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Uncovering leading compounds for alzheimer’s disease treatment: mendelian randomization and virtual screening insights into plasma protein modulation
Uncovering leading compounds for alzheimer’s disease treatment: mendelian randomization and virtual screening insights into plasma protein modulation
Alzheimer's disease (AD) is a neurodegenerative disorder influenced by both genetic and environmental factors. Identif...
Olfactory dysfunction and altered cortical excitability in the mouse model of Fragile X Syndrome
Olfactory dysfunction and altered cortical excitability in the mouse model of Fragile X Syndrome
Fragile X Syndrome (FXS) is the most common monogenetic cause of autism and inherited intellectual disability. A key featu...
Chaperone-assisted E3 ligase-engineered mesenchymal stem cells target hyperglycemia-induced p53 for ubiquitination and proteasomal degradation ameliorates self-renewal
Chaperone-assisted E3 ligase-engineered mesenchymal stem cells target hyperglycemia-induced p53 for ubiquitination and proteasomal degradation ameliorates self-renewal
Stem cell therapies may potentially be used in regenerative and reconstructive medicine due to their ability for self-rene...
Cardiac endothelial cells and cardiomyocytes alter their communication properties in diabetic mice
Cardiac endothelial cells and cardiomyocytes alter their communication properties in diabetic mice
We aimed to explore the heterogeneities and communication properties of cardiac CMs and ECs in diabetes. GSE213337 dataset...
Maternal stress during pregnancy alters circulating small extracellular vesicles and enhances their targeting to the placenta and fetus
Maternal stress during pregnancy alters circulating small extracellular vesicles and enhances their targeting to the placenta and fetus
Maternal psychological distress during pregnancy can negatively impact fetal development, resulting in long-lasting conseq...
Identification and functional characteristics of CHD1L gene variants implicated in human Müllerian duct anomalies
Identification and functional characteristics of CHD1L gene variants implicated in human Müllerian duct anomalies
Müllerian duct anomalies (MDAs) are congenital developmental disorders that present as a series of abnormalities with...
Ozone therapy mitigates parthanatos after ischemic stroke
Ozone therapy mitigates parthanatos after ischemic stroke
Stroke is a leading cause of death worldwide, with oxidative stress and calcium overload playing significant roles in the ...
H Antigen expression modulates epidermal Keratinocyte Integrity and differentiation
H Antigen expression modulates epidermal Keratinocyte Integrity and differentiation
ABO blood group antigens (ABH antigens) are carbohydrate chains glycosylated on epithelial and red blood cells. Recent fin...
Oviduct epithelial spheroids during in vitro culture of bovine embryos mitigate oxidative stress, improve blastocyst quality and change the embryonic transcriptome
Oviduct epithelial spheroids during in vitro culture of bovine embryos mitigate oxidative stress, improve blastocyst quality and change the embryonic transcriptome
In vitro embryo production is increasingly used for genetic improvement in cattle but bypasses the oviduct environment and...
Inhibition of astroglial hemichannels prevents synaptic transmission decline during spreading depression
Inhibition of astroglial hemichannels prevents synaptic transmission decline during spreading depression
Spreading depression (SD) is an intriguing phenomenon characterized by massive slow brain depolarizations that affect neur...
Loss of protein tyrosine phosphatase receptor delta PTPRD increases the number of cortical neurons, impairs synaptic function and induces autistic-like behaviors in adult mice
Loss of protein tyrosine phosphatase receptor delta PTPRD increases the number of cortical neurons, impairs synaptic function and induces autistic-like behaviors in adult mice
The brain cortex is responsible for many higher-level cognitive functions. Disruptions during cortical development have lo...
Exercise reduces physical alterations in a rat model of fetal alcohol spectrum disorders
Exercise reduces physical alterations in a rat model of fetal alcohol spectrum disorders
Prenatal alcohol exposure (PAE) has serious physical consequences for children such as behavioral disabilities, growth dis...
Molecular hydrogen promotes retinal vascular regeneration and attenuates neovascularization and neuroglial dysfunction in oxygen-induced retinopathy mice
Molecular hydrogen promotes retinal vascular regeneration and attenuates neovascularization and neuroglial dysfunction in oxygen-induced retinopathy mice
Retinopathy of Prematurity (ROP) is a proliferative retinal vascular disease occurring in the retina of premature infants ...
MSC-derived exosomes protect auditory hair cells from neomycin-induced damage via autophagy regulation
MSC-derived exosomes protect auditory hair cells from neomycin-induced damage via autophagy regulation
Sensorineural hearing loss (SNHL) poses a major threat to both physical and mental health; however, there is still a lack ...
Embryo development is impaired by sperm mitochondrial-derived ROS
Embryo development is impaired by sperm mitochondrial-derived ROS
Basal energetic metabolism in sperm, particularly oxidative phosphorylation, is known to condition not only their oocyte f...
Endometrial mesenchymal stromal/stem cells improve regeneration of injured endometrium in mice
Endometrial mesenchymal stromal/stem cells improve regeneration of injured endometrium in mice
The monthly regeneration of human endometrial tissue is maintained by the presence of human endometrial mesenchymal stroma...
Integration of ATAC-seq and RNA-seq identifies MX1-mediated AP-1 transcriptional regulation as a therapeutic target for Down syndrome
Integration of ATAC-seq and RNA-seq identifies MX1-mediated AP-1 transcriptional regulation as a therapeutic target for Down syndrome
Growing evidence has suggested that Type I Interferon (I-IFN) plays a potential role in the pathogenesis of Down Syndrome ...
The novel roles of YULINK in the migration, proliferation and glycolysis of pulmonary arterial smooth muscle cells: implications for pulmonary arterial hypertension
The novel roles of YULINK in the migration, proliferation and glycolysis of pulmonary arterial smooth muscle cells: implications for pulmonary arterial hypertension
Abnormal remodeling of the pulmonary vasculature, characterized by the proliferation and migration of pulmonary arterial s...
Electroacupuncture promotes neurogenesis in the dentate gyrus and improves pattern separation in an early Alzheimer's disease mouse model
Electroacupuncture promotes neurogenesis in the dentate gyrus and improves pattern separation in an early Alzheimer's disease mouse model
Impaired pattern separation occurs in the early stage of Alzheimer’s disease (AD), and hippocampal dentate gyrus (DG...
Advances towards the use of gastrointestinal tumor patient-derived organoids as a therapeutic decision-making tool
Advances towards the use of gastrointestinal tumor patient-derived organoids as a therapeutic decision-making tool
In December 2022 the US Food and Drug Administration (FDA) removed the requirement that drugs in development must undergo ...
Role of SYVN1 in the control of airway remodeling in asthma protection by promoting SIRT2 ubiquitination and degradation
Role of SYVN1 in the control of airway remodeling in asthma protection by promoting SIRT2 ubiquitination and degradation
Asthma is a heterogenous disease that characterized by airway remodeling. SYVN1 (Synoviolin 1) acts as an E3 ligase to med...
Melatonin alleviates pyroptosis by regulating the SIRT3/FOXO3α/ROS axis and interacting with apoptosis in Atherosclerosis progression
Melatonin alleviates pyroptosis by regulating the SIRT3/FOXO3α/ROS axis and interacting with apoptosis in Atherosclerosis progression
Atherosclerosis (AS), a significant contributor to cardiovascular disease (CVD), is steadily rising with the aging of the ...
Prenatal ethanol exposure and changes in fetal neuroendocrine metabolic programming
Prenatal ethanol exposure and changes in fetal neuroendocrine metabolic programming
Prenatal ethanol exposure (PEE) (mainly through maternal alcohol consumption) has become widespread. However, studies sugg...
Autologous non-invasively derived stem cells mitochondria transfer shows therapeutic advantages in human embryo quality rescue
Autologous non-invasively derived stem cells mitochondria transfer shows therapeutic advantages in human embryo quality rescue
The decline in the quantity and quality of mitochondria are closely associated with infertility, particularly in advanced ...
Chemogenetic inhibition of NTS astrocytes normalizes cardiac autonomic control and ameliorate hypertension during chronic intermittent hypoxia
Chemogenetic inhibition of NTS astrocytes normalizes cardiac autonomic control and ameliorate hypertension during chronic intermittent hypoxia
Obstructive sleep apnea (OSA) is characterized by recurrent episodes of chronic intermittent hypoxia (CIH), which has been...
Heat-responsive microRNAs participate in regulating the pollen fertility stability of CMS-D2 restorer line under high-temperature stress
Heat-responsive microRNAs participate in regulating the pollen fertility stability of CMS-D2 restorer line under high-temperature stress
Anther development and pollen fertility of cytoplasmic male sterility (CMS) conditioned by Gossypium harknessii cytoplasm ...
Development of synthetic modulator enabling long-term propagation and neurogenesis of human embryonic stem cell-derived neural progenitor cells
Development of synthetic modulator enabling long-term propagation and neurogenesis of human embryonic stem cell-derived neural progenitor cells
Neural progenitor cells (NPCs) are essential for in vitro drug screening and cell-based therapies for brain-related disord...
Two murine models of sepsis: immunopathological differences between the sexes—possible role of TGFβ1 in female resistance to endotoxemia
Two murine models of sepsis: immunopathological differences between the sexes—possible role of TGFβ1 in female resistance to endotoxemia
Endotoxic shock (ExSh) and cecal ligature and puncture (CLP) are models that induce sepsis. In this work, we investigated ...
An intracellular, non-oxidative factor activates in vitro chromatin fragmentation in pig sperm
An intracellular, non-oxidative factor activates in vitro chromatin fragmentation in pig sperm
In vitro incubation of epididymal and vas deferens sperm with Mn2+ induces Sperm Chromatin Fragmentation (SCF), a mechanis...
SARS-CoV-2 spike protein S1 activates Cx43 hemichannels and disturbs intracellular Ca2+ dynamics
SARS-CoV-2 spike protein S1 activates Cx43 hemichannels and disturbs intracellular Ca2+ dynamics
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the ongoing coronavirus disease 2019 (COVID-19). An as...
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