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Genetic and environmental contributions to epigenetic aging across adolescence and young adulthood
Genetic and environmental contributions to epigenetic aging across adolescence and young adulthood
Epigenetic aging estimators commonly track chronological and biological aging, quantifying its accumulation (i.e., epigene...
Maternal asthma and newborn DNA methylation
Maternal asthma and newborn DNA methylation
Prenatal exposure to maternal asthma may influence DNA methylation patterns in offspring, potentially affecting their susc...
Associations of epigenetic aging with self-rated health, access to care, and healthcare utilization in a representative sample of United States adults
Associations of epigenetic aging with self-rated health, access to care, and healthcare utilization in a representative sample of United States adults
Health status is closely linked to both healthcare access and utilization. While previous research has identified associat...
Unveiling the impact of DNA-methylation age acceleration on mortality risk in diabetes and pre-diabetes: insights from the US NHANES program
Unveiling the impact of DNA-methylation age acceleration on mortality risk in diabetes and pre-diabetes: insights from the US NHANES program
Diabetes ranks as the ninth leading cause of death globally, and DNA-methylation age acceleration (DNAmAA) is closely link...
DNA hypermethylation of PLTP mediated by DNMT3B aggravates vascular dysfunction in diabetic retinopathy via the AKT/GSK3β signaling pathway
DNA hypermethylation of PLTP mediated by DNMT3B aggravates vascular dysfunction in diabetic retinopathy via the AKT/GSK3β signaling pathway
This study aims to elucidate the effect and mechanism of phospholipid transfer protein (PLTP) on vascular dysfunction in D...
Association analysis between an epigenetic alcohol risk score and blood pressure
Association analysis between an epigenetic alcohol risk score and blood pressure
Epigenome‐wide association studies have identified multiple DNA methylation sites (CpGs) associated with alcohol con...
A multi-trait epigenome-wide association study identified DNA methylation signature of inflammation among men with HIV
A multi-trait epigenome-wide association study identified DNA methylation signature of inflammation among men with HIV
Inflammation underlies many conditions causing excess morbidity and mortality among people with HIV (PWH). A handful of si...
Epigenetic signatures of asthma: a comprehensive study of DNA methylation and clinical markers
Epigenetic signatures of asthma: a comprehensive study of DNA methylation and clinical markers
Asthma, a complex respiratory disease, presents with inflammatory symptoms in the lungs, blood, and other tissues. We inve...
DNA methylation biomarker panels for differentiating various liver adenocarcinomas, including hepatocellular carcinoma, cholangiocarcinoma, colorectal liver metastases and pancreatic adenocarcinoma liver metastases
DNA methylation biomarker panels for differentiating various liver adenocarcinomas, including hepatocellular carcinoma, cholangiocarcinoma, colorectal liver metastases and pancreatic adenocarcinoma liver metastases
DNA methylation biomarkers are one of the most promising tools for the diagnosis and differentiation of adenocarcinomas of...
Integrative analysis based on ATAC-seq and RNA-seq reveals a novel oncogene PRPF3 in hepatocellular carcinoma
Integrative analysis based on ATAC-seq and RNA-seq reveals a novel oncogene PRPF3 in hepatocellular carcinoma
Assay of Transposase Accessible Chromatin Sequencing (ATAC-seq) is a high-throughput sequencing technique that detects ope...
The chromatin accessibility and transcriptomic landscape of the aging mice cochlea and the identification of potential functional super-enhancers in age-related hearing loss
The chromatin accessibility and transcriptomic landscape of the aging mice cochlea and the identification of potential functional super-enhancers in age-related hearing loss
Presbycusis, also referred to as age-related hearing loss (ARHL), is a condition that results from the cumulative effects ...
A systematic review on the contribution of DNA methylation to hearing loss
A systematic review on the contribution of DNA methylation to hearing loss
DNA methylation may have a regulatory role in monogenic sensorineural hearing loss and complex, polygenic phenotypic forms...
Diagnosis of pediatric central nervous system tumors using methylation profiling of cfDNA from cerebrospinal fluid
Diagnosis of pediatric central nervous system tumors using methylation profiling of cfDNA from cerebrospinal fluid
Pediatric central nervous system tumors remain challenging to diagnose. Imaging approaches do not provide sufficient detai...
DNA methylation profile of inflammatory breast cancer and its impact on prognosis and outcome
DNA methylation profile of inflammatory breast cancer and its impact on prognosis and outcome
Inflammatory breast cancer (IBC) is a rare disease characterized by rapid progression, early metastasis, and a high mortal...
Effects of improved on-farm crop storage on DNA methylation of mothers and their infants: evidence from a randomized controlled trial in Kenya
Effects of improved on-farm crop storage on DNA methylation of mothers and their infants: evidence from a randomized controlled trial in Kenya
Stress during pregnancy can lead to adverse maternal and infant health outcomes through epigenetic changes in the hypothal...
MAL expression downregulation through suppressive H3K27me3 marks at the promoter in HPV16-related cervical cancers is prognostically relevant and manifested by the interplay of novel MAL antisense long noncoding RNA AC103563.8, E7 oncoprotein and EZH2
MAL expression downregulation through suppressive H3K27me3 marks at the promoter in HPV16-related cervical cancers is prognostically relevant and manifested by the interplay of novel MAL antisense long noncoding RNA AC103563.8, E7 oncoprotein and EZH2
MAL (T-lymphocyte maturation-associated protein) is highly downregulated in most cancers, including cervical cancer (CaCx)...
Epigenetic age acceleration and risk of aortic valve stenosis: a bidirectional Mendelian randomization study
Epigenetic age acceleration and risk of aortic valve stenosis: a bidirectional Mendelian randomization study
Aortic valve stenosis (AVS) is the most prevalent cardiac valve lesion in developed countries, and pathogenesis is closely...
Identification of miR-20b-5p as an inhibitory regulator in cardiac differentiation via TET2 and DNA hydroxymethylation
Identification of miR-20b-5p as an inhibitory regulator in cardiac differentiation via TET2 and DNA hydroxymethylation
Congenital heart disease (CHD) is a prevalent congenital cardiac malformation, which lacks effective early biological diag...
Mother adversity and co-residence time impact mother–child similarity in genome-wide and gene-specific methylation profiles
Mother adversity and co-residence time impact mother–child similarity in genome-wide and gene-specific methylation profiles
The effects of adverse life events on physical and psychological health, with DNA methylation (DNAm) as a critical underly...
Epigenetics of the far northern Yakutian population
Epigenetics of the far northern Yakutian population
Yakuts are one of the indigenous populations of the subarctic and arctic territories of Siberia characterized by a contine...
DNA methylation profiles reveal sex-specific associations between gestational exposure to ambient air pollution and placenta cell-type composition in the PRISM cohort study
DNA methylation profiles reveal sex-specific associations between gestational exposure to ambient air pollution and placenta cell-type composition in the PRISM cohort study
Gestational exposure to ambient air pollution has been associated with adverse health outcomes for mothers and newborns. T...
Epigenetic age acceleration in surviving versus deceased COVID-19 patients with acute respiratory distress syndrome following hospitalization
Epigenetic age acceleration in surviving versus deceased COVID-19 patients with acute respiratory distress syndrome following hospitalization
Aging has been reported as a major risk factor for severe symptoms and higher mortality rates in COVID-19 patients. Molecu...
Long-term decitabine/retinoic acid maintenance treatment in an elderly sAML patient with high-risk genetics
Long-term decitabine/retinoic acid maintenance treatment in an elderly sAML patient with high-risk genetics
Elderly patients with AML ineligible for induction have a dismal prognosis; hence disease stabilization is a primary treat...
EZH2 K63-polyubiquitination affecting migration in extranodal natural killer/T-cell lymphoma
EZH2 K63-polyubiquitination affecting migration in extranodal natural killer/T-cell lymphoma
Overexpressed EZH2 is oncogenically involved in the pathogenesis of different cancerous contexts including extranodal natu...
Targeting oncogenic TERT promoter variants by allele-specific epigenome editing
Targeting oncogenic TERT promoter variants by allele-specific epigenome editing
Activation of dominant oncogenes by small or structural genomic alterations is a common driver mechanism in many cancers. ...
A 2-decade bibliometric analysis of epigenetics of cardiovascular disease: from past to present
A 2-decade bibliometric analysis of epigenetics of cardiovascular disease: from past to present
Cardiovascular disease (CVD) remains a major health killer worldwide, and the role of epigenetic regulation in CVD has bee...
Retraction Note: Dissecting the role of novel EZH2 inhibitors in primary glioblastoma cell cultures: effects on proliferation, epithelialmesenchymal transition, migration, and on the pro-inflammatory phenotype
Retraction Note: Dissecting the role of novel EZH2 inhibitors in primary glioblastoma cell cultures: effects on proliferation, epithelialmesenchymal transition, migration, and on the pro-inflammatory phenotype
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Upregulation of RSPO3 via targeted promoter DNA demethylation inhibits the progression of cholangiocarcinoma
Upregulation of RSPO3 via targeted promoter DNA demethylation inhibits the progression of cholangiocarcinoma
Cholangiocarcinoma (CCA) refers to a collection of malignant tumors that develop from the biliary epithelium. Extensive cl...
Tazemetostat decreases β-catenin and CD13 protein expression in HEPG-2 and Hepatitis B virus-transfected HEPG-2 with decreased cell viability
Tazemetostat decreases β-catenin and CD13 protein expression in HEPG-2 and Hepatitis B virus-transfected HEPG-2 with decreased cell viability
Hepatocellular carcinoma (HCC) is one of the global health concerns. Hepatitis B virus (HBV) is one of the major causes of...
DNA methylation sites in early adulthood characterised by pubertal timing and development: a twin study
DNA methylation sites in early adulthood characterised by pubertal timing and development: a twin study
Puberty is a highly heritable and variable trait, with environmental factors having a role in its eventual timing and deve...
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