activation screen identifies ARL11 as a sensitivity determinant of PARP inhibitor therapy
Resistance to poly-(ADP)-ribose polymerase inhibitors (PARPi) remains a significant challenge in clinical practice, leadin...
MDSC checkpoint blockade therapy: a new breakthrough point overcoming immunosuppression in cancer immunotherapy
MDSC checkpoint blockade therapy: a new breakthrough point overcoming immunosuppression in cancer immunotherapy
Despite the success of cancer immunotherapy in treating hematologic malignancies, their efficacy in solid tumors remains l...
Cardamom synergizes with cisplatin against human osteosarcoma cells by mTOR-mediated autophagy
Cardamom synergizes with cisplatin against human osteosarcoma cells by mTOR-mediated autophagy
Cisplatin (DDP), a frontline chemotherapeutic agent in osteosarcoma (OS) treatment, is frequently paired with other compou...
Recent advances in the role of circRNA in cisplatin resistance in tumors
Recent advances in the role of circRNA in cisplatin resistance in tumors
Cancer remains a major threat to human health, with chemotherapy serving as one of the main treatment strategies to allevi...
RRM1 O-GlcNAcylation inhibition suppresses pancreatic cancer via TK1-mediated replication stress
RRM1 O-GlcNAcylation inhibition suppresses pancreatic cancer via TK1-mediated replication stress
O-GlcNAcylation of ribonucleotide reductase large subunit M1 (RRM1) at position 734 influences high glucose-induced genomi...
Tob negatively regulates NF-κB activation in breast cancer through its association with the TNF receptor complex
Tob negatively regulates NF-κB activation in breast cancer through its association with the TNF receptor complex
NF-κB mediates transcriptional regulation crucial to many biological functions, and elevated NF-κB activity lead...
ALKBH5-mediated m6A regulates the alternative splicing events of SRSF10 in ovarian cancer
ALKBH5-mediated m6A regulates the alternative splicing events of SRSF10 in ovarian cancer
N6-methyladenosine (m6A) methylation was found to be involved in the tumorigenesis and development of ovarian cancer. Unti...
Microbiota in tumors: new factor influencing cancer development
Microbiota in tumors: new factor influencing cancer development
Tumor microbiota research is a new field in oncology. With the advancement of high-throughput sequencing, there is growing...
Targeting CREB-binding protein (CBP) abrogates colorectal cancer stemness through epigenetic regulation of C-MYC
Targeting CREB-binding protein (CBP) abrogates colorectal cancer stemness through epigenetic regulation of C-MYC
Colorectal cancer (CRC) is a common cancer worldwide with an increasing annual incidence. Cancer stem cells (CSCs) play im...
Correction: PARD6A promotes lung adenocarcinoma cell proliferation and invasion through Serpina3
These authors contributed equally: Lanlin Hu, Mingxin Liu, Bo Tang.These authors jointly supervised this work: Sijia Liu, ...
AMIGO2 enhances the invasive potential of colorectal cancer by inducing EMT
AMIGO2 enhances the invasive potential of colorectal cancer by inducing EMT
In our previous studies, we identified amphoterin-inducible gene and open reading frame 2 (AMIGO2) as a driver gene for li...
Systemic delivery of tannic acid-ferric-masked oncolytic adenovirus reprograms tumor microenvironment for improved therapeutic efficacy in glioblastoma
Systemic delivery of tannic acid-ferric-masked oncolytic adenovirus reprograms tumor microenvironment for improved therapeutic efficacy in glioblastoma
Glioblastoma (GBM) represents the most aggressive primary brain tumor, and urgently requires effective treatments. Oncolyt...
AAV-mediated combination gene therapy of inducible Caspase 9 and miR-199a-5p is therapeutic in hepatocellular carcinoma
AAV-mediated combination gene therapy of inducible Caspase 9 and miR-199a-5p is therapeutic in hepatocellular carcinoma
Advanced-stage hepatocellular carcinoma (HCC) remains an untreatable disease with an overall survival of less than one yea...
Intraperitoneal administration of adeno-associated virus encoding microRNA-29b for the treatment of peritoneal metastasis
Intraperitoneal administration of adeno-associated virus encoding microRNA-29b for the treatment of peritoneal metastasis
This study explores a novel therapeutic approach for peritoneal metastasis (PM) using AAV-mediated delivery of tumor suppr...
γ-Glutamylcyclotransferase is transcriptionally regulated by c-Jun and controls proliferation of glioblastoma stem cells through Notch1 levels
γ-Glutamylcyclotransferase is transcriptionally regulated by c-Jun and controls proliferation of glioblastoma stem cells through Notch1 levels
Glioblastoma stem cells (GSCs) have been reported to cause poor prognosis of glioblastoma by contributing to therapy resis...
Retraction Note: miR-182 regulates trastuzumab resistance by targeting MET in breast cancer cells
Authors and AffiliationsDepartment of Immunology, China Medical University, Shenyang, ChinaDan YueLaboratory Medicine Depa...
Regulatory roles of N6-methyladenosine (m6A) methylation in RNA processing and non-communicable diseases
Regulatory roles of N6-methyladenosine (m6A) methylation in RNA processing and non-communicable diseases
Post-transcriptional RNA modification is an emerging epigenetic control mechanism in cells that is important in many diffe...
Proteomic profiling reveals ACSS2 facilitating metabolic support in acute myeloid leukemia
Proteomic profiling reveals ACSS2 facilitating metabolic support in acute myeloid leukemia
Acute myeloid leukemia (AML) is a heterogeneous disease characterized by genomic aberrations in oncogenes, cytogenetic abn...
Human adipose-derived stem cells genetically programmed to induce necroptosis for cancer immunotherapy
Human adipose-derived stem cells genetically programmed to induce necroptosis for cancer immunotherapy
Herein, we present human adipose-derived stem cells (ADSCs) inserted with the receptor-interacting protein kinase-3 (RIP3)...
RhoJ: an emerging biomarker and target in cancer research and treatment
RhoJ: an emerging biomarker and target in cancer research and treatment
RhoJ is a Rho GTPase that belongs to the Cdc42 subfamily and has a molecular weight of approximately 21 kDa. It can ...
Lower ratio of IMPDH1 to IMPDH2 sensitizes gliomas to chemotherapy
Lower ratio of IMPDH1 to IMPDH2 sensitizes gliomas to chemotherapy
Gliomas are the most common primary tumors of the central nervous system, with approximately half of patients presenting w...
ScRNA-seq revealed the tumor microenvironment heterogeneity related to the occurrence and metastasis in upper urinary tract urothelial carcinoma
ScRNA-seq revealed the tumor microenvironment heterogeneity related to the occurrence and metastasis in upper urinary tract urothelial carcinoma
Metastasis is the greatest clinical challenge for UTUCs, which may have distinct molecular and cellular characteristics fr...
Deciphering the role of post-translational modifications in fanconi anemia proteins and their influence on tumorigenesis
Deciphering the role of post-translational modifications in fanconi anemia proteins and their influence on tumorigenesis
Fanconi anemia (FA) is an autosomal or X-linked human disease, characterized by bone marrow failure, cancer susceptibility...
PLK1 and its substrate MISP facilitate intrahepatic cholangiocarcinoma progression by promoting lymphatic invasion and impairing E-cadherin adherens junctions
PLK1 and its substrate MISP facilitate intrahepatic cholangiocarcinoma progression by promoting lymphatic invasion and impairing E-cadherin adherens junctions
Intrahepatic cholangiocarcinoma (iCCA) is a subtype of CCA and has a high mortality rate and a relatively poor prognosis. ...
SPP1+ TAM subpopulations in tumor microenvironment promote intravasation and metastasis of head and neck squamous cell carcinoma
SPP1+ TAM subpopulations in tumor microenvironment promote intravasation and metastasis of head and neck squamous cell carcinoma
Macrophages are heterogeneous cells that play multifaceted roles in cancer progression and metastasis. However, the phenot...
Cancer-associated fibroblast exosome LINC00355 promotes epithelial-mesenchymal transition and chemoresistance in colorectal cancer through the miR-34b-5p/CRKL axis
Cancer-associated fibroblast exosome LINC00355 promotes epithelial-mesenchymal transition and chemoresistance in colorectal cancer through the miR-34b-5p/CRKL axis
This study was designed to investigate the role and mechanism of cancer-associated fibroblasts (CAFs)-derived exosomes (CA...
Leveraging synthetic lethality to uncover potential therapeutic target in gastric cancer
Leveraging synthetic lethality to uncover potential therapeutic target in gastric cancer
Since trastuzumab was approved in 2012 for the first-line treatment of gastric cancer (GC), no significant advancement in ...
Cell fusion upregulates PD-L1 expression for evasion from immunosurveillance
Cell fusion upregulates PD-L1 expression for evasion from immunosurveillance
MSCs (mesenchymal stem cells), responsible for tissue repair, rarely undergo cell fusion with somatic cells. Here, we show...
TNFRSF19 promotes endoplasmic reticulum stress-induced paraptosis via the activation of the MAPK pathway in triple-negative breast cancer cells
TNFRSF19 promotes endoplasmic reticulum stress-induced paraptosis via the activation of the MAPK pathway in triple-negative breast cancer cells
TNFRSF19 is a member of the tumor necrosis factor receptor superfamily, and its function exhibits variability among differ...
Chimeric TβRII-SE/Fc overexpression by a lentiviral vector exerts strong antitumoral activity on colorectal cancer-derived cell lines in vitro and on xenografts
Chimeric TβRII-SE/Fc overexpression by a lentiviral vector exerts strong antitumoral activity on colorectal cancer-derived cell lines in vitro and on xenografts
The TGF signaling pathway is a key regulator of cancer progression. In this work, we report for the first time the antitum...
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