Interventional Therapies to Treat Cancer Associated Pain

Cancer Pain [Internet]. International Association for the Study of Pain (IASP). [cited 2025 May 3]. Available from: https://www.iasp-pain.org/advocacy/global-year/cancer-pain/.

D'Souza RS, Saini C, Hussain N, Javed S, Prokop L, Her YF. Global estimates of prevalence of chronic painful neuropathy among patients with chemotherapy-induced peripheral neuropathy: systematic review and meta-analysis of data from 28 countries, 2000-24. Reg Anesth Pain Med. 2025:rapm-2024-106229. https://doi.org/10.1136/rapm-2024-106229.

Ferrell BR, Grant M, Borneman T, Juarez G, ter Veer A. Family caregiving in cancer pain management. J Palliat Med. 1999;2(2):185–95.

CAS  PubMed  Google Scholar 

Quinten C, Coens C, Mauer M, Comte S, Sprangers MAG, Cleeland C, et al. Baseline quality of life as a prognostic indicator of survival: a meta-analysis of individual patient data from EORTC clinical trials. Lancet Oncol. 2009;10(9):865–71.

PubMed  Google Scholar 

Hao D, Sidharthan S, Cotte J, Decker M, Salisu-Orhurhu M, Olatoye D, et al. Interventional therapies for pain in Cancer patients: a narrative review. Curr Pain Headache Rep. 2021;25(7):44.

PubMed  Google Scholar 

Makhlouf SM, Pini S, Ahmed S, Bennett MI. Managing pain in people with Cancer-a systematic review of the attitudes and knowledge of professionals, patients, caregivers and public. J Cancer Educ Off J Am Assoc Cancer Educ. 2020;35(2):214–40.

Google Scholar 

Plancarte R, Hernández Porras C. Interventional pain management in cancer patients. Postgrad Med. 2020;132(sup3):3–4.

PubMed  Google Scholar 

Hagedorn JM, Pittelkow TP, Hunt CL, D’Souza RS, Lamer TJ. Current perspectives on spinal cord stimulation for the treatment of Cancer pain. J Pain Res. 2020;13:3295–305.

PubMed  PubMed Central  Google Scholar 

Kelley GA, D'Souza RS. Narrative reviews in anesthesia and pain medicine: guidelines for producers, reviewers and consumers. Reg Anesth Pain Med. 2024:rapm-2024-105661. https://doi.org/10.1136/rapm-2024-105661.

Bonezzi C, Fornasari D, Cricelli C, Magni A, Ventriglia G. Not all pain is created equal: basic definitions and diagnostic Work-Up. Pain Ther. 2020;9(Suppl 1):1–15.

PubMed  PubMed Central  Google Scholar 

Davis MP. Cancer-Related neuropathic pain: review and selective topics. Hematol Oncol Clin North Am. 2018;32(3):417–31.

PubMed  Google Scholar 

Caraceni A, Shkodra M. Cancer pain assessment and classification. Cancers. 2019;11(4):510.

PubMed  PubMed Central  Google Scholar 

Portenoy RK, Ahmed E. Cancer pain syndromes. Hematol Oncol Clin North Am. 2018;32(3):371–86.

PubMed  Google Scholar 

D’Souza RS, Alvarez GAM, Dombovy-Johnson M, Eller J, Abd-Elsayed A. Evidence-Based treatment of pain in Chemotherapy-Induced peripheral neuropathy. Curr Pain Headache Rep. 2023;27(5):99–116.

PubMed  Google Scholar 

D’Souza RS, Her YF, Jin MY, Morsi M, Abd-Elsayed A. Neuromodulation therapy for Chemotherapy-Induced peripheral neuropathy: A systematic review. Biomedicines. 2022;10(8):1909.

PubMed  PubMed Central  Google Scholar 

Loukas M, Klaassen Z, Merbs W, Tubbs RS, Gielecki J, Zurada A. A review of the thoracic splanchnic nerves and Celiac ganglia. Clin Anat N Y N. 2010;23(5):512–22.

Google Scholar 

Beyaz F, Verhoeven RLJ, Hoogerwerf N, Mourisse JMJ, van der Heijden EHFM. Cone beam computed Tomography-Guided navigation bronchoscopy with augmented fluoroscopy for the diagnosis of peripheral pulmonary nodules: A Step-by-Step guide. Respir Int Rev Thorac Dis. 2025;104(3):216–28.

Google Scholar 

Puli SR, Reddy JBK, Bechtold ML, Antillon MR, Brugge WR. EUS-guided Celiac plexus neurolysis for pain due to chronic pancreatitis or pancreatic cancer pain: a meta-analysis and systematic review. Dig Dis Sci. 2009;54(11):2330–7.

PubMed  Google Scholar 

Polati E, Finco G, Gottin L, Bassi C, Pederzoli P, Ischia S. Prospective randomized double-blind trial of neurolytic coeliac plexus block in patients with pancreatic cancer. Br J Surg. 1998;85(2):199–201.

CAS  PubMed  Google Scholar 

Wong GY, Schroeder DR, Carns PE, Wilson JL, Martin DP, Kinney MO, et al. Effect of neurolytic Celiac plexus block on pain relief, quality of life, and survival in patients with unresectable pancreatic cancer: a randomized controlled trial. JAMA. 2004;291(9):1092–9.

CAS  PubMed  Google Scholar 

Amr YM, Makharita MY. Neurolytic sympathectomy in the management of cancer pain-time effect: a prospective, randomized multicenter study. J Pain Symptom Manage. 2014;48(5):944–e9562.

PubMed  Google Scholar 

Lavu H, Lengel HB, Sell NM, Baiocco JA, Kennedy EP, Yeo TP, et al. A prospective, randomized, double-blind, placebo controlled trial on the efficacy of ethanol Celiac plexus neurolysis in patients with operable pancreatic and periampullary adenocarcinoma. J Am Coll Surg. 2015;220(4):497–508.

PubMed  Google Scholar 

Dong D, Zhao M, Zhang J, Huang M, Wang Y, Qi L, et al. Neurolytic splanchnic nerve block and pain relief, survival, and quality of life in unresectable pancreatic cancer: A randomized controlled trial. Anesthesiology. 2021;135(4):686–98.

CAS  PubMed  Google Scholar 

Plancarte R, de Leon-Casasola OA, El-Helaly M, Allende S, Lema MJ. Neurolytic superior hypogastric plexus block for chronic pelvic pain associated with cancer. Reg Anesth. 1997;22(6):562–8.

CAS  PubMed  Google Scholar 

Mishra S, Bhatnagar S, Rana SPS, Khurana D, Thulkar S. Efficacy of the anterior ultrasound-guided superior hypogastric plexus neurolysis in pelvic cancer pain in advanced gynecological cancer patients. Pain Med Malden Mass. 2013;14(6):837–42.

Google Scholar 

Abdelghaffar NA, Farahat TE. Fluoroscopic anterior approach versus ultrasound guided superior hypogastric plexus neurolysis in cancer pelvic pain: a randomized controlled study. BMC Anesthesiol. 2022;22(1):403.

PubMed  PubMed Central  Google Scholar 

Hetta DF, Mohamed AA, Abdel Eman RM, Abd El Aal FA, Helal ME. Pulsed radiofrequency of the sacral roots improves the success rate of superior hypogastric plexus neurolysis in controlling pelvic and perineal Cancer pain. Pain Physician. 2020;23(2):149–57.

PubMed  Google Scholar 

Aman MM, Mahmoud A, Deer T, Sayed D, Hagedorn JM, Brogan SE, et al. The American society of pain and neuroscience (ASPN) best practices and guidelines for the interventional management of Cancer-Associated pain. J Pain Res. 2021;14:2139–64.

PubMed  PubMed Central  Google Scholar 

Sousa Correia J, Silva M, Castro C, Miranda L, Agrelo A. The efficacy of the ganglion impar block in perineal and pelvic cancer pain. Support Care Cancer Off J Multinatl Assoc Support Care Cancer. 2019;27(11):4327–30.

Google Scholar 

Ahmed DG, Mohamed MF, Mohamed SAE. Superior hypogastric plexus combined with ganglion impar neurolytic blocks for pelvic and/or perineal cancer pain relief. Pain Physician. 2015;18(1):E49–56.

PubMed  Google Scholar 

Waldman SD, Feldstein GS, Donohoe CD, Waldman KA. The relief of body wall pain secondary to malignant hepatic metastases by intercostal nerve block with bupivacaine and Methylprednisolone. J Pain Symptom Manage. 1988;3(1):39–43.

CAS  PubMed  Google Scholar 

Gulati A, Shah R, Puttanniah V, Hung JC, Malhotra V. A retrospective review and treatment paradigm of interventional therapies for patients suffering from intractable thoracic chest wall pain in the oncologic population. Pain Med Malden Mass. 2015;16(4):802–10.

Google Scholar 

Nasir KS, Hafeez H, Jamshed A, Hussain RT. Effectiveness of nerve blocks for the management of head and neck Cancer associated neuropathic pain disorders; a retrospective study. J Cancer Allied Spec. 2020;6(2):e367.

PubMed  PubMed Central  Google Scholar 

Melzack R, Wall PD. Pain mechanisms: a new theory. Science. 1965;150(3699):971–9.

CAS  PubMed  Google Scholar 

Crowther JE, Chen GH, Legler A, Gulati A. Spinal cord stimulation in the treatment of Cancer pain: A retrospective review. Neuromodulation J Int Neuromodulation Soc. 2022;25(5):693–9.

Google Scholar 

Yakovlev AE, Resch BE, Karasev SA. Treatment of cancer-related chest wall pain using spinal cord stimulation. Am J Hosp Palliat Care. 2010;27(8):552–6.

PubMed  Google Scholar 

Yakovlev AE, Resch BE. Spinal cord stimulation for cancer-related low back pain. Am J Hosp Palliat Care. 2012;29(2):93–7.

PubMed  Google Scholar 

Ege E, Briggi D, Mach S, Huh BK, Javed S. Dorsal root ganglion stimulation for chemotherapy-induced peripheral neuropathy. Pain Pract Off J World Inst Pain. 2023;23(7):793–9.

Google Scholar 

Strand N, D’Souza RS, Hagedorn JM, Pritzlaff S, Sayed D, Azeem N, et al. Evidence-Based clinical guidelines from the American society of pain and neuroscience for the use of implantable peripheral nerve stimulation in the treatment of chronic pain. J Pain Res. 2022;15:2483–504.

PubMed  PubMed Central  Google Scholar 

Mainkar O, Solla CA, Chen G, Legler A, Gulati A. Pilot study in temporary peripheral nerve stimulation in oncologic pain. Neuromodulation J Int Neuromodulation Soc. 2020;23(6):819–26.

Google Scholar 

Sudek EW, Mach S, Huh B, Javed S. Use of temporary percutaneous peripheral nerve stimulation in an oncologic population: A retrospective review. Neuromodulation J Int Neuromodulation Soc. 2024;27(1):118–25.

Google Scholar 

Smith TJ, Staats PS, Deer T, Stearns LJ, Rauck RL, Boortz-Marx RL, et al. Randomized clinical trial of an implantable drug delivery system compared with comprehensive medical management for refractory Cancer pain: impact on pain, drug-Related toxicity, and survival. J Clin Oncol. 2002;20(19):4040–9.

CAS  PubMed  Google Scholar 

Rosenthal D, Callstrom MR. Critical review and state of the Art in interventional oncology: benign and metastatic disease involving bone. Radiology. 2012;262(3):765–80.

PubMed  Google Scholar 

Papalexis N, Parmeggiani A, Peta G, Spinnato P, Miceli M, Facchini G. Minimally invasive interventional procedures for metastatic bone disease: A comprehensive review. Curr Oncol. 2022;29(6):4155–77.

PubMed  PubMed Central  Google Scholar 

Vatansever D, Tekin I, Tuglu I, Erbuyun K, Ok G. A comparison of the neuroablative effects of conventional and pulsed radiofrequency techniques. Clin J Pain. 2008;24(8):717–24.

PubMed 

Comments (0)

No login
gif