MZB1-Driven Endoplasmic reticulum stress model as a predictor of breast cancer progression and survival

Belkaya S, Murray SE, Eitson JL, de la Morena MT, Forman JA, van Oers NSC (2013) Transgenic expression of microrna-185 causes a developmental arrest of T cells by targeting multiple genes including Mzb1. J Biol Chem 288:30752–30762. https://doi.org/10.1074/jbc.M113.503532

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chang VC, Cotterchio M, Bondy SJ, Kotsopoulos J (2020) Iron intake, oxidative stress-related genes and breast cancer risk. Int J Cancer 147:1354–1373. https://doi.org/10.1002/ijc.32906

Article  CAS  PubMed  Google Scholar 

Chen X, Cubillos-Ruiz JR (2021) Endoplasmic reticulum stress signals in the tumour and its microenvironment. Nat Rev Cancer 21:71–88. https://doi.org/10.1038/s41568-020-00312-2

Article  CAS  PubMed  Google Scholar 

Chen B, Hu J, Hu X, Chen H, Bao R, Zhou Y, Ye Y, Zhan M, Cai W, Li H, Li HB (2022) DENR controls JAK2 translation to induce PD-L1 expression for tumor immune evasion. Nat Commun 13:2059. https://doi.org/10.1038/s41467-022-29754-y

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cherepanova N, Shrimal S, Gilmore R (2016) N-linked glycosylation and homeostasis of the endoplasmic reticulum. Curr Opin Cell Biol 41:57–65. https://doi.org/10.1016/j.ceb.2016.03.021

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cubillos-Ruiz JR, Bettigole SE, Glimcher LH (2017) Tumorigenic and immunosuppressive effects of endoplasmic reticulum stress in cancer. Cell 168:692–706. https://doi.org/10.1016/j.cell.2016.12.004

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fan P, Wang J, Li R, Chang K, Liu L, Wang Y, Wang Z, Zhang B, Ji C, Zhang J, Chen S, Ling R (2023) Development and validation of an endoplasmic reticulum stress-related molecular prognostic model for breast cancer. Front Oncol 13:1178595. https://doi.org/10.3389/fonc.2023.1178595

Article  CAS  PubMed  PubMed Central  Google Scholar 

He M, Yang T, Wang Y, Wang M, Chen X, Ding D, Zheng Y, Chen H (2021) Immune checkpoint Inhibitor-Based strategies for synergistic cancer therapy. Adv Healthc Mater 10:e2002104. https://doi.org/10.1002/adhm.202002104

Article  CAS  PubMed  Google Scholar 

Herold T, Mulaw MA, Jurinovic V, Seiler T, Metzeler KH, Dufour A, Schneider S, Kakadia PM, Spiekermann K, Mansmann U, Hiddemann W, Buske C, Dreyling M, Bohlander SK (2013) High expression of MZB1 predicts adverse prognosis in chronic lymphocytic leukemia, follicular lymphoma and diffuse large B-cell lymphoma and is associated with a unique gene expression signature. Leuk Lymphoma 54:1652–1657. https://doi.org/10.3109/10428194.2012.753445

Article  CAS  PubMed  Google Scholar 

Hu C, Xin Z, Sun X, Hu Y, Zhang C, Yan R, Wang Y, Lu M, Huang J, Du X, Xing B, Liu X (2023) Activation of ACLY by sect. 63 deploys metabolic reprogramming to facilitate hepatocellular carcinoma metastasis upon endoplasmic reticulum stress. J Exp Clin Cancer Res 42:108. https://doi.org/10.1186/s13046-023-02656-7

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kanda M, Tanaka C, Kobayashi D, Tanaka H, Shimizu D, Shibata M, Takami H, Hayashi M, Iwata N, Niwa Y, Yamada S, Fujii T, Nakayama G, Fujiwara M, Kodera Y (2016) Epigenetic suppression of the immunoregulator MZB1 is associated with the malignant phenotype of gastric cancer. Int J Cancer 139:2290–2298. https://doi.org/10.1002/ijc.30286

Article  CAS  PubMed  Google Scholar 

Kapoor T, Corrado M, Pearce EL, Pearce EJ, Grosschedl R (2020) MZB1 enables efficient interferon alpha secretion in stimulated plasmacytoid dendritic cells. Sci Rep 10:21626. https://doi.org/10.1038/s41598-020-78293-3

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kuo CY, Lin CH, Hsu T (2017) VHL inactivation in precancerous kidney cells induces an inflammatory response via ER stress-activated IRE1α signaling. Cancer Res 77:3406–3416. https://doi.org/10.1158/0008-5472.Can-16-3196

Article  CAS  PubMed  Google Scholar 

Li D, Zhu Y, Zhang L, Shi L, Deng L, Ding Z, Ai R, Zhang X, He Y (2022) MZB1 targeted by miR-185-5p inhibits the migration of human periodontal ligament cells through NF-kappaB signaling and promotes alveolar bone loss. J Periodontal Res 57:811–823. https://doi.org/10.1111/jre.13014

Article  CAS  PubMed  Google Scholar 

Lin X, Kang K, Chen P, Zeng Z, Li G, Xiong W, Yi M, Xiang B (2024) Regulatory mechanisms of PD-1/PD-L1 in cancers. Mol Cancer 23:108. https://doi.org/10.1186/s12943-024-02023-w

Article  PubMed  PubMed Central  Google Scholar 

Ling A, Löfgren-Burström A, Larsson P, Li X, Wikberg ML, Öberg Å, Stenling R, Edin S, Palmqvist R (2017) TAP1 down-regulation elicits immune escape and poor prognosis in colorectal cancer. Oncoimmunology 6:e1356143. https://doi.org/10.1080/2162402x.2017.1356143

Article  CAS  PubMed  PubMed Central  Google Scholar 

Linxweiler M, Schick B, Zimmermann R (2017) Let’s talk about secs: sect. 61, sect. 62 and sect. 63 in signal transduction, oncology and personalized medicine. Signal Transduct Target Ther 2:17002. https://doi.org/10.1038/sigtrans.2017.2

Article  PubMed  PubMed Central  Google Scholar 

Lu Q, Qin X, Chen C, Yu W, Lin J, Liu X, Guo R, Reiter RJ, Ashrafizadeh M, Yuan M, Ren J (2024) Elevated levels of alcohol dehydrogenase aggravate ethanol-evoked cardiac remodeling and contractile anomalies through FKBP5-Yap-mediated regulation of ferroptosis and ER stress. Life Sci 343:122508. https://doi.org/10.1016/j.lfs.2024.122508

Article  CAS  PubMed  Google Scholar 

Mades A, Gotthardt K, Awe K, Stieler J, Döring T, Füser S, Prange R (2012) Role of human sect. 63 in modulating the steady-state levels of multi-spanning membrane proteins. PLoS ONE 7:e49243. https://doi.org/10.1371/journal.pone.0049243

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mele L, la Noce M, Paino F, Regad T, Wagner S, Liccardo D, Papaccio G, Lombardi A, Caraglia M, Tirino V, Desiderio V, Papaccio F (2019) Glucose-6-phosphate dehydrogenase blockade potentiates tyrosine kinase inhibitor effect on breast cancer cells through autophagy perturbation. J Exp Clin Cancer Res 38:160. https://doi.org/10.1186/s13046-019-1164-5

Article  PubMed  PubMed Central  Google Scholar 

Paldino G, Fierabracci A (2023) Shedding new light on the role of ERAP1 in type 1 diabetes: a perspective on disease management. Autoimmun Rev 22:103291. https://doi.org/10.1016/j.autrev.2023.103291

Article  CAS  PubMed  Google Scholar 

Pan Z, Bao Y, Hu M, Zhu Y, Tan C, Fan L, Yu H, Wang A, Cui J, Sun G (2023) Role of NAT10-mediated ac4C-modified HSP90AA1 RNA acetylation in ER stress-mediated metastasis and lenvatinib resistance in hepatocellular carcinoma. Cell Death Discov 9:56. https://doi.org/10.1038/s41420-023-01355-8

Article  CAS  PubMed  PubMed Central  Google Scholar 

Patra A, Adhikary A, Ghosh S (2023) The unfolded protein response (UPR) pathway: the unsung hero in breast cancer management. Apoptosis 28:263–276. https://doi.org/10.1007/s10495-022-01803-3

Article  CAS  PubMed  Google Scholar 

Peppercorn J, Perou CM, Carey LA (2008) Molecular subtypes in breast cancer evaluation and management: divide and conquer. Cancer Invest 26:1–10. https://doi.org/10.1080/07357900701784238

Article  CAS  PubMed  Google Scholar 

Perou CM, Sorlie T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA, Pollack JR, Ross DT, Johnsen H, Akslen LA, Fluge O, Pergamenschikov A, Williams C, Zhu SX, Lonning PE, Borresen-Dale AL, Brown PO, Botstein D (2000) Molecular portraits of human breast tumours. Nature 406:747–752. https://doi.org/10.1038/35021093

Article  CAS  PubMed  Google Scholar 

Pleiner T, Hazu M, Tomaleri GP, Januszyk K, Oania RS, Sweredoski MJ, Moradian A, Guna A, Voorhees RM (2021) WNK1 is an assembly factor for the human ER membrane protein complex. Mol Cell 81:2693–2704e2612. ht

Comments (0)

No login
gif