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Alterations in starch, sucrose, and abscisic acid metabolism under drought stress in contrasting genotypes of chickpea
Alterations in starch, sucrose, and abscisic acid metabolism under drought stress in contrasting genotypes of chickpea
Plants respond to water scarcity by modifying transcription and metabolite accumulation; however, mechanisms leading to dr...
Co-chaperones fine-tune the function of heat shock protein 70 (Hsp70), whether to fold, hold, or degrade substrates in ensuring cellular protein homeostasis
Co-chaperones fine-tune the function of heat shock protein 70 (Hsp70), whether to fold, hold, or degrade substrates in ensuring cellular protein homeostasis
The molecular chaperone Hsp70 is a pivotal player in cellular protein quality control due to its wide range of substrates ...
Human adipose-derived stem cell exosomes alleviate human respiratory system-related cells damaged by exposure to SO derivatives
Human adipose-derived stem cell exosomes alleviate human respiratory system-related cells damaged by exposure to SO derivatives
Inhalation burns, especially when combined with thermal burns, can be fatal and significantly increase mortality rate thro...
Identification of components of the kallikrein–kinin system in the spine epithelium of the Atlantic stingray,
Identification of components of the kallikrein–kinin system in the spine epithelium of the Atlantic stingray,
The epithelial sheath covering the stingray spine results in wounds to humans that are characterized by edema, necrosis, e...
Enhanced whole-brain calcium imaging and cell identification in reveal AWC neuronal responses to 2-nonanone
Enhanced whole-brain calcium imaging and cell identification in reveal AWC neuronal responses to 2-nonanone
Whole-brain calcium imaging combined with multicolor cell identification is a revolutionary technique for elucidating stru...
Human papillomavirus vaccine: Success and challenges
Human papillomavirus vaccine: Success and challenges
Persistent infection with high-risk human papillomavirus (HPV) is a major etiological cause of cancers associated with the...
From the microscopic gladiator pit: Antibiotics vs resistance
From the microscopic gladiator pit: Antibiotics vs resistance
Abraham EP and Chain E 1940 An enzyme from bacteria able to destroy penicillin. Nature 146 837Article  CAS  ...
germline flux pulls its stem-cell niche cells into shape
germline flux pulls its stem-cell niche cells into shape
Agarwal P, Shemesh T and Zaidel-Bar R 2022 Directed cell invasion and asymmetric adhesion drive tissue elongation and turn...
Redefining the nitroplast: Recent insights into the endosymbiont-to-organelle transition
Redefining the nitroplast: Recent insights into the endosymbiont-to-organelle transition
Bodył A, Mackiewicz P and Gagat P 2012 Organelle evolution: Paulinella breaks a paradigm. Curr. Biol. 22 R304–306Coale TH,...
Postbiotic potential of SCFAs on metaflammation and gut microbiota alteration in diabetes
Postbiotic potential of SCFAs on metaflammation and gut microbiota alteration in diabetes
Gut microbiota regulate host metabolism via its fermentation products, mainly short-chain fatty acids (SCFAs), i.e., aceta...
Impact of HIV-1 TAT activation on retinal Müller glia: Implications for barrier properties
Impact of HIV-1 TAT activation on retinal Müller glia: Implications for barrier properties
HIV-associated immune activation is characterized by an increase in pro-inflammatory mediators and dysfunctional T-cells w...
Isa2p is essential in for mitochondrial function and stress resistance by allowing Rip1p subunit assembly into cytochrome complex
Isa2p is essential in for mitochondrial function and stress resistance by allowing Rip1p subunit assembly into cytochrome complex
In Saccharomyces cerevisiae, the iron–sulfur cluster biogenesis late-acting subsystem (Fe–S-IBG) comprises the...
Brassinolide sustains photosynthesis during high-light stress by modulating mitochondrial electron transport and cellular ROS
Brassinolide sustains photosynthesis during high-light stress by modulating mitochondrial electron transport and cellular ROS
Hormones such as abscisic acid and brassinosteroids ameliorate stress tolerance in plants. The present investigation demon...
Respiratory viruses and systemic lupus erythematosus: Biomarkers and mechanisms leading to autoimmunity
Respiratory viruses and systemic lupus erythematosus: Biomarkers and mechanisms leading to autoimmunity
Autoimmunity has been explored in various viral infections, and its relevance to respiratory viruses deserves more attenti...
Integrative analysis of coding and non-coding RNAs in rice reveals conserved molecular response signatures to heat, drought, and salt stresses
Integrative analysis of coding and non-coding RNAs in rice reveals conserved molecular response signatures to heat, drought, and salt stresses
Abiotic stresses such as heat, drought, and salinity significantly impact rice cultivation by affecting its yield and qual...
Decoding hepatitis B virus mutations that impact host–virus interactions and therapeutics
Decoding hepatitis B virus mutations that impact host–virus interactions and therapeutics
Hepatitis B virus (HBV), a lethal virus that results in the loss of two lives every minute, induces chronic and acute infe...
Effects of sampling methodology on phenology indices: Insights from sites across India and modelling
Effects of sampling methodology on phenology indices: Insights from sites across India and modelling
Plant phenology is the study of the timing and extent of leaf, flower, and fruit production. Phenology data are used to st...
Thirty years of the Baranyi and Roberts model: Predictions, precautions, risk assessment, and beyond
Thirty years of the Baranyi and Roberts model: Predictions, precautions, risk assessment, and beyond
In today's world, food safety is of paramount importance. Even a slight lapse can lead to significant economic losses ...
The first embryo, the origin of cancer and animal phylogeny. III. The totipotency as revealed by morphogenesis and the neoplasia controlled by cellular differentiation
The first embryo, the origin of cancer and animal phylogeny. III. The totipotency as revealed by morphogenesis and the neoplasia controlled by cellular differentiation
We have extensively described that the neoplastic process (NP) has deep evolutionary roots and we have made specific predi...
Trehalase inhibition in Helicoverpa armigera activates machinery for alternate energy acquisition
Trehalase inhibition in Helicoverpa armigera activates machinery for alternate energy acquisition
Trehalose serves as a primary circulatory sugar in insects which is crucial in energy metabolism and stress recovery. It i...
An in vitro model of adipose tissue-associated macrophages
An in vitro model of adipose tissue-associated macrophages
Obesity-related chronic low-grade inflammation plays a central role in the development of insulin resistance. Macrophages ...
Understanding pathophysiology of GNE myopathy and current progress towards drug development
Understanding pathophysiology of GNE myopathy and current progress towards drug development
GNE myopathy is a rare genetic neuromuscular disease that is caused due to mutations in the GNE gene responsible for siali...
Orphan drug development: Challenges, regulation, and success stories
Orphan drug development: Challenges, regulation, and success stories
Rare diseases, also known as orphan diseases, are diseases with low occurrence in the population. Developing orphan drugs ...
mRNA biotherapeutics landscape for rare genetic disorders
mRNA biotherapeutics landscape for rare genetic disorders
The medical emergency of COVID-19 brought to the forefront mRNA vaccine technology where the mRNA vaccine candidates mRNA-...
Enhancing access to treatment for Gaucher disease in India: The need for indigenous manufacturing
Enhancing access to treatment for Gaucher disease in India: The need for indigenous manufacturing
Gaucher disease (GD) is a prevalent lysosomal storage disorder (LSD) that significantly impacts individuals’ lives. ...
Spinal muscular atrophy: Molecular mechanism of pathogenesis, diagnosis, therapeutics, and clinical trials in the Indian context
Spinal muscular atrophy: Molecular mechanism of pathogenesis, diagnosis, therapeutics, and clinical trials in the Indian context
Spinal muscular atrophy (SMA) is a neuromuscular, rare genetic disorder caused due to loss-of-function mutations in the su...
Recent developments in gene therapy research in India
Recent developments in gene therapy research in India
Inherited genetic disorders are progressive in nature and lead to organ dysfunction or death in severe cases. At present, ...
Dynein functions in galectin-3 mediated processes of clathrin-independent endocytosis
Dynein functions in galectin-3 mediated processes of clathrin-independent endocytosis
Multiple endocytic processes operate in cells in tandem to uptake multiple cargoes involved in diverse cellular functions,...
Finding identical sequence repeats in multiple protein sequences: An algorithm
Finding identical sequence repeats in multiple protein sequences: An algorithm
In recent years, several experimental evidences suggest that amino acid repeats are closely linked to many disease conditi...
Cobra (Naja naja) venom L-amino acid oxidase (NNLAAO70) induces apoptosis and secondary necrosis in human lung epithelial cancer cells
Cobra (Naja naja) venom L-amino acid oxidase (NNLAAO70) induces apoptosis and secondary necrosis in human lung epithelial cancer cells
Snake venom L-amino acid oxidases (LAAOs) are flavoenzymes with diverse physiological and pharmacological effects. These e...
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