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Inter‐observer agreement for the histological diagnosis of invasive lobular breast carcinoma
Inter‐observer agreement for the histological diagnosis of invasive lobular breast carcinoma
Abstract Invasive lobular breast carcinoma (ILC) is the second most common breast carcinoma (BC) subtype and is mainly dri...
Mismatch repair deficiency in early‐onset duodenal, ampullary, and pancreatic carcinomas is a strong indicator for a hereditary defect
Mismatch repair deficiency in early‐onset duodenal, ampullary, and pancreatic carcinomas is a strong indicator for a hereditary defect
Abstract Mismatch repair deficiency (dMMR) is a hallmark of Lynch syndrome (LS), but its prevalence in early-onset (diagno...
Understanding the ethical and legal considerations of Digital Pathology
Understanding the ethical and legal considerations of Digital Pathology
Abstract Digital Pathology (DP) is a platform which has the potential to develop a truly integrated and global pathology c...
Expression of proteins associated with the Warburg‐effect and survival in colorectal cancer
Expression of proteins associated with the Warburg‐effect and survival in colorectal cancer
Abstract Previous research has suggested that the expression of proteins related to the Warburg effect may have prognostic...
Papillary thyroid carcinoma tall cell variant shares accumulation of mitochondria, mitochondrial DNA mutations, and loss of oxidative phosphorylation complex I integrity with oncocytic tumors
Papillary thyroid carcinoma tall cell variant shares accumulation of mitochondria, mitochondrial DNA mutations, and loss of oxidative phosphorylation complex I integrity with oncocytic tumors
Abstract Papillary thyroid carcinoma tall cell variant (PTC-TCV), a form of PTC regarded as an aggressive subtype, shares ...
Automated annotations of epithelial cells and stroma in hematoxylin–eosin‐stained whole‐slide images using cytokeratin re‐staining
Automated annotations of epithelial cells and stroma in hematoxylin–eosin‐stained whole‐slide images using cytokeratin re‐staining
Abstract The diagnosis of solid tumors of epithelial origin (carcinomas) represents a major part of the workload in clinic...
Diagnostic and prognostic implications of a three‐antibody molecular subtyping algorithm for non‐muscle invasive bladder cancer
Diagnostic and prognostic implications of a three‐antibody molecular subtyping algorithm for non‐muscle invasive bladder cancer
Abstract Intrinsic molecular subtypes may explain marked variation between bladder cancer patients in prognosis and respon...
Quantitative proteomics identifies biomarkers to distinguish pulmonary from head and neck squamous cell carcinomas by immunohistochemistry
Quantitative proteomics identifies biomarkers to distinguish pulmonary from head and neck squamous cell carcinomas by immunohistochemistry
Abstract The differentiation between a pulmonary metastasis and a newly developed squamous cell carcinoma of the lung in p...
Radiotherapy biobanking: current landscape, opportunities, challenges, and future aspirations
Radiotherapy biobanking: current landscape, opportunities, challenges, and future aspirations
Abstract Half of all cancer patients receive radiotherapy, which makes a substantial contribution to their long-term disea...
Characterizing the tumor microenvironment in rare renal cancer histological types
Characterizing the tumor microenvironment in rare renal cancer histological types
Abstract The tumor microenvironment (TME), including immune cells, cancer-associated fibroblasts, endothelial cells, adjac...
Selection of endometrial carcinomas for p53 immunohistochemistry based on nuclear features
Selection of endometrial carcinomas for p53 immunohistochemistry based on nuclear features
Abstract The World Health Organization endorses molecular subclassification of endometrial endometrioid carcinomas (EECs)....
Somatic intronic TP53 c.375+5G mutations are a recurrent but under‐recognized mode of TP53 inactivation
Somatic intronic TP53 c.375+5G mutations are a recurrent but under‐recognized mode of TP53 inactivation
Abstract TP53 is one of the most ubiquitously altered genes in human cancer. The biological impact of rare variants, parti...
Preoperative systemic chemotherapy alters the histopathological growth patterns of colorectal liver metastases
Preoperative systemic chemotherapy alters the histopathological growth patterns of colorectal liver metastases
Abstract Histopathological growth patterns (HGPs) are a reliable, reproducible, and strong prognostic biomarker that can b...
PD‐L1 expression in megakaryocytes and its clinicopathological features in primary myelofibrosis patients
PD‐L1 expression in megakaryocytes and its clinicopathological features in primary myelofibrosis patients
Abstract Myeloproliferative neoplasms (MPNs) are characterized by upregulation of proinflammatory cytokines and immune dys...
PRR11 unveiled as a top candidate biomarker within the RBM3‐regulated transcriptome in pancreatic cancer
PRR11 unveiled as a top candidate biomarker within the RBM3‐regulated transcriptome in pancreatic cancer
Abstract The outlook for patients with pancreatic cancer remains dismal. Treatment options are limited and chemotherapy re...
c‐MYC and p53 expression highlight starry‐sky pattern as a favourable prognostic feature in R‐CHOP‐treated diffuse large B‐cell lymphoma
c‐MYC and p53 expression highlight starry‐sky pattern as a favourable prognostic feature in R‐CHOP‐treated diffuse large B‐cell lymphoma
Abstract Diffuse large B-cell lymphoma (DLBCL) is a clinically heterogeneous entity, in which the first-line treatment cur...
Pattern of placental alkaline phosphatase (PLAP) expression in human tumors: a tissue microarray study on 12,381 tumors
Pattern of placental alkaline phosphatase (PLAP) expression in human tumors: a tissue microarray study on 12,381 tumors
Abstract Placental alkaline phosphatase (PLAP) is commonly expressed at high levels in testicular germ cell tumors. PLAP i...
Transcriptional profiling of paediatric ependymomas identifies prognostically significant groups
Transcriptional profiling of paediatric ependymomas identifies prognostically significant groups
Abstract The majority of supratentorial ependymomas in children contain oncogenic fusions, such as ZFTA–RELA or YAP...
Quick Annotator: an open‐source digital pathology based rapid image annotation tool
Quick Annotator: an open‐source digital pathology based rapid image annotation tool
Abstract Image-based biomarker discovery typically requires accurate segmentation of histologic structures (e.g. cell nucl...
Integration of NRP1, RGS5, and FOXM1 expression, and tumour necrosis, as a postoperative prognostic classifier based on molecular subtypes of clear cell renal cell carcinoma
Integration of NRP1, RGS5, and FOXM1 expression, and tumour necrosis, as a postoperative prognostic classifier based on molecular subtypes of clear cell renal cell carcinoma
Abstract Molecular mechanisms of progression of clear cell renal cell carcinoma (ccRCC) have been proven with recent genom...
More than just acral melanoma: the controversies of defining the disease
More than just acral melanoma: the controversies of defining the disease
Abstract Acral melanoma (AM) is a malignant cutaneous melanocytic tumour specifically located on the palms, soles, and nai...
Severity of arterial and/or arteriolar sclerosis in IgA nephropathy and the effects of renin–angiotensin system inhibitors on its prognosis
Severity of arterial and/or arteriolar sclerosis in IgA nephropathy and the effects of renin–angiotensin system inhibitors on its prognosis
Abstract IgA nephropathy (IgAN) patients often suffer from arterial and/or arteriolar sclerosis (AAS); however, it is uncl...
Increased diagnostic sensitivity of palpation‐guided thyroid nodule fine‐needle aspiration cytology by BRAF V600E‐mutation analysis
Increased diagnostic sensitivity of palpation‐guided thyroid nodule fine‐needle aspiration cytology by BRAF V600E‐mutation analysis
Abstract Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer and its incidence is increasing. Preo...
STING pathway expression in low‐grade serous carcinoma of the ovary: an unexpected therapeutic opportunity?
STING pathway expression in low‐grade serous carcinoma of the ovary: an unexpected therapeutic opportunity?
Abstract Ovarian carcinoma histotypes are distinct diseases with variable clinical outcomes and response to treatment. The...
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