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Stereoselective synthesis of a KRASG12C inhibitor with quinoline-piperazine scaffold
We developed a novel synthetic route for the KRASG12C inhibitor, focusing on the efficient construc-tion of its central qu...
PIDA-Mediated Synthesis of Kynurenine Derivatives by Oxidative Fragmentation of Tryptophan Scaffold
Kynurenine metabolite is derived from aromatic amino acid tryptophan and its chemical synthesis has been sought for unders...
Synthesis and stability of collagen mimetic peptides featuring δ-heteroatom-substituted prolines
We describe the first investigation of collagen mimetic peptides harboring proline surrogates with heteroatoms at the δ-po...
A MnCl2 Catalyzed Synthesis of Aldehydes from Organohalides by Using Samarium Metal in DMF
Catalyzed by MnCl2, a novel coupling reaction between organohalides and N,N-dimethylformamide (DMF) was investigated in th...
Artemselenoids A−H, eight guaiane-type sesquiterpenoid dimers from Artemisia selengensis and their antihepatoma activities
Eight undescribed guaiane-type sesquiterpenoid dimers (GSDs), artemselenoids A−H (1−8), together with nine known GSDs (9−1...
Phosphinylation/Cyclization of Propynolaldehydes to Isobenzo- furanylic Phosphine Oxides Displaying AIE Properties
Investigating organic reactions to synthesize novel molecules that exhibit aggregation-induced emission (AIE) characterist...
Energy Transfer Mediated Carbonylimination of Alkenes Using Bifunctional Reagent
A photoinduced EnT-mediated generation of acyl radicals has been accomplished using rationally designed acyl oxime ethers ...
Total Synthesis of (±)-Halichonine B
The stereocontrolled total synthesis of (±)-halichonine B was achieved in 18 steps for the longest linear sequence. T...
Brønsted Acid-Catalyzed Synthesis of Sulfinamidines and Sulfinimidate Esters through Electrophilic Fluorination and Substitution
In this work, we present an innovative Brønsted acid-catalyzed approach for the concurrent preparation of sulfinamidi...
A β-Hairpin Peptide Derived from Aβ Forms Different Oligomers in the Crystal State and in Aqueous Solution
The supramolecular assembly of amyloid β into soluble oligomers is critical Alzheimer’s disease (AD) progression. Soluble ...
Computational Exploration of Vinyl Sulfoxonium Ylide Chemistry
This review comprehensively examines the computational techniques employed to elucidate the reactivity, selectivity, and m...
Selenium-catalyzed Allylic C-H Phosphoramidation of Alkenes
We report herein a synthesis of allylic phosphoramidates from alkenes by selenium-catalyzed allylic C-H derivatization. Th...
Total synthesis and structure–antifouling activity relationship of scabrolide F
An efficient synthetic strategy for scabrolide F (7), a norcembranolide diterpene that was isolated from the Taiwanese sof...
Synthesis, characterization and photophysical studies of dual emissive base-modified fluorescent nucleosides
A straightforward and efficient methodology has been employed for the synthesis of a diverse set of base-modified fluoresc...
Chromic Properties of Dibenzo[j,l]fluoranthenes Exhibiting Different Resonance Contribution
Chromic molecules change colour in response to external stimuli and are utilized in applications such as food additive det...
Trivalent Dialkylaminopyridine-Catalyzed Site-Selective Mono-O-acylation of Partially-Protected Pyranosides
The work demonstrates trivalent tris-(3-N-methyl-N-pyridyl propyl)amine (1) catalyzing the site-selective mono-O-acylation...
Photo-induced glycosylation using the edible polyphenol curcumin
Photo-induced glycosylations of trichloroacetimidate donors and alcohols using an edible polyphenol, curcumin, were examin...
Synthetic approaches for carbohydrate based self-assembling systems
Carbohydrate based self-assembling systems are essential for the formation of advanced biocompatible materials via bottom-...
Enantioselective Synthesis of 4-Aryl-3,4-Dihydrocoumarins viaN-Heterocyclic Carbene Catalyzed β-Arylation/Cyclization of α-Bromoenals
4-Aryl-3,4-dihydrocoumarins are one of the most important structural motifs. Herein, we disclose an enantioselective N-Het...
Hydroboration of vinylsilanes providing diversity-oriented hydrophobic building blocks for biofunctional molecules
Hydroboration of vinylsilanes with BH3 affords two silylethanol regioisomers. Here, we investigated the regioisomeric rati...
Visualizing the cellular internalization of therapeutic antibodies via pH-sensitive release of AIEgen
Among the fastest-growing bio-pharmaceuticals, therapeutic antibodies have achieved unprecedented success in treating vari...
Bisindole-based Small Molecules as Transmembrane Anion Transporters and Potential Anticancer Agents
Few synthetic ion transporters have been reported incorporating indole as the core moiety. We have developed a novel bisin...
Carbonylative Cyclization of Biaryl Enones with Aldehydes and Oxamic Acids
An oxidative radical-promoted carbonylative cyclization strategy for the synthesis of phenanthren-9-(10H)-one frameworks f...
L-Proline-catalysed synthesis of chromeno[2,3-b]chromene from 4-hydroxy-2H-chromene-2-thione and some of their anti-proliferative study
The reactivity of 4-hydroxy-2H-chromene-2-thione is investigated with aryl aldehydes and 5,5-dimethylcylohexane-1,3-dione ...
Influence of a remote carbamate protective groups on the β-selectivity in rhamnosylations.
In this work, we present the synthesis of a series of L-thiorhamnosyl donors containing O-carbamate protective groups and ...
Visible Light-induced Reductive Aza-6π Electrocyclization Access to Phenanthridines
A visible light-induced aza-6π electrocyclization was developed for the synthesis of aza-arenes from nitroarenes with dive...
Site-Selective Benzylic C-H Hydroxylation in Electron-Deficient Heterocycles.
Benzylic C–H bonds can be converted into numerous functional groups, often by mechanisms that involve hydrogen atom transf...
Transition Metal Catalysed Cascade C-C and C-O Bond Forming Events of Alkynes
The past few decades have seen the emergence of domino reactions as a powerful tool for the multi-functionalization of alk...
Photoredox /Copper-Catalyzed gem-Difluoroalkylation-Cyanation of 1,3-Enynes
A photoredox/copper-catalyzed 1,4-difunctionalization of 1,3-enynes with readily available difluoroalkylating reagents and...
Molybdenum-Catalyzed Deoxygenative Heterocyclization of 2-Nitroazobenzenes: A Novel Strategy for Catalytic Synthesis of 2-Aryl-2H-benzo[d][1,2,3]triazoles
A novel strategy for catalytic synthesis of 2-aryl-2H-benzo[d][1,2,3]triazoles by non-noble molybdenum-catalyzed deoxygena...
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