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Macrophages support pancreatic development
Macrophages support pancreatic development
Engineering pancreatic tissue transplants to treat diabetes mellitus will require knowledge of how different cell types re...
Highlights from the Joint Irish–UK Endocrine Meeting 2024
This October, the first joint meeting between the Irish Endocrine Society (IES) and the British Society for Endocrinology ...
IL-17 has a role in whole-body homeostasis
IL-17 has a role in whole-body homeostasis
The immune system is known to have a circadian rhythm; however, how circadian rhythms might affect immune homeostasis and ...
Autologous stem-cell derived islets — the ultimate frontier in diabetes mellitus?
Autologous stem-cell derived islets — the ultimate frontier in diabetes mellitus?
A patient with longstanding type 1 diabetes mellitus has achieved insulin independence for at least 1 ye...
Growth hormone-releasing hormone and its analogues in health and disease
Growth hormone-releasing hormone and its analogues in health and disease
Growth hormone-releasing hormone (GHRH) and its ability to stimulate the production and release of growth hormone from the...
Expanding applications of therapies based on GLP1
Expanding applications of therapies based on GLP1
The evidence base in support of the use of medicines based on glucagon-like peptide 1 beyond glucose control and weight lo...
Leveraging research into sex differences and steroid hormones to improve brain health
Leveraging research into sex differences and steroid hormones to improve brain health
Sex differences, driven in part by steroid hormones, shape the structure and function of the brain throughout the lifespan...
Sex differences in skeletal muscle metabolism in exercise and type 2 diabetes mellitus
Sex differences in skeletal muscle metabolism in exercise and type 2 diabetes mellitus
This Review focuses on currently available literature describing sex differences in skeletal muscle metabolism in humans, ...
Graves disease: latest understanding of pathogenesis and treatment options
Graves disease: latest understanding of pathogenesis and treatment options
Graves disease is the most common cause of hyperthyroidism in iodine-sufficient areas. The main responsible mechanism is r...
The interactions between energy homeostasis and neurovascular plasticity
The interactions between energy homeostasis and neurovascular plasticity
Food intake and energy expenditure are sensed and processed by multiple brain centres to uphold energy homeostasis. Eviden...
Endocrine effects of heat exposure and relevance to climate change
Endocrine effects of heat exposure and relevance to climate change
Climate change is increasing both seasonal temperatures and the frequency and severity of heat extremes. As the endocrine ...
Tumour fibrosis in dopamine agonist-exposed prolactinomas is a diminishing concern
We applaud the Pituitary Society on the latest prolactinoma Consensus Statement (Petersenn, S. et al....
Sex differences in diabetic kidney disease explained
Sex differences in diabetic kidney disease explained
Diabetic kidney disease (DKD) is a common complication of diabetes mellitus and can lead to chronic kidney failure. Howeve...
The hypothalamic–pituitary–gonadal axis and the enigma of Alzheimer disease sex differences
The hypothalamic–pituitary–gonadal axis and the enigma of Alzheimer disease sex differences
Alzheimer disease has a sex bias: women are twice as likely as men to be affected. Studies have linked elevated follicle-s...
Reply to ‘Slowly progressive insulin dependent diabetes mellitus in type 1 diabetes endotype 2’
We are grateful to Tetsuro Kobayashi and Takashi Kadowaki for their correspondence on our Review (Red...
Slowly progressive insulin-dependent diabetes mellitus in type 1 diabetes endotype 2
We have read with great interest the Review by Maria J. Redondo and Noel G. Morgan (Redondo, M.J., Mo...
Endocrine and cellular physiology and pathology of the insulin-like growth factor acid-labile subunit
Endocrine and cellular physiology and pathology of the insulin-like growth factor acid-labile subunit
The acid-labile subunit (ALS) of the insulin-like growth factor (IGF) binding protein (IGFBP) complex, encoded in humans b...
Protein tyrosine phosphatase 1B in metabolic diseases and drug development
Protein tyrosine phosphatase 1B in metabolic diseases and drug development
Protein tyrosine phosphatase 1B (PTP1B), a non-transmembrane phosphatase, has a major role in a variety of signal...
Metformin acts through appetite-suppressing metabolite: Lac-Phe
Metformin acts through appetite-suppressing metabolite: Lac-Phe
Metformin is a first-line medication for type 2 diabetes mellitus (T2DM) that acts to reduce blood levels of glucose, food...
Type 1 diabetes mellitus: a brave new world
Type 1 diabetes mellitus: a brave new world
One hundred years after the Nobel prize was bestowed on Banting and McLeod for the ‘discovery’ of insulin, we ...
Highlights from SfE BES 2023
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Advances in incretin-based therapeutics for obesity
The year 2023 brought reports of highly effective glucagon-like peptide 1 (GLP1) mono-agonists or combinations with amylin...
Harnessing the inflammatory processes in endometriosis
The pathophysiology of endometriosis is underpinned by a complex interplay of inflammatory processes that are responsible ...
Endocrinology in the multi-omics era
Endocrinology in the multi-omics era
Over the past decade, technological advances have enabled cost-efficient, high-throughput analysis of different types of o...
Metabolic control of puberty: 60 years in the footsteps of Kennedy and Mitra’s seminal work
Metabolic control of puberty: 60 years in the footsteps of Kennedy and Mitra’s seminal work
An individual’s nutritional status has a powerful effect on sexual maturation. Puberty onset is delayed in response ...
Genomic alterations in thyroid cancer: biological and clinical insights
Genomic alterations in thyroid cancer: biological and clinical insights
Tumours can arise from thyroid follicular cells if they acquire driver mutations that constitutively activate the MAPK sig...
GIP regulates body weight via GABAergic neurons
GIP regulates body weight via GABAergic neurons
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β-cells protected from T1DM by early senescence programme
β-cells protected from T1DM by early senescence programme
Pancreatic β-cells undergo high levels of cellular stress in the early stages of type 1 diabetes mellitus (T1DM), includin...
SGLT inhibitors: a serendipitous glycaemic tale
Competing interests S.A. declares no competing interests. I.L. has received gran...
The metabolic mythos of ketones
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