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Anticancer Activity of Holothuria Leucospilota-Derived Saponin on MNK45 Gastric Cancer Cell via Upregulation of CDH1 Hub Gene
Background: The treatment of gastric cancer (GC) is still quite challenging. Yet, marine invertebrates have been found to ...
Deciphering the Genetic Alterations in PIK3CA Gene Interacting Network and Their Putative Association with Breast Cancer: A Computational Approach
Background: Cancer is a polygenic complex disorder involving a network of genes. The phosphatidylinositol 3-kinase (PIK3CA...
The Implication of Chuang's Prognostic Scale in Metastatic Gastric Cancer
Background: Patients with metastatic gastric cancer (mGC) endure a significant symptom burden following subsequent lines o...
Importance of Nectin2, NUF2, and Nectin4 Gene Expression in the Pathogenesis of Different Subtypes of Breast Cancer
Background: The targeted therapy using breast cancer (BC)-associated biomarkers has significantly minimized the side effec...
The Impact of Glutamine Mouthwash on Preventing Mucositis Following Administration of High Doses of Methotrexate in Children with Acute Lymphoblastic Leukemia: A Randomized Clinical Trial
Background: Acute lymphoblastic leukemia (ALL) represents the predominant childhood cancer. High-dose methotrexate is inte...
Regorafenib versus Cetuximab plus Irinotecan in Third-line Metastatic Colorectal Cancer in Iran: A Model-based Cost-utility Analysis
Background: Metastatic colorectal cancer (mCRC) constitutes a significant health burden globally, accompanied by elevated ...
Prognostic Significance of TRPS1, GATA3, and CYP4Z1 Expression in Triple-Negative Breast Cancer Patients: An Immunohistochemical Study
Background: Triple-negative breast cancer (TNBC) is characterized by a poor prognosis. Consequently, the current research ...
Effectiveness of Tom and Jerry Cartoon in Reducing Anxiety in Cancer Patients Undergoing Chemotherapy: A Pilot Study
Background: Anxiety is a significant psychological challenge for patients newly diagnosed with cancer and scheduled for ch...
Uterine Sarcoma and Carcinosarcoma: A Two-Center Experience in Iran
Background: Uterine sarcomas (US) represent a rare and heterogeneous spectrum of tumors characterized by diverse clinical ...
Impact of Pretreatment Inflammatory Markers in Locally Advanced Head and Neck Cancer Treated with Concurrent Chemoradiotherapy
Background: Inflammation, when associated with cancer, has been shown to correlate with a worse prognosis. Neutrophil-lymp...
Lifetime Attributable Risk of Breast Cancer Incidence in Brain CT Scans
Background: The breast, being a highly radiosensitive organ, is exposed to scattered radiation during brain computed tomog...
Endometriosis-associated Ovarian Cancer, from Risk Factors to Survival Rate: A Systematic Review and Meta-Analysis
Background: Endometriosis experts recommend monitoring patients until menopause before considering surgery, with concerns ...
Investigating Post-treatment Breast Pain Severity in Breast Cancer Patients and Its Correlation with Serum Vitamin D and hs-CRP Levels
Background: Current data indicate that serum vitamin D and susceptible C-reactive protein (hs-CRP) levels, both indicative...
Triple-Negative Breast Cancer: Emerging Biomarkers for Early Diagnosis, Prognosis, and Treatment
Breast cancer (BC) is a heterogeneous disease characterized by significant global mortality and incidence rates. Annually,...
A Randomized, Double-Blinded, Placebo-Controlled Study on the Protective Effects of Curcumin against Chemoradiotherapy-Induced Enteritis
Background: Colorectal cancer ranks as the third most prevalent cancer type globally. In addition to surgery, chemotherapy...
The Clinical Utility of Biochemical Biomarkers in Colorectal Cancer
Colorectal cancer (CRC) ranks as the third most prevalent cancer worldwide and is a leading cause of cancer-related mortal...
GLUT1 Expression in Oral Squamous Cell Carcinoma and Its Significance
Background: GLUT1, a glucose transport protein, exhibits heightened expression in malignant cells, leading to increased gl...
A Mimicry of the Tumor Microenvironment's Impact on SLC4A7 (NBCn1) and Caspase-3 Gene Expression in Breast Cancer, along with in Silico Traits of NBCn1
Background: This study investigates the relative expression of the Na+, HCO3- cotransport gene NBCn1, and caspase-3 within...
Cell-in-Cell Phenomena or Tumor-APCs? A Pathologist's Perspective
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Can Dietary Iron Bioavailability Influence Colorectal Cancer Risk and Prognosis?
Colorectal cancer (CRC) stands apart from other malignancies due to its pronounced association with dietary patterns. Appr...
The Value of Serum Nestin in Monitoring the Effects of Surgery and Chemotherapy in Female Breast Cancer Patients: A Comparison with Serum CA15.3
Background: Traditional tumor markers such as cancer antigen 15.3 (CA15.3) and carcinoembryonic antigen (CEA) exhibit limi...
Molecular Characterization and Metastatic Gene Signatures Based on Targeted Cancer Treatment Modalities
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Evaluation of the Interchangeability of Cone Beam Computed Tomography and Catalyst for Patient Positioning in Radiotherapy for Head and Neck Cancer Patients
Background: This study aims to evaluate the interchangeability between cone beam computed tomography (CBCT) and the optica...
An Ensemble Deep Learning Model for the Detection and Classification of Breast Cancer
Background: Detecting breast cancer in its early stages remains a significant challenge in the present context and is a le...
Disseminated Metastasis after Resection of Sacrococcygeal Teratoma with Mucinous Adenocarcinoma: A Case Report
Mature teratoma is a common tumor that can undergo malignant transformation, either in ovarian or extragonadal sites. Whil...
Primary Extraskeletal Ewing Sarcoma of the Pancreas - A Case Report
Extraskeletal Ewing sarcomas (EES) is a rare, aggressive malignancy that typically affects adolescents or young adults, pr...
Sipple Syndrome: From Diagnosis to Management - A Case Report
Multiple endocrine neoplasia (MEN) is a rare inherited disease caused by multiple complex mutations in the RET gene. It is...
Prognostic Significance of Notch-4, SATB-2, and Glutaminase-1 in Colorectal Adenocarcinoma
Background: Neurogenic Locus Notch Homology 4 (Notch-4) is crucial in maintaining stem cells. Special AT-rich sequence-bin...
Vitamin D Serum Levels in Oral Lichen Planus and Oral Cancer Patients
Background: This study aimed to evaluate serum vitamin D levels in patients with oral lichen planus (OLP) and oral squamou...
Evaluation of Fis-1 and miR-484 Expression Levels in Tumor Tissue Samples and Healthy Tumor Margins in Lung Cancer
Background: MicroRNAs (miRNAs) regulate gene expression and various cellular activities. They also hold significant import...
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