Postbiotic potential of SCFAs on metaflammation and gut microbiota alteration in diabetes

Anand S, Kaur H and Mande SS 2016 Comparative in silico analysis of butyrate production pathways in gut commensals and pathogens. Front. Microbiol. 7 1945

Article  PubMed  PubMed Central  Google Scholar 

Chambers ES, Viardot A, Psichas A, et al. 2015 Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults. Gut 64 1744–1754

Article  CAS  PubMed  Google Scholar 

Chen G, Liang G, Ou J, et al. 2004 Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver. Proc. Natl. Acad. Sci. USA 101 11245–11250

Article  CAS  PubMed  PubMed Central  Google Scholar 

De Vadder F, Kovatcheva-Datchary P, Goncalves D, et al. 2014 Microbiota-generated metabolites promote metabolic benefits via gut-brain neural circuits. Cell 156 84–96

Article  PubMed  Google Scholar 

den Besten G, Bleeker A, Gerding A, et al. 2015 Short-chain fatty acids protect against high-fat diet-induced obesity via a PPARγ-dependent switch from lipogenesis to fat oxidation. Diabetes 64 2398–2408

Article  Google Scholar 

Depommier C, Everard A, Druart C, et al. 2019 Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study. Nat. Med. 25 1096–1103

Article  CAS  PubMed  PubMed Central  Google Scholar 

Everard A, Belzer C, Geurts L, et al. 2013 Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. Proc. Natl. Acad. Sci. USA 110 9066–9071

Article  CAS  PubMed  PubMed Central  Google Scholar 

Frost G, Sleeth ML, Sahuri-Arisoylu M, et al. 2014 The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism. Nat. Commun. 5 3611

Article  CAS  PubMed  Google Scholar 

Jadeja RN, Jones MA, Fromal O, et al. 2019 Loss of GPR109A/HCAR2 induces aging-associated hepatic steatosis. Aging 11 386–400

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kadooka Y, Sato M, Imaizumi K, et al. 2010 Regulation of abdominal adiposity by probiotics (Lactobacillus gasseri SBT2055) in adults with obese tendencies in a randomized controlled trial. Eur. J. Clin. Nutr. 64 636–643

Article  CAS  PubMed  Google Scholar 

Kimura I, Ozawa K, Inoue D, et al. 2013 The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43. Nat. Commun. 4 1829

Article  PubMed  Google Scholar 

Larsen N, Vogensen FK, van den Berg FW, et al. 2010 Gut microbiota in human adults with type 2 diabetes differs from non-diabetic adults. PLoS One 5 e9085

Article  PubMed  PubMed Central  Google Scholar 

Lecomte V, Kaakoush NO, Maloney CA, et al. 2015 Changes in gut microbiota in rats fed a high fat diet correlate with obesity-associated metabolic parameters. PLoS One 10 e0126931

Article  PubMed  PubMed Central  Google Scholar 

Lednovich KR, Gough S, Priyadarshini M, et al. 2024 Intestinal FFA2 promotes obesity by altering food intake in Western diet-fed mice. J. Endocrinol. 260 e230184

CAS  PubMed  PubMed Central  Google Scholar 

Lee DH, Kim MT and Han JH 2024 GPR41 and GPR43: from development to metabolic regulation. Biomed. Pharmacother. 175 116735

Article  CAS  PubMed  Google Scholar 

Ley RE, Turnbaugh PJ, Klein S, et al. 2006 Microbial ecology: human gut microbes associated with obesity. Nature 444 1022–1023

Article  CAS  PubMed  Google Scholar 

Lin HV, Frassetto A, Klein S, et al. 2012 Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms. PLoS One 7 e35240

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lu Y, Fan C, Li P, et al. 2016 Short chain fatty acids prevent high-fat-diet-induced obesity in mice by regulating G protein-coupled receptors and gut microbiota. Sci. Rep. 6 37589

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mandaliya DK and Seshadri S 2019 Short chain fatty acids, pancreatic dysfunction and type 2 diabetes. Pancreatology 19 280–284

Article  CAS  PubMed  Google Scholar 

Mandaliya DK, Patel S, Seshadri S, et al. 2021 The combinatorial effect of acetate and propionate on high-fat diet induced diabetic inflammation or metaflammation and T cell polarization. Inflammation 44 68–79

Article  CAS  PubMed  Google Scholar 

May KS and den Hartigh LJ 2023 Gut microbial-derived short chain fatty acids: impact on adipose tissue physiology. Nutrients 15 272

Article  CAS  PubMed  PubMed Central  Google Scholar 

Moens F, Verce M and De Vuyst L 2017 Lactate- and acetate-based cross-feeding interactions between selected strains of lactobacilli, bifidobacteria and colon bacteria in the presence of inulin-type fructans. Int. J. Food Microbiol. 241 225–236

Article  CAS  PubMed  Google Scholar 

Mosser RE, Maulis MF, Moulle VS, et al. 2015 High-fat diet-induced beta-cell proliferation occurs prior to insulin resistance in C57Bl/6J male mice. Am. J. Physiol. Endocrinol. Metab. 308 E573–E582

Article  CAS  PubMed  PubMed Central  Google Scholar 

Patel S, Mandaliya D, Prajapati B, et al. 2019 Cefdinir microsphere modulated microflora and liver immunological response to diet induced diabetes in mice. Endocr. Metab. Immune Disord. Drug Targets 19 349–357

Article  CAS  PubMed  Google Scholar 

Postic C and Girard J 2008 The role of the lipogenic pathway in the development of hepatic steatosis. Diabetes Metab. 34 643–648

Article  CAS  PubMed  Google Scholar 

Priyadarshini M, Wicksteed B, Schiltz GE, et al. 2016 SCFA receptors in pancreatic beta cells: novel diabetes targets? Trends Endocrinol. Metab. 27 653–664

Article  CAS  PubMed  PubMed Central  Google Scholar 

Puddu A, Sanguineti R, Montecucco F, et al. 2014 Evidence for the gut microbiota short-chain fatty acids as key pathophysiological molecules improving diabetes. Mediators Inflamm. 162021

Reddy JK and Rao MS 2006 Lipid metabolism and liver inflammation. II. Fatty liver disease and fatty acid oxidation. Am. J. Physiol. Gastrointest. Liver Physiol. 290 G852–G858

Article  CAS  PubMed  Google Scholar 

Rivière A, Selak M, Lantin D, et al. 2016 Bifidobacteria and butyrate-producing colon bacteria: importance and strategies for their stimulation in the human gut. Front. Microbiol. 7 979

Article  PubMed  PubMed Central  Google Scholar 

Saligram S, Williams EJ and Masding MG 2012 Raised liver enzymes in newly diagnosed type 2 diabetes are associated with weight and lipids, but not glycaemic control. Indian J. Endocrinol. Metab. 16 1012–1014

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schwiertz A, Taras D, Schafer K, et al. 2010 Microbiota and SCFA in lean and overweight healthy subjects. Obesity 18 190–195

Article  PubMed  Google Scholar 

Shimizu H, Masujima Y, Ushiroda C, et al. 2019 Dietary short-chain fatty acid intake improves the hepatic metabolic condition via FFAR3. Sci. Rep. 9 16574

Comments (0)

No login
gif