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Improving Neurological Health in Aging Via Neuroplasticity-Based Computerized Exercise: Protocol for a Randomized Controlled Trial
Improving Neurological Health in Aging Via Neuroplasticity-Based Computerized Exercise: Protocol for a Randomized Controlled Trial
Background: Our current understanding of how computerized brain training drives cognitive and functional benefits remains ...
Protective Assets Reinforced With Integrated Care and Technology (PARITY): Protocol for a Randomized Controlled Trial
Protective Assets Reinforced With Integrated Care and Technology (PARITY): Protocol for a Randomized Controlled Trial
Background: Black women are significantly more likely to experience severe maternal morbidity and are 3 times as likely to...
An Automated Text Messaging Intervention to Reduce Substance Use Self-Stigma (Project RESTART): Protocol for a Feasibility and Acceptability Pilot Study
An Automated Text Messaging Intervention to Reduce Substance Use Self-Stigma (Project RESTART): Protocol for a Feasibility and Acceptability Pilot Study
Background: Stigma is a barrier to treatment and harm reduction seeking in people who use drugs. Most stigma reduction int...
Childhood Gender Diversity and Mental Health: Protocol for the Longitudinal, Observational Gender Journey Project
Childhood Gender Diversity and Mental Health: Protocol for the Longitudinal, Observational Gender Journey Project
Background: Prepubertal transgender, nonbinary, and gender-diverse (TGD) children (ie, those asserting gender identity, ex...
Preventing Cognitive Decline in Older Latino Adults With HIV Through a Culturally Tailored Health Promotion Intervention: Protocol for a Single-Arm Pilot Trial
Preventing Cognitive Decline in Older Latino Adults With HIV Through a Culturally Tailored Health Promotion Intervention: Protocol for a Single-Arm Pilot Trial
Background: Older Latino adults with HIV are at increased risk for mild cognitive impairment and earlier onset of aging-re...
Development of Automated Triggers in Ambulatory Settings in Brazil: Protocol for a Machine Learning–Based Design Thinking Study
Development of Automated Triggers in Ambulatory Settings in Brazil: Protocol for a Machine Learning–Based Design Thinking Study
Background: The use of technologies has had a significant impact on patient safety and the quality of care and has increas...
Ameliorating Racial Disparities in HIV Prevention via a Nurse-Led, AI-Enhanced Program for Pre-Exposure Prophylaxis Utilization Among Black Cisgender Women: Protocol for a Mixed Methods Study
Ameliorating Racial Disparities in HIV Prevention via a Nurse-Led, AI-Enhanced Program for Pre-Exposure Prophylaxis Utilization Among Black Cisgender Women: Protocol for a Mixed Methods Study
Background: HIV pre-exposure prophylaxis (PrEP) is a critical biomedical strategy to prevent HIV transmission among cisgen...
The Association Between Physical Distancing Behaviors to Avoid COVID-19 and Health-Related Quality of Life in Immunocompromised and Nonimmunocompromised Individuals: Patient-Informed Protocol for the Observational, Cross-Sectional EAGLE Study
The Association Between Physical Distancing Behaviors to Avoid COVID-19 and Health-Related Quality of Life in Immunocompromised and Nonimmunocompromised Individuals: Patient-Informed Protocol for the Observational, Cross-Sectional EAGLE Study
Background: Immunocompromised individuals are known to respond inadequately to SARS-CoV-2 vaccines, placing them at high r...
Improving the Well-Being of People With Advanced Cancer and Their Family Caregivers: Protocol for an Effectiveness-Implementation Trial of a Dyadic Digital Health Intervention (FOCUSau)
Improving the Well-Being of People With Advanced Cancer and Their Family Caregivers: Protocol for an Effectiveness-Implementation Trial of a Dyadic Digital Health Intervention (FOCUSau)
Background: Advanced cancer significantly impacts patients’ and family caregivers’ quality of life. When patients and care...
Efficacy and Safety of Shi Cervical Rotational Manipulation in Patients With Atlantoaxial Joint Subluxation: Protocol for a Randomized Controlled Trial
Efficacy and Safety of Shi Cervical Rotational Manipulation in Patients With Atlantoaxial Joint Subluxation: Protocol for a Randomized Controlled Trial
Background: The clinical diagnosis of atlantoaxial joint subluxation (AJS) in traditional Chinese medicine (TCM) is charac...
Associations Between Stress, Health Behaviors, and Quality of Life in Young Couples During the Transition to Survivorship: Protocol for a Measurement Burst Study
Associations Between Stress, Health Behaviors, and Quality of Life in Young Couples During the Transition to Survivorship: Protocol for a Measurement Burst Study
Background: Cancer is a life-threatening, stressful event, particularly for young adults due to delays and disruptions in ...
Impact of Digital Interventions on the Treatment Burden of Patients With Chronic Conditions: Protocol for a Systematic Review
Impact of Digital Interventions on the Treatment Burden of Patients With Chronic Conditions: Protocol for a Systematic Review
Background: There is great potential for delivering cost-effective, quality health care for patients with chronic conditio...
Testing the Effectiveness of an Intervention to Improve Romanian Teachers’ LGBT+-Related Attitudes, Cognitions, Behaviors, and Affect: Protocol for a Randomized Controlled Trial
Testing the Effectiveness of an Intervention to Improve Romanian Teachers’ LGBT+-Related Attitudes, Cognitions, Behaviors, and Affect: Protocol for a Randomized Controlled Trial
Background: Repeated stigmatization due to group membership constitutes a recurrent stressor with negative impact on physi...
Leveraging AI and Machine Learning to Develop and Evaluate a Contextualized User-Friendly Cough Audio Classifier for Detecting Respiratory Diseases: Protocol for a Diagnostic Study in Rural Tanzania
Leveraging AI and Machine Learning to Develop and Evaluate a Contextualized User-Friendly Cough Audio Classifier for Detecting Respiratory Diseases: Protocol for a Diagnostic Study in Rural Tanzania
Background: Respiratory diseases, including active tuberculosis (TB), asthma, and chronic obstructive pulmonary disease (C...
The Conceptualization and Measurement of Research Impact in Primary Health Care: Protocol for a Rapid Scoping Review
The Conceptualization and Measurement of Research Impact in Primary Health Care: Protocol for a Rapid Scoping Review
Background: The generation of research evidence and knowledge in primary health care (PHC) is crucial for informing the de...
Exploring the Pathways of Diabetes Foot Complications Treatment and Investigating Experiences From Frontline Health Care Professionals: Protocol for a Mixed Methods Study
Exploring the Pathways of Diabetes Foot Complications Treatment and Investigating Experiences From Frontline Health Care Professionals: Protocol for a Mixed Methods Study
Background: Diabetes affects more than 4.3 million individuals in the United Kingdom, with 19% to 34% developing diabetes-...
Real-World Registry on the Pharmacotherapy of Multiple Myeloma and Associated Renal and Pulmonary Impairments in the Greater Gulf Region: Protocol for a Retrospective Real-World Data Study
Real-World Registry on the Pharmacotherapy of Multiple Myeloma and Associated Renal and Pulmonary Impairments in the Greater Gulf Region: Protocol for a Retrospective Real-World Data Study
Background: Multiple myeloma (MM) is the second-most common cancer among hematological malignancies. Patients with active ...
An Integrated mHealth App for Smoking Cessation in Black Smokers With HIV: Protocol for a Randomized Controlled Trial
An Integrated mHealth App for Smoking Cessation in Black Smokers With HIV: Protocol for a Randomized Controlled Trial
Background: Black adults who smoke and have HIV experience immense stressors (eg, racial discrimination and HIV stigma) th...
Tobacco Smoking or Nicotine Phenotype and Severity of Clinical Presentation at the Emergency Department (SMOPHED): Protocol for a Noninterventional Observational Study
Tobacco Smoking or Nicotine Phenotype and Severity of Clinical Presentation at the Emergency Department (SMOPHED): Protocol for a Noninterventional Observational Study
Background: In the last few years, several nicotine products have become available as alternatives to smoking tobacco. Whi...
Investigating Rhythmicity in App Usage to Predict Depressive Symptoms: Protocol for Personalized Framework Development and Validation Through a Countrywide Study
Investigating Rhythmicity in App Usage to Predict Depressive Symptoms: Protocol for Personalized Framework Development and Validation Through a Countrywide Study
Background: Understanding a student’s depressive symptoms could facilitate significantly more precise diagnosis and treatm...
Treatments for Trauma-Induced Coagulopathy: Protocol for a Systematic Review and Meta-Analysis
Treatments for Trauma-Induced Coagulopathy: Protocol for a Systematic Review and Meta-Analysis
Background: Trauma-induced coagulopathy (TIC) is a common and potentially life-threatening coagulopathy as a result of tra...
Economic Burden of Mosquito-Borne Diseases in Low- and Middle-Income Countries: Protocol for a Systematic Review
Economic Burden of Mosquito-Borne Diseases in Low- and Middle-Income Countries: Protocol for a Systematic Review
Background: Globally, among all the vector-borne diseases, mosquito-borne diseases are responsible for a substantial numbe...
AI Conversational Agent to Improve Varenicline Adherence: Protocol for a Mixed Methods Feasibility Study
AI Conversational Agent to Improve Varenicline Adherence: Protocol for a Mixed Methods Feasibility Study
Background: Varenicline is a pharmacological intervention for tobacco dependence that is safe and effective in facilitatin...
Repetitive Transcranial Magnetic Stimulation With and Without Text4Support for the Treatment of Resistant Depression: Protocol for a Patient-Centered Multicenter Randomized Controlled Pilot Trial
Repetitive Transcranial Magnetic Stimulation With and Without Text4Support for the Treatment of Resistant Depression: Protocol for a Patient-Centered Multicenter Randomized Controlled Pilot Trial
Background: Treatment-resistant depression (TRD) is the inability of a patient with major depressive disorder (MDD) to acc...
Postpandemic Evaluation of the Eco-Efficiency of Personal Protective Equipment Against COVID-19 in Emergency Departments: Proposal for a Mixed Methods Study
Postpandemic Evaluation of the Eco-Efficiency of Personal Protective Equipment Against COVID-19 in Emergency Departments: Proposal for a Mixed Methods Study
Background: The COVID-19 pandemic has had a profound impact on emergency department (ED) care in Canada and around the wor...
Analgesic Effect of Intraoperative Intravenous S(+)-Ketamine During Total Knee Arthroplasty Surgery: Study Protocol for a Randomized Controlled Clinical Trial
Analgesic Effect of Intraoperative Intravenous S(+)-Ketamine During Total Knee Arthroplasty Surgery: Study Protocol for a Randomized Controlled Clinical Trial
Background: Total knee arthroplasty (TKA) is currently the main treatment for end-stage knee disease. The number of cases ...
Investigating the Impact of Automation on the Health Care Workforce Through Autonomous Telemedicine in the Cataract Pathway: Protocol for a Multicenter Study
Investigating the Impact of Automation on the Health Care Workforce Through Autonomous Telemedicine in the Cataract Pathway: Protocol for a Multicenter Study
Background: While digital health innovations are increasingly being adopted by health care organizations, implementation i...
Implications of Agile Values in Software Engineering for Agility in Breast Cancer Treatment: Protocol for a Comparative Study
Implications of Agile Values in Software Engineering for Agility in Breast Cancer Treatment: Protocol for a Comparative Study
Background: Breast cancer treatment has been described as a dynamic and patient-centered approach that emphasizes adaptabi...
A Neuro-Influence Experiment to Evaluate the Persuasiveness of Pre-Exposure Prophylaxis Promotion Messages Among Men Who Have Sex With Men: Protocol for a Randomized Controlled Trial
A Neuro-Influence Experiment to Evaluate the Persuasiveness of Pre-Exposure Prophylaxis Promotion Messages Among Men Who Have Sex With Men: Protocol for a Randomized Controlled Trial
Background: Pre-exposure prophylaxis (PrEP) is recommended by the US Centers for Disease Control and Prevention, but behav...
Phenotypic Environmental Sensitivity and Mental Health During Pregnancy and Post Partum: Protocol for the Experiences of Pregnancy Longitudinal Cohort Study
Phenotypic Environmental Sensitivity and Mental Health During Pregnancy and Post Partum: Protocol for the Experiences of Pregnancy Longitudinal Cohort Study
Background: Mental health problems during pregnancy and post partum are common and associated with negative short- and lon...
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