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Looking Beyond the Surface: Olutasidenib and Ivosidenib for Treatment of mIDH1 Acute Myeloid Leukemia
Looking Beyond the Surface: Olutasidenib and Ivosidenib for Treatment of mIDH1 Acute Myeloid Leukemia
Mutations in isocitrate dehydrogenase-1 (IDH1) are recurrent in several malignancies and prevalent in acute myeloid leukem...
An Update on the Management of Rectal Neuroendocrine Neoplasms
An Update on the Management of Rectal Neuroendocrine Neoplasms
Rectal neuroendocrine neoplasms (NENs) are increasing in incidence. Most lesions are low grade, well-differentiated neuroe...
A Review of Current and Future Antibody Drug Conjugates in Breast Cancer
A Review of Current and Future Antibody Drug Conjugates in Breast Cancer
Antibody–drug conjugates (ADCs) are a novel class of anti-cancer agents that have changed the standard of care for p...
Molecular Secrets Revealed: How Diabetes may be Paving the Way for Leukemia
Molecular Secrets Revealed: How Diabetes may be Paving the Way for Leukemia
Type 2 Diabetes Mellitus (T2DM) and leukemia are two major global health concerns, both contributing significantly to morb...
“When Less is More”: Paradigm Shifts in Radiation Treatment for Early-Stage Breast Cancer
“When Less is More”: Paradigm Shifts in Radiation Treatment for Early-Stage Breast Cancer
Recent advancements in the treatment of early-stage breast cancer have significantly shifted the radiotherapy landscape. T...
Updates in Treatment of HER2-positive Metastatic Breast Cancer
Updates in Treatment of HER2-positive Metastatic Breast Cancer
The therapeutic landscape for HER2-positive metastatic breast cancer has exploded in the last two decades following the in...
From Subtypes to Solutions: Integrating CMS Classification with Precision Therapeutics in Colorectal Cancer
From Subtypes to Solutions: Integrating CMS Classification with Precision Therapeutics in Colorectal Cancer
The biological heterogeneity of colorectal cancer makes its molecular characteristics essential for therapeutic decision-m...
Unveiling the Potential of Cyclin-Dependent Kinases 4 and 6 Inhibitors Beyond Progression in Hormone Receptor Positive/Human Epidermal Growth Factor Negative Advanced Breast Cancer – A Clinical Review
Unveiling the Potential of Cyclin-Dependent Kinases 4 and 6 Inhibitors Beyond Progression in Hormone Receptor Positive/Human Epidermal Growth Factor Negative Advanced Breast Cancer – A Clinical Review
Cyclin-dependent kinases 4 and 6 inhibitors (CDK4/6i) have revolutionized the management of hormone receptor-positive (HR&...
New Therapeutic Targets in RAS Wild-type Pancreatic Cancer
New Therapeutic Targets in RAS Wild-type Pancreatic Cancer
The landscape of treatment of advanced PDAC is witnessing significant changes. This is in part due to the advent of molecu...
A Review on Integrating Breast Cancer Clinical Data: A Unified Platform Perspective
A Review on Integrating Breast Cancer Clinical Data: A Unified Platform Perspective
Integrating clinical datasets in breast cancer research emerges as a necessary tool for advancing our knowledge of the dis...
Modern Management of Gastric Neuroendocrine Neoplasms
Modern Management of Gastric Neuroendocrine Neoplasms
Gastric neuroendocrine neoplasms (G-NENs) are a heterogeneous group of tumors that broadly fall into two groups. The first...
Advancements in Melanoma Therapies: From Surgery to Immunotherapy
Advancements in Melanoma Therapies: From Surgery to Immunotherapy
Melanoma is defined as the most aggressive and deadly form of skin cancer. The treatment of melanoma depends on the&nb...
Precision Treatment of Anthracycline-Induced Cardiotoxicity: An Updated Review
Precision Treatment of Anthracycline-Induced Cardiotoxicity: An Updated Review
Anthracycline (ANT)-induced cardiotoxicity (AIC) is a particularly prominent form of cancer therapy-related cardiovascular...
Small Cell Lung Cancer—An Update on Chemotherapy Resistance
Small Cell Lung Cancer—An Update on Chemotherapy Resistance
Compared to other types of lung cancer, small cell lung cancer (SCLC) exhibits aggressive characteristics that promote dru...
Cardiovascular Considerations in Patients Undergoing Hematopoietic Cell Transplantation
Cardiovascular Considerations in Patients Undergoing Hematopoietic Cell Transplantation
Cardiac dysfunction is a serious adverse effect of cancer therapies that can interfere with quality of life and impact lon...
Recent Advances in Immunotherapy for Advanced Biliary Tract Cancer
Recent Advances in Immunotherapy for Advanced Biliary Tract Cancer
Biliary tract cancer (BTC) is a heterogeneous group of aggressive malignancies that arise from the epithelium of the bilia...
Opportunities and Challenges in Soft Tissue Sarcoma Risk Stratification in the Era of Personalised Medicine
Opportunities and Challenges in Soft Tissue Sarcoma Risk Stratification in the Era of Personalised Medicine
Soft tissue sarcomas (STS) are a rare and heterogeneous group of cancers. Treatment options have changed little in the pas...
Gastrointestinal Cancer Therapy and Cardiotoxicity
Gastrointestinal Cancer Therapy and Cardiotoxicity
Gastrointestinal cancers are a heterogenous group of cancers that share common risk factors with cardiovascular disease. T...
Management Approaches for High-Risk Cutaneous Squamous Cell Carcinoma with Perineural Invasion: An Updated Review
Management Approaches for High-Risk Cutaneous Squamous Cell Carcinoma with Perineural Invasion: An Updated Review
Cutaneous squamous cell carcinoma (cSCC) stands as the second most prevalent non-melanoma skin cancer worldwide, comprisin...
Current status of Complementary and Alternative Medicine Interventions in the Management of Pancreatic Cancer – An Overview
Current status of Complementary and Alternative Medicine Interventions in the Management of Pancreatic Cancer – An Overview
Pancreatic cancer (PC) remains the deadliest cancer worldwide. Most patients are diagnosed at the advanced or metastatic s...
Cardiovascular Adverse Events of Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia: Clinical Relevance, Impact on Outcome, Preventive Measures and Treatment Strategies
Cardiovascular Adverse Events of Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia: Clinical Relevance, Impact on Outcome, Preventive Measures and Treatment Strategies
The introduction of TKIs into the therapeutic armamentarium of CML has changed the disease paradigm, increasing long-term ...
The Quest for Circulating Biomarkers in Neuroendocrine Neoplasms: a Clinical Perspective
The Quest for Circulating Biomarkers in Neuroendocrine Neoplasms: a Clinical Perspective
Given the considerable heterogeneity in neuroendocrine neoplasms (NENs), it appears unlikely that a sole biomarker exists ...
Updates in Management of Malignant Pleural Mesothelioma
Updates in Management of Malignant Pleural Mesothelioma
Malignant pleural mesothelioma (MPM) is an aggressive asbestos-associated thoracic malignancy that is usually incurable. A...
The Evolving Treatment Landscape of Medullary Thyroid Cancer
The Evolving Treatment Landscape of Medullary Thyroid Cancer
Genetic assessment is crucial to address the correct treatment for advanced medullary thyroid cancer (MTC). Multi tyrosine...
Application of Engineered Dendritic Cell Vaccines in Cancer Immunotherapy: Challenges and Opportunities
Application of Engineered Dendritic Cell Vaccines in Cancer Immunotherapy: Challenges and Opportunities
The primary objective of this study is to evaluate the effectiveness of cancer vaccines containing genetically modified de...
Selecting Optimal First-Line Treatment for Microsatellite Stable and Non-Mutated RAS/BRAF Metastatic Colorectal Cancer
Selecting Optimal First-Line Treatment for Microsatellite Stable and Non-Mutated RAS/BRAF Metastatic Colorectal Cancer
Standard frontline treatment of metastatic colorectal cancer (CRC) is cytotoxic chemotherapy plus a biologic agent such as...
Anti-HER2 Drugs for the Treatment of Advanced HER2 Positive Breast Cancer
Anti-HER2 Drugs for the Treatment of Advanced HER2 Positive Breast Cancer
Approximately 15–20% of breast cancers (BC) demonstrate HER2 overexpression/gene amplification. Historically, before...
Update of Diagnosis and Targeted Therapy for ALK+ Inflammation Myofibroblastic Tumor
Update of Diagnosis and Targeted Therapy for ALK+ Inflammation Myofibroblastic Tumor
Inflammatory myofibroblastic tumor (IMT), characterized by intermediate malignancy and a propensity for recurrence, has pr...
Frontiers of Ovarian Carcinosarcoma
Frontiers of Ovarian Carcinosarcoma
Ovarian carcinosarcoma (OCS), also known as a malignant mixed Müllerian tumour (MMMT), is a rare and aggressive form ...
The Role of Liver Transplantation in the Treatment of Liver Metastases from Neuroendocrine Tumors
The Role of Liver Transplantation in the Treatment of Liver Metastases from Neuroendocrine Tumors
Transplant oncology is a new field of medicine referred to the use of solid organ transplantation, particularly the liver,...
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