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“Strumal Carcinoid”: A Well-Described but Unexplained Intratumoral Tumor
“Strumal Carcinoid”: A Well-Described but Unexplained Intratumoral Tumor
Rindi G, Klimstra DS, Abedi-Ardekani B, et al. (2018) A common classification framework for neuroendocrine neoplasms: an I...
The Clinicopathological Significance of Tumor Cell Subtyping in Appendiceal Neuroendocrine Tumors: A Series of 135 Tumors
The Clinicopathological Significance of Tumor Cell Subtyping in Appendiceal Neuroendocrine Tumors: A Series of 135 Tumors
Appendiceal neuroendocrine tumors (NETs) are common and often are identified as incidental lesions at the time of appendec...
Somatic Molecular Heterogeneity in Bilateral Macronodular Adrenocortical Disease (BMAD) Differs Among the Pathological Subgroups
Somatic Molecular Heterogeneity in Bilateral Macronodular Adrenocortical Disease (BMAD) Differs Among the Pathological Subgroups
Bilateral macronodular adrenocortical disease (BMAD) is an uncommon cause of Cushing’s syndrome leading to bilateral...
PD-L1 and B7-H3 are Effective Prognostic Factors and Potential Therapeutic Targets for High-Risk Thyroid Cancer
PD-L1 and B7-H3 are Effective Prognostic Factors and Potential Therapeutic Targets for High-Risk Thyroid Cancer
The prognosis of thyroid cancer in patients varies significantly based on different pathological types or distinct clinica...
Novel Drop-off PCR Assay for USP8 Hotspot Variant Detection in Corticotroph Tumors
Novel Drop-off PCR Assay for USP8 Hotspot Variant Detection in Corticotroph Tumors
Asa SL, Mete O, Perry A, Osamura RY. Overview of the 2022 WHO Classification of Pituitary Tumors. Endocr Pathol. 2022 Mar ...
Spindle Epithelial Tumor with Thymus-Like Elements (SETTLE)
Spindle Epithelial Tumor with Thymus-Like Elements (SETTLE)
Ethics Approval This is a retrospective study. For this typ...
Primary Secretory Carcinoma of the Thyroid Gland with ETV6::NTRK3 Gene Fusion
Primary Secretory Carcinoma of the Thyroid Gland with ETV6::NTRK3 Gene Fusion
Ethics Approval Retrospective study. For this type of study...
Co-existing Neuroendocrine Tumors in the Ileum and Pancreas: A Clinico-Pathological Challenge
Co-existing Neuroendocrine Tumors in the Ileum and Pancreas: A Clinico-Pathological Challenge
Ileal (I) and pancreatic (Pan) neuroendocrine tumors (NETs) are among the most common digestive neuroendocrine neoplasms (...
Isolated Tumor Cells Node Micro-metastasis in Early-Stage Small Intestinal Neuroendocrine Tumor
Isolated Tumor Cells Node Micro-metastasis in Early-Stage Small Intestinal Neuroendocrine Tumor
Ethics Approval and Consent to Participate This study did n...
Detection of RAS p.Q61R by Immunohistochemistry in Practice: A Clinicopathologic Study of 217 Thyroid Nodules with Molecular Correlates
Detection of RAS p.Q61R by Immunohistochemistry in Practice: A Clinicopathologic Study of 217 Thyroid Nodules with Molecular Correlates
RAS p.Q61R is the most prevalent hot-spot mutation in RAS and RAS-like mutated thyroid nodules. A few studies evaluated RA...
Granulation Patterns of Functional Corticotroph Tumors Correlate with Tumor Size, Proliferative Activity, T2 Intensity-to-White Matter Ratio, and Postsurgical Early Biochemical Remission
Granulation Patterns of Functional Corticotroph Tumors Correlate with Tumor Size, Proliferative Activity, T2 Intensity-to-White Matter Ratio, and Postsurgical Early Biochemical Remission
Unlike somatotroph tumors, the data on correlates of tumor granulation patterns in functional TPIT lineage pituitary neuro...
Transcriptomic Differences in Medullary Thyroid Carcinoma According to Grade
Transcriptomic Differences in Medullary Thyroid Carcinoma According to Grade
Medullary thyroid carcinoma (MTC) is a rare cancer derived from neuroendocrine C-cells of the thyroid. In contrast to othe...
High Fatty Acid-Binding Protein 4 Expression Associated with Favorable Clinical Characteristics and Prognosis in Papillary Thyroid Carcinoma
High Fatty Acid-Binding Protein 4 Expression Associated with Favorable Clinical Characteristics and Prognosis in Papillary Thyroid Carcinoma
Fatty acid-binding protein 4 (FABP4), a fatty acid transporter that coordinates lipid metabolism, is reported to exert a t...
RAS-Mutant Follicular Thyroid Tumors: A Continuous Challenge for Pathologists
RAS-Mutant Follicular Thyroid Tumors: A Continuous Challenge for Pathologists
The classification of thyroid nodules, particularly those with a follicular growth pattern, has significantly evolved. The...
Spatial Transcriptomics in a Case of Follicular Thyroid Carcinoma Reveals Clone-Specific Dysregulation of Genes Regulating Extracellular Matrix in the Invading Front
Spatial Transcriptomics in a Case of Follicular Thyroid Carcinoma Reveals Clone-Specific Dysregulation of Genes Regulating Extracellular Matrix in the Invading Front
Follicular thyroid carcinoma (FTC) is recognized by its ability to invade the tumor capsule and blood vessels, although th...
Pancreatic Neuroendocrine Microtumors (WHO 2022) Are Not Always Low-Grade Neoplasms: A Case with a Highly Increased Proliferation Rate
Pancreatic Neuroendocrine Microtumors (WHO 2022) Are Not Always Low-Grade Neoplasms: A Case with a Highly Increased Proliferation Rate
Traditionally considered non-functional low proliferative benign neuroendocrine proliferations measuring less than 5&n...
Hand2 Immunohistochemistry in the Diagnosis of Paragangliomas and Other Neuroendocrine Neoplasms
Hand2 Immunohistochemistry in the Diagnosis of Paragangliomas and Other Neuroendocrine Neoplasms
Hand2 is a core transcription factor responsible for chromaffin cell differentiation. However, its potential utility in su...
Thyroid Gland Blastomycosis
Thyroid Gland Blastomycosis
Ethics Approval and Consent to Participate Retrospective st...
Focal Tall Cell Change in Papillary Thyroid Carcinoma: Lessons Learned from Practices Adopting Rigid Criteria (Height to Width Ratio of 3)
Focal Tall Cell Change in Papillary Thyroid Carcinoma: Lessons Learned from Practices Adopting Rigid Criteria (Height to Width Ratio of 3)
Ethical Approval All patients consented to their procedure....
Not All Parafibromin Deficiency Relates to Parathyroid Carcinoma: The Role of Morphological Assessment
Not All Parafibromin Deficiency Relates to Parathyroid Carcinoma: The Role of Morphological Assessment
During gross examination, the weight was 1.1 g. The gland measured 20 × 15 × 7 mm and displayed a brownish cut surface. No...
Primary Multiglandular Parathyroid Disease in the Setting of Pompe Disease
Primary Multiglandular Parathyroid Disease in the Setting of Pompe Disease
Ethics Approval Retrospective study. For this type of study...
A Comprehensive Approach to the Thyroid Bethesda Category III (AUS) in the Transition Zone Between 2nd Edition and 3rd Edition of The Bethesda System for Reporting Thyroid Cytopathology: Subcategorization, Nuclear Scoring, and More
A Comprehensive Approach to the Thyroid Bethesda Category III (AUS) in the Transition Zone Between 2nd Edition and 3rd Edition of The Bethesda System for Reporting Thyroid Cytopathology: Subcategorization, Nuclear Scoring, and More
Significant interobserver variabilities exist for Bethesda category III: atypia of undetermined significance (AUS) of The ...
The Role of 5-Hydroxymethylcytosine as a Potential Epigenetic Biomarker in a Large Series of Thyroid Neoplasms
The Role of 5-Hydroxymethylcytosine as a Potential Epigenetic Biomarker in a Large Series of Thyroid Neoplasms
Cytosine modifications at the 5-carbon position play a critical role in gene expression regulation and have been implicate...
Uncommon Mimicker of a High-Grade Thyroid Carcinoma: Solitary Thyroid Metastasis of Gastrointestinal Stromal Tumor (GIST)
Uncommon Mimicker of a High-Grade Thyroid Carcinoma: Solitary Thyroid Metastasis of Gastrointestinal Stromal Tumor (GIST)
Ethics Approval Not required for this article. ...
Molecular Classification of Gastrointestinal and Pancreatic Neuroendocrine Neoplasms: Are We Ready for That?
Molecular Classification of Gastrointestinal and Pancreatic Neuroendocrine Neoplasms: Are We Ready for That?
In the last two decades, the increasing availability of technologies for molecular analyses has allowed an insight in the ...
Clinicopathologic Features and Cytologic Correlation of ALK-Rearranged Papillary Thyroid Carcinoma: A Series of Eight Cases
Clinicopathologic Features and Cytologic Correlation of ALK-Rearranged Papillary Thyroid Carcinoma: A Series of Eight Cases
Anaplastic lymphoma kinase (ALK) gene fusions are rare in papillary thyroid carcinoma (PTC) but may serve as a therapeutic...
Mixed Adenoma and Well-Differentiated Neuroendocrine Tumor (MANET) of the Middle Ear
Mixed Adenoma and Well-Differentiated Neuroendocrine Tumor (MANET) of the Middle Ear
MiNEN is a mixed epithelial neoplasm with combined neuroendocrine and non-neuroendocrine components. Each component is mor...
Clinical and Molecular Characteristics of Gonadotroph Pituitary Tumors According to the WHO Classification
Clinical and Molecular Characteristics of Gonadotroph Pituitary Tumors According to the WHO Classification
Since 2017, hormone-negative pituitary neuroendocrine tumors expressing the steroidogenic factor SF1 have been recognized ...
Artificial Intelligence Detected the Relationship Between Nuclear Morphological Features and Molecular Abnormalities of Papillary Thyroid Carcinoma
Artificial Intelligence Detected the Relationship Between Nuclear Morphological Features and Molecular Abnormalities of Papillary Thyroid Carcinoma
Papillary thyroid carcinoma (PTC) is the most common type of thyroid carcinoma and has characteristic nuclear features. Ge...
Morphometric Analysis of Lateral Cervical Lymph Node Metastasis in Papillary Thyroid Carcinoma Using Digital Pathology
Morphometric Analysis of Lateral Cervical Lymph Node Metastasis in Papillary Thyroid Carcinoma Using Digital Pathology
Digital pathology uses digitized images for cancer research. We aimed to assess morphometric parameters using digital path...
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