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Beta cell extracellular vesicle PD-L1 as a novel regulator of CD8+ T cell activity and biomarker during the evolution of type 1 diabetes
Beta cell extracellular vesicle PD-L1 as a novel regulator of CD8+ T cell activity and biomarker during the evolution of type 1 diabetes
Surviving beta cells in type 1 diabetes respond to inflammation by upregulating programmed death-ligand 1 (PD-L1) to engag...
Simplified meal announcement study (SMASH) using hybrid closed-loop insulin delivery in youth and young adults with type 1 diabetes: a randomised controlled two-centre crossover trial
Simplified meal announcement study (SMASH) using hybrid closed-loop insulin delivery in youth and young adults with type 1 diabetes: a randomised controlled two-centre crossover trial
The majority of hybrid closed-loop systems still require carbohydrate counting (CC) but the evidence for its justification...
Increased risk of major adverse cardiovascular events in patients with deep and infected diabetes-related foot ulcers
Increased risk of major adverse cardiovascular events in patients with deep and infected diabetes-related foot ulcers
Diabetes-related foot ulceration (DFU) is associated with increased cardiovascular risk, but the mechanisms remain unclear...
The use of automated insulin delivery around physical activity and exercise in type 1 diabetes: a position statement of the European Association for the Study of Diabetes (EASD) and the International Society for Pediatric and Adolescent Diabetes (ISPAD)
The use of automated insulin delivery around physical activity and exercise in type 1 diabetes: a position statement of the European Association for the Study of Diabetes (EASD) and the International Society for Pediatric and Adolescent Diabetes (ISPAD)
Regular physical activity and exercise (PA) are cornerstones of diabetes care for individuals with type 1 diabetes. In rec...
Correction: Quantifying beta cell function in the preclinical stages of type 1 diabetes
Correction: Quantifying beta cell function in the preclinical stages of type 1 diabetes
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
A polygenic risk score derived from common variants of monogenic diabetes genes is associated with young-onset type 2 diabetes and cardiovascular–kidney complications
A polygenic risk score derived from common variants of monogenic diabetes genes is associated with young-onset type 2 diabetes and cardiovascular–kidney complications
Monogenic diabetes is caused by rare mutations in genes usually implicated in beta cell biology. Common variants of monoge...
The metabolic and circadian signatures of gestational diabetes in the postpartum period characterised using multiple wearable devices
The metabolic and circadian signatures of gestational diabetes in the postpartum period characterised using multiple wearable devices
Gestational diabetes mellitus (GDM) affects 14% of all pregnancies worldwide and is associated with cardiometabolic risk. ...
Evidence on the effectiveness and equity of population-based policies to reduce the burden of type 2 diabetes: a narrative review
Evidence on the effectiveness and equity of population-based policies to reduce the burden of type 2 diabetes: a narrative review
There is increasing evidence for the effectiveness of population-based policies to reduce the burden of type 2 diabetes. Y...
Diabetes knowledge and behaviour: a cross-sectional study of Jordanian adults
Diabetes knowledge and behaviour: a cross-sectional study of Jordanian adults
Diabetes mellitus is a significant global health concern that is projected to affect 7.7% of the global population by 2030...
NT-proBNP improves prediction of cardiorenal complications in type 2 diabetes: the Hong Kong Diabetes Biobank
NT-proBNP improves prediction of cardiorenal complications in type 2 diabetes: the Hong Kong Diabetes Biobank
N-terminal pro B-type natriuretic peptide (NT-proBNP) is a natriuretic peptide that is strongly associated with congestive...
A whole-food, plant-based intensive lifestyle intervention improves glycaemic control and reduces medications in individuals with type 2 diabetes: a randomised controlled trial
A whole-food, plant-based intensive lifestyle intervention improves glycaemic control and reduces medications in individuals with type 2 diabetes: a randomised controlled trial
We conducted the largest and longest clinical trial comparing a whole-food, plant-based intervention with standard medical...
Postprandial hypoglycaemia after gastric bypass in type 2 diabetes: pathophysiological mechanisms and clinical implications
Postprandial hypoglycaemia after gastric bypass in type 2 diabetes: pathophysiological mechanisms and clinical implications
Postprandial hypoglycaemia (PPHG) is a frequent late complication of Roux-en-Y gastric bypass (RYGB) in people without dia...
Inhibition of CD226 co-stimulation suppresses diabetes development in the NOD mouse by augmenting regulatory T cells and diminishing effector T cell function
Inhibition of CD226 co-stimulation suppresses diabetes development in the NOD mouse by augmenting regulatory T cells and diminishing effector T cell function
Immunotherapeutics targeting T cells are crucial for inhibiting autoimmune disease progression proximal to disease onset i...
Prediabetes is associated with elevated risk of clinical outcomes even without progression to diabetes
Prediabetes is associated with elevated risk of clinical outcomes even without progression to diabetes
Prediabetes (HbA1c 39–47 mmol/mol [5.7–6.4%] or fasting glucose 5.6–6.9 mmol/l) is associated with eleva...
Autoimmune diseases and the risk and prognosis of latent autoimmune diabetes in adults
Autoimmune diseases and the risk and prognosis of latent autoimmune diabetes in adults
The aim of this study was to clarify the impact of autoimmune disease (AD) comorbidity on the risk and prognosis of latent...
Determinants of plasma levels of proglucagon and the metabolic impact of glucagon receptor signalling: a UK Biobank study
Determinants of plasma levels of proglucagon and the metabolic impact of glucagon receptor signalling: a UK Biobank study
Glucagon and glucagon-like peptide-1 (GLP-1) are derived from the same precursor; proglucagon, and dual agonists of their ...
Differential CpG methylation at Nnat in the early establishment of beta cell heterogeneity
Differential CpG methylation at Nnat in the early establishment of beta cell heterogeneity
Beta cells within the pancreatic islet represent a heterogenous population wherein individual sub-groups of cells make dis...
Dysregulated 24 h melatonin secretion associated with intrinsically photosensitive retinal ganglion cell function in diabetic retinopathy: a cross-sectional study
Dysregulated 24 h melatonin secretion associated with intrinsically photosensitive retinal ganglion cell function in diabetic retinopathy: a cross-sectional study
The aim of this study was to explore whether diabetic retinopathy is associated with alterations of the circadian system, ...
Incidence trend of type 2 diabetes from 2012 to 2021 in Germany: an analysis of health claims data of 11 million statutorily insured people
Incidence trend of type 2 diabetes from 2012 to 2021 in Germany: an analysis of health claims data of 11 million statutorily insured people
The aim of the study is to describe the time trend of type 2 diabetes incidence in the largest state of Germany, Bavaria, ...
No association between long-chain n-3 fatty acid intake during pregnancy and risk of type 1 diabetes in offspring in two large Scandinavian pregnancy cohorts
No association between long-chain n-3 fatty acid intake during pregnancy and risk of type 1 diabetes in offspring in two large Scandinavian pregnancy cohorts
The aim of this study was to investigate whether higher dietary intake of marine n-3 fatty acids during pregnancy is assoc...
Associations between daily step count classifications and continuous glucose monitoring metrics in adults with type 1 diabetes: analysis of the Type 1 Diabetes Exercise Initiative (T1DEXI) cohort
Associations between daily step count classifications and continuous glucose monitoring metrics in adults with type 1 diabetes: analysis of the Type 1 Diabetes Exercise Initiative (T1DEXI) cohort
Adults with type 1 diabetes should perform daily physical activity to help maintain health and fitness, but the influence ...
Circulating small extracellular vesicles mediate vascular hyperpermeability in diabetes
Circulating small extracellular vesicles mediate vascular hyperpermeability in diabetes
A hallmark chronic complication of type 2 diabetes mellitus is vascular hyperpermeability, which encompasses dysfunction o...
Metabolic effect of adrenaline infusion in people with type 1 diabetes and healthy individuals
Metabolic effect of adrenaline infusion in people with type 1 diabetes and healthy individuals
As a result of early loss of the glucagon response, adrenaline is the primary counter-regulatory hormone in type 1 diabete...
Transcutaneous vagal nerve stimulation for treating gastrointestinal symptoms in individuals with diabetes: a randomised, double-blind, sham-controlled, multicentre trial
Transcutaneous vagal nerve stimulation for treating gastrointestinal symptoms in individuals with diabetes: a randomised, double-blind, sham-controlled, multicentre trial
Diabetic gastroenteropathy frequently causes debilitating gastrointestinal symptoms. Previous uncontrolled studies have sh...
Relationship of device measured physical activity type and posture with cardiometabolic health markers: pooled dose–response associations from the Prospective Physical Activity, Sitting and Sleep Consortium
Relationship of device measured physical activity type and posture with cardiometabolic health markers: pooled dose–response associations from the Prospective Physical Activity, Sitting and Sleep Consortium
The aim of this study was to examine the dose–response associations of device-measured physical activity types and p...
Assisting the implementation of screening for type 1 diabetes by using artificial intelligence on publicly available data
Assisting the implementation of screening for type 1 diabetes by using artificial intelligence on publicly available data
The type 1 diabetes community is coalescing around the benefits and advantages of early screening for disease risk. To be ...
Hyperlipidaemia in diabetes: are there particular considerations for next-generation therapies?
Hyperlipidaemia in diabetes: are there particular considerations for next-generation therapies?
Dyslipidaemias are major cardiovascular risk factors, especially in people with diabetes. In this area, next-generation th...
Correction to: Pancreatic T cell protein–tyrosine phosphatase deficiency affects beta cell function in mice
Correction to: Pancreatic T cell protein–tyrosine phosphatase deficiency affects beta cell function in mice
Department of Nutrition, University of California Davis, 3135 Meyer Hall, Davis, CA, 95616, USAYannan Xi, Siming Liu, Ahme...
ADGRL1 is a glucose receptor involved in mediating energy and glucose homeostasis
ADGRL1 is a glucose receptor involved in mediating energy and glucose homeostasis
The brain is a major consumer of glucose as an energy source and regulates systemic glucose as well as energy balance. Alt...
A first-in-human, open-label Phase 1b and a randomised, double-blind Phase 2a clinical trial in recent-onset type 1 diabetes with AG019 as monotherapy and in combination with teplizumab
A first-in-human, open-label Phase 1b and a randomised, double-blind Phase 2a clinical trial in recent-onset type 1 diabetes with AG019 as monotherapy and in combination with teplizumab
We hypothesised that islet beta cell antigen presentation in the gut along with a tolerising cytokine would lead to antige...
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